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Journal articles

Navas LE; Blanco-Alcaina E; Suarez-Martinez E; Verdugo-Sivianes EM; Espinosa-Sanchez A; Sanchez-Diaz L; Dominguez-Medina E; Fernandez-Rozadilla C; Carracedo A; Wu LE; Carnero A, 2023, 'NAD pool as an antitumor target against cancer stem cells in head and neck cancer', Journal of Experimental and Clinical Cancer Research, 42, http://dx.doi.org/10.1186/s13046-023-02631-2

Wu LE; Fiveash CE; Bentley NL; Kang MJ; Govindaraju H; Barbour JA; Wilkins BP; Hancock SE; Madawala R; Das A; Massudi H; Li C; Kim LJ; Wong ASA; Marinova MB; Sultani G; Das A; Youngson NA; Le Couteur DG; Sinclair DA; Turner N, 2023, 'SIRT2 transgenic over-expression does not impact lifespan in mice', Aging Cell, 22, http://dx.doi.org/10.1111/acel.14027

Kim LJ; Chalmers TJ; Madawala R; Smith GC; Li C; Das A; Poon EWK; Wang J; Tucker SP; Sinclair DA; Quek LE; Wu LE, 2023, 'Host–microbiome interactions in nicotinamide mononucleotide (NMN) deamidation', FEBS Letters, 597, pp. 2196 - 2220, http://dx.doi.org/10.1002/1873-3468.14698

Gilchrist R; Ho W-HJ; Marinova MB; Listijono DR; Bertoldo MJ; Richani D; Lynn-Jee K; Brown A; Riepsamen AH; Cabot S; Bustamante S; Zhong L; Selesniemi K; Wong D; Goss DM; Li C; Araki T; Livingston DJ; Turner N; Sinclair DA; Walters KA; Homer HA; Wu LE, 2023, '#389 : Fertility Preservation During Chemotherapy Treatment by NAD+ Repletion in Mice', Fertility & Reproduction, 05, pp. 518 - 518, http://dx.doi.org/10.1142/s2661318223742790

Aflatounian A; Paris VR; Richani D; Edwards MC; Cochran BJ; Ledger WL; Gilchrist RB; Bertoldo MJ; Wu LE; Walters KA, 2022, 'Declining muscle NAD+ in a hyperandrogenism PCOS mouse model: Possible role in metabolic dysregulation', Molecular Metabolism, 65, http://dx.doi.org/10.1016/j.molmet.2022.101583

Habibalahi A; Campbell JM; Bertoldo MJ; Mahbub SB; Goss DM; Ledger WL; Gilchrist RB; Wu LE; Goldys EM, 2022, 'Unique Deep Radiomic Signature Shows NMN Treatment Reverses Morphology of Oocytes from Aged Mice', Biomedicines, 10, http://dx.doi.org/10.3390/biomedicines10071544

Campbell JM; Mahbub SB; Bertoldo MJ; Habibalahi A; Goss DM; Ledger WL; Gilchrist RB; Wu LE; Goldys EM, 2022, 'Multispectral autofluorescence characteristics of reproductive aging in old and young mouse oocytes', Biogerontology, 23, pp. 237 - 249, http://dx.doi.org/10.1007/s10522-022-09957-y

HABIBALAHI A; BERTOLDO MJ; MAHBUB SB; CAMPBELL JM; GOSS DM; LEDGER WL; GILCHRIST RB; WU LE; GOLDYS EM, 2022, 'Assessment of Oocyte Quality Using Deep Radiomic Signature of Oocyte Morphology in the Mouse', Fertility & Reproduction, 04, pp. 135 - 135, http://dx.doi.org/10.1142/s2661318222740474

MARINOVA MB; HO W-HJ; BERTOLDO MJ; LOVRIC V; SELESNIEMI K; WALSH WR; SINCLAIR DA; WALTERS K; GILCHRIST RB; WU LE, 2022, 'NMN Supplementation Rescues Fertility and Bone Strength in Chemotherapy-Treated Mice', Fertility & Reproduction, 04, pp. 149 - 149, http://dx.doi.org/10.1142/s2661318222740619

Li C; Wu LE, 2021, 'Risks and rewards of targeting NAD+ homeostasis in the brain', Mechanisms of Ageing and Development, 198, http://dx.doi.org/10.1016/j.mad.2021.111545

