By Dr Jean Borges Bertoldo

Journal articles

Bertoldo JB; Müller S; Hüttelmaier S, 2023, 'RNA-binding proteins in cancer drug discovery', Drug Discovery Today, 28, http://dx.doi.org/10.1016/j.drudis.2023.103580

Pessatti TB; Terenzi H; Bertoldo JB, 2021, 'Protein modifications: From chemoselective probes to novel biocatalysts', Catalysts, 11, http://dx.doi.org/10.3390/catal11121466

Bell JL; Malyukova A; Bertoldo JB; Summers MK; Sun Y, 2021, 'Editorial: Ubiquitin-Modifying Enzymes as Drug Targets and Biomarkers in Cancer', Frontiers in Oncology, 11, pp. 758983, http://dx.doi.org/10.3389/fonc.2021.758983

Martínez DG; Hüttelmaier S; Bertoldo JB, 2020, 'Unveiling Druggable Pockets by Site-Specific Protein Modification: Beyond Antibody-Drug Conjugates', Frontiers in Chemistry, 8, http://dx.doi.org/10.3389/fchem.2020.586942

Müller S; Bley N; Busch B; Glaß M; Lederer M; Misiak C; Fuchs T; Wedler A; Haase J; Bertoldo JB; Michl P; Hüttelmaier S, 2020, 'The oncofetal RNA-binding protein IGF2BP1 is a druggable, post-transcriptional super-enhancer of E2F-driven gene expression in cancer', Nucleic Acids Research, 48, pp. 8576 - 8590, http://dx.doi.org/10.1093/nar/gkaa653

Lindstedt PR; Aprile FA; Matos MJ; Perni M; Bertoldo JB; Bernardim B; Peter Q; Jiménez-Osés G; Knowles TPJ; Dobson CM; Corzana F; Vendruscolo M; Bernardes GJL, 2019, 'Enhancement of the Anti-Aggregation Activity of a Molecular Chaperone Using a Rationally Designed Post-Translational Modification', ACS Central Science, 5, pp. 1417 - 1424, http://dx.doi.org/10.1021/acscentsci.9b00467

Bertoldo JB; Terenzi H; Hüttelmaier S; Bernardes GJL, 2018, 'Posttranslational Chemical Mutagenesis: To Reveal the Role of Noncatalytic Cysteine Residues in Pathogenic Bacterial Phosphatases', Biochemistry, 57, pp. 6144 - 6152, http://dx.doi.org/10.1021/acs.biochem.8b00639

Romagny S; Bouaouiche S; Lucchi G; Ducoroy P; Bertoldo JB; Terenzi H; Bettaieb A; Plenchette S, 2018, 'S-Nitrosylation of cIAP1 switches cancer cell fate from TNFa/TNFR1-Mediated cell survival to cell death', Cancer Research, 78, pp. 1948 - 1957, http://dx.doi.org/10.1158/0008-5472.CAN-17-2078

Matos MJ; Oliveira BL; Martínez-Sáez N; Guerreiro A; Cal PMSD; Bertoldo J; Maneiro M; Perkins E; Howard J; Deery MJ; Chalker JM; Corzana F; Jiménez-Osés G; Bernardes GJL, 2018, 'Chemo- and Regioselective Lysine Modification on Native Proteins', Journal of the American Chemical Society, 140, pp. 4004 - 4017, http://dx.doi.org/10.1021/jacs.7b12874

Bertoldo JB; Rodrigues T; Dunsmore L; Aprile FA; Marques MC; Rosado LA; Boutureira O; Steinbrecher TB; Sherman W; Corzana F; Terenzi H; Bernardes GJL, 2017, 'A Water-Bridged Cysteine-Cysteine Redox Regulation Mechanism in Bacterial Protein Tyrosine Phosphatases', Chem, 3, pp. 665 - 677, http://dx.doi.org/10.1016/j.chempr.2017.07.009

Bertoldo J, 2017, 'The Critical Role of Non-catalytic Cysteine Residues in Proteins', CHEM, 3, pp. 525 - 526, http://dx.doi.org/10.1016/j.chempr.2017.09.013

