By Dr Peter Richard Wich

Journal articles

Wang W; Hassan MM; Kapoor-Kaushik N; Livni L; Musrie B; Tang J; Mahmud Z; Lai S; Wich PR; Ananthanarayanan V; Moalem-Taylor G; Mao G, 2024, 'Neural Tracing Protein-Functionalized Nanoparticles Capable of Fast Retrograde Axonal Transport in Live Neurons', Small, 20, http://dx.doi.org/10.1002/smll.202311921

De Rubis G; Chakraborty A; Paudel KR; Wang C; Kannaujiya V; Wich P; Hansbro PM; Samuel CS; Oliver B; Dua K, 2024, 'Exploring the anti-inflammatory and anti-fibrotic activity of NFκB decoy oligodeoxynucleotide-loaded spermine-functionalized acetalated nanoparticles', Chemico-Biological Interactions, 396, http://dx.doi.org/10.1016/j.cbi.2024.111059

Kaltbeitzel J; Kersten C; Wich PR, 2024, 'Amine-containing donepezil analogues as potent acetylcholinesterase inhibitors with increased polarity', RSC Medicinal Chemistry, 15, pp. 2037 - 2044, http://dx.doi.org/10.1039/d3md00635b

Kannaujiya VK; Qiao Y; Sheikh RH; Xue J; Dargaville TR; Liang K; Wich PR, 2024, 'pH-Responsive Micellar Nanoparticles for the Delivery of a Self-Amplifying ROS-Activatable Prodrug', Biomacromolecules, 25, pp. 1775 - 1789, http://dx.doi.org/10.1021/acs.biomac.3c01240

Kaltbeitzel J; Wich PR, 2023, 'Protein-based Nanoparticles: From Drug Delivery to Imaging, Nanocatalysis and Protein Therapy', Angewandte Chemie - International Edition, 62, http://dx.doi.org/10.1002/anie.202216097

Kaltbeitzel J; Wich PR, 2023, 'Protein‐basierte Nanopartikel: Von Wirkstofftransport zu Bildgebung, Nanokatalyse und Proteintherapie', Angewandte Chemie, 135, http://dx.doi.org/10.1002/ange.202216097

Konhäuser M; Kannaujiya VK; Kaltbeitzel J; Winterwerber P; Böhm E; Breitenbach B; Wich PR, 2023, 'Dual-Responsive Enzyme-Polysaccharide Conjugate as a Nanocarrier System for Enzyme Prodrug Therapy', Biomacromolecules, 24, pp. 2138 - 2148, http://dx.doi.org/10.1021/acs.biomac.3c00031

Kannaujiya VK; De Rubis G; Paudel KR; Manandhar B; Chellappan DK; Singh SK; MacLoughlin R; Gupta G; Xenaki D; Kumar P; Hansbro PM; Oliver BGG; Wich PR; Dua K, 2023, 'Anticancer activity of NFκB decoy oligonucleotide-loaded nanoparticles against human lung cancer', Journal of Drug Delivery Science and Technology, 82, http://dx.doi.org/10.1016/j.jddst.2023.104328

Prasher P; Sharma M; Kumar Singh S; Gulati M; Kumar D; Gupta G; Kumar Chellappan D; Gregory George Oliver B; Wich PR; Dua K, 2022, 'Versatility of acetalated dextran in nanocarriers targeting respiratory diseases', Materials Letters, 323, http://dx.doi.org/10.1016/j.matlet.2022.132600

Prasher P; Sharma M; Singh SK; Haghi M; MacLoughlin R; Chellappan DK; Gupta G; Paudel KR; Hansbro PM; George Oliver BG; Wich PR; Dua K, 2022, 'Advances and applications of dextran-based nanomaterials targeting inflammatory respiratory diseases', Journal of Drug Delivery Science and Technology, 74, http://dx.doi.org/10.1016/j.jddst.2022.103598

Konhäuser M; Kannaujiya VK; Steiert E; Schwickert K; Schirmeister T; Wich PR, 2022, 'Co-encapsulation of L-asparaginase and etoposide in dextran nanoparticles for synergistic effect in chronic myeloid leukemia cells', International Journal of Pharmaceutics, 622, http://dx.doi.org/10.1016/j.ijpharm.2022.121796

Paudel KR; Panth N; Manandhar B; Singh SK; Gupta G; Wich PR; Nammi S; Macloughlin R; Adams J; Warkiani ME; Chellappan DK; Oliver BG; Hansbro PM; Dua K, 2022, 'Attenuation of Cigarette-Smoke-Induced Oxidative Stress, Senescence, and Inflammation by Berberine-Loaded Liquid Crystalline Nanoparticles: In Vitro Study in 16HBE and RAW264.7 Cells', Antioxidants, 11, http://dx.doi.org/10.3390/antiox11050873

