By Dr Megan Denise Lenardon

Book Chapters

Hall RA; Lenardon MD; Alverez FJ; Nogueira FM; Mukaremera L; Gow NAR, 2013, 'The Candida albicans cell wall: structure and role in morphogenesis and immune recognition', in Mora-Montes HM (ed.), The fungal cell wall, Nova Science Publishers, New York, pp. 1 - 26, https://www.novapublishers.com/catalog/product_info.php?products_id=40080

Journal articles

Gmedhin H; Aquib M; Corrigan N; Lenardon MD; Boyer C, 2026, 'Photoactivated antifungal polymers prepared by PET-RAFT polymerization', Chemical Science, 17, pp. 3178 - 3188, http://dx.doi.org/10.1039/d5sc08534a

Giri A; Aquib M; Kannaujiya VK; Quan T; Choudhury A; Gmedhin H; Lim JL; Gu Z; Lenardon MD; Boyer C, 2026, 'PET-RAFT polymerization of redox-responsive lipoic acid-derived cationic polymers: influence of hydrophobicity and degree of polymerization on antimicrobial activity', Journal of Materials Chemistry B, http://dx.doi.org/10.1039/d6tb00667a

Gmedhin H; Wu P; Gu Z; Lenardon MD; Boyer C, 2025, 'Influence of end-group functionality and composition on the antifungal activity and biocompatibility of polyacrylamide-based polymers', European Polymer Journal, 241, pp. 114384, http://dx.doi.org/10.1016/j.eurpolymj.2025.114384

Giri A; Aquib M; Choudhury A; Kannaujiya VK; Lim JL; Gu Z; Lenardon MD; Boyer C, 2025, 'Lipoic Acid Based Redox-Responsive Degradable Antimicrobial Polymers', Macromolecular Rapid Communications, 46, pp. e00224, http://dx.doi.org/10.1002/marc.202500224

Dinh H; Fernandes KE; Erpf PE; Clay EJM; Tay AP; Nagy SS; Schaefer S; Maharjan R; Lenardon MD; Multari DH; Haynes PA; Paulsen IT; Santiago MJ; Connor M; Carter D; Cain AK, 2025, 'Uncovering the antifungal potential of Cannabidiol and Cannabidivarin', Plos Neglected Tropical Diseases, 19, pp. e0013081, http://dx.doi.org/10.1371/journal.pntd.0013081

Gmedhin H; Schaefer S; Corrigan N; Wu P; Gu Z; Lenardon MD; Boyer C, 2025, 'Effect of Defined Block Sequence Terpolymers on Antifungal Activity and Biocompatibility', Macromolecular Bioscience, 25, http://dx.doi.org/10.1002/mabi.202400429

Schaefer S; Corrigan N; Brunke S; Lenardon MD; Boyer C, 2024, 'Combatting Fungal Infections: Advances in Antifungal Polymeric Nanomaterials', Biomacromolecules, 25, pp. 5670 - 5701, http://dx.doi.org/10.1021/acs.biomac.4c00866

Schaefer S; Vij R; Sprague JL; Austermeier S; Dinh H; Judzewitsch PR; Müller-Loennies S; Lopes Silva T; Seemann E; Qualmann B; Hertweck C; Scherlach K; Gutsmann T; Cain AK; Corrigan N; Gresnigt MS; Boyer C; Lenardon MD; Brunke S, 2024, 'A synthetic peptide mimic kills Candida albicans and synergistically prevents infection.', Nat Commun, 15, pp. 6818, http://dx.doi.org/10.1038/s41467-024-50491-x

McCrory C; Lenardon M; Traven A, 2024, 'Bacteria-derived short-chain fatty acids as potential regulators of fungal commensalism and pathogenesis', Trends in Microbiology, 32, pp. 1106 - 1118, http://dx.doi.org/10.1016/j.tim.2024.04.004

Schaefer S; Melodia D; Corrigan N; Lenardon MD; Boyer C, 2024, 'Effect of Star Topology Versus Linear Polymers on Antifungal Activity and Mammalian Cell Toxicity', Macromolecular Bioscience, 24, http://dx.doi.org/10.1002/mabi.202300452

Schaefer S; Melodia D; Pracey C; Corrigan N; Lenardon MD; Boyer C, 2024, 'Mimicking Charged Host-Defense Peptides to Tune the Antifungal Activity and Biocompatibility of Amphiphilic Polymers', Biomacromolecules, 25, pp. 871 - 889, http://dx.doi.org/10.1021/acs.biomac.3c01038

