By Dr John George Lock

Preprints

Allan KM; Zhang S; Wong SL; Capraro A; McCarron A; Skinner D; Kardia E; Zheng Y; Zhong L; Ng C-A; Bell JL; Farrow N; Umashankar B; Banks C; Herbert C; Kilian KA; Pandzic E; Vittorio O; Vandenberg JI; Lock JG; Jaffe A; Donnelley M; Parsons D; Woodworth BA; Cho D-Y; Waters SA, 2025, Gene-Corrected Basal Cells Restore CFTR In Vitro; Transplants Regenerate Epithelium in a Preclinical Sinus Model., http://dx.doi.org/10.1101/2025.07.21.666023

Latham SL; O’Donnell YEI; Girgis-Cook O; Clearwater MS; Bryce NS; Mok ETY; Lynn SA; Ni J; Alfred S; Leong KH; Quek L-E; Murphy KJ; Pantarelli C; Dragutinovic I; Naeini MM; Thiel C; Cadell A; Phimmachanh M; Sharma R; Millar E; Han JZR; Hastings JF; Köhler M; Brummer T; Young A; O’Toole S; Oakes SR; Hardeman E; Lock J; Kolch W; Taft MH; Nobis M; Goldstein L; Timpson P; Parker BL; Holst J; Gunning PW; Cox TR; Morris JC; Croucher DR, 2025, A selective inhibitor of oncogenic JNK signalling perturbs metastatic outgrowth of triple-negative breast cancer through metabolic blockade, http://dx.doi.org/10.1101/2025.04.16.649243

Kohane F; Johnstone C; Neumann D; Gunawan I; Huang T; Vafaee F; Chaffer C; Lock J, 2025, Epithelial–mesenchymal cell state heterogeneity predetermines differential phospho-signaling responses to EGF stimulation, http://dx.doi.org/10.1101/2025.07.05.658545

Gunawan I; Dey M; Neumann D; Kohane F; He Y; Meijering E; Lock J, 2025, Generative semantic multiplexing (SemaPlex) for accessible and scalable multiplexed fluorescence imaging, http://dx.doi.org/10.1101/2025.09.15.676186

Gunawan I; Marsh R; Aggarwal N; Meijering E; Cox S; Lock J; Culley S, 2025, Image quality metrics fail to accurately represent biological information in fluorescence microscopy, http://dx.doi.org/10.1101/2025.08.05.668508

Lock J; Gunawan I; Kohane F; Nguyen K; Zheng Y; Neumann D; Vafaee F; Meijering E, 2024, Seeing more with less: Extensible Immunofluorescence (ExIF) accessibly generates high-plexity datasets by integrating standard 4-plex imaging data, http://dx.doi.org/10.21203/rs.3.rs-4872456/v1

Krishnaswamy S; Tong A; Kuchroo M; Gupta S; Venkat A; Juan BS; Rangel L; Zhu B; Lock J; Chaffer C, 2023, Revealing dynamic temporal regulatory networks driving cancer cell state plasticity with neural ODE-based optimal transport, http://dx.doi.org/10.21203/rs.3.rs-3605296/v1

Sun X; Gupta S; Tong A; Tong A; Kuchroo M; Kuchroo M; Bhaskar D; Liu C; Venkat A; Juan BS; Rangel L; Rodriguez V; Lock J; Chaffer C; Krishnaswamy S, 2023, Revealing dynamic temporal trajectories and underlying regulatory networks with Cflows, http://dx.doi.org/10.1101/2023.03.28.534644

Khan T; Lock J; Ma Y; Harman D; Souza P; Chua W; Balakrishnar B; Scott KF; Becker TM, 2022, Choice of antibody is critical for specific and sensitive detection of androgen receptor splice variant-7 in circulating tumor cells, http://dx.doi.org/10.21203/rs.3.rs-1602818/v2

