By Dr Robin Du

Book Chapters

Sharpe LJ; Du XR; Brown AJ, 2008, 'Approaches to investigate the role of signaling in ER-to-Golgi transport', in Sheehan D; Tyther R (ed.), Methods in Molecular Biology, Two Dimensional Electrophoresis Protocols, Humana Press, Inc., United States, pp. 215 - 227

Journal articles

Coates HW; Nguyen TB; Du X; Olzomer EM; Farrell R; Byrne FL; Yang H; Brown AJ, 2024, 'The constitutively active form of a key cholesterol synthesis enzyme is lipid droplet-localized and upregulated in endometrial cancer tissues', Journal of Biological Chemistry, 300, http://dx.doi.org/10.1016/j.jbc.2024.107232

Li YE; Norris DM; Xiao FN; Pandzic E; Whan RM; Fok S; Zhou M; Du G; Liu Y; Du X; Yang H, 2024, 'Phosphatidylserine regulates plasma membrane repair through tetraspanin-enriched macrodomains', Journal of Cell Biology, 223, http://dx.doi.org/10.1083/jcb.202307041

Lin Y; Ran L; Du X; Yang H; Wu Y, 2023, 'Oxysterol-Binding Protein: new insights into lipid transport functions and human diseases', Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1868, http://dx.doi.org/10.1016/j.bbalip.2023.159365

Zadoorian A; Du X; Yang H, 2023, 'Lipid droplet biogenesis and functions in health and disease', Nature Reviews Endocrinology, 19, pp. 443 - 459, http://dx.doi.org/10.1038/s41574-023-00845-0

Coates HW; Capell-Hattam IM; Olzomer EM; Du X; Farrell R; Yang H; Byrne FL; Brown AJ, 2023, 'Hypoxia truncates and constitutively activates the key cholesterol synthesis enzyme squalene monooxygenase', eLife, 12, http://dx.doi.org/10.7554/eLife.82843

Lukmantara I; Chen F; Mak HY; Zadoorian A; Du X; Xiao FN; MacMurray Norris D; Pandzic E; Whan R; Zhong Q; Yang H, 2022, 'PI(3)P and DFCP1 regulate the biogenesis of lipid droplets', Molecular Biology of the Cell, 33, http://dx.doi.org/10.1091/mbc.E22-07-0279

Keable R; Hu S; Pfundstein G; Kozlova I; Su F; Du X; Yang H; Gunnersen J; Schachner M; Leshchyns’ka I; Sytnyk V, 2022, 'The BACE1-generated C-terminal fragment of the neural cell adhesion molecule 2 (NCAM2) promotes BACE1 targeting to Rab11-positive endosomes', Cellular and Molecular Life Sciences, 79, http://dx.doi.org/10.1007/s00018-022-04575-w

Mak HY; Ouyang Q; Tumanov S; Xu J; Rong P; Dong F; Lam SM; Wang X; Lukmantara I; Du X; Gao M; Brown AJ; Gong X; Shui G; Stocker R; Huang X; Chen S; Yang H, 2021, 'AGPAT2 interaction with CDP-diacylglycerol synthases promotes the flux of fatty acids through the CDP-diacylglycerol pathway', Nature Communications, 12, http://dx.doi.org/10.1038/s41467-021-27279-4

Li YE; Wang Y; Du X; Zhang T; Mak H; Hancock SE; McEwen H; Pandzic E; Whan RM; Aw YC; Lukmantara IE; Yuan Y; Dong X; Don A; Turner N; Qi S; Yang H, 2021, 'TMEM41B and VMP1 are scramblases and regulate the distribution of cholesterol and phosphatidylserine', Journal of Cell Biology, 220, http://dx.doi.org/10.1083/jcb.202103105

Yan R; Cao P; Song W; Qian H; Du X; Coates HW; Zhao X; Li Y; Gao S; Gong X; Liu X; Sui J; Lei J; Yang H; Brown AJ; Zhou Q; Yan C; Yan N, 2021, 'A structure of human scap bound to insig-2 suggests how their interaction is regulated by sterols', Science, 371, pp. 1012 - +, http://dx.doi.org/10.1126/science.abb2224

