Researcher

My Expertise

https://www.neuromodulab.org/

While our team has a broad interest in Systems Neuroscience, our studies aim to understand how learning is encoded in brain circuits, and how new behaviours that did not exist before imprint in neuronal circuits when they are generated, matured and adapted upon changes in environmental rules. We focus our studies on neuromodulatory systems (e.g. dopamine, acetylcholine, neuropeptides) supporting plasticity in subcortical brain networks (striatum, basal ganglia pathways), a central process for generating and modifying voluntary behaviours. We capitalise on animal learning theory, allowing us to design accurate behavioural paradigms that expose very specific forms of learning, and we deploy a series of quantitative fluorescence techniques as well as in vivo approaches to explore neuronal correspondence. Using mice as experimental model, the approach taken includes instrumental conditioning, AAV-based circuit- and cell-specific tracing and manipulation in behaving animals, in vivo photometry and computational analysis of behavioural and neuronal data. We are also interested in studying how these systems fail by modelling certain pathologies in mice such as age-associated motivational decline and behavioural control disorders.

Fields of Research (FoR)

Neurosciences, Animal Behaviour, Animal Physiology - Systems

Biography

Jan 2024 - Associate Professor, Director of the Australasian Course in Advanced Neuroscience (ACAN). Member of the Australasian Neuroscience Society Council and the ACAN Course Management Committee

Jan 2021 - Dec 2024: Australian Research Council Future Fellow, Head of Neuromodulatory Systems & Behaviour Team, Decision Neuroscience Laboratory (School of Psychology, The University of New South Wales, Australia).

Sept 2019 - : Senior Lecturer,...view more

Location

L4 Rm 404a F23 Mathews building

Map reference (Google map)

Contact

+61 2 9385 2388

Videos

Matamales et al. Neuron 90(2); 362-373. http://www.cell.com/neuron/fulltext/S0896-6273(16)00185-9