Gow NAR; Lenardon MD, 2023, 'Architecture of the dynamic fungal cell wall', Nature Reviews Microbiology, 21, pp. 248 - 259, http://dx.doi.org/10.1038/s41579-022-00796-9

Ricci L; Mackie J; Donachie GE; Chapuis A; Mezerová K; Lenardon MD; Brown AJP; Duncan SH; Walker AW, 2022, 'Human gut bifidobacteria inhibit the growth of the opportunistic fungal pathogen Candida albicans', FEMS Microbiology Ecology, 98, http://dx.doi.org/10.1093/femsec/fiac095

da Silva Dantas A; Nogueira F; Lee KK; Walker LA; Edmondson M; Brand AC; Lenardon MD; Gow NAR, 2021, 'Crosstalk between the calcineurin and cell wall integrity pathways prevents chitin overexpression in Candida albicans', Journal of Cell Science, 134, pp. jcs258889, http://dx.doi.org/10.1242/jcs.258889

Schaefer S; Pham TTP; Brunke S; Hube B; Jung K; Lenardon MD; Boyer C, 2021, 'Rational Design of an Antifungal Polyacrylamide Library with Reduced Host-Cell Toxicity', ACS Applied Materials and Interfaces, 13, pp. 27430 - 27444, http://dx.doi.org/10.1021/acsami.1c05020

Lenardon MD; Sood P; Dorfmueller HC; Brown AJP; Gow NAR, 2020, 'Scalar nanostructure of the Candida albicans cell wall; a molecular, cellular and ultrastructural analysis and interpretation', Cell Surface, 6, pp. 100047, http://dx.doi.org/10.1016/j.tcsw.2020.100047

Walker L; Sood P; Lenardon MD; Milne G; Olson J; Jensen G; Wolf J; Casadevall A; Adler-Moore J; Gow NAR, 2018, 'The viscoelastic properties of the fungal cell wall allow traffic of ambisome as intact liposome vesicles', Mbio, 9, pp. 10.1128/mbio.02383 - 10.1128/mbio.02317, http://dx.doi.org/10.1128/mBio.02383-17

Sherrington SL; Sorsby E; Mahtey N; Kumwenda P; Lenardon MD; Brown I; Ballou ER; MacCallum DM; Hall RA, 2017, 'Adaptation of Candida albicans to environmental pH induces cell wall remodelling and enhances innate immune recognition', Plos Pathogens, 13, pp. e1006403, http://dx.doi.org/10.1371/journal.ppat.1006403

Childers DS; Raziunaite I; Mol Avelar G; Mackie J; Budge S; Stead D; Gow NAR; Lenardon MD; Ballou ER; MacCallum DM; Brown AJP, 2016, 'The Rewiring of Ubiquitination Targets in a Pathogenic Yeast Promotes Metabolic Flexibility, Host Colonization and Virulence', Plos Pathogens, 12, pp. e1005566, http://dx.doi.org/10.1371/journal.ppat.1005566

Preechasuth K; Anderson JC; Peck SC; Brown AJP; Gow NAR; Lenardon MD, 2015, 'Cell wall protection by the Candida albicans class I chitin synthases', Fungal Genetics and Biology, 82, pp. 264 - 276, http://dx.doi.org/10.1016/j.fgb.2015.08.001

Wagener J; Malireddi RKS; Lenardon MD; Köberle M; Vautier S; MacCallum DM; Biedermann T; Schaller M; Netea MG; Kanneganti TD; Brown GD; Brown AJP; Gow NAR, 2014, 'Fungal Chitin Dampens Inflammation through IL-10 Induction Mediated by NOD2 and TLR9 Activation', Plos Pathogens, 10, pp. e1004050, http://dx.doi.org/10.1371/journal.ppat.1004050

Walker LA; Lenardon MD; Preechasuth K; Munro CA; Gow NAR, 2013, 'Cell wall stress induces alternative fungal cytokinesis and septation strategies', Journal of Cell Science, 126, pp. 2668 - 2677, http://dx.doi.org/10.1242/jcs.118885

