By Dr Francisco Cruz

Journal articles

Silva J; Pinto R; Carvallho T; Coelho A; Avelino A; Dinis P; Cruz F, 2009, 'Mechanisms of Prostate Atrophy after Glandular Botulinum Neurotoxin Type A Injection: An Experimental Study in the Rat', European Urology, 56, pp. 134 - 141, http://dx.doi.org/10.1016/j.eururo.2008.07.003

Ferreira SG; Lomaglio T; Avelino A; Cruz F; Oliveira CR; Cunha RA; Köfalvi A, 2009, 'N-acyldopamines control striatal input terminals via novel ligand-gated cation channels', Neuropharmacology, 56, pp. 676 - 683, http://dx.doi.org/10.1016/j.neuropharm.2008.12.001

Andersson K-E; Chapple CR; Cardozo L; Cruz F; Hashim H; Michel MC; Tannenbaum C; Wein AJ, 2009, 'Pharmacological treatment of overactive bladder: report from the International Consultation on Incontinence', Current Opinion in Urology, 19, pp. 380 - 394, http://dx.doi.org/10.1097/mou.0b013e32832ce8a4

Cruz F; Silva J; Pinto R; Carvallho T; Coelho A; Avelino A; Dinis P, 2009, 'Reply to Tomasz Drewa, Zbigniew Wolski and Janusz Tyloch's Letter to the Editor re: João Silva, Rui Pinto, Tiago Carvallho, et al. Mechanisms of Prostate Atrophy after Glandular Botulinum Neurotoxin Type A Injection: An Experimental Study in the Rat. Eur Urol 2009;56:134–41', European Urology, 56, pp. e28 - e29, http://dx.doi.org/10.1016/j.eururo.2009.07.034

Oliveira R; Silva A; Pinto R; Silva J; Silva C; Guimarães M; Dinis P; Cruz F, 2009, 'Short‐term assessment of a tension‐free vaginal tape for treating female stress urinary incontinence', BJU International, 104, pp. 225 - 228, http://dx.doi.org/10.1111/j.1464-410x.2008.08330.x

Charrua A; Reguenga C; Paule CC; Nagy I; Cruz F; Avelino A, 2008, 'Cystitis is associated with TRPV1b-downregulation in rat dorsal root ganglia', Neuroreport, 19, pp. 1469 - 1472, http://dx.doi.org/10.1097/wnr.0b013e32830f1e73

Silva J; Silva C; Saraiva L; Silva A; Pinto R; Dinis P; Cruz F, 2008, 'Intraprostatic Botulinum Toxin Type A Injection in Patients Unfit for Surgery Presenting with Refractory Urinary Retention and Benign Prostatic Enlargement. Effect on Prostate Volume and Micturition Resumption', European Urology, 53, pp. 153 - 159, http://dx.doi.org/10.1016/j.eururo.2007.08.050

Cruz CD; Charrua A; Vieira E; Valente J; Avelino A; Cruz F, 2008, 'Intrathecal delivery of resiniferatoxin (RTX) reduces detrusor overactivity and spinal expression of TRPV1 in spinal cord injured animals', Experimental Neurology, 214, pp. 301 - 308, http://dx.doi.org/10.1016/j.expneurol.2008.08.016

Dinis P; Cruz F, 2008, 'Intravesical strategies to manage the neurogenic bladder', Current Bladder Dysfunction Reports, 3, pp. 133, http://dx.doi.org/10.1007/s11884-008-0021-8

Chapple C; Cruz F; Chapple C; Cruz F, 2008, 'The Motion: Antimuscarinics are the Mainstay of Therapy for Overactive Bladder', European Urology, 54, pp. 226 - 230, http://dx.doi.org/10.1016/j.eururo.2008.04.020

, 2007, 'Neurochemical characterization of insulin receptor‐expressing primary sensory neurons in wild‐type and vanilloid type 1 transient receptor potential receptor knockout mice', The Journal of Comparative Neurology, 504, pp. 599 - 599, http://dx.doi.org/10.1002/cne.21456

Baiou D; Santha P; Avelino A; Charrua A; Bacskai T; Matesz K; Cruz F; Nagy I, 2007, 'Neurochemical characterization of insulin receptor‐expressing primary sensory neurons in wild‐type and vanilloid type 1 transient receptor potential receptor knockout mice', The Journal of Comparative Neurology, 503, pp. 334 - 347, http://dx.doi.org/10.1002/cne.21389