Yu J; Laybutt DR; Kim LJ; Quek LE; Wu LE; Morris MJ; Youngson NA, 2021, 'Exercise-induced benefits on glucose handling in a model of diet-induced obesity are reduced by concurrent nicotinamide mononucleotide', American Journal of Physiology - Endocrinology and Metabolism, 321, pp. E176 - E189, http://dx.doi.org/10.1152/AJPENDO.00446.2020

Bertoldo MJ; Paris VR; Gook DA; Edwards MC; Wu K; Liang CJJ; Marinova MB; Wu LE; Walters KA; Gilchrist RB; Rodriguez Paris V, 2021, 'Impact of nicotinamide mononucleotide on transplanted mouse ovarian tissue', Reproduction, 161, pp. 215 - 226, http://dx.doi.org/10.1530/REP-20-0539

Capraro A; Wong S; Adhikari A; Allan K; Patel H; Zhong L; Raftery M; Jaffe A; Yeang M; Aggarwal A; Wu L; Pandzic E; Whan R; Turville S; Vittorio O; Bull R; Kaakoush N; Rawlinson W; Tedla N; Vafaee F; Waters S, 2021, 'Ageing impairs the airway epithelium defence response to SARS-CoV-2', , http://dx.doi.org/10.1101/2021.04.05.437453

Bertoldo MJ; Smitz J; Wu LE; Lee HC; Woodruff TK; Gilchrist RB, 2020, 'Prospects of Rescuing Young Eggs for Oncofertility', Trends in Endocrinology and Metabolism, 31, pp. 708 - 711, http://dx.doi.org/10.1016/j.tem.2020.07.004

Kim L-J; Chalmers TJ; Madawala R; Smith GC; Li C; Das A; Keung Poon EW; Wang J; Tucker SP; Sinclair DA; Quek L-E; Wu LE, 2020, 'Nicotinamide mononucleotide (NMN) deamidation by host-microbiome interactions', , http://dx.doi.org/10.1101/2020.09.10.289561

Solon-Biet SM; McMahon AC; Ballard JWO; Ruohonen K; Wu LE; Cogger VC; Warren A; Huang X; Pichaud N; Melvin RG; Gokarn R; Khalil M; Turner N; Cooney GJ; Sinclair DA; Raubenheimer D; Le Couteur DG; Simpson SJ, 2020, 'Erratum: The Ratio of Macronutrients, Not Caloric Intake, Dictates Cardiometabolic Health, Aging, and Longevity in Ad Libitum-Fed Mice (Cell Metabolism (2014) 19(3) (418–430), (S1550413114000655), (10.1016/j.cmet.2014.02.009))', Cell Metabolism, 31, pp. 654, http://dx.doi.org/10.1016/j.cmet.2020.01.010

Chalmers TJ; Wu LE, 2020, 'Transposable Elements Cross Kingdom Boundaries and Contribute to Inflammation and Ageing: Somatic Acquisition of Foreign Transposable Elements as a Catalyst of Genome Instability, Epigenetic Dysregulation, Inflammation, Senescence, and Ageing', BioEssays, 42, pp. e1900197, http://dx.doi.org/10.1002/bies.201900197

Bertoldo MJ; Listijono DR; Ho WHJ; Riepsamen AH; Goss DM; Richani D; Jin XL; Mahbub S; Campbell JM; Habibalahi A; Loh WGN; Youngson NA; Maniam J; Wong ASA; Selesniemi K; Bustamante S; Li C; Zhao Y; Marinova MB; Kim LJ; Lau L; Wu RM; Mikolaizak AS; Araki T; Le Couteur DG; Turner N; Morris MJ; Walters KA; Goldys E; O'Neill C; Gilchrist RB; Sinclair DA; Homer HA; Wu LE, 2020, 'NAD+ Repletion Rescues Female Fertility during Reproductive Aging', Cell Reports, 30, pp. 1670 - 1681.e7, http://dx.doi.org/10.1016/j.celrep.2020.01.058

Yu J; Laybutt DR; Kim L-J; Quek L-E; Wu LE; Morris MJ; Youngson NA, 2020, 'EXERCISE-INDUCED BENEFITS ON GLUCOSE HANDLING IN A MODEL OF DIET-INDUCED OBESITY ARE REDUCED BY CONCURRENT NICOTINAMIDE MONONUCLEOTIDE', , pp. 2020.06.22.164459, http://dx.doi.org/10.1101/2020.06.22.164459

