By Dr Megan Denise Lenardon

Book Chapters

Hall RA; Lenardon MD; Alverez FJ; Nogueira FM; Mukaremera L; Gow NAR, 2013, 'The Candida albicans cell wall: structure and role in morphogenesis and immune recognition', in Mora-Montes HM (ed.), The fungal cell wall, Nova Science Publishers, New York, pp. 1 - 26, https://www.novapublishers.com/catalog/product_info.php?products_id=40080

Journal articles

Schaefer S; Corrigan N; Brunke S; Lenardon MD; Boyer C, 2024, 'Combatting Fungal Infections: Advances in Antifungal Polymeric Nanomaterials', Biomacromolecules, 25, pp. 5670 - 5701, http://dx.doi.org/10.1021/acs.biomac.4c00866

Schaefer S; Vij R; Sprague JL; Austermeier S; Dinh H; Judzewitsch PR; Müller-Loennies S; Lopes Silva T; Seemann E; Qualmann B; Hertweck C; Scherlach K; Gutsmann T; Cain AK; Corrigan N; Gresnigt MS; Boyer C; Lenardon MD; Brunke S, 2024, 'A synthetic peptide mimic kills Candida albicans and synergistically prevents infection', Nature Communications, 15, pp. 1 - 22, http://dx.doi.org/10.1038/s41467-024-50491-x

McCrory C; Lenardon M; Traven A, 2024, 'Bacteria-derived short-chain fatty acids as potential regulators of fungal commensalism and pathogenesis', Trends in Microbiology, 32, pp. 1106 - 1118, http://dx.doi.org/10.1016/j.tim.2024.04.004

Schaefer S; Melodia D; Corrigan N; Lenardon MD; Boyer C, 2024, 'Effect of Star Topology Versus Linear Polymers on Antifungal Activity and Mammalian Cell Toxicity', Macromolecular Bioscience, 24, http://dx.doi.org/10.1002/mabi.202300452

Schaefer S; Melodia D; Pracey C; Corrigan N; Lenardon MD; Boyer C, 2024, 'Mimicking Charged Host-Defense Peptides to Tune the Antifungal Activity and Biocompatibility of Amphiphilic Polymers', Biomacromolecules, 25, pp. 871 - 889, http://dx.doi.org/10.1021/acs.biomac.3c01038

Gow NAR; Lenardon MD, 2023, 'Architecture of the dynamic fungal cell wall', Nature Reviews Microbiology, 21, pp. 248 - 259, http://dx.doi.org/10.1038/s41579-022-00796-9

Ricci L; Mackie J; Donachie GE; Chapuis A; Mezerová K; Lenardon MD; Brown AJP; Duncan SH; Walker AW, 2022, 'Human gut bifidobacteria inhibit the growth of the opportunistic fungal pathogen Candida albicans', FEMS Microbiology Ecology, 98, pp. fiac095, http://dx.doi.org/10.1093/femsec/fiac095

da Silva Dantas A; Nogueira F; Lee KK; Walker LA; Edmondson M; Brand AC; Lenardon MD; Gow NAR, 2021, 'Crosstalk between the calcineurin and cell wall integrity pathways prevents chitin overexpression in Candida albicans', Journal of Cell Science, 134, pp. jcs258889, http://dx.doi.org/10.1242/jcs.258889

Schaefer S; Pham TTP; Brunke S; Hube B; Jung K; Lenardon MD; Boyer C, 2021, 'Rational Design of an Antifungal Polyacrylamide Library with Reduced Host-Cell Toxicity', ACS Applied Materials and Interfaces, 13, pp. 27430 - 27444, http://dx.doi.org/10.1021/acsami.1c05020

Lenardon MD; Sood P; Dorfmueller HC; Brown AJP; Gow NAR, 2020, 'Scalar nanostructure of the Candida albicans cell wall; a molecular, cellular and ultrastructural analysis and interpretation', The Cell Surface, 6, pp. 100047, http://dx.doi.org/10.1016/j.tcsw.2020.100047

Walker L; Sood P; Lenardon MD; Milne G; Olson J; Jensen G; Wolf J; Casadevall A; Adler-Moore J; Gow NAR, 2018, 'The viscoelastic properties of the fungal cell wall allow traffic of ambisome as intact liposome vesicles', mBio, 9, pp. 10.1128/mbio.02383 - 10.1128/mbio.02317, http://dx.doi.org/10.1128/mBio.02383-17

Sherrington SL; Sorsby E; Mahtey N; Kumwenda P; Lenardon MD; Brown I; Ballou ER; MacCallum DM; Hall RA, 2017, 'Adaptation of Candida albicans to environmental pH induces cell wall remodelling and enhances innate immune recognition', PLoS Pathogens, 13, pp. e1006403, http://dx.doi.org/10.1371/journal.ppat.1006403

Childers DS; Raziunaite I; Mol Avelar G; Mackie J; Budge S; Stead D; Gow NAR; Lenardon MD; Ballou ER; MacCallum DM; Brown AJP, 2016, 'The Rewiring of Ubiquitination Targets in a Pathogenic Yeast Promotes Metabolic Flexibility, Host Colonization and Virulence', PLoS Pathogens, 12, pp. e1005566, http://dx.doi.org/10.1371/journal.ppat.1005566

