Researcher

Dr Michael Lovelace

Keywords

Fields of Research (FoR)

Neurobiology, Central Nervous System, Regenerative Medicine (incl. Stem Cells and Tissue Engineering), Animal Neurobiology

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Biography

Dr. Lovelace has over 10 years’ experience working in the interrelated fields of neuroscience, immunology and developmental neurobiology/stem cell biology, and currently works as a Senior Postdoctoral Research Scientist in the laboratory of clinical neurologist Prof. Bruce Brew (August 2015-present). He is also the manager of the St. Vincent's Centre for Applied Medical Research (AMR) Live Imaging Facility (LIF), a flow cytometry and...view more

Dr. Lovelace has over 10 years’ experience working in the interrelated fields of neuroscience, immunology and developmental neurobiology/stem cell biology, and currently works as a Senior Postdoctoral Research Scientist in the laboratory of clinical neurologist Prof. Bruce Brew (August 2015-present). He is also the manager of the St. Vincent's Centre for Applied Medical Research (AMR) Live Imaging Facility (LIF), a flow cytometry and microscope core facility. His previous positions have included working with esteemed neuroscientist Prof. Max Bennett OA, at Brain and Mind Research Institute, University of Sydney, and Opthalmologist and Developmental Neurobiologist Prof. Tailoi Chan-Ling in 2009-11 (an ongoing collaboration). He has 19 total publications (8 of those first author), which in total to date have garnered 591 citations (516 last 5 years). An additional 10 publications are in revision or preparation for submission.

Positions - 2015 Aug – present: St. Vincent’s Centre for Applied Medical Research. 2015: Haematology Laboratory, Nepean Clinical School, USYD (2 x 3 month 0.5 FTE positions). 2012-2014: Research Officer, Vascular Lab, Centenary Institute, Sydney. 2009-October 2011: Postdoctoral Fellow, Retinal and Developmental Neurobiology Laboratory, Department of Anatomy and Histology, USYD, including previous Charles D. Kelman M.D. Postdoctoral Scholar (International Retinal Research Foundation, United States).


My Grants

Dr. Lovelace has attracted a total of $1,214,808 in competitive grant funding - $144,000 in grants for salary and research support (including 1 x $75,000 Perpetual IMPACT Grant), $150,000 for Investigator Initiated Trial (IIT) completion, $911,808 from 27 equipment grants in a variety of schemes (2 x NHMRC equipment grants, 3 x Rebecca Cooper Medical Research Foundation grants, multiple Bosch Institute small equipment grants, 6 x St. Vincent's AMR Equipment Grants, 2 x Ian Potter Foundation grants (2018 and 2020) and one 2019 Perpetual IMPACT grant (funded by Baxter Charitable Foundation). Also $9,000 in travel grants for conference or collaborator short-stays.

Grants for Research and Salary Support (subtotal $144,000)

3.   Title: “Trialing a therapy in a brain organoid model: a potential therapy for neurodegenerative disease”
Chief Investigators: Prof. Bruce Brew and Dr. Michael Lovelace
Funding Agency: Perpetual IMPACT grant
Goals: This grant funded a project to investigate a therapeutic in a human brain organoid model.
Total Budget: $75,000            Duration of Funding: 2022

2.   Title: “The kynurenine pathway as therapeutic target for Multiple Sclerosis”
       Principal Investigators: Prof. Bruce Brew    Other Investigators: Dr. M. Lovelace (12 CIs)
       Funding Agency: St. Vincent’s Clinic Research Grant
       Goals: This grant funded a project to examine therapeutic inhibition of the kynurenine pathway as a possible mechanism for MS therapy.
        Total Budget: $30,000                Duration of Funding: 2017 

1.    Title: “Elucidating the role of Astrocytes in Glaucoma”
       Principal Investigator: Prof. Tailoi Chan-Ling      Other Investigators: Dr. Michael Lovelace
       Funding Agency: International Retinal Research Foundation (IRRF) Charles D. Kelman Postdoctoral Scholar Award 2010.
       Goals and Responsibilities: The grant funded salary support for myself, to perform experiments into the role of astrocytes in glaucoma.
       Total Budget: $39,000                Duration of Funding: 2010