Das A; Huang GX; Bonkowski MS; Longchamp A; Li C; Schultz MB; Kim LJ; Osborne B; Joshi S; Lu Y; Treviño-Villarreal JH; Kang MJ; Hung TT; Lee B; Williams EO; Igarashi M; Mitchell JR; Wu LE; Turner N; Arany Z; Guarente L; Sinclair DA, 2019, 'Erratum: Impairment of an Endothelial NAD+-H2S Signaling Network Is a Reversible Cause of Vascular Aging (Cell (2018) 173(1) (74–89.e20), (S0092867418301521) (10.1016/j.cell.2018.02.008))', Cell, 176, pp. 944 - 945, http://dx.doi.org/10.1016/j.cell.2019.01.026

Wu LE; Sinclair DA, 2019, 'The elusive NMN transporter is found', Nature Metabolism, 1, pp. 8 - 9, http://dx.doi.org/10.1038/s42255-018-0015-6

Latorre-Muro P; Baeza J; Armstrong EA; Hurtado-Guerrero R; Corzana F; Wu LE; Sinclair DA; López-Buesa P; Carrodeguas JA; Denu JM, 2018, 'Dynamic Acetylation of Phosphoenolpyruvate Carboxykinase Toggles Enzyme Activity between Gluconeogenic and Anaplerotic Reactions', Molecular Cell, 71, pp. 718 - 732.e9, http://dx.doi.org/10.1016/j.molcel.2018.07.031

Das A; Huang GX; Bonkowski MS; Longchamp A; Li C; Schultz MB; Kim LJ; Osborne B; Joshi S; Lu Y; Treviño-Villarreal JH; Kang MJ; Hung TT; Lee B; Williams EO; Igarashi M; Mitchell JR; Wu LE; Turner N; Arany Z; Guarente L; Sinclair DA, 2018, 'Impairment of an Endothelial NAD+-H2S Signaling Network Is a Reversible Cause of Vascular Aging', Cell, 173, pp. 74 - 89.e20, http://dx.doi.org/10.1016/j.cell.2018.02.008

Bustamante S; Jayasena T; Richani D; Gilchrist RB; Wu LE; Sinclair DA; Sachdev PS; Braidy N, 2018, 'Quantifying the cellular NAD+ metabolome using a tandem liquid chromatography mass spectrometry approach', Metabolomics, 14, http://dx.doi.org/10.1007/s11306-017-1310-z

Bonkowski MS; Das A; Schultz M; Lu Y; Mitchell J; Wu L; Guarente L; Sinclair D, 2018, 'IMPAIRMENT OF AN ENDOTHELIAL NAD+-H2S SIGNALING NETWORK IS A REVERSIBLE CAUSE OF VASCULAR AGING', Innovation in aging, 2, pp. 388 - 388

Bonkowski MS; Das A; Schultz MB; Lu Y; Mitchell J; Wu L; Guarente L; Sinclair DA, 2018, 'IMPAIRMENT OF AN ENDOTHELIAL NAD+-H2S SIGNALING NETWORK IS A REVERSIBLE CAUSE OF VASCULAR AGING', Innovation in aging, 2, pp. 799 - 799

Sultani G; Bentley N; Osborne B; Joshi S; Araki T; Montgomery M; Polly P; Byrne F; Wu L; Turner N, 2018, 'PO-011 Impact of compartment-specific changes in NAD biosynthesis on diethylnitrosamine-induced liver cancer', ESMO Open, 3, pp. A25 - A25, http://dx.doi.org/10.1136/esmoopen-2018-eacr25.56

Nelson ME; Lahiri S; Chow JDY; Byrne FL; Hargett SR; Breen DS; Olzomer EM; Wu LE; Cooney GJ; Turner N; James DE; Slack-Davis JK; Lackner C; Caldwell SH; Hoehn KL, 2017, 'Inhibition of hepatic lipogenesis enhances liver tumorigenesis by increasing antioxidant defence and promoting cell survival', Nature Communications, 8, pp. 14689, http://dx.doi.org/10.1038/ncomms14689