Preechasuth K; Anderson JC; Peck SC; Brown AJP; Gow NAR; Lenardon MD, 2015, 'Cell wall protection by the Candida albicans class I chitin synthases', Fungal Genetics and Biology, 82, pp. 264 - 276, http://dx.doi.org/10.1016/j.fgb.2015.08.001

Wagener J; Malireddi RKS; Lenardon MD; Köberle M; Vautier S; MacCallum DM; Biedermann T; Schaller M; Netea MG; Kanneganti TD; Brown GD; Brown AJP; Gow NAR, 2014, 'Fungal Chitin Dampens Inflammation through IL-10 Induction Mediated by NOD2 and TLR9 Activation', PLoS Pathogens, 10, pp. e1004050, http://dx.doi.org/10.1371/journal.ppat.1004050

Walker LA; Lenardon MD; Preechasuth K; Munro CA; Gow NAR, 2013, 'Cell wall stress induces alternative fungal cytokinesis and septation strategies', Journal of Cell Science, 126, pp. 2668 - 2677, http://dx.doi.org/10.1242/jcs.118885

Hall RA; Bates S; Lenardon MD; MacCallum DM; Wagener J; Lowman DW; Kruppa MD; Williams DL; Odds FC; Brown AJP; Gow NAR, 2013, 'The Mnn2 Mannosyltransferase Family Modulates Mannoprotein Fibril Length, Immune Recognition and Virulence of Candida albicans', PLoS Pathogens, 9, http://dx.doi.org/10.1371/journal.ppat.1003276

Kaloriti D; Tillmann A; Cook E; Jacobsen M; You T; Lenardon M; Ames L; Barahona M; Chandrasekaran K; Coghill G; Goodman D; Gow NAR; Grebogi C; Ho HL; Ingram P; McDonagh A; De Moura APS; Pang W; Puttnam M; Radmaneshfar E; Romano MC; Silk D; Stark J; Stumpf M; Thiel M; Thorne T; Usher J; Yin Z; Haynes K; Brown AJP, 2012, 'Combinatorial stresses kill pathogenic Candida species', Medical Mycology, 50, pp. 699 - 709, http://dx.doi.org/10.3109/13693786.2012.672770

You T; Ingram P; Jacobsen MD; Cook E; McDonagh A; Thorne T; Lenardon MD; De Moura AP; Romano MC; Thiel M; Stumpf M; Gow NAR; Haynes K; Grebogi C; Stark J; Brown AJP, 2012, 'A systems biology analysis of long and short-term memories of osmotic stress adaptation in fungi', BMC Research Notes, 5, http://dx.doi.org/10.1186/1756-0500-5-258

Lenardon MD; Nantel A, 2012, 'Rapid detection of aneuploidy following the generation of mutants in candida albicans', , 845, pp. 41 - 49, http://dx.doi.org/10.1007/978-1-61779-539-8_3

Cheng SC; van de Veerdonk FL; Lenardon M; Stoffels M; Plantinga T; Smeekens S; Rizzetto L; Mukaremera L; Preechasuth K; Cavalieri D; Kanneganti TD; van der Meer JWM; Kullberg BJ; Joosten LAB; Gow NAR; Netea MG, 2011, 'The dectin-1/inflammasome pathway is responsible for the induction of protective T-helper 17 responses that discriminate between yeasts and hyphae of Candida albicans', Journal of Leukocyte Biology, 90, pp. 357 - 366, http://dx.doi.org/10.1189/jlb.1210702

Mora-Montes HM; Netea MG; Ferwerda G; Lenardon MD; Brown GD; Mistry AR; Kullberg BJ; O'Callaghan CA; Sheth CC; Odds FC; Brown AJP; Munro CA; Gow NAR, 2011, 'Recognition and blocking of innate immunity cells by Candida albicans chitin', Infection and Immunity, 79, pp. 1961 - 1970, http://dx.doi.org/10.1128/IAI.01282-10

Lenardon MD; Munro CA; Gow NAR, 2010, 'Chitin synthesis and fungal pathogenesis', Current Opinion in Microbiology, 13, pp. 416 - 423, http://dx.doi.org/10.1016/j.mib.2010.05.002

Lenardon MD; Milne SA; Mora-Montes HM; Kaffarnik FAR; Peck SC; Brown AJP; Munro CA; Gow NAR, 2010, 'Phosphorylation regulates polarisation of chitin synthesis in Candida albicans', Journal of Cell Science, 123, pp. 2199 - 2206, http://dx.doi.org/10.1242/jcs.060210

Lenardon MD; Lesiak I; Munro CA; Gow NAR, 2009, 'Dissection of the Candida albicans class i chitin synthase promoters', Molecular Genetics and Genomics, 281, pp. 459 - 471, http://dx.doi.org/10.1007/s00438-009-0423-0

