By Dr Neil Alexander Youngson

Journal articles

Yu J; Youngson NA; Laybutt DR; Morris MJ; Leigh SJ, 2024, 'Complementary yet divergent effects of exercise and an exercise mimetic on microbiome in high-fat diet-induced obesity', Physiological Genomics, 56, pp. 136 - 144, http://dx.doi.org/10.1152/physiolgenomics.00066.2023

Cherubini A; Ostadreza M; Jamialahmadi O; Pelusi S; Rrapaj E; Casirati E; Passignani G; Norouziesfahani M; Sinopoli E; Baselli G; Meda C; Dongiovanni P; Dondossola D; Youngson N; Tourna A; Chokshi S; Bugianesi E; Ronzoni L; Bianco C; Cerami L; Torcianti V; Periti G; Margarita S; Carpani R; Malvestiti F; Marini I; Tomasi M; Lombardi A; Rondena J; Maggioni M; D’Ambrosio R; Vaira V; Fracanzani AL; Rosso C; Pennisi G; Petta S; Liguori A; Miele L; Tavaglione F; Vespasiani-Gentilucci U; Dallio M; Federico A; Soardo G; Pihlajamäki J; Männistö V; Della Torre S; Prati D; Romeo S; Valenti L, 2024, 'Author Correction: Interaction between estrogen receptor-α and PNPLA3 p.I148M variant drives fatty liver disease susceptibility in women (Nature Medicine, (2023), 29, 10, (2643-2655), 10.1038/s41591-023-02553-8)', Nature Medicine, http://dx.doi.org/10.1038/s41591-024-02817-x

Assante G; Chandrasekaran S; Ng S; Tourna A; Chung CH; Isse KA; Banks JL; Soffientini U; Filippi C; Dhawan A; Liu M; Rozen SG; Hoare M; Campbell P; Ballard JWO; Turner N; Morris MJ; Chokshi S; Youngson NA, 2023, 'Correction: Acetyl-CoA metabolism drives epigenome change and contributes to carcinogenesis risk in fatty liver disease (Genome Medicine, (2022), 14, 1, (67), 10.1186/s13073-022-01071-5)', Genome Medicine, 15, http://dx.doi.org/10.1186/s13073-023-01190-7

Wu LE; Fiveash CE; Bentley NL; Kang MJ; Govindaraju H; Barbour JA; Wilkins BP; Hancock SE; Madawala R; Das A; Massudi H; Li C; Kim LJ; Wong ASA; Marinova MB; Sultani G; Das A; Youngson NA; Le Couteur DG; Sinclair DA; Turner N, 2023, 'SIRT2 transgenic over-expression does not impact lifespan in mice', Aging Cell, 22, http://dx.doi.org/10.1111/acel.14027

Cherubini A; Ostadreza M; Jamialahmadi O; Pelusi S; Rrapaj E; Casirati E; Passignani G; Norouziesfahani M; Sinopoli E; Baselli G; Meda C; Dongiovanni P; Dondossola D; Youngson N; Tourna A; Chokshi S; Bugianesi E; Ronzoni L; Bianco C; Cerami L; Torcianti V; Periti G; Margarita S; Carpani R; Malvestiti F; Marini I; Tomasi M; Lombardi A; Rondena J; Maggioni M; D’Ambrosio R; Vaira V; Fracanzani AL; Rosso C; Pennisi G; Petta S; Liguori A; Miele L; Tavaglione F; Vespasiani-Gentilucci U; Dallio M; Federico A; Soardo G; Pihlajamäki J; Männistö V; Della Torre S; Prati D; Romeo S; Valenti L, 2023, 'Interaction between estrogen receptor-α and PNPLA3 p.I148M variant drives fatty liver disease susceptibility in women', Nature Medicine, 29, pp. 2643 - 2655, http://dx.doi.org/10.1038/s41591-023-02553-8

da Rocha ST; Lin SP; Youngson NA, 2023, 'Editorial: Legacies of epigenetic perturbations', Frontiers in Cell and Developmental Biology, 11, http://dx.doi.org/10.3389/fcell.2023.1228115