Cal PMSD; Sieglitz F; Santos FMF; Parente Carvalho C; Guerreiro A; Bertoldo JB; Pischel U; Gois PMP; Bernardes GJL, 2017, 'Site-selective installation of BASHY fluorescent dyes to Annexin V for targeted detection of apoptotic cells', Chemical Communications, 53, pp. 368 - 371, http://dx.doi.org/10.1039/c6cc08671c

Bertoldo JB; Terenzi H, 2016, 'Oxidation and Tyrosine Nitration Induce Structural Changes and Inhibits Plasmodium falciparum Falcipain-2 Activity In Vitro', Protein and Peptide Letters, 23, pp. 562 - 572, http://dx.doi.org/10.2174/0929866523666160411144635

Bertoldo JB; Chiaradia-Delatorre LD; Mascarello A; Leal PC; Cordeiro MNS; Nunes RJ; Sarduy ES; Rosenthal PJ; Terenzi H, 2015, 'Synthetic compounds from an in house library as inhibitors of falcipain-2 from Plasmodium falciparum', Journal of Enzyme Inhibition and Medicinal Chemistry, 30, pp. 299 - 307, http://dx.doi.org/10.3109/14756366.2014.920839

Lamotte O; Bertoldo JB; Besson-Bard A; Rosnoblet C; Aimé S; Hichami S; Terenzi H; Wendehenne D, 2015, 'Protein S-nitrosylation: specificity and identification strategies in plants', Frontiers in Chemistry, 2, http://dx.doi.org/10.3389/fchem.2014.00114

Astier J; Besson-Bard A; Lamotte O; Bertoldo J; Bourque S; Terenzi H; Wendehenne D, 2012, 'Nitric oxide inhibits the ATPase activity of the chaperone-like AAA + ATPase CDC48, a target for S-nitrosylation in cryptogein signalling in tobacco cells', Biochemical Journal, 447, pp. 249 - 260, http://dx.doi.org/10.1042/BJ20120257

Balsamo GM; Cangahuala-Inocente GC; Bertoldo JB; Terenzi H; Arisi ACM, 2011, 'Proteomic analysis of four Brazilian MON810 maize varieties and their four non-genetically-modified isogenic varieties', Journal of Agricultural and Food Chemistry, 59, pp. 11553 - 11559, http://dx.doi.org/10.1021/jf202635r

Bertoldo JB; Razzera G; Vernal J; Brod FCA; Arisi ACM; Terenzi H, 2011, 'Structural stability of Staphylococcus xylosus lipase is modulated by Zn²⁺ ions', Biochimica et Biophysica Acta - Proteins and Proteomics, 1814, pp. 1120 - 1126, http://dx.doi.org/10.1016/j.bbapap.2011.04.020

Kolling DJ; Bertoldo JB; Brod FCA; Vernal J; Terenzi H; Arisi ACM, 2010, 'Biochemical and structural characterization of two site-directed mutants of Staphylococcus xylosus lipase', Molecular Biotechnology, 46, pp. 168 - 175, http://dx.doi.org/10.1007/s12033-010-9282-5

Brod FCA; Vernal J; Bertoldo JB; Terenzi H; Arisi ACM, 2010, 'Cloning, expression, purification, and characterization of a novel esterase from lactobacillus plantarum', Molecular Biotechnology, 44, pp. 242 - 249, http://dx.doi.org/10.1007/s12033-009-9232-2

Brod FCA; Pelisser MR; Bertoldo JB; Vernal J; Bloch C; Terenzi H; Arisi ACM, 2010, 'Heterologous expression and purification of a heat-tolerant staphylococcus xylosus lipase', Molecular Biotechnology, 44, pp. 110 - 119, http://dx.doi.org/10.1007/s12033-009-9218-0

Matiollo C; Vernal J; Ecco G; Bertoldo JB; Razzera G; de Souza EM; Pedrosa FO; Terenzi H, 2009, 'A transthyretin-related protein is functionally expressed in Herbaspirillum seropedicae', Biochemical and Biophysical Research Communications, 387, pp. 712 - 716, http://dx.doi.org/10.1016/j.bbrc.2009.07.094

Bortolotto T; Bertoldo JB; Silveira FZD; Defaveri TM; Silvano J; Pich CT, 2009, 'Evaluation of the toxic and genotoxic potential of landfill leachates using bioassays', Environmental Toxicology and Pharmacology, 28, pp. 288 - 293, http://dx.doi.org/10.1016/j.etap.2009.05.007

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