Cruz F, 2007, 'Re: Liu L, Mansfield KJ, Kristiana I, et al. 2007. The molecular basis of urgency: regional difference of vanilloid receptor expression in the human urinary bladder. Neurourol Urodynam 26:433–438', Neurourology and Urodynamics, 26, pp. 439 - 439, http://dx.doi.org/10.1002/nau.20419

Cruz CD; Ferreira D; Cruz CD; Ferreira D; Mcmahon SB; Cruz F, 2007, 'The activation of the ERK pathway contributes to the spinal c-fos expression observed after noxious bladder stimulation', Somatosensory & Motor Research, 24, pp. 15 - 20, http://dx.doi.org/10.1080/08990220601143265

Cruz CD; Cruz F, 2007, 'The ERK 1 and 2 Pathway in the Nervous System: From Basic Aspects to Possible Clinical Applications in Pain and Visceral Dysfunction', Current Neuropharmacology, 5, pp. 244 - 252, http://dx.doi.org/10.2174/157015907782793630

Charrua A; Cruz CD; Cruz F; Avelino A, 2007, 'Transient Receptor Potential Vanilloid Subfamily 1 is Essential for the Generation of Noxious Bladder Input and Bladder Overactivity in Cystitis', Journal of Urology, 177, pp. 1537 - 1541, http://dx.doi.org/10.1016/j.juro.2006.11.046

Almazan A; Sierra L; Cruz F; Encalada I; Perez F; Leon SR; Ibarra C, 2006, 'Arthroscopic Transarticular Distal Clavicle Resection', Techniques in Shoulder & Elbow Surgery, 7, pp. 206 - 209, http://dx.doi.org/10.1097/01.bte.0000235404.51976.2f

Dickson A; Avelino A; Cruz F; Ribeiro-da-Silva A, 2006, 'Erratum to “Peptidergic sensory and parasympathetic fiber sprouting in the mucosa of the rat urinary bladder in a chronic model of cyclophosphamide-induced cystitis” [Neuroscience 139 (2006) 671–685]', Neuroscience, 141, pp. 1631, http://dx.doi.org/10.1016/j.neuroscience.2006.06.006

CRUZ F; SILVA C, 2006, 'Refractory neurogenic detrusor overactivity', International Journal of Clinical Practice Supplement, 60, pp. 22 - 26, http://dx.doi.org/10.1111/j.1742-1241.2006.01182.x

Cruz CD; McMahon SB; Cruz F, 2006, 'Spinal ERK activation contributes to the regulation of bladder function in spinal cord injured rats', Experimental Neurology, 200, pp. 66 - 73, http://dx.doi.org/10.1016/j.expneurol.2006.01.016

Avelino A; Cruz F, 2006, 'TRPV1 (vanilloid receptor) in the urinary tract: expression, function and clinical applications', Naunyn-Schmiedeberg's Archives of Pharmacology, 373, pp. 287 - 299, http://dx.doi.org/10.1007/s00210-006-0073-2

Szallasi A; Cruz F; Geppetti P, 2006, 'TRPV1: a therapeutic target for novel analgesic drugs?', Trends in Molecular Medicine, 12, pp. 545 - 554, http://dx.doi.org/10.1016/j.molmed.2006.09.001

Cruz CD; Avelino A; McMahon SB; Cruz F, 2005, 'Increased spinal cord phosphorylation of extracellular signal‐regulated kinases mediates micturition overactivity in rats with chronic bladder inflammation', European Journal of Neuroscience, 21, pp. 773 - 781, http://dx.doi.org/10.1111/j.1460-9568.2005.03893.x

Cruz CD; Neto FL; CastroLopes J; McMahon SB; Cruz F, 2005, 'Inhibition of ERK phosphorylation decreases nociceptive behaviour in monoarthritic rats', Pain, 116, pp. 411 - 419, http://dx.doi.org/10.1016/j.pain.2005.05.031

Dinis P; Charrua A; Avelino A; Nagy I; Quintas J; Ribau U; Cruz F, 2005, 'The Distribution of Sensory Fibers Immunoreactive for the TRPV1 (Capsaicin) Receptor in the Human Prostate', European Urology, 48, pp. 162 - 167, http://dx.doi.org/10.1016/j.eururo.2005.01.009