Equipment Grants (subtotal $911,808)

27.    Title: “Upgrades for Leica Thunder microscope and AMR Live Imaging Facility”
          Principal Investigators: Dr. M. Lovelace and Prof. Bruce Brew (23 CIs)
          Funding Agency: St. Vincent’s AMR Equipment Grant
          Goals: This grant funded purchase of upgrades to a Thunder live cell imaging microscope.
         Total Budget: $15,000                Duration of Funding: 2022

26.     Title: “Upgrades to the Leica Thunder microscope”
          Principal Investigators: Dr. M. Lovelace and Prof. Bruce Brew (15 CIs)
          Funding Agency: St. Vincent’s AMR Equipment Grant
          Goals: This grant funded purchase of upgrades to a Thunder live cell imaging microscope.
          Total Budget: $30,000                Duration of Funding: 2021

25.     Title: “High-speed 2D/3D microscope imaging platform with image-enhancing capability for disease modelling and testing novel therapies”
          Principal Investigators: Prof. Bruce Brew and Dr. M. Lovelace (15 CIs)
          Funding Agency: Ian Potter Foundation Medical Research Grant
          Goals: This grant funded purchase of a live cell imaging microscope with tissue clearing capability.
          Total Budget: $100,000              Duration of Funding: 2020

24.     Title: “Tri-gas mixer upgrade for Cellasic microfluidic perfusion system”
          Chief Investigators: Dr. Michael Lovelace and Prof. Bruce Brew
          Funding Agency: St. Vincent’s AMR Equipment Grant
          Goals: This grant funded a digital gas mixer upgrade for a Cellasic microfluidic perfusion system.
          Total Budget: $15,000            Duration of Funding: 2020

23.     Title: “Automated high-throughput and specific live cell imaging facility for drug discovery and targeted therapies”
          Chief Investigators: Prof. Bruce Brew and Prof. David Ma
          Project Lead, Activity contact and co-grant writer: Dr. M Lovelace
          Funding Agency: Perpetual IMPACT grant.
          Goals: This grant funded a scratch wound migration assay upgrade for the Incucyte Zoom and an Incustore extended storage module.
          Total Budget: $50,000            Duration of Funding: 2019

22.    Title: “Automated high-throughput and specific live cell imaging facility for drug discovery and targeted therapies”
          Principal Investigators: Prof. Bruce Brew and Dr. M. Lovelace (12 CIs)
          Funding Agency: St. Vincent’s AMR Equipment Grant
          Goals: This grant funded purchase of an Incucyte automated live imaging machine and a Cellasic microfluidic perfusion machine.
          Total Budget: $15,000                Duration of Funding: 2019

21.     Title: “Automated high-throughput and specific live cell imaging facility for drug discovery and targeted therapies”
          Principal Investigators: Prof. Bruce Brew and Dr. M. Lovelace (17 CIs)
          Funding Agency: Ian Potter Foundation Medical Research Grant
          Goals: This grant funded purchase of an Incucyte automated live imaging machine and a Cellasic microfluidic perfusion machine.
          Total Budget: $100,000                Duration of Funding: 2019

20.     Title: “Muse benchtop flow cytometer”
          Principal Investigator: Prof. Bruce Brew Other Investigators: Dr. M. Lovelace, Assoc. Prof. Kurosh Parsi, Dr. David Connor
          Funding Agency: St. Vincent’s AMR Equipment Grant 
          Goals: This grant funded a Muse benchtop flow cytometer.
          Total Budget: $17,500                Duration of Funding: 2018

19.     Title: “Cellasic ONIX microfluidic system for live cell imaging”
          Principal Investigator: Prof. Tailoi Chan-Ling  Other Investigators: Dr. M. Lovelace (13 CIs)
          Funding Agency: Bosch Institute Small Equipment Grant
          Goals: This grant funded a Cellasic ONIX microfluidic system for live cell imaging.
          Total Budget: $12,000 + $15,000 co-funding    Duration of Funding: 2017

