By Dr Mykola Pinkevych

Journal articles

Keele BF; Okoye AA; Fennessey CM; Varco-Merth B; Immonen TT; Kose E; Conchas A; Pinkevych M; Lipkey L; Newman L; MacAiran A; Bosche M; Bosche WJ; Berkemeier B; Fast R; Hull M; Oswald K; Shoemaker R; Silipino L; Gorelick RJ; Duell D; Marenco A; Brantley W; Smedley J; Axthelm M; Davenport MP; Lifson JD; Picker LJ, 2024, 'Early antiretroviral therapy in SIV-infected rhesus macaques reveals a multiphasic, saturable dynamic accumulation of the rebound competent viral reservoir', PLoS Pathogens, 20, http://dx.doi.org/10.1371/journal.ppat.1012135

Docken SS; McCormick K; Pampena MB; Samer S; Lindemuth E; Pinkevych M; Viox EG; Wu Y; Schlub TE; Cromer D; Keele BF; Paiardini M; Betts MR; Bar KJ; Davenport MP, 2023, 'Preferential selection of viral escape mutants by CD8+ T cell 'sieving' of SIV reactivation from latency', PLoS Pathogens, 19, http://dx.doi.org/10.1371/journal.ppat.1011755

Pinkevych M; Docken SS; Okoye AA; Fennessey CM; Del Prete GQ; Pino M; Harper JL; Betts MR; Paiardini M; Keele BF; Davenport MP, 2023, 'Timing of initiation of anti-retroviral therapy predicts post-treatment control of SIV replication', PLoS Pathogens, 19, http://dx.doi.org/10.1371/journal.ppat.1011660

Statzu M; Jin W; Fray EJ; Wong AKH; Kumar MR; Ferrer E; Docken SS; Pinkevych M; McBrien JB; Fennessey CM; Keele BF; Liang S; Harper JL; Mutascio S; Franchitti L; Wang H; Cicetti D; Bosinger SE; Carnathan DG; Vanderford TH; Margolis DM; Garcia-Martinez JV; Chahroudi A; Paiardini M; Siliciano J; Davenport MP; Kulpa DA; Siliciano RS; Silvestri G, 2023, 'CD8+ lymphocytes do not impact SIV reservoir establishment under ART', Nature Microbiology, 8, pp. 299 - 308, http://dx.doi.org/10.1038/s41564-022-01311-9

Okoye AA; Duell DD; Fukazawa Y; Varco-Merth B; Marenco A; Behrens H; Chaunzwa M; Selseth AN; Gilbride RM; Shao J; Edlefsen PT; Geleziunas R; Pinkevych M; Davenport MP; Busman-Sahay K; Nekorchuk M; Park H; Smedley J; Axthelm MK; Estes JD; Hansen SG; Keele BF; Lifson JD; Picker LJ, 2021, 'CD8⁺T cells fail to limit SIV reactivation following ART withdrawal until after viral amplification', Journal of Clinical Investigation, 131, http://dx.doi.org/10.1172/JCI141677

Wu Y; Pinkevych M; Xu Z; Keele BF; Davenport MP; Cromer D, 2020, 'Impact of fluctuation in frequency of human immunodeficiency virus/simian immunodeficiency virus reactivation during antiretroviral therapy interruption', Proceedings of the Royal Society B: Biological Sciences, 287, http://dx.doi.org/10.1098/rspb.2020.0354

Pinkevych M; Fennessey CM; Cromer D; Reid C; Trubey CM; Lifson JD; Keele BF; Davenport MP, 2019, 'Predictors of SIV recrudescence following antiretroviral treatment interruption', eLife, 8, pp. e49022, http://dx.doi.org/10.7554/eLife.49022

Pinkevych M; Fennessey CM; Cromer D; Tolstrup M; Søgaard OS; Rasmussen TA; Keele BF; Davenport MP, 2018, 'Estimating initial viral levels during simian immunodeficiency virus/human immunodeficiency virus reactivation from latency', Journal of Virology, 92, http://dx.doi.org/10.1128/JVI.01667-17

Cromer D; Pinkevych M; Rasmussen TA; Lewin SR; Kent SJ; Davenport MP, 2017, 'Modeling of antilatency treatment in HIV: What is the optimal duration of antiretroviral therapy-free HIV remission?', Journal of Virology, 91, pp. 10.1128/jvi.01395 - 10.1128/jvi.01317, http://dx.doi.org/10.1128/JVI.01395-17

Fennessey CM; Pinkevych M; Immonen TT; Reynaldi A; Venturi V; Nadella P; Reid C; Newman L; Lipkey L; Oswald K; Bosche WJ; Trivett MT; Ott DE; Estes JD; Del Prete GQ; Lifson JD; Davenport MP; Keele BF, 2017, 'Genetically-barcoded SIV facilitates enumeration of rebound variants and estimation of reactivation rates in nonhuman primates following interruption of suppressive antiretroviral therapy', PLoS Pathogens, 13, pp. e1006359, http://dx.doi.org/10.1371/journal.ppat.1006359

