Select Publications
Journal articles
2014, 'RNAi-mediated stathmin suppression reduces lung metastasis in an orthotopic neuroblastoma mouse model', Oncogene, 33, pp. 882 - 890, http://dx.doi.org/10.1038/onc.2013.11
,2012, 'N-Myc Regulates Expression of the Detoxifying Enzyme Glutathione Transferase GSTP1, a Marker of Poor Outcome in Neuroblastoma', Cancer Research, 72, pp. 845 - 853, http://dx.doi.org/10.1158/0008-5472.CAN-11-1885
,2011, 'Structural basis for the inhibition of apoptosis by Epstein–Barr virus BHRF1', Acta Crystallographica Section A Foundations of Crystallography, 67, pp. C76 - C76, http://dx.doi.org/10.1107/s010876731109814x
,2011, 'ABCC Multidrug Transporters in Childhood Neuroblastoma: Clinical and Biological Effects Independent of Cytotoxic Drug Efflux', Journal of the National Cancer Institute, 103, pp. 1236 - 1251, http://dx.doi.org/10.1093/jnci/djr256
,2010, 'Structural basis for apoptosis inhibition by Epstein-Barr virus bhrf1', PLoS Pathogens, 6, http://dx.doi.org/10.1371/journal.ppat.1001236
,2010, 'ABC transporters in cancer: more than just drug efflux pumps', Nature Reviews Cancer, 10, pp. 147 - 156, http://dx.doi.org/10.1038/nrc2789
,2009, 'Discovery of Inhibitors of Lupin Diadenosine 5 ',5 '''-P-1,P-4-Tetraphosphate Hydrolase by Virtual Screening', BIOCHEMISTRY, 48, pp. 7614 - 7620, http://dx.doi.org/10.1021/bi900813x
,2008, 'Apoptosis is triggered when prosurvival Bcl-2 proteins cannot restrain Bax', Proceedings of the National Academy of Sciences of the United States of America, 105, pp. 18081 - 18087, http://dx.doi.org/10.1073/pnas.0808691105
,2008, 'Controlling the cell death mediators Bax and Bak - Puzzles and conundrums', CELL CYCLE, 7, pp. 39 - 44, http://dx.doi.org/10.4161/cc.7.1.5178
,2007, 'Programmed Anuclear Cell Death Delimits Platelet Life Span', Cell, 128, pp. 1173 - 1186, http://dx.doi.org/10.1016/j.cell.2007.01.037
,2007, 'Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak', SCIENCE, 315, pp. 856 - 859, http://dx.doi.org/10.1126/science.1133289
,2006, 'The Bcl-2 Protein Family Is Essential for Platelet Survival In Vivo.', Blood, 108, pp. 697 - 697, http://dx.doi.org/10.1182/blood.v108.11.697.697
,2006, 'BH3-only proteins: orchestrating cell death', CELL DEATH AND DIFFERENTIATION, 13, pp. 1268 - 1271, http://dx.doi.org/10.1038/sj.cdd.4401995
,2005, 'Proapoptotic Bak is sequestered by Mcl-1 and Bcl-x(L), but not Bcl-2, until displaced by BH3-only proteins', GENES & DEVELOPMENT, 19, pp. 1294 - 1305, http://dx.doi.org/10.1101/gad.1304105
,2005, 'Calcium-dependent plasma membrane binding and cell lysis by perforin are mediated through its C2 domain', JOURNAL OF BIOLOGICAL CHEMISTRY, 280, pp. 8426 - 8434, http://dx.doi.org/10.1074/jbc.M413303200
,2005, 'Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function', MOLECULAR CELL, 17, pp. 393 - 403, http://dx.doi.org/10.1016/j.molcel.2004.12.030
,2005, 'Letter to the Editor: H-1, C-13, and N-15 resonance assignments of the 17 kDa Ap4A hydrolase from Homo sapiens in the presence and absence of ATP', JOURNAL OF BIOMOLECULAR NMR, 31, pp. 181 - 182, http://dx.doi.org/10.1007/s10858-004-7440-4
,2005, 'Subversion of the Bcl-2 life/death switch in cancer development and therapy', Molecular Approaches to Controlling Cancer, 70, pp. 469 - 477, http://dx.doi.org/10.1101/sqb.2005.70.009
,2004, 'The alpha-M1 segment of the nicotinic acetylcholine receptor exhibits conformational flexibility in a membrane environment', BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 1665, pp. 40 - 47, http://dx.doi.org/10.1016/j.bbamem.2004.06.021
,2002, 'The structure of Ap(4)A hydrolase complexed with ATP-MgFx reveals the basis of substrate binding', STRUCTURE, 10, pp. 205 - 213, http://dx.doi.org/10.1016/S0969-2126(02)00696-2
,2001, 'Functional Significance of the β-Hairpin in the Insecticidal Neurotoxin ω-Atracotoxin-Hv1a', Journal of Biological Chemistry, 276, pp. 26568 - 26576, http://dx.doi.org/10.1074/jbc.M102199200
,1999, 'High-resolution solution structure of gurmarin, a sweet-taste- suppressing plant polypeptide', European Journal of Biochemistry, 264, pp. 525 - 533, http://dx.doi.org/10.1046/j.1432-1327.1999.00659.x
,1999, 'Structure-function studies of ω-atracotoxin, a potent antagonist of insect voltage-gated calcium channels', European Journal of Biochemistry, 264, pp. 488 - 494, http://dx.doi.org/10.1046/j.1432-1327.1999.00646.x