Hall RA; Bates S; Lenardon MD; MacCallum DM; Wagener J; Lowman DW; Kruppa MD; Williams DL; Odds FC; Brown AJP; Gow NAR, 2013, 'The Mnn2 Mannosyltransferase Family Modulates Mannoprotein Fibril Length, Immune Recognition and Virulence of Candida albicans', Plos Pathogens, 9, http://dx.doi.org/10.1371/journal.ppat.1003276

Kaloriti D; Tillmann A; Cook E; Jacobsen M; You T; Lenardon M; Ames L; Barahona M; Chandrasekaran K; Coghill G; Goodman D; Gow NAR; Grebogi C; Ho HL; Ingram P; McDonagh A; De Moura APS; Pang W; Puttnam M; Radmaneshfar E; Romano MC; Silk D; Stark J; Stumpf M; Thiel M; Thorne T; Usher J; Yin Z; Haynes K; Brown AJP, 2012, 'Combinatorial stresses kill pathogenic Candida species', Medical Mycology, 50, pp. 699 - 709, http://dx.doi.org/10.3109/13693786.2012.672770

You T; Ingram P; Jacobsen MD; Cook E; McDonagh A; Thorne T; Lenardon MD; De Moura AP; Romano MC; Thiel M; Stumpf M; Gow NAR; Haynes K; Grebogi C; Stark J; Brown AJP, 2012, 'A systems biology analysis of long and short-term memories of osmotic stress adaptation in fungi', BMC Research Notes, 5, http://dx.doi.org/10.1186/1756-0500-5-258

Lenardon MD; Nantel A, 2012, 'Rapid detection of aneuploidy following the generation of mutants in candida albicans', , 845, pp. 41 - 49, http://dx.doi.org/10.1007/978-1-61779-539-8_3

Cheng SC; van de Veerdonk FL; Lenardon M; Stoffels M; Plantinga T; Smeekens S; Rizzetto L; Mukaremera L; Preechasuth K; Cavalieri D; Kanneganti TD; van der Meer JWM; Kullberg BJ; Joosten LAB; Gow NAR; Netea MG, 2011, 'The dectin-1/inflammasome pathway is responsible for the induction of protective T-helper 17 responses that discriminate between yeasts and hyphae of Candida albicans', Journal of Leukocyte Biology, 90, pp. 357 - 366, http://dx.doi.org/10.1189/jlb.1210702

Mora-Montes HM; Netea MG; Ferwerda G; Lenardon MD; Brown GD; Mistry AR; Kullberg BJ; O'Callaghan CA; Sheth CC; Odds FC; Brown AJP; Munro CA; Gow NAR, 2011, 'Recognition and blocking of innate immunity cells by Candida albicans chitin', Infection and Immunity, 79, pp. 1961 - 1970, http://dx.doi.org/10.1128/IAI.01282-10

Lenardon MD; Munro CA; Gow NAR, 2010, 'Chitin synthesis and fungal pathogenesis', Current Opinion in Microbiology, 13, pp. 416 - 423, http://dx.doi.org/10.1016/j.mib.2010.05.002

Lenardon MD; Milne SA; Mora-Montes HM; Kaffarnik FAR; Peck SC; Brown AJP; Munro CA; Gow NAR, 2010, 'Phosphorylation regulates polarisation of chitin synthesis in Candida albicans', Journal of Cell Science, 123, pp. 2199 - 2206, http://dx.doi.org/10.1242/jcs.060210

Lenardon MD; Lesiak I; Munro CA; Gow NAR, 2009, 'Dissection of the Candida albicans class i chitin synthase promoters', Molecular Genetics and Genomics, 281, pp. 459 - 471, http://dx.doi.org/10.1007/s00438-009-0423-0

Walker LA; Munro CA; De Bruijn I; Lenardon MD; McKinnon A; Gow NAR, 2008, 'Stimulation of chitin synthesis rescues Candida albicans from echinocandins', Plos Pathogens, 4, http://dx.doi.org/10.1371/journal.ppat.1000040

Lenardon MD; Whitton RK; Munro CA; Marshall D; Gow NAR, 2007, 'Individual chitin synthase enzymes synthesize microfibrils of differing structure at specific locations in the Candida albicans cell wall', Molecular Microbiology, 66, pp. 1164 - 1173, http://dx.doi.org/10.1111/j.1365-2958.2007.05990.x

