Select Publications

Book Chapters

Sharpe LJ; Du X; Brown AJ, 2008, 'Approaches to investigate the role of signaling in ER-to-Golgi transport.', in Methods in molecular biology (Clifton, N.J.), pp. 215 - 225

Journal articles

Dong J; Du X; Wang H; Wang J; Lu C; Chen X; Zhu Z; Luo Z; Yu L; Brown AJ; Yang H; Wu JW, 2019, 'Allosteric enhancement of ORP1-mediated cholesterol transport by PI(4,5)P 2 /PI(3,4)P 2', Nature Communications, vol. 10, http://dx.doi.org/10.1038/s41467-019-08791-0

Wang H; Ma Q; Qi Y; Dong J; Du X; Rae J; Wang J; Wu WF; Brown AJ; Parton RG; Wu JW; Yang H, 2019, 'ORP2 Delivers Cholesterol to the Plasma Membrane in Exchange for Phosphatidylinositol 4, 5-Bisphosphate (PI(4,5)P 2 )', Molecular Cell, vol. 73, pp. 458 - 473.e7, http://dx.doi.org/10.1016/j.molcel.2018.11.014

Yan R; Qian H; Lukmantara I; Gao M; Du X; Yan N; Yang H, 2018, 'Human SEIPIN Binds Anionic Phospholipids', Developmental Cell, vol. 47, pp. 248 - 256.e4, http://dx.doi.org/10.1016/j.devcel.2018.09.010

Du X; Zadoorian A; Lukmantara IE; Qi Y; Brown AJ; Yang H, 2018, 'Oxysterol-binding protein–related protein 5 (ORP5) promotes cell proliferation by activation of MTORC1 signaling', Journal of Biological Chemistry, vol. 293, pp. 3806 - 3818, http://dx.doi.org/10.1074/jbc.RA117.001558

Du X; Turner N; Yang H, 2018, 'The role of oxysterol-binding protein and its related proteins in cancer', Seminars in Cell and Developmental Biology, vol. 81, pp. 149 - 153, http://dx.doi.org/10.1016/j.semcdb.2017.07.017

Ghai R; Du X; Wang H; Dong J; Ferguson C; Brown AJ; Parton RG; Wu JW; Yang H, 2017, 'ORP5 and ORP8 bind phosphatidylinositol-4, 5-biphosphate (PtdIns(4,5)P 2) and regulate its level at the plasma membrane', Nature Communications, vol. 8, http://dx.doi.org/10.1038/s41467-017-00861-5

Du X; Lukmantara I; Yang H, 2017, 'CRISPR/Cas9-mediated generation of niemann–pick C1 knockout cell line', Methods in Molecular Biology, vol. 1583, pp. 73 - 83, http://dx.doi.org/10.1007/978-1-4939-6875-6_7

Pagac M; Cooper DE; Qi Y; Lukmantara IE; Mak HY; Wu Z; Tian Y; Liu Z; Lei M; Du X; Ferguson C; Kotevski D; Sadowski P; Chen W; Boroda S; Harris TE; Liu G; Parton RG; Huang X; Coleman RA; Yang H, 2016, 'SEIPIN Regulates Lipid Droplet Expansion and Adipocyte Development by Modulating the Activity of Glycerol-3-phosphate Acyltransferase', Cell Reports, vol. 17, pp. 1546 - 1559, http://dx.doi.org/10.1016/j.celrep.2016.10.037

Qi Y; Kapterian TS; Du X; Ma Q; Fei W; Zhang Y; Huang X; Dawes IW; Yang H, 2016, 'CDP-diacylglycerol synthases regulate the growth of lipid droplets and adipocyte development', Journal of Lipid Research, vol. 57, pp. 767 - 780, http://dx.doi.org/10.1194/jlr.M060574

Wang M; Gao M; Liao J; Qi Y; Du X; Wang Y; Li L; Liu G; Yang H, 2016, 'Adipose tissue deficiency results in severe hyperlipidemia and atherosclerosis in the low-density lipoprotein receptor knockout mice', Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, vol. 1861, pp. 410 - 418, http://dx.doi.org/10.1016/j.bbalip.2016.02.018

Tuong ZK; Lau P; Du X; Condon ND; Goode JM; Oh TG; Yeo JC; Muscat GE O; Stow JL, 2016, 'RORα and 25-hydroxycholesterol crosstalk regulates lipid droplet homeostasis in macrophages', PLoS ONE, vol. 11, http://dx.doi.org/10.1371/journal.pone.0147179

Liu X; Xie B; Qi Y; Du X; Wang S; Zhang Y; Paxinos G; Yang H; Liang H, 2016, 'The expression of SEIPIN in the mouse central nervous system', Brain Structure and Function, vol. 221, pp. 4111 - 4127, http://dx.doi.org/10.1007/s00429-015-1151-3