Manikkath J; Jishnu PV; Wich PR; Manikkath A; Radhakrishnan R, 2022, 'Nanoparticulate strategies for the delivery of miRNA mimics and inhibitors in anticancer therapy and its potential utility in oral submucous fibrosis', Nanomedicine, 17, pp. 181 - 195, http://dx.doi.org/10.2217/nnm-2021-0381

Allam VSRR; Chellappan DK; Jha NK; Shastri MD; Gupta G; Shukla SD; Singh SK; Sunkara K; Chitranshi N; Gupta V; Wich PR; MacLoughlin R; Oliver BGG; Wernersson S; Pejler G; Dua K, 2022, 'Treatment of chronic airway diseases using nutraceuticals: Mechanistic insight', Critical Reviews in Food Science and Nutrition, 62, pp. 7576 - 7590, http://dx.doi.org/10.1080/10408398.2021.1915744

Prasher P; Sharma M; R Wich P; Jha NK; Singh SK; Chellappan DK; Dua K, 2021, 'Can dextran-based nanoparticles mitigate inflammatory lung diseases?', Future Medicinal Chemistry, 13, pp. 2027 - 2031, http://dx.doi.org/10.4155/fmc-2021-0218

Mehta M; Paudel KR; Shukla SD; Allam VSRR; Kannaujiya VK; Panth N; Das A; Parihar VK; Chakraborty A; Ali MK; Jha NK; Xenaki D; Su QP; Wich PR; Adams J; Hansbro PM; Chellappan DK; Oliver BGG; Dua K, 2021, 'Recent trends of NFκB decoy oligodeoxynucleotide-based nanotherapeutics in lung diseases', Journal of Controlled Release, 337, pp. 629 - 644, http://dx.doi.org/10.1016/j.jconrel.2021.08.010

Mehta M; Satija S; Paudel KR; Malyla V; Kannaujiya VK; Chellappan DK; Bebawy M; Hansbro PM; Wich PR; Dua K, 2021, 'Targeting respiratory diseases using miRNA inhibitor based nanotherapeutics: Current status and future perspectives', Nanomedicine: Nanotechnology, Biology, and Medicine, 31, http://dx.doi.org/10.1016/j.nano.2020.102303

Liu J; Guo Z; Kordanovski M; Kaltbeitzel J; Zhang H; Cao Z; Gu Z; Wich PR; Lord M; Liang K, 2020, 'Metal-organic frameworks as protective matrices for peptide therapeutics', Journal of Colloid and Interface Science, 576, pp. 356 - 363, http://dx.doi.org/10.1016/j.jcis.2020.05.057

Mehta M; Dhanjal DS; Paudel KR; Singh B; Gupta G; Rajeshkumar S; Thangavelu L; Tambuwala MM; Bakshi HA; Chellappan DK; Pandey P; Dureja H; Charbe NB; Singh SK; Shukla SD; Nammi S; Aljabali AA; Wich PR; Hansbro PM; Satija S; Dua K, 2020, 'Cellular signalling pathways mediating the pathogenesis of chronic inflammatory respiratory diseases: an update', Inflammopharmacology, 28, pp. 795 - 817, http://dx.doi.org/10.1007/s10787-020-00698-3

Rao NRH; Granville AM; Wich PR; Henderson RK, 2020, 'Detailed algal extracellular carbohydrate-protein characterisation lends insight into algal solid-liquid separation process outcomes', Water Research, 178, http://dx.doi.org/10.1016/j.watres.2020.115833

Prasher P; Sharma M; Mehta M; Paudel KR; Satija S; Chellappan DK; Dureja H; Gupta G; Tambuwala MM; Negi P; Wich PR; Hansbro NG; Hansbro PM; Dua K, 2020, 'Plants derived therapeutic strategies targeting chronic respiratory diseases: Chemical and immunological perspective', Chemico-Biological Interactions, 325, http://dx.doi.org/10.1016/j.cbi.2020.109125

Mehta M; Chellappan DK; Wich PR; Hansbro NG; Hansbro PM; Dua K, 2020, 'MiRNA nanotherapeutics: Potential and challenges in respiratory disorders', Future Medicinal Chemistry, 12, pp. 987 - 990, http://dx.doi.org/10.4155/fmc-2020-0066

Barthels F; Marincola G; Marciniak T; Konhäuser M; Hammerschmidt S; Bierlmeier J; Distler U; Wich PR; Tenzer S; Schwarzer D; Ziebuhr W; Schirmeister T, 2020, 'Asymmetric Disulfanylbenzamides as Irreversible and Selective Inhibitors of Staphylococcus aureus Sortase A', ChemMedChem, 15, pp. 839 - 850, http://dx.doi.org/10.1002/cmdc.201900687