Pinkevych M; Cromer D; Tolstrup M; Grimm AJ; Cooper DA; Lewin SR; Søgaard OS; Rasmussen TA; Kent SJ; Kelleher AD; Davenport MP, 2016, 'Erratum: HIV Reactivation from Latency after Treatment Interruption Occurs on Average Every 5-8 Days-Implications for HIV Remission (PLoS Pathogens (2015) 11:7 (e1005000) DOI: 10.1371/journal.ppat.1005000)', PLoS Pathogens, 12, pp. e1005745, http://dx.doi.org/10.1371/journal.ppat.1005745

Pinkevych M; Kent SJ; Tolstrup M; Lewin SR; Cooper DA; Søgaard OS; Rasmussen TA; Kelleher AD; Cromer D; Davenport MP, 2016, 'Modeling of Experimental Data Supports HIV Reactivation from Latency after Treatment Interruption on Average Once Every 5–8 Days', PLoS Pathogens, 12, pp. e1005740, http://dx.doi.org/10.1371/journal.ppat.1005740

Pinkevych M; Reynaldi A; Fennessey C; Reid C; Nadella P; Lipkey L; Newman L; Ayala V; Jain S; Del Prete G; Estes J; Ott D; Lifson J; Ohlen C; Keele B; Davenport M, 2016, 'OA2-1 Frequent and ‘burst-like’ reactivation from latency in SIVmac239M infected macaques', Journal of Virus Eradication, 2, pp. 2 - 2, http://dx.doi.org/10.1016/s2055-6640(20)31008-6

, 2016, 'Oral abstracts of the 21st International AIDS Conference 18-22 July 2016, Durban, South Africa.', J Int AIDS Soc, 19, pp. 21264, http://dx.doi.org/10.7448/IAS.19.6.21264

Pinkevych M; Cromer D; Tolstrup M; Grimm AJ; Cooper DA; Lewin SR; Søgaard OS; Rasmussen TA; Kent SJ; Kelleher AD; Davenport MP, 2015, 'HIV Reactivation from Latency after Treatment Interruption Occurs on Average Every 5-8 Days—Implications for HIV Remission', PLoS Pathogens, 11, pp. e1005000, http://dx.doi.org/10.1371/journal.ppat.1005000

Pinkevych M; Petravic J; Bereczky S; Rooth I; Färnert A; Davenport MP, 2015, 'Understanding the relationship between plasmodium falciparum growth rate and multiplicity of infection', Journal of Infectious Diseases, 211, pp. 1121 - 1127, http://dx.doi.org/10.1093/infdis/jiu561

Adekunle AI; Pinkevych M; McGready R; Luxemburger C; White LJ; Nosten F; Cromer D; Davenport MP, 2015, 'Modeling the Dynamics of Plasmodium vivax Infection and Hypnozoite Reactivation In Vivo', PLoS Neglected Tropical Diseases, 9, pp. e0003595, http://dx.doi.org/10.1371/journal.pntd.0003595

Pinkevych M; Chelimo K; Vulule J; Kazura JW; Moormann AM; Davenport MP, 2015, 'Time-to-infection by Plasmodium falciparum is largely determined by random factors', BMC Medicine, 13, pp. 19, http://dx.doi.org/10.1186/s12916-014-0252-9

Liehl P; Meireles P; Albuquerque IS; Pinkevych M; Baptista F; Mota MM; Davenport MP; Prudêncio M, 2015, 'Innate immunity induced by Plasmodium liver infection inhibits malaria reinfections', Infection and Immunity, 83, pp. 1172 - 1180, http://dx.doi.org/10.1128/IAI.02796-14

Pinkevych M; Petravic J; Chelimo K; Vulule J; Kazura JW; Moormann AM; Davenport MP, 2014, 'Decreased growth rate of P. falciparum blood stage parasitemia with age in a holoendemic population', Journal of Infectious Diseases, 209, pp. 1136 - 1143, http://dx.doi.org/10.1093/infdis/jit613

Pinkevych M; Petravic J; Chelimo K; Vulule J; Kazura JW; Moormann AM; Davenport MP, 2013, 'Density-dependent blood stage Plasmodium falciparum suppresses malaria super-infection in a malaria holoendemic population', American Journal of Tropical Medicine and Hygiene, 89, pp. 850 - 856, http://dx.doi.org/10.4269/ajtmh.13-0049

Freeman MW; Burkum CE; Lanzer KG; Roberts AJ; Pinkevych M; Davenport MP; Kummer LW; Szaba FM; Woodland DL; Smiley ST, 2013, 'Gammaherpesvirus latency induces antibody-associated thrombocytopenia in mice', Journal of Autoimmunity, 42, pp. 71 - 79, http://dx.doi.org/10.1016/j.jaut.2012.11.005