Silva C; Silva J; Ribeiro M-J; Avelino A; Cruz F, 2005, 'Urodynamic Effect of Intravesical Resiniferatoxin in Patients with Neurogenic Detrusor Overactivity of Spinal Origin: Results of a Double-Blind Randomized Placebo-Controlled Trial', European Urology, 48, pp. 650 - 655, http://dx.doi.org/10.1016/j.eururo.2005.04.012

Dinis P; Charrua A; Avelino A; Yaqoob M; Bevan S; Nagy I; Cruz F, 2004, 'Anandamide-Evoked Activation of Vanilloid Receptor 1 Contributes to the Development of Bladder Hyperreflexia and Nociceptive Transmission to Spinal Dorsal Horn Neurons in Cystitis', Journal of Neuroscience, 24, pp. 11253 - 11263, http://dx.doi.org/10.1523/jneurosci.2657-04.2004

Dinis P; Silva J; Ribeiro MJ; Avelino A; Reis M; Cruz F, 2004, 'Bladder C-Fiber Desensitization Induces a Long-Lasting Improvement of BPH-Associated Storage LUTS: A Pilot Study', European Urology, 46, pp. 88 - 94, http://dx.doi.org/10.1016/j.eururo.2004.01.016

Cruz F; Silva C, 2004, 'Botulinum toxin in the management of lower urinary tract dysfunction: contemporary update', Current Opinion in Urology, 14, pp. 329 - 334, http://dx.doi.org/10.1097/00042307-200411000-00006

Dinis P; Charrua A; Avelino A; Cruz F, 2004, 'Intravesical resiniferatoxin decreases spinal c‐fos expression and increases bladder volume to reflex micturition in rats with chronic inflamed urinary bladders', BJU International, 94, pp. 153 - 157, http://dx.doi.org/10.1111/j.1464-4096.2004.04855.x

Sathianathan V; Avelino A; Charrua A; Santha P; Matesz K; Cruz F; Nagy I, 2003, 'Insulin induces cobalt uptake in a subpopulation of rat cultured primary sensory neurons', European Journal of Neuroscience, 18, pp. 2477 - 2486, http://dx.doi.org/10.1046/j.1460-9568.2003.03004.x

Avelino A; Cruz C; Cruz F, 2002, 'Nerve growth factor regulates galanin and c-jun overexpression occurring in dorsal root ganglion cells after intravesical resiniferatoxin application', Brain Research, 951, pp. 264 - 269, http://dx.doi.org/10.1016/s0006-8993(02)03171-2

Silva C; Ribeiro MJ; Cruz F, 2002, 'The Effect Of Intravesical Resiniferatoxin In Patients With Idiopathic Detrusor Instability Suggests That Involuntary Detrusor Contractions Are Triggered By C-Fiber Input', Journal of Urology, 168, pp. 575 - 579, http://dx.doi.org/10.1016/s0022-5347(05)64683-6

Avelino A; Cruz C; Nagy I; Cruz F, 2002, 'Vanilloid receptor 1 expression in the rat urinary tract', Neuroscience, 109, pp. 787 - 798, http://dx.doi.org/10.1016/s0306-4522(01)00496-1

Silva C; Avelino A; Souto‐Moura C; Cruz F, 2001, 'A light‐ and electron‐microscopic histopathological study of human bladder mucosa after intravesical resiniferatoxin application', BJU International, 88, pp. 355 - 360, http://dx.doi.org/10.1046/j.1464-410x.2001.02339.x

Naber KG; Bergman B; Bishop MC; Bjerklund-Johansen TE; Botto H; Lobel B; Cruz FJ; Selvaggi FP, 2001, 'EAU Guidelines for the Management of Urinary and Male Genital Tract Infections1', European Urology, 40, pp. 576 - 588, http://dx.doi.org/10.1159/000049840

Silva C; Rio M-E; Cruz F, 2000, 'Desensitization of Bladder Sensory Fibers by Intravesical Resiniferatoxin, a Capsaicin Analog: Long–Term Results for the Treatment of Detrusor Hyperreflexia', European Urology, 38, pp. 444 - 452, http://dx.doi.org/10.1159/000020322