Steiert E; Ewald J; Wagner A; Hellmich UA; Frey H; Wich PR, 2020, 'PH-Responsive protein nanoparticles: Via conjugation of degradable PEG to the surface of cytochrome c', Polymer Chemistry, 11, pp. 551 - 559, http://dx.doi.org/10.1039/c9py01162e

Butzbach K; Konhäuser M; Fach M; Bamberger DN; Breitenbach B; Epe B; Wich PR, 2019, 'Receptor-mediated uptake of folic acid-functionalized dextran nanoparticles for applications in photodynamic therapy', Polymers, 11, http://dx.doi.org/10.3390/polym11050896

Kühlborn J; Konhäuser M; Groß J; Wich PR; Opatz T, 2019, 'Xylochemical Synthesis of Cytotoxic 2-Aminophenoxazinone-Type Natural Products Through Oxidative Cross Coupling', ACS Sustainable Chemistry and Engineering, 7, pp. 4414 - 4419, http://dx.doi.org/10.1021/acssuschemeng.8b06353

Breitenbach BB; Steiert E; Konhäuser M; Vogt LM; Wang Y; Parekh SH; Wich PR, 2019, 'Double stimuli-responsive polysaccharide block copolymers as green macrosurfactants for near-infrared photodynamic therapy', Soft Matter, 15, pp. 1423 - 1434, http://dx.doi.org/10.1039/c8sm02204f

Paßlick D; Piradashvili K; Bamberger D; Li M; Jiang S; Strand D; R. Wich P; Landfester K; Bros M; Grabbe S; Mailänder V, 2018, 'Delivering all in one: Antigen-nanocapsule loaded with dual adjuvant yields superadditive effects by DC-directed T cell stimulation', Journal of Controlled Release, 289, pp. 23 - 34, http://dx.doi.org/10.1016/j.jconrel.2018.09.008

Steiert E; Radi L; Fach M; Wich PR, 2018, 'Protein-Based Nanoparticles for the Delivery of Enzymes with Antibacterial Activity', Macromolecular Rapid Communications, 39, http://dx.doi.org/10.1002/marc.201800186

, 2018, 'FCI Literature Prize: T. Schirmeister, C. Schmuck, P. R. Wich / Foundation for Polish Science Award: D. T. Gryko / Heinz Award: J. M. DeSimone.', Angew Chem Int Ed Engl, 57, pp. 1745, http://dx.doi.org/10.1002/anie.201800076

, 2018, 'FCI‐Literaturpreis: T. Schirmeister, C. Schmuck, P. R. Wich / FNP‐Preis: D. T. Gryko / Heinz Award: J. M. DeSimone', Angewandte Chemie, 130, pp. 1761 - 1761, http://dx.doi.org/10.1002/ange.201800076

Bamberger D; Hobernik D; Konhäuser M; Bros M; Wich PR, 2017, 'Surface Modification of Polysaccharide-Based Nanoparticles with PEG and Dextran and the Effects on Immune Cell Binding and Stimulatory Characteristics', Molecular Pharmaceutics, 14, pp. 4403 - 4416, http://dx.doi.org/10.1021/acs.molpharmaceut.7b00507

Breitenbach BB; Schmid I; Wich PR, 2017, 'Amphiphilic Polysaccharide Block Copolymers for pH-Responsive Micellar Nanoparticles (vol 18, pg 2839, 2017)', BIOMACROMOLECULES, 18, pp. 3844 - 3845, http://dx.doi.org/10.1021/acs.biomac.7b01342

Breitenbach BB; Schmid I; Wich PR, 2017, 'Amphiphilic Polysaccharide Block Copolymers for pH-Responsive Micellar Nanoparticles', Biomacromolecules, 18, pp. 2839 - 2848, http://dx.doi.org/10.1021/acs.biomac.7b00771

Previti S; Ettari R; Cosconati S; Amendola G; Chouchene K; Wagner A; Hellmich UA; Ulrich K; Krauth-Siegel RL; Wich PR; Schmid I; Schirmeister T; Gut J; Rosenthal PJ; Grasso S; Zappalà M, 2017, 'Development of Novel Peptide-Based Michael Acceptors Targeting Rhodesain and Falcipain-2 for the Treatment of Neglected Tropical Diseases (NTDs)', Journal of Medicinal Chemistry, 60, pp. 6911 - 6923, http://dx.doi.org/10.1021/acs.jmedchem.7b00405

