By Dr Francisco Cruz Naranjo

Journal articles

Cruz F; Silva J; Pinto R; Carvallho T; Coelho A; Avelino A; Dinis P, 2009, 'Re: Joao Silva, Rui Pinto, Tiago Carvallho, et al. Mechanisms of Prostate Atrophy after Glandular Botulinum Neurotoxin Type A Injection: An Experimental Study in the Rat. Eur Urol 2009; 56: 134-41 Reply', EUROPEAN UROLOGY, 56, pp. E28 - E29, http://dx.doi.org/10.1016/j.eururo.2009.07.034

Oliveira R; Silva A; Pinto R; Silva J; Silva C; Guimaraes M; Dinis P; Cruz F, 2009, 'Short-term assessment of a tension-free vaginal tape for treating female stress urinary incontinence', BJU INTERNATIONAL, 104, pp. 225 - 228, http://dx.doi.org/10.1111/j.1464-410X.2008.08330.x

Charrua A; Reguenga C; Paule CC; Nagye I; Cruz F; Avelino A, 2008, 'Cystitis is associated with TRPV1b-downregulation in rat dorsal root ganglia', NEUROREPORT, 19, pp. 1469 - 1472, http://dx.doi.org/10.1097/WNR.0b013e32830f1e73

Silva J; Silva C; Saraiva L; Silva A; Pinto R; Dinis P; Cruz F, 2008, 'Intraprostatic botulinum toxin type a injection in patients unfit for surgery presenting with refractory urinary retention and benign prostatic enlargement. Effect on prostate volume and micturition resumption', EUROPEAN UROLOGY, 53, pp. 153 - 159, http://dx.doi.org/10.1016/j.eururo.2007.08.050

Cruz CD; Charrua A; Vieira E; Valente J; Avelino A; Cruz F, 2008, 'Intrathecal delivery of resiniferatoxin (RTX) reduces detrusor overactivity and spinal expression of TRPV1 in spinal cord injured animals', EXPERIMENTAL NEUROLOGY, 214, pp. 301 - 308, http://dx.doi.org/10.1016/j.expneurol.2008.08.016

Dinis P; Cruz F, 2008, 'Intravesical Strategies to Manage the Neurogenic Bladder', CURRENT BLADDER DYSFUNCTION REPORTS, 3, pp. 133 - 139, http://dx.doi.org/10.1007/s11884-008-0021-8

Chapple C; Cruz F, 2008, 'The motion: Antimuscarinics are the mainstay of therapy for overactive bladder', EUROPEAN UROLOGY, 54, pp. 226 - 230, http://dx.doi.org/10.1016/j.eururo.2008.04.020

Baiou D; Santha P; Avelino A; Charrua A; Bacskai T; Matesz K; Cruz F; Nagy I, 2007, 'Neurochemical characterization of insulin receptor-expressing primary sensory neurons in wild-type and vanilloid type 1 transient receptor potential receptor knockout mice (vol 503, pg 334, 2007)', JOURNAL OF COMPARATIVE NEUROLOGY, 504, pp. 599 - 599, http://dx.doi.org/10.1002/cne.21456

Baiou D; Santha P; Avelino A; Charrua A; Bacskai T; Matesz K; Cruz F; Nagy I, 2007, 'Neurochemical characterization of insulin receptor-expressing primary sensory neurons in wild-type and vanilloid type 1 transient receptor potential receptor knockout mice', JOURNAL OF COMPARATIVE NEUROLOGY, 503, pp. 334 - 347, http://dx.doi.org/10.1002/cne.21389

Cruz F, 2007, 'Re:: Liu!L, Mansfield!KJ, Kristiana!I, et al.: 2007.: The molecular basis of urgency:: Regional difference of vanilloid receptor expression in the human urinary bladder.: Neurourol Urodynam 26:433-438', NEUROUROLOGY AND URODYNAMICS, 26, pp. 439 - 439, http://dx.doi.org/10.1002/nau.20419

Cruz CD; Ferreira D; Mcmahon SB; Cruz F, 2007, 'The activation of the ERK pathway contributes to the spinal c-fos expression observed after noxious bladder stimulation', SOMATOSENSORY AND MOTOR RESEARCH, 24, pp. 15 - 20, http://dx.doi.org/10.1080/08990220601143265

Cruz CD; Cruz F, 2007, 'The ERK 1 and 2 pathway in the nervous system: From basic aspects to possible clinical applications in pain and visceral dysfunction', CURRENT NEUROPHARMACOLOGY, 5, pp. 244 - 252, http://dx.doi.org/10.2174/157015907782793630