18.     Title: “Repair of Gamma Counter”
          Principal Investigator: Prof. Des Richardson     Other Investigators: Dr. M. Lovelace (multiple CIs)
          Funding Agency: Bosch Institute Small Equipment Grant
          Goals: This grant funded repair of a gamma counter machine.
          Total Budget: $7,000 + $2000 departmental co-funding    Duration of Funding: 2017

17.     Title: “QIAExpert System”
          Principal Investigator: Prof. Rebecca Mason     Other Investigators: Dr. M. Lovelace (multiple CIs)
          Funding Agency: Bosch Institute Small Equipment Grant
          Goals: This grant funded a QIAExpert System for amino acid analysis.
          Total Budget: $12,000                Duration of Funding: 2017

16.     Title: “Countess II automated cell counter”
          Principal Investigator: Prof. Bruce Brew    Other Investigators: Dr. M. Lovelace (8 CIs)
          Funding Agency: St. Vincent’s AMR Equipment Grant
          Goals: This grant funded a Countess II automated cell counter for counting cultured cells.
          Total Budget: $15,000                Duration of Funding: 2017

15.     Title: “State-of-the-Art Nanolive 3D Cell Explorer for the Multi-User Bosch Molecular Biology Facility”
          Principal Investigator: Prof. Des Richardson    Other Investigators: Dr. M. Lovelace (24 CIs)
          Funding Agency: Bosch Institute Small Equipment Grant
          Goals: This grant funded a Nanolive 3D explorer for imaging of live cells.
          Total Budget: $29,600                Duration of Funding: 2016

14.     Title: “State-of-the-Art Nitric Oxide Analyser for the Multi-User Bosch Molecular Biology Facility”
          Principal Investigator: Prof. Des Richardson    Other Investigators: Dr. M. Lovelace (31 CIs)
          Funding Agency: Bosch Institute Small Equipment Grant
          Goals: This grant funded a Nitric oxide analyser for animal studies of inflammatory diseases.
          Total Budget: $26,000                Duration of Funding: 2014

13.     Title: “Application for Nuance FX Multispectral Imaging System”
          Principal Investigator:             Other Investigators: Dr. M. Lovelace (38 CIs)
          Funding Agency: Bosch Institute Small Equipment Grant
          Goals: This grant funded a Nuance spectral camera for microscope separation of fluorophores.
          Total Budget: $23,500                Duration of Funding: 2014

12.     Title: “A light-sheet microscope; revolutionary technology for improved imaging of thick fluorescent samples, tissues and whole small organisms”
          Principal Investigator: Prof. Chris Murphy    Other Investigators: Dr. M. Lovelace (16 CIs)
          Funding Agency: NHMRC Equipment Grant Scheme
          Goals: This grant funded a light sheet microscope for imaging of biological specimens in high detail.
          Total Budget: $198,038                Duration of Funding: 2014

10-11. I sequentially wrote equipment grants which facilitated the purchase of a CO2 controller and heated stage live cell imaging upgrade to an existing PALM Laser Capture Microdissection microscope, and also a micromanipulator                     stand enabling the use of an existing micromanipulator in physiology experiments.

          Title: “Application for heated stage for PALM Laser Capture Microdissection microscope and accessories, enabling long-term live cell imaging and physiological experiments”
          Principal Investigator: Dr. Michael Morris         Other Investigators: Dr. M. Lovelace (10 CIs total)
          Funding Agency: Bosch Institute Small Equipment Grant
          Total Budget: $4008 (2013) and $15,900 (2014)    Duration of Funding: 2013/2014

9.       Title: “State-of-the-Art Hypoxia Chamber for Incubation at Physiological Oxygen Concentrations for the Multi-User Bosch Molecular Biology Facility”
          Principal Investigator: Prof. Des Richardson Other Investigators: Dr. M. Lovelace (21 CIs)
          Funding Agency: Bosch Institute Small Equipment Grant
          Goals: This grant funded a hypoxia chamber for culture culture studies under physiological conditions.
          Total Budget: $16,400                Duration of Funding: 2013

