Select Publications

Book Chapters

Sharpe LJ;Du X;Brown AJ, 2008, 'Approaches to investigate the role of signaling in ER-to-Golgi transport.', in Methods in molecular biology (Clifton, N.J.), pp. 215 - 225

Journal articles

Wang H;Ma Q;Qi Y;Dong J;Du X;Rae J;Wang J;Wu W-F;Brown AJ;Parton RG;Wu J-W;Yang H, 2019, 'ORP2 Delivers Cholesterol to the Plasma Membrane in Exchange for Phosphatidylinositol 4, 5-Bisphosphate (PI(4,5)P2).', Mol Cell, vol. 73, pp. 458 - 473.e7,

Yan R;Qian H;Lukmantara I;Gao M;Du X;Yan N;Yang H, 2018, 'Human SEIPIN Binds Anionic Phospholipids', Developmental Cell, vol. 47, pp. 248 - 256.e4,

Du X;Zadoorian A;Lukmantara IE;Qi Y;Brown AJ;Yang H, 2018, 'Oxysterol-binding protein–related protein 5 (ORP5) promotes cell proliferation by activation of MTORC1 signaling', Journal of Biological Chemistry, vol. 293, pp. 3806 - 3818,

Du X;Turner N;Yang H, 2018, 'The role of oxysterol-binding protein and its related proteins in cancer', Seminars in Cell and Developmental Biology, vol. 81, pp. 149 - 153,

Ghai R;Du X;Wang H;Dong J;Ferguson C;Brown AJ;Parton RG;Wu JW;Yang H, 2017, 'ORP5 and ORP8 bind phosphatidylinositol-4, 5-biphosphate (PtdIns(4,5)P 2) and regulate its level at the plasma membrane', Nature Communications, vol. 8,

Du X;Lukmantara I;Yang H, 2017, 'CRISPR/Cas9-mediated generation of niemann–pick C1 knockout cell line', Methods in Molecular Biology, vol. 1583, pp. 73 - 83,

Pagac M;Cooper DE;Qi Y;Lukmantara IE;Mak HY;Wu Z;Tian Y;Liu Z;Lei M;Du X;Ferguson C;Kotevski D;Sadowski P;Chen W;Boroda S;Harris TE;Liu G;Parton RG;Huang X;Coleman RA;Yang H, 2016, 'SEIPIN Regulates Lipid Droplet Expansion and Adipocyte Development by Modulating the Activity of Glycerol-3-phosphate Acyltransferase', Cell Reports, vol. 17, pp. 1546 - 1559,

Qi Y;Kapterian TS;Du X;Ma Q;Fei W;Zhang Y;Huang X;Dawes IW;Yang H, 2016, 'CDP-diacylglycerol synthases regulate the growth of lipid droplets and adipocyte development', Journal of Lipid Research, vol. 57, pp. 767 - 780,

Wang M;Gao M;Liao J;Qi Y;Du X;Wang Y;Li L;Liu G;Yang H, 2016, 'Adipose tissue deficiency results in severe hyperlipidemia and atherosclerosis in the low-density lipoprotein receptor knockout mice', Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, vol. 1861, pp. 410 - 418,

Tuong ZK;Lau P;Du X;Condon ND;Goode JM;Oh TG;Yeo JC;Muscat GE O;Stow JL, 2016, 'RORα and 25-hydroxycholesterol crosstalk regulates lipid droplet homeostasis in macrophages', PLoS ONE, vol. 11,

Liu X;Xie B;Qi Y;Du X;Wang S;Zhang Y;Paxinos G;Yang H;Liang H, 2016, 'The expression of SEIPIN in the mouse central nervous system', Brain Structure and Function, vol. 221, pp. 4111 - 4127,

Du X;Zhang Y;Jo SR;Liu X;Qi Y;Osborne B;Byrne FL;Smith GC;Turner N;Hoehn KL;Brown AJ;Yang H, 2015, 'Akt activation increases cellular cholesterol by promoting the proteasomal degradation of Niemann-Pick C1', Biochemical Journal, vol. 471, pp. 243 - 253,

Du X;Brown AJ;Yang H, 2015, 'Novel mechanisms of intracellular cholesterol transport: oxysterol-binding proteins and membrane contact sites.', Curr Opin Cell Biol, vol. 35, pp. 37 - 42,

Chu B-B;Liao Y-C;Qi W;Xie C;Du X;Wang J;Yang H;Miao H-H;Li B-L;Song B-L, 2015, 'Cholesterol transport through lysosome-peroxisome membrane contacts.', Cell, vol. 161, pp. 291 - 306,

Du X;Yang H, 2013, 'Endosomal cholesterol trafficking: protein factors at a glance.', Acta Biochim Biophys Sin (Shanghai), vol. 45, pp. 11 - 17,

Du X;Kazim AS;Dawes IW;Brown AJ;Yang H, 2013, 'The AAA ATPase VPS4/SKD1 regulates endosomal cholesterol trafficking independently of ESCRT-III.', Traffic, vol. 14, pp. 107 - 119,

Du X;Kazim AS;Brown AJ;Yang H, 2012, 'An essential role of Hrs/Vps27 in endosomal cholesterol trafficking.', Cell Rep, vol. 1, pp. 29 - 35,

Ta MT;Kapterian TS;Fei W;Du X;Brown AJ;Dawes IW;Yang H, 2012, 'Accumulation of squalene is associated with the clustering of lipid droplets.', FEBS J, vol. 279, pp. 4231 - 4244,

Fei W;Du X;Yang H, 2011, 'Seipin, adipogenesis and lipid droplets.', Trends Endocrinol Metab, vol. 22, pp. 204 - 210,

Du X;Kumar J;Ferguson C;Schulz TA;Ong YS;Hong W;Prinz WA;Parton RG;Brown AJ;Yang H, 2011, 'A role for oxysterol-binding protein-related protein 5 in endosomal cholesterol trafficking.', J Cell Biol, vol. 192, pp. 121 - 135,

Fei W;Li H;Shui G;Kapterian TS;Bielby C;Du X;Brown AJ;Li P;Wenk MR;Liu P;Yang H, 2011, 'Molecular characterization of seipin and its mutants: implications for seipin in triacylglycerol synthesis.', J Lipid Res, vol. 52, pp. 2136 - 2147,

Du X;Yang H, 2011, 'Sterol-binding proteins and endosomal cholesterol transport', Frontiers in Biology, vol. 6, pp. 190 - 196

Sharpe LJ;Du X;Brown AJ, 2008, 'Approaches to investigate the role of signaling in ER-to-golgi transport', Methods in Molecular Biology, vol. 457, pp. 215 - 225,

Fei W;Shui G;Gaeta B;Du X;Kuerschner L;Li P;Brown AJ;Wenk MR;Parton RG;Yang H, 2008, 'Fld1p, a functional homologue of human seipin, regulates the size of lipid droplets in yeast.', J Cell Biol, vol. 180, pp. 473 - 482,

Du X;Kristiana I;Wong J;Brown AJ, 2006, 'Involvement of Akt in ER-to-Golgi transport of SCAP/SREBP: a link between a key cell proliferative pathway and membrane synthesis.', Mol Biol Cell, vol. 17, pp. 2735 - 2745,

Du X;Pham YH;Brown AJ, 2004, 'Effects of 25-hydroxycholesterol on cholesterol esterification and sterol regulatory element-binding protein processing are dissociable: implications for cholesterol movement to the regulatory pool in', J Biol Chem, vol. 279, pp. 47010 - 47016,

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