Charrua A; Cruz CD; Cruz F; Avelino A, 2007, 'Transient receptor potential vanilloid subfamily 1 is essential for the generation of noxious bladder input and bladder overactivity in cystitis', JOURNAL OF UROLOGY, 177, pp. 1537 - 1541, http://dx.doi.org/10.1016/j.juro.2006.11.046

Almazan A; Sierra L; Cruz F; Encalada I; Perez F; Leon SR; Ibarra C, 2006, 'Arthroscopic Transarticular Distal Clavicle Resection', TECHNIQUES IN SHOULDER AND ELBOW SURGERY, 7, pp. 206 - 209, http://dx.doi.org/10.1097/01.bte.0000235404.51976.2f

Dickson A; Avelino A; Cruz F; Ribeiro-Da-Silva A, 2006, 'Peptidergic sensory and parasympathetic fiber sprouting in the mucosa of the rat urinary bladder in a chronic model of cyclophosphamide-induced cystitis (vol 139, pg 671, 2006)', NEUROSCIENCE, 141, pp. 1631 - +, http://dx.doi.org/10.1016/j.neuroscience.2006.06.006

Cruz F; Silva C, 2006, 'Refractory neurogenic detrusor overactivity', INTERNATIONAL JOURNAL OF CLINICAL PRACTICE, 60, pp. 22 - 26, http://dx.doi.org/10.1111/j.1742-1241.2006.01182.x

Cruz CD; McMahon SB; Cruz F, 2006, 'Spinal ERK activation contributes to the regulation of bladder function in spinal cord injured rats', EXPERIMENTAL NEUROLOGY, 200, pp. 66 - 73, http://dx.doi.org/10.1016/j.expneurol.2006.01.016

Avelino A; Cruz F, 2006, 'TRPV1 (vanilloid receptor) in the urinary tract: expression, function and clinical applications', NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 373, pp. 287 - 299, http://dx.doi.org/10.1007/s00210-006-0073-2

Szallasi A; Cruz F; Geppetti P, 2006, 'TRPV1: a therapeutic target for novel analgesic drugs?', TRENDS IN MOLECULAR MEDICINE, 12, pp. 545 - 554, http://dx.doi.org/10.1016/j.molmed.2006.09.001

Cruz CD; Avelino A; McMahon SB; Cruz F, 2005, 'Increased spinal cord phosphorylation of extracellular signal-regulated kinases mediates micturition overactivity in rats with chronic bladder inflammation', EUROPEAN JOURNAL OF NEUROSCIENCE, 21, pp. 773 - 781, http://dx.doi.org/10.1111/j.1460-9568.2005.03893.x

Cruz CD; Neto FL; Castro-Lopes J; McMahon SB; Cruz F, 2005, 'Inhibition of ERK phosphorylation decreases nociceptive behaviour in monoarthritic rats', PAIN, 116, pp. 411 - 419, http://dx.doi.org/10.1016/j.pain.2005.05.031

Dinis P; Charrua A; Avelino A; Nagy I; Quintas J; Ribau U; Cruz F, 2005, 'The distribution of sensory fibers immunoreactive for the TRPV1 (capsaicin) receptor in the human prostate', EUROPEAN UROLOGY, 48, pp. 162 - 167, http://dx.doi.org/10.1016/j.eururo.2005.01.009

Silva C; Silva J; Ribeiro MJ; Avelino A; Cruz F, 2005, 'Urodynamic effect of intravesical resiniferatoxin in patients with neurogenic detrusor overactivity of spinal origin: Results of a double-blind randomized placebo-controlled trial', EUROPEAN UROLOGY, 48, pp. 650 - 655, http://dx.doi.org/10.1016/j.eururo.2005.04.012

Dinis P; Charrua A; Avelino A; Yaqoob M; Bevan S; Nagy I; Cruz F, 2004, 'Anandamide-evoked activation of vanilloid receptor 1 contributes to the development of bladder hyperreflexia and nociceptive transmission to spinal dorsal horn neurons in cystitis', JOURNAL OF NEUROSCIENCE, 24, pp. 11253 - 11263, http://dx.doi.org/10.1523/JNEUROSCI.2657-04.2004

Dinis P; Silva J; Ribeiro MJ; Avelino A; Reis M; Cruz F, 2004, 'Bladder C-fiber desensitization induces a long-lasting improvement of BPH-associated storage LUTS: A pilot study', EUROPEAN UROLOGY, 46, pp. 88 - 94, http://dx.doi.org/10.1016/j.eururo.2004.01.016