Weinberg-Shukron A; Youngson NA; Ferguson-Smith AC; Edwards CA, 2023, 'Epigenetic control and genomic imprinting dynamics of the Dlk1-Dio3 domain', Frontiers in Cell and Developmental Biology, 11, http://dx.doi.org/10.3389/fcell.2023.1328806

Stamouli M; Konstantinou C; Jeyanesan D; Wright J; Elliott Z; Dwarampudi S; Zamalloa A; Youngson N; Patel VC; Hadjihambi A, 2023, 'P7 Plasma Neurofilament Light Chain as a Novel Potential Biomarker for the Stratification and Risk Profiling of Hepatic Encephalopathy in Cirrhosis', American Journal of Gastroenterology, 118, pp. S6 - S7, http://dx.doi.org/10.14309/01.ajg.0000948308.65364.f4

Assante G; Chandrasekaran S; Ng S; Tourna A; Chung CH; Isse KA; Banks JL; Soffientini U; Filippi C; Dhawan A; Liu M; Rozen SG; Hoare M; Campbell P; Ballard JWO; Turner N; Morris MJ; Chokshi S; Youngson NA, 2022, 'Acetyl-CoA metabolism drives epigenome change and contributes to carcinogenesis risk in fatty liver disease', Genome Medicine, 14, http://dx.doi.org/10.1186/s13073-022-01071-5

Assante G; Tourna A; Carpani R; Ferrari F; Prati D; Peyvandi F; Blasi F; Bandera A; Le Guennec A; Chokshi S; Patel VC; Cox IJ; Valenti L; Youngson NA, 2022, 'Reduced circulating FABP2 in patients with moderate to severe COVID-19 may indicate enterocyte functional change rather than cell death', Scientific Reports, 12, http://dx.doi.org/10.1038/s41598-022-23282-x

Yu J; Laybutt DR; Youngson NA; Morris MJ, 2022, 'Concurrent betaine administration enhances exercise-induced improvements to glucose handling in obese mice', Nutrition, Metabolism and Cardiovascular Diseases, 32, pp. 2439 - 2449, http://dx.doi.org/10.1016/j.numecd.2022.08.012

Youngson N, 2022, 'The relationships between retrotransposons and local and genome-wide epigenetic state', TOXICOLOGY LETTERS, 368, pp. S40 - S41, http://dx.doi.org/10.1016/j.toxlet.2022.07.128

Youngson NA; Castino MR; Stuart A; Kershaw KA; Holmes NM; Heffernan EC; Waters PD; Morris KV; Clemens KJ, 2022, 'A role for a novel natural antisense-BDNF in the maintenance of nicotine-seeking', Addiction Neuroscience, 2, http://dx.doi.org/10.1016/j.addicn.2022.100010

Yamashita H; Tourna A; Akita M; Itoh T; Chokshi S; Ajiki T; Fukumoto T; Youngson NA; Zen Y, 2022, 'Epigenetic upregulation of TET2 is an independent poor prognostic factor for intrahepatic cholangiocarcinoma', Virchows Archiv, 480, pp. 1077 - 1085, http://dx.doi.org/10.1007/s00428-021-03251-x

Towarnicki SG; Youngson NA; Corley SM; St. John JC; Melvin RG; Turner N; Morris MJ; Ballard JWO, 2022, 'Ancestral dietary change alters the development of Drosophila larvae through MAPK signalling', Fly, 16, pp. 299 - 311, http://dx.doi.org/10.1080/19336934.2022.2088032

Yu J; Laybutt DR; Kim LJ; Quek LE; Wu LE; Morris MJ; Youngson NA, 2021, 'Exercise-induced benefits on glucose handling in a model of diet-induced obesity are reduced by concurrent nicotinamide mononucleotide', American Journal of Physiology - Endocrinology and Metabolism, 321, pp. E176 - E189, http://dx.doi.org/10.1152/AJPENDO.00446.2020

Assante G; Williams R; Youngson NA, 2021, 'Is the increased risk for MAFLD patients to develop severe COVID-19 linked to perturbation of the gut-liver axis?', Journal of Hepatology, 74, pp. 487 - 488, http://dx.doi.org/10.1016/j.jhep.2020.05.051