Munro CA; Selvaggini S; De Bruijn I; Walker L; Lenardon MD; Gerssen B; Milne S; Brown AJP; Gow NAR, 2007, 'The PKC, HOG and Ca2+ signalling pathways co-ordinately regulate chitin synthesis in Candida albicans', Molecular Microbiology, 63, pp. 1399 - 1413, http://dx.doi.org/10.1111/j.1365-2958.2007.05588.x

Conference Abstracts

Schaefer S; Vij R; Sprague J; Seemann E; Hube B; Lenardon M; Boyer C; Brunke S, 2022, 'P003 Synthetic antifungal peptide mimic kills Candida albicans by targeting protein glycosylation and synergistically prevents infection', in Medical Mycology, Oxford University Press (OUP), Vol. 60, pp. myac072p003, http://dx.doi.org/10.1093/mmy/myac072.p003

Lenardon M, 2021, 'The colon microcosm: a novel in vitro model to study Candida albicans colonisation of the human colon', in Access Microbiology, Microbiology Society, Vol. 3, http://dx.doi.org/10.1099/acmi.cc2021.po0011

Ricci L; Mackie J; Lenardon MD; Jukes C; Hegazy AN; Brown AJP; Duncan SH; Walker AW, 2020, 'Bifidobacterium adolescentis shows potential to strengthen host defence against gastrointestinal infection via inhibition of the opportunistic pathogen Candida albicans and stimulation of human-isolated macrophages killing capacity in vitro', in Access Microbiology, Microbiology Society, Vol. 2, http://dx.doi.org/10.1099/acmi.ac2020.po0743

Spyrou M; Brown AJP; Gow NAR; Lenardon MD, 2018, 'Orchestration of chitin synthesis at the septation site of Candida albicans', in MEDICAL MYCOLOGY, OXFORD UNIV PRESS, Vol. 56, pp. S157 - S157, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000434852700889&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Wagener J; Malireddi RKS; Lenardon MD; Koberle M; Vautier S; MacCallum DM; Alvarez FJ; Biedermann T; Schaller M; Netea MG; Kanneganti TD; Brown GD; Brown AJP; Gow NAR, 2013, 'Chitin recognition in fungal infections and its impact on the immune response', in GLYCOBIOLOGY, OXFORD UNIV PRESS INC, FL, St Petersburg, Vol. 23, pp. 1343 - 1343, presented at Annual Conference of the Society-for-Glycobiology, FL, St Petersburg, 17 November 2013 - 20 November 2013, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000326972400050&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Wagener J; Malireddi RKS; Lenardon MD; Koeberle M; Vautier S; MacCallum DM; Biedermann T; Schaller M; Netea MG; Kanneganti T-D; Brown GD; Brown AJP; Gow NAR, 2013, 'Chitin recognition in fungal infections and its impact on the immune response', in MYCOSES, WILEY-BLACKWELL, Vol. 56, pp. 7 - 7, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000322918300023&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Lenardon MD; Gow NAR, 2012, 'Building a scalar model of the Candida albicans cell wall', in MYCOSES, WILEY-BLACKWELL, Vol. 55, pp. 187 - 187, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000305069800590&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Preechasuth K; Lenardon MD; Gow NA, 2012, 'Phosphorylation of Chs2 is required for its localization in Candida albicans', in MYCOSES, WILEY-BLACKWELL, Vol. 55, pp. 181 - 181, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000305069800567&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Theses / Dissertations

Lenardon MD, 2006, The role of auxiliary transcription factors in the regulation of gene expression during sporulation in Saccharomyces cerevisiae.

Preprints

Schaefer S; Vij R; Sprague JL; Austermeier S; Dinh H; Judzewitsch PR; Seemann E; Qualmann B; Cain AK; Corrigan N; Gresnigt MS; Boyer C; Lenardon MD; Brunke S, A synthetic peptide mimic kills Candida albicans and synergistically prevents infection, http://dx.doi.org/10.1101/2023.09.25.559234

Ricci L; Mackie J; Donachie GE; Chapuis A; Mezerová K; Lenardon MD; Brown AJP; Duncan SH; Walker AW, Human gut bifidobacteria inhibit the growth of the opportunistic fungal pathogen Candida albicans, http://dx.doi.org/10.1101/2021.12.21.473717

Schaefer S; Melodia D; Corrigan N; Lenardon M; Boyer C, Mimicking charged host-defence peptides to tune antifungal activity and biocompatibility of amphiphilic polymers, http://dx.doi.org/10.26434/chemrxiv-2023-9c9xg

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