Chowdhury MKH; Turner N; Bentley NL; Das A; Wu LE; Richani D; Bustamante S; Gilchrist RB; Morris MJ; Shepherd PR; Smith GC; Chowdhury M, 2017, 'Niclosamide reduces glucagon sensitivity via hepatic PKA inhibition in obese mice: Implications for glucose metabolism improvements in type 2 diabetes', Scientific Reports, 7, pp. 40159, http://dx.doi.org/10.1038/srep40159

Das A; Sinclair D; Bonkowski M; Johnston I; Wu L, 2017, 'Extension of physical endurance and protection against physical, chemical and radiological trauma by NAD + precursors', Journal of Science and Medicine in Sport, 20, pp. S165 - S166, http://dx.doi.org/10.1016/j.jsams.2017.09.564

Wu LE; Sinclair DA, 2016, 'Restoring stem cells-all you need is NAD+', Cell Research, 26, pp. 971 - 972, http://dx.doi.org/10.1038/cr.2016.80

Awan Z; Tay ESE; Eyre NS; Wu LE; Beard MR; Boo I; Drummer HE; George J; Douglas MW, 2016, 'Calsyntenin-1 mediates hepatitis C virus replication', Journal of General Virology, 97, pp. 1877 - 1887, http://dx.doi.org/10.1099/jgv.0.000511

Mohamad M; Mitchell SJ; Wu LE; White MY; Cordwell SJ; Mach J; Solon-Biet SM; Boyer D; Nines D; Das A; Catherine Li SY; Warren A; Hilmer SN; Fraser R; Sinclair DA; Simpson SJ; de Cabo R; Le Couteur DG; Cogger VC, 2016, 'Ultrastructure of the liver microcirculation influences hepatic and systemic insulin activity and provides a mechanism for age-related insulin resistance', Aging Cell, 15, pp. 706 - 715, http://dx.doi.org/10.1111/acel.12481

Chowdhury MKH; Wu LE; Coleman JLJ; Smith NJ; Morris MJ; Shepherd PR; Smith GC; Chowdhury M, 2016, 'Niclosamide blocks glucagon phosphorylation of Ser552 on β-catenin in primary rat hepatocytes via PKA signalling', Biochemical Journal, 473, pp. 1247 - 1255, http://dx.doi.org/10.1042/BCJ20160121

Cagnone GLM; Tsai TS; Makanji Y; Matthews P; Gould J; Bonkowski MS; Elgass KD; Wong ASA; Wu LE; McKenzie M; Sinclair DA; John JCS, 2016, 'Restoration of normal embryogenesis by mitochondrial supplementation in pig oocytes exhibiting mitochondrial DNA deficiency', Scientific Reports, 6, http://dx.doi.org/10.1038/srep23229

Wu LE; Levina A; Harris HH; Cai Z; Lai B; Vogt S; James DE; Lay PA, 2016, 'Carcinogenic Chromium(VI) Compounds Formed by Intracellular Oxidation of Chromium(III) Dietary Supplements by Adipocytes', Angewandte Chemie - International Edition, 55, pp. 1742 - 1745, http://dx.doi.org/10.1002/anie.201509065

Wu LE; Levina A; Harris HH; Cai Z; Lai B; Vogt S; James DE; Lay PA, 2016, 'Carcinogenic Chromium(VI) Compounds Formed by Intracellular Oxidation of Chromium(III) Dietary Supplements by Adipocytes', Angewandte Chemie, 128, pp. 1774 - 1777, http://dx.doi.org/10.1002/ange.201509065

Pratap CB; Scanu T; Spaapen RM; Bakker JM; Wu L-E; Hofland I; Broeks A; Shukla VK; Kumar M; Janssen H; Song J-Y; Riele HT; Holden DW; Nath G; Neefjes J, 2016, 'Salmonella manipulation of host signalling pathways promotes cellular transformation and cancer of infected tissues', International Journal of Infectious Diseases, 45, pp. 145 - 145, http://dx.doi.org/10.1016/j.ijid.2016.02.353

Wu LE; Fazakerley DJ; Cantley J, 2015, 'Circulating AFABP promotes insulin secretion', Obesity, 23, pp. 1525, http://dx.doi.org/10.1002/oby.21175

Riepsamen A; Wu L; Lau L; Listijono D; Ledger W; Sinclair DA; Homer H, 2015, 'Erratum: Nicotinamide impairs entry into and exit from meiosis I in mouse oocytes (PLoS ONE (2015) 10:5 (e0126194) DOI:10.1371/journal.pone.0126194)', PLoS ONE, 10, pp. e0126194, http://dx.doi.org/10.1371/journal.pone.0126194