8.       Title: “Bringing CLARITY to Bosch Institute Research”
          Principal Investigator: Dr. Dan Johnstone Other Investigators: Dr. M. Lovelace (13 CIs)
          Funding Agency: Bosch Institute Small Equipment Grant
          Goals: This grant funded a tissue clearing technique for ultrastructural imaging of thick tissue specimens.
          Total Budget: $3,480                Duration of Funding: 2013

7.       Title: “Wide field super-resolution microscopy with ground state depletion — Exploring nanoscopic life in chronic diseases”
          Principal Investigator: Assoc. Prof. Filip Braet Other Investigators: Dr. M. Lovelace (14 CIs)
          Funding Agency: University of Sydney DVC Research/Equipment Grant
          Goals: This grant part funded a super-resolution microscope for localization of small proteins and protein-protein interactions inside cells with high spatial resolution.
          Total Budget: $89,262                Duration of Funding: 2013

6.       Title: “Leica PowerMosaic Plus Microscope Upgrade for Flexible, High-Resolution Slide Scanning”
          Principal Investigator: Prof. Jennifer Gamble        Other Investigators: Dr. M. Lovelace (20 CIs)
          Funding Agency: NHMRC Equipment Grant Scheme
          Goals: This grant funded a slide scanner upgrade; scans of slides for archival purposes and analyses.
          Total Budget: $40,120                Duration of Funding: 2013

5.       Title: “An Investigation of purinergic nucleotides in directing the differentiation of human neural precursor cell populations: application to cell therapy for Parkinson’s disease”
          Principal Investigator: Dr. M. Lovelace     Other Investigators: Prof. Tailoi Chan-Ling
          Funding Agency: Rebecca Cooper Medical Research Foundation
          Goals: The goals of this grant were to determine the potential of purinergic nucleotides to direct the lineage specification of neural precursor cells into the neuronal lineage, for future cell therapy use.
          Total Budget: $22,000             Duration of Funding: 2012 

4.       Title: “Application for CO2 controller, facilitating long term live-cell imaging and physiological experiments”
          Principal Investigator: Dr. M. Lovelace  Other Investigators: D. Richardson, A. Sharland, S. Assinder.
          Funding Agency: Bosch Institute Small Equipment Grant Scheme
          Total Budget: $10,000                Duration of Funding: 2011

3.       Title: “A live cell Imaging-based investigation of novel physiological functions of neural stem cells”
          Principal Investigator: Dr. Michael Lovelace     Other Investigators: Prof. Tailoi Chan-Ling
          Funding Agency: Rebecca Cooper Medical Research Foundation
          Goals: The goals of this grant were to determine the roles of calcium signaling in human neural precursor cells, specifically the signaling initiated by purinergic receptors.
          Total Budget: $20,000                Duration of Funding: 2010

2.        Title: “Pathogenic mechanisms of neuronal dysfunction and drug discovery for neurodegenerative diseases”
          Principal Investigators: Dr. Michael Lovelace, Dr. Claire Goldsbury, Prof. Michael Kassiou, Dr. Emily Mathey and Dr. Padraig Strappe     
          Funding Agency: Rebecca Cooper Medical Research Foundation
          Goals: This grant part funded the purchase of a Carl Zeiss AxioObserver Live Cell Imaging microscope.
          Total Budget: $20,000                Duration of Funding: 2009

1.        Title: “Homogeniser for assay of Salmonellla Typhimurium Infection load”
          Principal Investigator: Dr. Michael Lovelace     Other Investigators: Prof. Denise Jackson
          Funding Agency: Burnet Institute Equipment Grant Scheme
          Goals: This was an equipment grant to purchase a homogeniser for plating of homogenates of different organs, in an mouse in vivo assay of Salmonella bacteria infection.
          Total Budget: $5,000                Duration of Funding: 2008

Travel Grants for Conference Attendance or Research Training (subtotal $9,000)

  • Research Training: April-May 2017, Montreal, Canada - Recipient of the 2017 Ian Ballard Travel Award ($6,000) from Multiple Sclerosis Research Australia (MSRA) for 5 week's overseas training.
  • Conference: Focus on Microscopy 2015, Gottingen, Germany. $2,000 from The University of Sydney to support my attendance and oral presentation.
  • Conference: Purine 2012, Fukuoka, Japan. $1,000 to support my attendance and poster presentation.