Du X; Zhang Y; Jo SR; Liu X; Qi Y; Osborne B; Byrne FL; Smith GC; Turner N; Hoehn KL; Brown AJ; Yang H, 2015, 'Akt activation increases cellular cholesterol by promoting the proteasomal degradation of Niemann-Pick C1', Biochemical Journal, vol. 471, pp. 243 - 253, http://dx.doi.org/10.1042/BJ20150602

Du X; Brown AJ; Yang H, 2015, 'Novel mechanisms of intracellular cholesterol transport: oxysterol-binding proteins and membrane contact sites.', Curr Opin Cell Biol, vol. 35, pp. 37 - 42, http://dx.doi.org/10.1016/j.ceb.2015.04.002

Chu B-B; Liao Y-C; Qi W; Xie C; Du X; Wang J; Yang H; Miao H-H; Li B-L; Song B-L, 2015, 'Cholesterol transport through lysosome-peroxisome membrane contacts.', Cell, vol. 161, pp. 291 - 306, http://dx.doi.org/10.1016/j.cell.2015.02.019

Du X; Yang H, 2013, 'Endosomal cholesterol trafficking: protein factors at a glance.', Acta Biochim Biophys Sin (Shanghai), vol. 45, pp. 11 - 17, http://dx.doi.org/10.1093/abbs/gms095

Du X; Kazim AS; Dawes IW; Brown AJ; Yang H, 2013, 'The AAA ATPase VPS4/SKD1 regulates endosomal cholesterol trafficking independently of ESCRT-III.', Traffic, vol. 14, pp. 107 - 119, http://dx.doi.org/10.1111/tra.12015

Du X; Kazim AS; Brown AJ; Yang H, 2012, 'An essential role of Hrs/Vps27 in endosomal cholesterol trafficking.', Cell Rep, vol. 1, pp. 29 - 35, http://dx.doi.org/10.1016/j.celrep.2011.10.004

Ta MT; Kapterian TS; Fei W; Du X; Brown AJ; Dawes IW; Yang H, 2012, 'Accumulation of squalene is associated with the clustering of lipid droplets.', FEBS J, vol. 279, pp. 4231 - 4244, http://dx.doi.org/10.1111/febs.12015

Fei W; Du X; Yang H, 2011, 'Seipin, adipogenesis and lipid droplets.', Trends Endocrinol Metab, vol. 22, pp. 204 - 210, http://dx.doi.org/10.1016/j.tem.2011.02.004

Du X; Kumar J; Ferguson C; Schulz TA; Ong YS; Hong W; Prinz WA; Parton RG; Brown AJ; Yang H, 2011, 'A role for oxysterol-binding protein-related protein 5 in endosomal cholesterol trafficking.', J Cell Biol, vol. 192, pp. 121 - 135, http://dx.doi.org/10.1083/jcb.201004142

Fei W; Li H; Shui G; Kapterian TS; Bielby C; Du X; Brown AJ; Li P; Wenk MR; Liu P; Yang H, 2011, 'Molecular characterization of seipin and its mutants: implications for seipin in triacylglycerol synthesis.', J Lipid Res, vol. 52, pp. 2136 - 2147, http://dx.doi.org/10.1194/jlr.M017566

Du X; Yang H, 2011, 'Sterol-binding proteins and endosomal cholesterol transport', Frontiers in Biology, vol. 6, pp. 190 - 196

Sharpe LJ; Du X; Brown AJ, 2008, 'Approaches to investigate the role of signaling in ER-to-golgi transport', Methods in Molecular Biology, vol. 457, pp. 215 - 225, http://dx.doi.org/10.1007/978-1-59745-261-8_16

Fei W; Shui G; Gaeta B; Du X; Kuerschner L; Li P; Brown AJ; Wenk MR; Parton RG; Yang H, 2008, 'Fld1p, a functional homologue of human seipin, regulates the size of lipid droplets in yeast.', J Cell Biol, vol. 180, pp. 473 - 482, http://dx.doi.org/10.1083/jcb.200711136

Du X; Kristiana I; Wong J; Brown AJ, 2006, 'Involvement of Akt in ER-to-Golgi transport of SCAP/SREBP: a link between a key cell proliferative pathway and membrane synthesis.', Mol Biol Cell, vol. 17, pp. 2735 - 2745, http://dx.doi.org/10.1091/mbc.e05-11-1094

Du X; Pham YH; Brown AJ, 2004, 'Effects of 25-hydroxycholesterol on cholesterol esterification and sterol regulatory element-binding protein processing are dissociable: implications for cholesterol movement to the regulatory pool in', J Biol Chem, vol. 279, pp. 47010 - 47016, http://dx.doi.org/10.1074/jbc.M408690200


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