Campit SE; Meliki A; Youngson NA; Chandrasekaran S, 2020, 'Nutrient Sensing by Histone Marks: Reading the Metabolic Histone Code Using Tracing, Omics, and Modeling', BioEssays, 42, http://dx.doi.org/10.1002/bies.202000083

Uddin GM; Youngson NA; Chowdhury SS; Hagan C; Sinclair DA; Morris MJ, 2020, 'Administration of nicotinamide mononucleotide (NMN) reduces metabolic impairment in male mouse offspring from obese mothers', Cells, 9, http://dx.doi.org/10.3390/cells9040791

Bertoldo MJ; Listijono DR; Ho WHJ; Riepsamen AH; Goss DM; Richani D; Jin XL; Mahbub S; Campbell JM; Habibalahi A; Loh WGN; Youngson NA; Maniam J; Wong ASA; Selesniemi K; Bustamante S; Li C; Zhao Y; Marinova MB; Kim LJ; Lau L; Wu RM; Mikolaizak AS; Araki T; Le Couteur DG; Turner N; Morris MJ; Walters KA; Goldys E; O'Neill C; Gilchrist RB; Sinclair DA; Homer HA; Wu LE, 2020, 'NAD⁺ Repletion Rescues Female Fertility during Reproductive Aging', Cell Reports, 30, pp. 1670 - 1681.e7, http://dx.doi.org/10.1016/j.celrep.2020.01.058

Morris MJ; Hesson LB; Youngson NA, 2020, 'Non-CpG methylation biases bisulphite PCR towards low or unmethylated mitochondrial DNA: recommendations for the field', ENVIRONMENTAL EPIGENETICS, 6, http://dx.doi.org/10.1093/eep/dvaa001

Cespiati A; Youngson NA; Tourna A; Valenti L, 2020, 'Genetics and epigenetics in the clinic: Precision medicine in the management of fatty liver disease', Current Pharmaceutical Design, 26, pp. 998 - 1009, http://dx.doi.org/10.2174/1381612826666200122151251

Yu J; Laybutt DR; Kim L-J; Quek L-E; Wu LE; Morris MJ; Youngson NA, 2020, 'EXERCISE-INDUCED BENEFITS ON GLUCOSE HANDLING IN A MODEL OF DIET-INDUCED OBESITY ARE REDUCED BY CONCURRENT NICOTINAMIDE MONONUCLEOTIDE', , pp. 2020.06.22.164459, http://dx.doi.org/10.1101/2020.06.22.164459

Bajracharya R; Youngson NA; Ballard JWO, 2019, 'Dietary macronutrient management to treat mitochondrial dysfunction in parkinson’s disease', International Journal of Molecular Sciences, 20, http://dx.doi.org/10.3390/ijms20081850

Zieba J; Uddin GM; Youngson NA; Karl T; Morris MJ, 2019, 'Long-term behavioural effects of maternal obesity in C57BL/6J mice', Physiology and Behavior, 199, pp. 306 - 313, http://dx.doi.org/10.1016/j.physbeh.2018.11.004

Youngson NA; Mezbah Uddin G; Das A; Martinez C; Connaughton HS; Whiting S; Yu J; Sinclair DA; John Aitken R; Morris MJ, 2019, 'Impacts of obesity, maternal obesity and nicotinamide mononucleotide supplementation on sperm quality in mice', Reproduction, 158, pp. 169 - 179, http://dx.doi.org/10.1530/REP-18-0574

Morris MJ; Hesson LB; Poulos RC; Ward RL; Wong JWH; Youngson NA, 2018, 'Reduced nuclear DNA methylation and mitochondrial transcript changes in adenomas do not associate with mtDNA methylation', Biomarker Research, 6, http://dx.doi.org/10.1186/s40364-018-0151-x

