By Dr Kurt Ward

Journal articles

Mok S; Yeo T; Hong D; Shears MJ; Ross LS; Ward KE; Dhingra SK; Kanai M; Bridgford JL; Tripathi AK; Mlambo G; Burkhard AY; Ansbro MR; Fairhurst KJ; Gil-Iturbe E; Park H; Rozenberg FD; Kim J; Mancia F; Fairhurst RM; Quick M; Uhlemann AC; Sinnis P; Fidock DA, 2023, 'Mapping the genomic landscape of multidrug resistance in Plasmodium falciparum and its impact on parasite fitness', Science Advances, 9, http://dx.doi.org/10.1126/SCIADV.ADI2364

Bennett JM; Ward KE; Muir RK; Kabeche S; Yoo E; Yeo T; Lam G; Zhang H; Almaliti J; Berger G; Faucher FF; Lin G; Gerwick WH; Yeh E; Fidock DA; Bogyo M, 2023, 'Covalent Macrocyclic Proteasome Inhibitors Mitigate Resistance in Plasmodium falciparum', ACS Infectious Diseases, 9, pp. 2036 - 2047, http://dx.doi.org/10.1021/acsinfecdis.3c00310

Deni I; Stokes BH; Ward KE; Fairhurst KJ; Pasaje CFA; Yeo T; Akbar S; Park H; Muir R; Bick DS; Zhan W; Zhang H; Liu YJ; Ng CL; Kirkman LA; Almaliti J; Gould AE; Duffey M; O'Donoghue AJ; Uhlemann AC; Niles JC; da Fonseca PCA; Gerwick WH; Lin G; Bogyo M; Fidock DA, 2023, 'Mitigating the risk of antimalarial resistance via covalent dual-subunit inhibition of the Plasmodium proteasome', Cell Chemical Biology, 30, pp. 470 - 485.e6, http://dx.doi.org/10.1016/j.chembiol.2023.03.002

Ward KE; Christensen P; Racklyeft A; Dhingra SK; Chua ACY; Remmert C; Suwanarusk R; Matheson J; Blackman MJ; Kaneko O; Kyle DE; Lee MCS; Moon RW; Snounou G; Renia L; Fidock DA; Russell B; Bifani P, 2023, 'Integrative Genetic Manipulation of Plasmodium cynomolgi Reveals Multidrug Resistance-1 Y976F Associated with Increased in Vitro Susceptibility to Mefloquine', Journal of Infectious Diseases, 227, pp. 1121 - 1126, http://dx.doi.org/10.1093/infdis/jiac469

Mihreteab S; Platon L; Berhane A; Stokes BH; Warsame M; Campagne P; Criscuolo A; Ma L; Petiot N; Doderer-Lang C; Legrand E; Ward KE; Zehaie Kassahun A; Ringwald P; Fidock DA; Ménard D, 2023, 'Increasing Prevalence of Artemisinin-Resistant HRP2-Negative Malaria in Eritrea.', New England Journal of Medicine, 389, pp. 1191 - 1202, http://dx.doi.org/10.1056/NEJMoa2210956

Ward KE; Fidock DA; Bridgford JL, 2022, 'Plasmodium falciparum resistance to artemisinin-based combination therapies', Current Opinion in Microbiology, 69, http://dx.doi.org/10.1016/j.mib.2022.102193

Christensen P; Racklyeft A; Ward KE; Matheson J; Suwanarusk R; Chua ACY; Kaneko O; Aung HL; Rénia L; Amanzougaghene N; Magneron V; Lemaitre J; Le Grand R; Kyle D; Bifani P; Cook GM; Snounou G; Russell B, 2022, 'Improving in vitro continuous cultivation of Plasmodium cynomolgi, a model for P. vivax', Parasitology International, 89, http://dx.doi.org/10.1016/j.parint.2022.102589

Stokes BH; Ward KE; Fidock DA, 2022, 'Evidence of Artemisinin-Resistant Malaria in Africa', New England Journal of Medicine, 386, pp. 1385 - 1386, http://dx.doi.org/10.1056/NEJMc2117480

Xie SC; Metcalfe RD; Mizutani H; Puhalovich T; Hanssen E; Morton CJ; Du Y; Dogovski C; Huang SC; Ciavarri J; Hales P; Griffin RJ; Cohen LH; Chuang BC; Wittlin S; Deni I; Yeo T; Ward KE; Barry DC; Liu B; Gillett DL; Crespo-Fernandez BF; Ottilie S; Mittal N; Churchyard A; Ferguson D; Aguiar ACC; Guido RVC; Baum J; Hanson KK; Winzeler EA; Gamo FJ; Fidock DA; Baud D; Parker MW; Brand S; Dick LR; Griffin MDW; Gould AE; Tilley L, 2021, 'Design of proteasome inhibitors with oral efficacy in vivo against Plasmodium falciparum and selectivity over the human proteasome', Proceedings of the National Academy of Sciences of the United States of America, 118, http://dx.doi.org/10.1073/pnas.2107213118

Stokes BH; Dhingra SK; Rubiano K; Mok S; Straimer J; Gnädig NF; Deni I; Schindler KA; Bath JR; Ward KE; Striepen J; Yeo T; Ross LS; Legrand E; Ariey F; Cunningham CH; Souleymane IM; Gansané A; Nzoumbou-Boko R; Ndayikunda C; Kabanywanyi AM; Uwimana A; Smith SJ; Kolley O; Ndounga M; Warsame M; Leang R; Nosten F; Anderson TJC; Rosenthal PJ; Ménard D; Fidock DA, 2021, 'Plasmodium falciparum k13 mutations in africa and asia impact artemisinin resistance and parasite fitness', eLife, 10, http://dx.doi.org/10.7554/eLife.66277

Harding CR; Sidik SM; Petrova B; Gnädig NF; Okombo J; Herneisen AL; Ward KE; Markus BM; Boydston EA; Fidock DA; Lourido S, 2020, 'Genetic screens reveal a central role for heme metabolism in artemisinin susceptibility', Nature Communications, 11, http://dx.doi.org/10.1038/s41467-020-18624-0

Preprints

Stokes BH; Rubiano K; Dhingra SK; Mok S; Straimer J; Gnädig NF; Bath JR; Deni I; Ward KE; Striepen J; Yeo T; Ross LS; Legrand E; Ariey F; Cunningham CH; Souleymane IM; Gansané A; Nzoumbou-Boko R; Ndayikunda C; Kabanywanyi AM; Uwimana A; Smith SJ; Kolley O; Ndounga M; Warsame M; Leang R; Nosten F; Anderson TJC; Rosenthal PJ; Ménard D; Fidock DA, 2021, P. falciparumK13 mutations present varying degrees of artemisinin resistance and reduced fitness in African parasites, http://dx.doi.org/10.1101/2021.01.27.428390

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