Wich PR, 2017, 'Neuaufnahmen: Die GDCh begrüßt als neue Mitglieder', Nachrichten aus der Chemie, 65, pp. 615, http://dx.doi.org/10.1002/NADC.20174062443

Fach M; Radi L; Wich PR, 2016, 'Nanoparticle Assembly of Surface-Modified Proteins', Journal of the American Chemical Society, 138, pp. 14820 - 14823, http://dx.doi.org/10.1021/jacs.6b06243

Foerster F; Bamberger D; Schupp J; Weilbächer M; Kaps L; Strobl S; Radi L; Diken M; Strand D; Tuettenberg A; Wich PR; Schuppan D, 2016, 'Dextran-based therapeutic nanoparticles for hepatic drug delivery', Nanomedicine, 11, pp. 2663 - 2677, http://dx.doi.org/10.2217/nnm-2016-0156

Schirmeister T; Kesselring J; Jung S; Schneider TH; Weickert A; Becker J; Lee W; Bamberger D; Wich PR; Distler U; Tenzer S; Johé P; Hellmich UA; Engels B, 2016, 'Quantum Chemical-Based Protocol for the Rational Design of Covalent Inhibitors', Journal of the American Chemical Society, 138, pp. 8332 - 8335, http://dx.doi.org/10.1021/jacs.6b03052

Radi L; Fach M; Montigny M; Berger-Nicoletti E; Tremel W; Wich PR, 2016, 'Methods of protein surface PEGylation under structure preservation for the emulsion-based formation of stable nanoparticles', MedChemComm, 7, pp. 1738 - 1744, http://dx.doi.org/10.1039/c5md00475f

Foerster F; Kaps L; Strobl S; Bamberger D; Diken M; Tüttenberg A; Wich P; Schuppan D, 2015, 'Präklinische Evaluation Dextran-basierter Nanopartikel für die Leber- und Makrophagen-spezifische Pharmakotherapie', Zeitschrift für Gastroenterologie, 53, http://dx.doi.org/10.1055/s-0035-1559117

Wich PR, 2015, 'Building blocks of nature', Nachrichten aus der Chemie, 63, pp. 128 - 132, http://dx.doi.org/10.1002/nadc.201590046

Wich PR, 2015, 'Baukasten der Natur', Nachrichten aus der Chemie, 63, pp. 128 - 132, http://dx.doi.org/10.1002/nadc.201590046

Jiang QQ; Bartsch L; Sicking W; Wich PR; Heider D; Hoffmann D; Schmuck C, 2013, 'A new approach to inhibit human β-tryptase by protein surface binding of four-armed peptide ligands with two different sets of arms', Organic and Biomolecular Chemistry, 11, pp. 1631 - 1639, http://dx.doi.org/10.1039/c3ob27302d

Ornelas-Megiatto C; Shah PN; Wich PR; Cohen JL; Tagaev JA; Smolen JA; Wright BD; Panzner MJ; Youngs WJ; Fréchet JMJ; Cannon CL, 2012, 'Aerosolized antimicrobial agents based on degradable dextran nanoparticles loaded with silver carbene complexes', Molecular Pharmaceutics, 9, pp. 3012 - 3022, http://dx.doi.org/10.1021/mp3004379

Cui L; Cohen JL; Chu CK; Wich PR; Kierstead PH; Fréchet JMJ, 2012, 'Conjugation chemistry through acetals toward a dextran-based delivery system for controlled release of siRNA', Journal of the American Chemical Society, 134, pp. 15840 - 15848, http://dx.doi.org/10.1021/ja305552u

Wich PR; Fŕchet JMJ, 2012, 'Degradable dextran particles for gene delivery applications', Australian Journal of Chemistry, 65, pp. 15 - 19, http://dx.doi.org/10.1071/CH11370

Ornelas-Megiatto C; Wich PR; Fréchet JMJ, 2012, 'Polyphosphonium polymers for siRNA delivery: An efficient and nontoxic alternative to polyammonium carriers', Journal of the American Chemical Society, 134, pp. 1902 - 1905, http://dx.doi.org/10.1021/ja207366k

Cohen JL; Schubert S; Wich PR; Cui L; Cohen JA; Mynar JL; Fréchet JMJ, 2011, 'Acid-degradable cationic dextran particles for the delivery of siRNA therapeutics', Bioconjugate Chemistry, 22, pp. 1056 - 1065, http://dx.doi.org/10.1021/bc100542r

Wich PR; Schmuck C, 2010, 'Reversible and noncompetitive inhibition of β-tryptase by protein surface binding of tetravalent peptide ligands identified from a combinatorial split-mix library', Angewandte Chemie - International Edition, 49, pp. 4113 - 4116, http://dx.doi.org/10.1002/anie.200907221

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