Aw WC; Towarnicki SG; Melvin RG; Youngson NA; Garvin MR; Hu Y; Nielsen S; Thomas T; Pickford R; Bustamante S; Vila-Sanjurjo A; Smyth GK; Ballard JWO, 2018, 'Genotype to phenotype: Diet-by-mitochondrial DNA haplotype interactions drive metabolic flexibility and organismal fitness', PLoS Genetics, 14, http://dx.doi.org/10.1371/journal.pgen.1007735

Hsu CL; Chou CH; Huang SC; Lin CY; Lin MY; Tung CC; Lin CY; Lai IP; Zou YF; Youngson NA; Lin SP; Yang CH; Chen SK; Gau SSF; Huang HS, 2018, 'Analysis of experience-regulated transcriptome and imprintome during critical periods of mouse visual system development reveals spatiotemporal dynamics', Human Molecular Genetics, 27, pp. 1039 - 1054, http://dx.doi.org/10.1093/hmg/ddy023

Gokarn R; Solon-Biet S; Youngson NA; Wahl D; Cogger VC; McMahon AC; Cooney GJ; Ballard JWO; Raubenheimer D; Morris MJ; Simpson SJ; Le Couteur DG, 2018, 'The Relationship between Dietary Macronutrients and Hepatic Telomere Length in Aging Mice', Journals of Gerontology - Series A Biological Sciences and Medical Sciences, 73, pp. 446 - 449, http://dx.doi.org/10.1093/gerona/glx186

Castino MR; Baker-Andresen D; Ratnu VS; Shevchenko G; Morris KV; Bredy TW; Youngson NA; Clemens KJ, 2018, 'Persistent histone modifications at the BDNF and Cdk-5 promoters following extinction of nicotine-seeking in rats', Genes, Brain and Behavior, 17, pp. 98 - 106, http://dx.doi.org/10.1111/gbb.12421

Bertoldo MJ; Uddin GM; Youngson NA; Agapiou D; Walters KA; Sinclair DA; Morris MJ; Gilchrist RB, 2018, 'Multigenerational obesity-induced perturbations in oocyte-secreted factor signalling can be ameliorated by exercise and nicotinamide mononucleotide.', Hum Reprod Open, 2018, pp. hoy010 - hoy010, http://dx.doi.org/10.1093/hropen/hoy010

Uddin GM; Youngson NA; Doyle BM; Sinclair DA; Morris MJ, 2017, 'Nicotinamide mononucleotide (NMN) supplementation ameliorates the impact of maternal obesity in mice: Comparison with exercise', Scientific Reports, 7, pp. 15063, http://dx.doi.org/10.1038/s41598-017-14866-z

Youngson NA; Morris MJ; Ballard B, 2017, 'The mechanisms mediating the antiepileptic effects of the ketogenic diet, and potential opportunities for improvement with metabolism-altering drugs', Seizure, 52, pp. 15 - 19, http://dx.doi.org/10.1016/j.seizure.2017.09.005

Youngson N; Lecomte V; Maloney C; Leung P; Liu J; Hesson L; Luciani F; Krause L; Morris M, 2016, 'Obesity-induced sperm DNA methylation changes at satellite repeats are reprogrammed in rat offspring', Asian Journal of Andrology, 18, pp. 930 - 936, http://dx.doi.org/10.4103/1008-682X.163190

Uddin GM; Youngson NA; Sinclair DA; Morris MJ, 2016, 'Head to head comparison of short-term treatment with the NAD⁺ precursor nicotinamide mononucleotide (NMN) and 6 weeks of exercise in obese female mice', Frontiers in Pharmacology, 7, pp. 258, http://dx.doi.org/10.3389/fphar.2016.00258

Daxinger L; Oey H; Isbel L; Whitelaw NC; Youngson NA; Spurling A; Vonk KKD; Whitelaw E, 2016, 'Hypomethylation of ERVs in the sperm of mice haploinsufficient for the histone methyltransferase Setdb1 correlates with a paternal effect on phenotype', Scientific Reports, 6, http://dx.doi.org/10.1038/srep25004

Maniam J; Antoniadis CP; Youngson NA; Sinha JK; Morris MJ, 2016, 'Sugar consumption produces effects similar to early life stress exposure on hippocampal markers of neurogenesis and stress response', Frontiers in Molecular Neuroscience, 8, http://dx.doi.org/10.3389/fnmol.2015.00086