,1999, 'Solution structure of a defensin-like peptide from platypus venom', Biochemical Journal, 341, pp. 785 - 794, http://dx.doi.org/10.1042/0264-6021:3410785
,1999, 'Spider toxins: A new group of potassium channel modulators', Perspectives in Drug Discovery and Design, 15-16, pp. 61 - 69, http://dx.doi.org/10.1023/A:1017039418046
,1997, 'The structure of versutoxin (δ-atracotoxin-Hv1) provides insights into the binding of site 3 neurotoxins to the voltage-gated sodium channel', Structure, 5, pp. 1525 - 1535, http://dx.doi.org/10.1016/S0969-2126(97)00301-8
,1997, 'The structure of a novel insecticidal neurotoxin, atracotoxin-HVI, from the venom of an Australian funnel web spider', Nature Structural Biology, 4, pp. 559 - 566
,Conference Papers
2021, 'Analysis of DNA minimal residual disease markers in pediatric solid cancers using quantitative real time PCR and droplet digital PCR', in Analysis of DNA minimal residual disease markers in pediatric solid cancers using quantitative real time PCR and droplet digital PCR, American Association for Cancer Research (AACR), pp. 639 - 639, presented at AACR 2021, http://dx.doi.org/10.1158/1538-7445.AM2021-639
,2019, 'Abstract 3809: Modulation of MRP1 activity reverses chemotherapy resistance in adult cancer cells', in Cancer Research, American Association for Cancer Research (AACR), pp. 3809 - 3809, http://dx.doi.org/10.1158/1538-7445.am2019-3809
,2019, 'Modulation of MRP1 activity reverses chemotherapy resistance in adult cancer cells', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, GA, Atlanta, presented at Annual Meeting of the American-Association-for-Cancer-Research (AACR), GA, Atlanta, 29 March 2019 - 03 April 2019, http://dx.doi.org/10.1158/1538-7445.SABCS18-3809
,2017, 'ABCE1 regulates the translational profile of neuroblastoma to drive tumor progression', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, DC, Washington, presented at Annual Meeting of the American-Association-for-Cancer-Research (AACR), DC, Washington, 01 April 2017 - 05 April 2017, http://dx.doi.org/10.1158/1538-7445.AM2017-1956
,2017, 'Abstract 4056: A modulator of multidrug resistance protein 1 selectively depletes glutathione and synergizes with L-buthionine sulfoximine to sensitize MRP1-expressing cancer cells to chemotherapy', in Cancer Research, American Association for Cancer Research (AACR), DC, Washington, pp. 4056 - 4056, presented at Annual Meeting of the American-Association-for-Cancer-Research (AACR), DC, Washington, 01 April 2017 - 05 April 2017, http://dx.doi.org/10.1158/1538-7445.am2017-4056
,2016, 'Targeting PA2G4, a novel MYCN co-factor, for the treatment of neuroblastoma', in EUROPEAN JOURNAL OF CANCER, ELSEVIER SCI LTD, pp. S7 - S7, http://dx.doi.org/10.1016/S0959-8049(16)61016-X
,2015, 'High DKC1 expression supports neuroblastoma tumor cell proliferation and is strongly associated with poor patient outcomes', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, PA, Philadelphia, presented at 106th Annual Meeting of the American-Association-for-Cancer-Research (AACR), PA, Philadelphia, 18 April 2015 - 22 April 2015, http://dx.doi.org/10.1158/1538-7445.AM2015-488
,2015, 'PA2G4 predicts poor prognosis in neuroblastoma patients and promotes neuroblastoma progression by enhancing MYCN protein stability', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, PA, Philadelphia, presented at 106th Annual Meeting of the American-Association-for-Cancer-Research (AACR), PA, Philadelphia, 18 April 2015 - 22 April 2015, http://dx.doi.org/10.1158/1538-7445.AM2015-962
,2012, 'GSTP1 expression is regulated by MycN and is a marker of poor outcome in childhood neuroblastoma', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, http://dx.doi.org/10.1158/1538-7445.AM2012-789
,2012, 'Targeting ABC transporters in cancer through small molecule inhibitors', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, http://dx.doi.org/10.1158/1538-7445.AM2012-1834
,2011, 'ABCC/MRP multidrug transporters contribute to neuroblastoma biology, pathogenesis and clinical outcome, independently of any role in cytotoxic drug efflux', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, http://dx.doi.org/10.1158/1538-7445.AM2011-954
,Conference Abstracts