Walker LA; Munro CA; De Bruijn I; Lenardon MD; McKinnon A; Gow NAR, 2008, 'Stimulation of chitin synthesis rescues Candida albicans from echinocandins', PLoS Pathogens, 4, http://dx.doi.org/10.1371/journal.ppat.1000040

Lenardon MD; Whitton RK; Munro CA; Marshall D; Gow NAR, 2007, 'Individual chitin synthase enzymes synthesize microfibrils of differing structure at specific locations in the Candida albicans cell wall', Molecular Microbiology, 66, pp. 1164 - 1173, http://dx.doi.org/10.1111/j.1365-2958.2007.05990.x

Munro CA; Selvaggini S; De Bruijn I; Walker L; Lenardon MD; Gerssen B; Milne S; Brown AJP; Gow NAR, 2007, 'The PKC, HOG and Ca²⁺ signalling pathways co-ordinately regulate chitin synthesis in Candida albicans', Molecular Microbiology, 63, pp. 1399 - 1413, http://dx.doi.org/10.1111/j.1365-2958.2007.05588.x

Conference Abstracts

Schaefer S; Vij R; Sprague J; Seemann E; Hube B; Lenardon M; Boyer C; Brunke S, 2022, 'Synthetic antifungal peptide mimic kills Candida albicans by targeting protein glycosylation and synergistically prevents infection', in MEDICAL MYCOLOGY, OXFORD UNIV PRESS, Vol. 60, pp. 38 - 38, http://dx.doi.org/10.1093/mmy/myac072.P003

Lenardon M, 2021, 'The colon microcosm: a novel in vitro model to study Candida albicans colonisation of the human colon', in Access Microbiology, Microbiology Society, Vol. 3, http://dx.doi.org/10.1099/acmi.cc2021.po0011

Ricci L; Mackie J; Lenardon MD; Jukes C; Hegazy AN; Brown AJP; Duncan SH; Walker AW, 2020, 'Bifidobacterium adolescentis shows potential to strengthen host defence against gastrointestinal infection via inhibition of the opportunistic pathogen Candida albicans and stimulation of human-isolated macrophages killing capacity in vitro', in Access Microbiology, Microbiology Society, Vol. 2, http://dx.doi.org/10.1099/acmi.ac2020.po0743

Spyrou M; Brown AJP; Gow NAR; Lenardon MD, 2018, 'Orchestration of chitin synthesis at the septation site of Candida albicans', in MEDICAL MYCOLOGY, OXFORD UNIV PRESS, Vol. 56, pp. S157 - S157, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000434852700889&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Wagener J; Malireddi RKS; Lenardon MD; Koberle M; Vautier S; MacCallum DM; Alvarez FJ; Biedermann T; Schaller M; Netea MG; Kanneganti TD; Brown GD; Brown AJP; Gow NAR, 2013, 'Chitin recognition in fungal infections and its impact on the immune response', in GLYCOBIOLOGY, OXFORD UNIV PRESS INC, FL, St Petersburg, Vol. 23, pp. 1343 - 1343, presented at Annual Conference of the Society-for-Glycobiology, FL, St Petersburg, 17 November 2013 - 20 November 2013, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000326972400050&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Wagener J; Malireddi RKS; Lenardon MD; Koeberle M; Vautier S; MacCallum DM; Biedermann T; Schaller M; Netea MG; Kanneganti T-D; Brown GD; Brown AJP; Gow NAR, 2013, 'Chitin recognition in fungal infections and its impact on the immune response', in MYCOSES, WILEY-BLACKWELL, Vol. 56, pp. 7 - 7, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000322918300023&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Lenardon MD; Gow NAR, 2012, 'Building a scalar model of the Candida albicans cell wall', in MYCOSES, WILEY-BLACKWELL, Vol. 55, pp. 187 - 187, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000305069800590&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Preechasuth K; Lenardon MD; Gow NA, 2012, 'Phosphorylation of Chs2 is required for its localization in Candida albicans', in MYCOSES, WILEY-BLACKWELL, Vol. 55, pp. 181 - 181, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000305069800567&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Theses / Dissertations

Lenardon MD, 2006, The role of auxiliary transcription factors in the regulation of gene expression during sporulation in Saccharomyces cerevisiae.

Preprints

Schaefer S; Melodia D; Corrigan N; Lenardon M; Boyer C, 2023, Mimicking charged host-defence peptides to tune antifungal activity and biocompatibility of amphiphilic polymers, http://dx.doi.org/10.26434/chemrxiv-2023-9c9xg

Schaefer S; Vij R; Sprague J; Austermeier S; Dinh H; Judzewitsch P; Seemann E; Qualmann B; Cain A; Corrigan N; Gresnigt M; Boyer C; Lenardon M; Brunke S, 2023, A synthetic peptide mimic killsCandida albicansand synergistically prevents infection, http://dx.doi.org/10.1101/2023.09.25.559234

Ricci L; Mackie J; Donachie G; Chapuis A; Mezerová K; Lenardon M; Brown A; Duncan S; Walker A, 2021, Human gut bifidobacteria inhibit the growth of the opportunistic fungal pathogen Candida albicans, http://dx.doi.org/10.1101/2021.12.21.473717

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