Avelino A; Cruz F, 2000, 'Peptide immunoreactivity and ultrastructure of rat urinary bladder nerve fibers after topical desensitization by capsaicin or resiniferatoxin', Autonomic Neuroscience, 86, pp. 37 - 46, http://dx.doi.org/10.1016/s1566-0702(00)00204-6

Vendeira P; Guimaraes M; Silva C; Cruz F; Reis M, 1999, 'Extra-adrenal pheochromocytoma and renal cell carcinoma - An unusual case of tumour synchronism', SCANDINAVIAN JOURNAL OF UROLOGY AND NEPHROLOGY, 33, pp. 133 - 135

Avelino A; Cruz F; Coimbra A, 1999, 'Intravesical resiniferatoxin desensitizes rat bladder sensory fibres without causing intense noxious excitation. A c-fos study', European Journal of Pharmacology, 378, pp. 17 - 22, http://dx.doi.org/10.1016/s0014-2999(99)00451-3

Avelino A; Cruz F; Coimbra A, 1998, 'LIDOCAINE PREVENTS NOXIOUS EXCITATION OF BLADDER AFFERENTS INDUCED BY INTRAVESICAL CAPSAICIN WITHOUT INTERFERING WITH THE ENSUING SENSORY DESENSITIZATION: AN EXPERIMENTAL STUDY IN THE RAT', Journal of Urology, 159, pp. 567 - 570, http://dx.doi.org/10.1016/s0022-5347(01)63985-5

Avelino A; Cruz F; Coimbra A, 1997, 'Sites of renal pain processing in the rat spinal cord. A c-fos study using a percutaneous method to perform ureteral obstruction', Autonomic Neuroscience, 67, pp. 60 - 66, http://dx.doi.org/10.1016/s0165-1838(97)00105-7

Cruz F; Guimaràes M; Silva C; Reis M, 1997, 'Suppression of bladder hyperreflexia by intravesical resiniferatoxin', The Lancet, 350, pp. 640 - 641, http://dx.doi.org/10.1016/s0140-6736(05)63330-2

Cruz F; Avelino A; Coimbra A, 1996, 'Desensitization follows excitation of bladder primary afferents by intravesical capsaicin, as shown by c‐fos activation in the rat spinal cord', Pain, 64, pp. 553 - 557, http://dx.doi.org/10.1016/0304-3959(95)00157-3

Cruz F; Avelino A; Lima D; Coimbra A, 1994, 'Activation of the c-fos Proto-Oncogene in the Spinal Cord Following Noxious Stimulation of the Urinary Bladder', Somatosensory & Motor Research, 11, pp. 319 - 325, http://dx.doi.org/10.3109/08990229409028876

PIGNATELLI D; FALCÃO H; COIMBRA-PEIXOTO A; CRUZ F, 1994, 'Unilateral Adrenal Hyperplasia', Southern Medical Journal, 87, pp. 664 - 667, http://dx.doi.org/10.1097/00007611-199406000-00017

Cruz F; Lima D; Coimbra A, 1993, 'Periterminal synaptic organization of primary afferents in laminae I and IIo of the rat spinal cord, as shown after anterograde HRP labelling', Brain Cell Biology, 22, pp. 191 - 204, http://dx.doi.org/10.1007/bf01246358

Merighi A; Cruz F; Coimbra A, 1992, 'Immunocytochemical staining of neuropeptides in terminal arborization of primary afferent fibers anterogradely labeled and identified at light and electron microscopic levels', Journal of Neuroscience Methods, 42, pp. 105 - 113, http://dx.doi.org/10.1016/0165-0270(92)90140-9

Cruz F; Lima D; Zieglgänsberger W; Coimbra A, 1991, 'Fine structure and synaptic architecture of HRP‐labelled primary afferent terminations in lamina IIi of the rat dorsal horn', The Journal of Comparative Neurology, 305, pp. 3 - 16, http://dx.doi.org/10.1002/cne.903050103

Cruz F; Lima D; Coimbra A, 1987, 'Several morphological types of terminal arborizations of primary afferents in laminae I‐II of the rat spinal cord, as shown after HRP labeling and golgi impregnation', The Journal of Comparative Neurology, 261, pp. 221 - 236, http://dx.doi.org/10.1002/cne.902610205

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