2023, 'Abstract 4670: True bench-to-bedside science: An international pilot study modeling hard-to-cure pediatric cancers to prioritize therapeutic intervention', in Cancer Research, American Association for Cancer Research (AACR), Vol. 83, pp. 4670 - 4670, http://dx.doi.org/10.1158/1538-7445.am2023-4670
,2022, 'THE CHILDHOOD BRAIN CANCER CELL LINE ATLAS: A RESOURCE FOR BIOMARKER IDENTIFICATION AND THERAPEUTIC DEVELOPMENT', in NEURO-ONCOLOGY, OXFORD UNIV PRESS INC, GERMANY, Hamburg, Vol. 24, pp. 172 - 172, presented at 20th International Symposium on Pediatric Neuro-Oncology (ISPNO) / Annual Meeting of the Brain-Tumor-Group-of-SIOP-Europe (SIOPE-BTG), GERMANY, Hamburg, 11 June 2022 - 15 June 2022
,2021, 'Using BET inhibitors to potentiate CAR T-cell therapy for neuroblastoma', in ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY, WILEY, Vol. 17, pp. 41 - 41, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000693805000074&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
,2020, 'Abstract A35: P-Glycoprotein is a resistance mechanism for conventional induction chemotherapy but not ALK inhibitors in high-risk neuroblastoma', in Cancer Research, American Association for Cancer Research (AACR), Vol. 80, pp. A35 - A35, http://dx.doi.org/10.1158/1538-7445.pedca19-a35
,2020, 'Abstract A52: Zero Childhood Cancer (ZERO): A comprehensive precision medicine platform for children with high-risk cancer', in Cancer Research, American Association for Cancer Research (AACR), Vol. 80, pp. A52 - A52, http://dx.doi.org/10.1158/1538-7445.pedca19-a52
,2019, 'Molecular targeted therapies and precision medicine for children with neuroblastoma and other refractory malignancies', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, CANADA, Montreal, Vol. 80, pp. 23 - 24, presented at AACR Special Conference on the Advances in Pediatric Cancer Research, CANADA, Montreal, 17 September 2019 - 20 September 2019, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000551367400013&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
,2019, 'P-Glycoprotein is a resistance mechanism for conventional induction chemotherapy but not ALK inhibitors in high-risk neuroblastoma', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, CANADA, Montreal, Vol. 80, pp. 61 - 61, presented at AACR Special Conference on the Advances in Pediatric Cancer Research, CANADA, Montreal, 17 September 2019 - 20 September 2019, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000551367400079&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
,2019, 'Zero Childhood Cancer (ZERO): A comprehensive precision medicine platform for children with highrisk cancer', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, CANADA, Montreal, Vol. 80, pp. 70 - 71, presented at AACR Special Conference on the Advances in Pediatric Cancer Research, CANADA, Montreal, 17 September 2019 - 20 September 2019, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000551367400096&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
,2019, 'Abstract 2884: Establishment of patient-derived xenograft models for high-risk neuroblastoma', in Tumor Biology, American Association for Cancer Research, pp. 2884 - 2884, presented at Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA, http://dx.doi.org/10.1158/1538-7445.sabcs18-2884
,2019, 'Abstract 4741: Re-evaluating the role of P-glycoprotein in the resistance of high-risk neuroblastoma to standard-of-care chemotherapies', in Cancer Research, American Association for Cancer Research (AACR), Vol. 79, pp. 4741 - 4741, http://dx.doi.org/10.1158/1538-7445.am2019-4741
,2019, 'Abstract 4824: Targeting CD30 as a novel treatment strategy inRANBP2-ALK-rearranged inflammatory myofibroblastic tumor', in Experimental and Molecular Therapeutics, American Association for Cancer Research, pp. 4824 - 4824, presented at Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA, http://dx.doi.org/10.1158/1538-7445.sabcs18-4824
,2019, 'Abstract 5209: Efficacious targeting of TERT oncogene rearrangement with BET bromodomain inhibitor and proteasome inhibitor combination therapy', in Molecular and Cellular Biology / Genetics, American Association for Cancer Research, pp. 5209 - 5209, presented at Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA, http://dx.doi.org/10.1158/1538-7445.sabcs18-5209
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