Cruz F; Silva C, 2004, 'Botulinum toxin in the management of lower urinary tract dysfunction: contemporary update', CURRENT OPINION IN UROLOGY, 14, pp. 329 - 334, http://dx.doi.org/10.1097/00042307-200411000-00006

Dinis P; Charrua A; Avelino A; Cruz F, 2004, 'Intravesical resiniferatoxin decreases spinal c-fos expression and increases bladder volume to reflex micturition in rats with chronic inflamed urinary bladders', BJU INTERNATIONAL, 94, pp. 153 - 157, http://dx.doi.org/10.1111/j.1464-4096.2004.04855.x

Sathianathan V; Avelino A; Charrua A; Santha P; Matesz K; Cruz F; Nagy I, 2003, 'Insulin induces cobalt uptake in a subpopulation of rat cultured primary sensory neurons', EUROPEAN JOURNAL OF NEUROSCIENCE, 18, pp. 2477 - 2486, http://dx.doi.org/10.1046/j.1460-9568.2003.03004.x

Avelino A; Cruz U; Cruz F, 2002, 'Nerve growth factor regulates galanin and c-jun coverexpression occurring in dorsal root ganglion cells after intravesical resiniferatoxin application', BRAIN RESEARCH, 951, pp. 264 - 269, http://dx.doi.org/10.1016/S0006-8993(02)03171-2

Silva C; Ribeiro MJ; Cruz F, 2002, 'The effect of intravesical resiniferatoxin in patients with idiopathic detrusor instability suggests that involuntary detrusor contractions are triggered by C-fiber input', JOURNAL OF UROLOGY, 168, pp. 575 - 579, http://dx.doi.org/10.1016/S0022-5347(05)64683-6

Avelino A; Cruz C; Nagy I; Cruz F, 2002, 'Vanilloid receptor 1 expression in the rat urinary tract', NEUROSCIENCE, 109, pp. 787 - 798, http://dx.doi.org/10.1016/S0306-4522(01)00496-1

Silva C; Avelino A; Souto-Moura C; Cruz F, 2001, 'A light- and electron-microscopic histopathological study of human bladder mucosa after intravesical resiniferatoxin application', BJU INTERNATIONAL, 88, pp. 355 - 360, http://dx.doi.org/10.1046/j.1464-410X.2001.02339.x

Naber KG; Bergman B; Bishop MC; Bjerklund-Johansen TE; Botto H; Lobel B; Cruz FJ; Selvaggi FP, 2001, 'EAU guidelines for the management of urinary and male genital tract infections - Urinary Tract Infection (UTI) Working Group of the Health Care Office (HCO) of the European Association of Urology (EAU)', EUROPEAN UROLOGY, 40, pp. 576 - 588, http://dx.doi.org/10.1159/000049840

Avelino A; Cruz F, 2000, 'Peptide immunoreactivity and ultrastructure of rat urinary bladder nerve fibers after topical desensitization by capsaicin or resiniferatoxin', AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL, 86, pp. 37 - 46, http://dx.doi.org/10.1016/S1566-0702(00)00204-6

Silva C; Rio ME; Cruz F, 2000, 'Desensitization of bladder sensory fibers by intravesical resiniferatoxin, a capsaicin analog: Long-term results for the treatment of detrusor hyperreflexia', EUROPEAN UROLOGY, 38, pp. 444 - 452, http://dx.doi.org/10.1159/000020322

Avelino A; Cruz F; Coimbra A, 1999, 'Intravesical resiniferatoxin desensitizes rat bladder sensory fibres without causing intense noxious excitation.: A c-fos study', EUROPEAN JOURNAL OF PHARMACOLOGY, 378, pp. 17 - 22, http://dx.doi.org/10.1016/S0014-2999(99)00451-3

Vendeira P; Guimaraes M; Silva C; Cruz F; Reis M, 1999, 'Extra-adrenal pheochromocytoma and renal cell carcinoma - An unusual case of tumour synchronism', SCANDINAVIAN JOURNAL OF UROLOGY AND NEPHROLOGY, 33, pp. 133 - 135

Avelino A; Cruz F; Coimbra A, 1998, 'Lidocaine prevents noxious excitation of bladder afferents induced by intravesical capsaicin without interfering with the ensuing sensory desensitization: An experimental study in the rat', JOURNAL OF UROLOGY, 159, pp. 567 - 570, http://dx.doi.org/10.1016/S0022-5347(01)63985-5