Khan T; Lock J; Ma Y; Harman D; Souza P; Chua W; Balakrishnar B; Scott KF; Becker TM, 2022, Choice of antibody is critical for specific and sensitive detection of androgen receptor splice variant-7 in circulating tumor cells, http://dx.doi.org/10.21203/rs.3.rs-1602818/v1

Poursani EM; Mercatelli D; Raninga P; Bell JL; Saletta F; Kohane FV; Zheng Y; Rouaen J; Jue TR; Michniewicz FT; Kasiou E; Tsoli M; Cirillo G; Waters S; Shai-Hee T; Valli E; Brettle M; Whan R; Vahadat L; Ziegler D; Lock JG; Giorgi FM; Khanna KK; Vittorio O, 2022, Copper chelation inhibits TGF-βpathways and suppresses epithelial-mesenchymal transition in cancer, http://dx.doi.org/10.1101/2022.10.03.510707

San Juan B; Hediyeh-Zadeh S; Rangel L; Milioli H; Rodriguez V; Bunkum A; Kohane F; Purcell C; Bhuva D; Kurumlian A; Castillo L; Lim E; Gill A; Ganju V; Dear R; O’Toole S; Vargas C; Hickey T; Goldstein L; Lock J; Davis M; Chaffer C, 2022, Targeting phenotypic plasticity prevents metastasis and the development of chemotherapy-resistant disease, http://dx.doi.org/10.1101/2022.03.21.22269988

Lock J; Jones M; Askari J; Gong X; Oddone A; Olofsson H; Göransson S; Lakadamyali M; Humphries M; Strömblad S, 2017, Reticular adhesions: A new class of adhesion complex that mediates cell-matrix attachment during mitosis, http://dx.doi.org/10.1101/234237

Other

Venkat A; Youlten SE; San Juan BP; Purcell CA; Gupta S; Amodio M; Neumann DP; Lock JG; Westacott AE; McCool CS; Burkhardt DB; Benz A; Mollbrink A; Lundeberg J; van Dijk D; Holst J; Goldstein LD; Kummerfeld S; Krishnaswamy S; Chaffer CL, 2025, Data from AAnet Resolves a Continuum of Spatially Localized Cell States to Unveil Intratumoral Heterogeneity, http://dx.doi.org/10.1158/2159-8290.c.8072557

Venkat A; Youlten SE; San Juan BP; Purcell CA; Gupta S; Amodio M; Neumann DP; Lock JG; Westacott AE; McCool CS; Burkhardt DB; Benz A; Mollbrink A; Lundeberg J; van Dijk D; Holst J; Goldstein LD; Kummerfeld S; Krishnaswamy S; Chaffer CL, 2025, Figures S1-9 from AAnet Resolves a Continuum of Spatially Localized Cell States to Unveil Intratumoral Heterogeneity, http://dx.doi.org/10.1158/2159-8290.30284386

Venkat A; Youlten SE; San Juan BP; Purcell CA; Gupta S; Amodio M; Neumann DP; Lock JG; Westacott AE; McCool CS; Burkhardt DB; Benz A; Mollbrink A; Lundeberg J; van Dijk D; Holst J; Goldstein LD; Kummerfeld S; Krishnaswamy S; Chaffer CL, 2025, Supplementary Table 1 from AAnet Resolves a Continuum of Spatially Localized Cell States to Unveil Intratumoral Heterogeneity, http://dx.doi.org/10.1158/2159-8290.30284383

Venkat A; Youlten SE; San Juan BP; Purcell CA; Gupta S; Amodio M; Neumann DP; Lock JG; Westacott AE; McCool CS; Burkhardt DB; Benz A; Mollbrink A; Lundeberg J; van Dijk D; Holst J; Goldstein LD; Kummerfeld S; Krishnaswamy S; Chaffer CL, 2025, Supplementary Table 2 from AAnet Resolves a Continuum of Spatially Localized Cell States to Unveil Intratumoral Heterogeneity, http://dx.doi.org/10.1158/2159-8290.30284380

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