Riepsamen A; Wu L; Lau L; Listijono D; Ledger W; Sinclair D; Homer H, 2015, 'Nicotinamide impairs entry into and exit from meiosis I in mouse oocytes', PLoS ONE, 10, pp. e0130058, http://dx.doi.org/10.1371/journal.pone.0130058

Wu LE; Sinclair DA, 2014, 'SIRT2 controls the pentose phosphate switch', EMBO Journal, 33, pp. 1287 - 1288, http://dx.doi.org/10.15252/embj.201488713

Wu LE; Samocha-Bonet D; Whitworth PT; Fazakerley DJ; Turner N; Biden TJ; James DE; Cantley J, 2014, 'Identification of fatty acid binding protein 4 as an adipokine that regulates insulin secretion during obesity', Molecular Metabolism, 3, pp. 465 - 473, http://dx.doi.org/10.1016/j.molmet.2014.02.005

Solon-Biet SM; McMahon AC; Ballard JWO; Ruohonen K; Wu LE; Cogger VC; Warren A; Huang X; Pichaud N; Melvin RG; Gokarn R; Khalil M; Turner N; Cooney GJ; Sinclair DA; Raubenheimer D; Le Couteur DG; Simpson SJ, 2014, 'The ratio of macronutrients, not caloric intake, dictates cardiometabolic health, aging, and longevity in ad libitum-fed mice', Cell Metabolism, 19, pp. 418 - 430, http://dx.doi.org/10.1016/j.cmet.2014.02.009

Wu LE; Solon S; McMahon AC; Ballard JWO; Ruohonen K; Cogger VC; Warren A; Pichaud N; Melvin RG; Gokarn R; Khalil M; Huang X; Turner N; Cooney GJ; Sinclair DA; Raubenheimer D; Le Couteur DG; Simpson SJ, 2014, 'Disparate consequences of macronutrients on appetite, longevity and cardiometabolic health reconciled by nutritional geometry', Cell Metabolism

Wu LE; Gomes AP; Sinclair DA, 2014, 'Geroncogenesis: Metabolic Changes during Aging as a Driver of Tumorigenesis', Cancer Cell, 25, pp. 12 - 19, http://dx.doi.org/10.1016/j.ccr.2013.12.005

Ma X; Yang P; Kaplan WH; Lee BH; Wu LE; Yang JYH; Yasunaga M; Sato K; Chisholm DJ; James DE, 2014, 'ISL1 regulates peroxisome proliferator-activated receptor γ activation and early adipogenesis via bone morphogenetic protein 4-dependent and -independent mechanisms', Molecular and Cellular Biology, 34, pp. 3607 - 3617, http://dx.doi.org/10.1128/MCB.00583-14

North BJ; Rosenberg MA; Jeganathan KB; Hafner AV; Michan S; Dai J; Baker DJ; Cen Y; Wu LE; Sauve AA; Van Deursen JM; Rosenzweig A; Sinclair DA, 2014, 'SIRT2 induces the checkpoint kinase BubR1 to increase lifespan', EMBO Journal, 33, pp. 1438 - 1453, http://dx.doi.org/10.15252/embj.201386907

Wu LE; Meoli CC; Mangiafico SP; Fazakerley DJ; Cogger VC; Mohamad M; Pant H; Kang MJ; Powter E; Burchfield JG; Xirouchaki CE; Mikolaizak AS; Stöckli J; Kolumam G; Van Bruggen N; Gamble JR; Le Couteur DG; Cooney GJ; Andrikopoulos S; James DE, 2014, 'Systemic VEGF-A neutralization ameliorates diet-induced metabolic dysfunction', Diabetes, 63, pp. 2656 - 2667, http://dx.doi.org/10.2337/db13-1665

Poorten DVD; Samer CF; Ramezani-Moghadam M; Coulter S; Kacevska M; Schrijnders D; Wu LE; McLeod D; Bugianesi E; Komuta M; Roskams T; Hebbard L; George J, 2013, 'Hepatic fat loss in advanced nonalcoholic steatohepatitis: Are alterations in serum adiponectin the cause?†', Hepatology, http://dx.doi.org/10.1002/hep.26072


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