Pinkevych M; Petravic J; Chelimo K; Kazura J; Moormann A; Davenport MP, 2012, 'The Dynamics of Naturally Acquired Immunity to Plasmodium falciparum Infection', PLoS Computational Biology, 8, pp. Article number e1002729, http://dx.doi.org/10.1371/journal.pcbi.1002729

Liang SX; Pinkevych M; Khachigian LM; Parish CR; Davenport MP; Chong BH, 2010, 'Drug-induced thrombocytopenia (DITP): development of a novel NOD/SCID mouse model to evaluate clearance of circulating platelets by drug-dependent antibodies and the efficacy of IVIG', Blood, 116, pp. 1958 - 1960

Conference Papers

Statzu M; Wong A; McBrien J; Choe Y; Enemuo C; Ngo J; Jimenez L; Wang J; Pinkevych M; Docken S; Davenport M; Keele B; Vanderford T; Paiardini M; Silvestri G; Kulpa D, 2022, 'CD8(+) T cell depletion does not affect viral reservoir size, but influences the rebound after ART interruption in SIV-infected rhesus macaques', in JOURNAL OF MEDICAL PRIMATOLOGY, WILEY, pp. 323 - 324, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000852720100075&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Lau JSY; Cromer D; Pinkevych M; Lewin SR; Rasmussen TA; McMahon JH; Davenport MP, 2022, 'Balancing Statistical Power and Risk in HIV Cure Clinical Trial Design', in Journal of Infectious Diseases, pp. 236 - 245, http://dx.doi.org/10.1093/infdis/jiac032

Okoye A; Duell D; Maxwel A; Brantley W; Marenco A; Lidell M; Behrens H; Selseth A; Varco-Merth B; Smedley J; Hesselgesser J; Geleziunas R; Pinkevych M; Davenport M; Axthelm M; Hansen S; Deeks S; Keele B; Lifson J; Picker L, 2018, 'CD8+T Cells Do Not Control SIV Replication During ART or Viral Relapse After ART Withdrawal', in AIDS RESEARCH AND HUMAN RETROVIRUSES, MARY ANN LIEBERT, INC, SPAIN, Madrid, pp. 33 - 33, presented at HIV Research for Prevention Meeting (HIVR4P) - AIDS Vaccine, Microbicide and ARV-Based Prevention Science, SPAIN, Madrid, 21 October 2018 - 25 October 2018, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000448371600042&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Posters

Docken S; McCormick K; Pampena M; Pinkevych M; Viox E; Keele B; Paiardini M; Betts M; Bar K; Davenport M; Samer S; Cromer D; Schlub T, 2022, 'PP 2.3 – 00034 CD8+ T-Cell Sieving During SIV Reactivation from Latency', Vol. 8, pp. 100159 - 100159, http://dx.doi.org/10.1016/j.jve.2022.100159

Conference Abstracts

Keele B; Okoye A; Immonen T; Pinkevych M; Fennessey C; Varco-Merth B; Davenport M; Lifson J; Picker L, 2022, 'Early antiretroviral therapy in SIV-infected rhesus macaques reveals a highly dynamic accumulation of the rebound competent viral reservoir', in JOURNAL OF MEDICAL PRIMATOLOGY, WILEY, Vol. 51, pp. 303 - 303, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000852720100032&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Viox E; Samer S; Nguyen K; Docken S; Lindemuth E; Mampe F; Pinkevych M; Keele B; Betts M; Davenport M; Paiardini M; Bar K, 2022, 'Impact of CD4 binding-site bNAb therapy on viral rebound in barcoded TF-SHIV-D-infected rhesus macaques at ATI', in JOURNAL OF MEDICAL PRIMATOLOGY, WILEY, Vol. 51, pp. 301 - 302, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000852720100028&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Fennessey C; Pinkevych M; Immonen T; Camus C; Del Prete G; Estes J; Lifson J; Davenport M; Keele B, 2017, 'Assessing individual viral reactivations of the latent reservoir using a novel barcoded virus', in JOURNAL OF THE INTERNATIONAL AIDS SOCIETY, JOHN WILEY & SONS LTD, Vol. 20, pp. 1 - 1, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000406429800002&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Adekunle AI; Pinkevych M; Cromer D; Davenport MP, 2016, 'UNDERSTANDING THE MECHANISM OF PLASMODIUM VIVAX HYPNOZOITES REACTIVATION', in AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, AMER SOC TROP MED & HYGIENE, GA, Atlanta, Vol. 95, pp. 115 - 115, presented at 65th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene (ASTMH), GA, Atlanta, 13 November 2016 - 16 November 2016

Pinkevych M; Reynaldi A; Fennessey C; Reid C; Nadella P; Lipkey L; Newman L; Ayala V; Jain S; Del Prete G; Estes J; Ott D; Lifson J; Ohlen C; Keele B; Davenport M, 2016, 'Frequent and "burst-like'' reactivation from latency in SIVmac239M infected macaques', in JOURNAL OF THE INTERNATIONAL AIDS SOCIETY, JOHN WILEY & SONS LTD, Vol. 19, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000395394300134&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

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