 


My Qualifications

B. Sc (Hons). Deakin University 1999, PhD 2006


My Awards

Prizes and Awards

2019 Winner of Association for Research in Vision and Opthalmology (ARVO) Scientific Image Contest.

2017 – 5th Prize, Bosch Institute Annual Scientific Meeting poster prize.

2016 – Top 20 Finalist, Bosch Institute Advanced Microscopy Facility Micrograph of the Year competition.

2016 – Second prize in the Light Microscopy Australia (LMA) Micrograph Competition.

2015 – Shortlisted finalist for Stem Cells (Peer-Reviewed Scientific Journal) Young Investigator Award.

2014Winner of Rebecca L. Cooper Medal and Prize for best postdoctoral publication in a Bosch Institute Laboratory, University of Sydney.

2013 – Finalist in the Australasian Society for Stem Cell Research “Small Objects, Big Impact Image Competition. Image selected for exhibition at Questacon, and toured around Australia.

2013 Winner of the National Health & Medical Research Council (NHMRC) Science to Art Prize.

2013 – Joint 3rd Prize, Centenary Institute Scientific Image Award.

2013 – Top 10 Finalist and highly commended award, Australia Museum New Scientist Eureka Prize for Science Photography.

2012 – Top 20 Finalist (2 images) and 9th prize winner, Bosch Institute Advanced Microscopy Facility Micrograph of the Year competition.

2012 – Top 5 Finalist, Centenary Institute Scientific Image Award.

2011 – Highly commended award in the Bosch Institute Advanced Microscopy Facility Molecular Probes Image Prize.

2011 – Highly commended award in the National Health and Medical Research Council (NHMRC) Science to Art Prize.

2010 Awarded 2nd prize in the Bosch Institute Advanced Microscopy Facility Micrograph of the Year competition.

2010 Awarded 2nd prize in the Mater Medical Research Institute Stem Cell Symposium poster competition.

2010 Awarded the Charles D Kelman Postdoctoral Scholar Award (International Retinal Research Foundation, USA).

2009 Awarded the Dintenfass Memorial Plaque for most interesting or innovative Rebecca Cooper Medical Research Foundation research grant proposal


My Research Activities

Dr. Lovelace has current interests in understanding the impact of a dysregulated Kynurenine pathway and production of neurotoxic metabolites on regeneration and repair in Multiple Sclerosis, using mouse cell culture and disease models, and human iPS-derived cells.


My Research Supervision


Supervision keywords


Areas of supervision

Project: The characterisation of biological pathways and other biomarkers for the development of treatment and diagnostic strategies in MS and neurodegenerative diseases.

Discipline: Neurology

Project level: Project can be tailored to all levels

Supervisory Team: Bruce Brew AM and Dr Michael Lovelace

Project commencement: Variable

Summary: Currently there is a lack of effective treatments for a broad spectrup of acute and chronic neurological diseases. In many neurological diseases such as Multiple Sclerosis (MS), Motor Neurone Disease (MND) and Alzheimer’s disease, there is no cure, and the majority of patients continue to deteriorate over time. There are some similarities between the diseases in that the overall symptoms are generally driven by the death of neurons or associated oligodendrocytes (cells which envelop adjacent neurons in layers of insulating myelin protein needed for the successful transmission of nerve impulses between neurons).

Our research group is interested in a number of research areas including how we can:

* Modulate the kynurenine pathway to promote mobilization of adult brain stem cells.

* Understand the kynurenine pathway in different phases of Multiple sclerosis to predict disease progression.

* Design potential therapies for Multiple Sclerosis including antibodies directed at specific targets in the kynurenine pathway.

* Understand biomarkers related to MS pathology.

Contact: Dr Michael Lovelace at m.lovelace@amr.org.au

 

***Applications for ILP/Honours for 2023 in the Brew lab are currently CLOSED***

 


Currently supervising

One UNSW Med Honours student in 2022.

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Location

St. Vincent's Centre for Applied Medical Research

Map reference
Map reference (Google map)

Contact

02 8382 4931

Publications

by Dr Michael Lovelace