Maniam J; Antoniadis CP; Youngson NA; Sinha JK; Morris MJ, 2016, 'Sugar Consumption Produces Effects Similar to Early Life Stress Exposure on Hippocampal Markers of Neurogenesis and Stress Response', FRONTIERS IN MOLECULAR NEUROSCIENCE, 8, http://dx.doi.org/10.5589/fnmol.2015.00086

O. Ballard JW; Youngson NA, 2015, 'Review: Can diet influence the selective advantage of mitochondrial DNA haplotypes?', Bioscience Reports, 35, http://dx.doi.org/10.1042/BSR20150232

Crean AJ; Youngson NA, 2015, 'Both negative and positive data are needed for understanding non-genetic inheritance', Non-Genetic Inheritance, 2, http://dx.doi.org/10.1515/ngi-2015-0001

Ng SF; Lin RCY; Maloney CA; Youngson NA; Owens JA; Morris MJ, 2014, 'Paternal high-fat diet consumption induces common changes in the transcriptomes of retroperitoneal adipose and pancreatic islet tissues in female rat offspring', FASEB Journal, 28, pp. 1830 - 1841, http://dx.doi.org/10.1096/fj.13-244046

Nelson AC; Cauceglia JW; Merkley SD; Youngson NA; Oler AJ; Nelson RJ; Cairns BR; Whitelaw E; Potts WK, 2013, 'Reintroducing domesticated wild mice to sociality induces adaptive transgenerational effects on MUP expression', Proceedings of the National Academy of Sciences of the United States of America, 110, pp. 19848 - 19853, http://dx.doi.org/10.1073/pnas.1310427110

Youngson NA; Epp T; Roberts AR; Daxinger L; Ashe A; Huang E; Lester KL; Harten SK; Kay GF; Cox T; Matthews JM; Chong S; Whitelaw E, 2013, 'No evidence for cumulative effects in a Dnmt3b hypomorph across multiple generations', Mammalian Genome, 24, pp. 206 - 217, http://dx.doi.org/10.1007/s00335-013-9451-5

Reddington JP; Perricone SM; Nestor CE; Reichmann J; Youngson NA; Suzuki M; Reinhardt D; Dunican DS; Prendergast JG; Mjoseng H; Ramsahoye BH; Whitelaw E; Greally JM; Adams IR; Bickmore WA; Meehan RR, 2013, 'Redistribution of H3K27me3 upon DNA hypomethylation results in de-repression of Polycomb target genes', Genome Biology, 14, http://dx.doi.org/10.1186/gb-2013-14-3-r25

Youngson NA; Lin P-C; Lin S-S, 2013, 'The convergence of autophagy, small RNA and the stress response – implications for transgenerational epigenetic inheritance in plants', BioMolecular Concepts, 5, pp. 1 - 8, http://dx.doi.org/10.1515/bmc-2013-0032

Lecomte V; Youngson NA; Maloney CA; Morris MJ, 2013, 'Parental programming: How can we improve study design to discern the molecular mechanisms?', BioEssays, 35, pp. 787 - 793, http://dx.doi.org/10.1002/bies.201300051

Youngson NA, 2012, 'Challenges and future prospects for non-genetic inheritance', Non-Genetic Inheritance, 1, pp. 1 - 8, http://dx.doi.org/10.2478/ngi-2012-0001

Roberts AR; Blewitt ME; Youngson NA; Whitelaw E; Chong S, 2011, 'Reduced dosage of the modifiers of epigenetic reprogramming Dnmt1, Dnmt3L, SmcHD1 and Foxo3a has no detectable effect on mouse telomere length in vivo', Chromosoma, 120, pp. 377 - 385, http://dx.doi.org/10.1007/s00412-011-0318-9

Oey HM; Youngson NA; Whitelaw E, 2011, 'The characterisation of piRNA-related 19mers in the mouse', BMC Genomics, 12, http://dx.doi.org/10.1186/1471-2164-12-315

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