Avelino A; Cruz F; Coimbra A, 1997, 'Sites of renal pain processing in the rat spinal cord.: A c-fos study using a percutaneous method to perform ureteral obstruction', JOURNAL OF THE AUTONOMIC NERVOUS SYSTEM, 67, pp. 60 - 66, http://dx.doi.org/10.1016/S0165-1838(97)00105-7

Cruz F; Guimaraes M; Silva C; Reis M, 1997, 'Suppression of bladder hyperreflexia by intravesical resiniferatoxin', LANCET, 350, pp. 640 - 641, http://dx.doi.org/10.1016/S0140-6736(05)63330-2

Cruz F; Avelino A; Coimbra A, 1996, 'Desensitization follows excitation of bladder primary afferents by intravesical capsaicin, as shown by c-fos activation in the rat spinal cord', PAIN, 64, pp. 553 - 557, http://dx.doi.org/10.1016/0304-3959(95)00157-3

CRUZ F; AVELINO A; LIMA D; COIMBRA A, 1994, 'ACTIVATION OF THE C-FOS PROTOONCOGENE IN THE SPINAL-CORD FOLLOWING NOXIOUS-STIMULATION OF THE URINARY-BLADDER', SOMATOSENSORY AND MOTOR RESEARCH, 11, pp. 319 - 325, http://dx.doi.org/10.3109/08990229409028876

PIGNATELLI D; FALCAO H; COIMBRAPEIXOTO A; CRUZ F, 1994, 'UNILATERAL ADRENAL-HYPERPLASIA', SOUTHERN MEDICAL JOURNAL, 87, pp. 664 - 667, http://dx.doi.org/10.1097/00007611-199406000-00017

CRUZ F; LIMA D; COIMBRA A, 1993, 'PERITERMINAL SYNAPTIC ORGANIZATION OF PRIMARY AFFERENTS IN LAMINAE-I AND IIO OF THE RAT SPINAL-CORD, AS SHOWN AFTER ANTEROGRADE HRP LABELING', JOURNAL OF NEUROCYTOLOGY, 22, pp. 191 - 204, http://dx.doi.org/10.1007/BF01246358

MERIGHI A; CRUZ F; COIMBRA A, 1992, 'IMMUNOCYTOCHEMICAL STAINING OF NEUROPEPTIDES IN TERMINAL ARBORIZATION OF PRIMARY AFFERENT-FIBERS ANTEROGRADELY LABELED AND IDENTIFIED AT LIGHT AND ELECTRON-MICROSCOPIC LEVELS', JOURNAL OF NEUROSCIENCE METHODS, 42, pp. 105 - 113, http://dx.doi.org/10.1016/0165-0270(92)90140-9

CRUZ F; LIMA D; ZIEGLGANSBERGER W; COIMBRA A, 1991, 'FINE-STRUCTURE AND SYNAPTIC ARCHITECTURE OF HRP-LABELED PRIMARY AFFERENT TERMINATIONS IN LAMINA-III OF THE RAT DORSAL HORN', JOURNAL OF COMPARATIVE NEUROLOGY, 305, pp. 3 - 16, http://dx.doi.org/10.1002/cne.903050103

CRUZ F; LIMA D; COIMBRA A, 1987, 'SEVERAL MORPHOLOGICAL TYPES OF TERMINAL ARBORIZATIONS OF PRIMARY AFFERENTS IN LAMINAE I-II OF THE RAT SPINAL-CORD, AS SHOWN AFTER HRP LABELING AND GOLGI IMPREGNATION', JOURNAL OF COMPARATIVE NEUROLOGY, 261, pp. 221 - 236, http://dx.doi.org/10.1002/cne.902610205

LINDORO J; CASTRO JC; CRUZ F; MARQUES R, 1984, 'TREATMENT OF PRIAPISM', LANCET, 2, pp. 1348 - 1348

Botelho F; Pina F; Silva P; Figueiredo G; Cruz F; Lunet N, 'Vascular Endothelial Growth Factor (VEGF) and Prostate Pathology', INTERNATIONAL BRAZ J UROL, 36, pp. 430 - 437, http://dx.doi.org/10.1590/S1677-55382010000400006

Conference Papers

Meng Z; Althubyani M; Xie S; Razzak I; Sandoval EB; Bamdad M; Cruz F, 2026, 'PERCY: Personal Emotional Robotic Conversational System', in Lecture Notes in Computer Science, pp. 466 - 478, http://dx.doi.org/10.1007/978-981-95-4972-6_36

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