Chu BB; Liao YC; Qi W; Xie C; Du X; Wang J; Yang H; Miao HH; Li BL; Song BL, 2021, 'Erratum: Cholesterol Transport through Lysosome-Peroxisome Membrane Contacts (Cholesterol Transport through Lysosome-Peroxisome Membrane Contacts (2015) 161(2) (291–306), (S0092867415001853), (10.1016/j.cell.2015.02.019))', Cell, 184, pp. 289, http://dx.doi.org/10.1016/j.cell.2020.12.023

Du X; Yang H, 2021, 'Seipin regulates the formation of nuclear lipid droplets from a distance', Journal of Cell Biology, 220, http://dx.doi.org/10.1083/JCB.202011166

Zhang T; Li YE; Yuan Y; Du X; Wang Y; Dong X; Yang H; Qi S, 2021, 'TMEM41B and VMP1 are phospholipid scramblases', Autophagy, 17, pp. 2048 - 2050, http://dx.doi.org/10.1080/15548627.2021.1937898

Du X; Zhou L; Aw YC; Mak HY; Xu Y; Rae J; Wang W; Zadoorian A; Hancock SE; Osborne B; Chen X; Wu JW; Turner N; Parton RG; Li P; Yang H, 2020, 'ORP5 localizes to ER-lipid droplet contacts and regulates the level of PI(4)P on lipid droplets', Journal of Cell Biology, 219, http://dx.doi.org/10.1083/jcb.201905162

Du X; Yang H, 2020, 'Triacylglycerol Measurement in HeLa Cells', Bio-protocol, 10, http://dx.doi.org/10.21769/BioProtoc.3852

Qian H; Zhao X; Yan R; Yao X; Gao S; Sun X; Du X; Yang H; Wong CCL; Yan N, 2020, 'Structural basis for catalysis and substrate specificity of human ACAT1', Nature, 581, pp. 333 - 338

Qian H; Wu X; Du X; Yao X; Zhao X; Lee J; Yang H; Yan N, 2020, 'Structural Basis of Low-pH-Dependent Lysosomal Cholesterol Egress by NPC1 and NPC2', Cell

Xu Y; Du X; Turner N; Brown AJ; Yang H, 2019, 'Enhanced acyl-CoA:cholesterol acyltransferase activity increases cholesterol levels on the lipid droplet surface and impairs adipocyte function', Journal of Biological Chemistry, 294, pp. 19306 - 19321, http://dx.doi.org/10.1074/jbc.RA119.011160

Dong J; Du X; Wang H; Wang J; Lu C; Chen X; Zhu Z; Luo Z; Yu L; Brown AJ; Yang H; Wu JW, 2019, 'Allosteric enhancement of ORP1-mediated cholesterol transport by PI(4,5)P 2 /PI(3,4)P 2', Nature Communications, 10, http://dx.doi.org/10.1038/s41467-019-08791-0

Xu Y; Mak HY; Lukmantara I; Li YE; Hoehn KL; Huang X; Du X; Yang H, 2019, 'CDP-DAG synthase 1 and 2 regulate lipid droplet growth through distinct mechanisms', Journal of Biological Chemistry, 294, pp. 16740 - 16755, http://dx.doi.org/10.1074/jbc.RA119.009992

Wang H; Ma Q; Qi Y; Dong J; Du X; Rae J; Wang J; Wu WF; Brown AJ; Parton RG; Wu JW; Yang H, 2019, 'ORP2 Delivers Cholesterol to the Plasma Membrane in Exchange for Phosphatidylinositol 4, 5-Bisphosphate (PI(4,5)P 2 )', Molecular Cell, 73, pp. 458 - 473.e7, http://dx.doi.org/10.1016/j.molcel.2018.11.014

Du X; Turner N; Yang H, 2018, 'The role of oxysterol-binding protein and its related proteins in cancer', Seminars in Cell and Developmental Biology, 81, pp. 149 - 153, http://dx.doi.org/10.1016/j.semcdb.2017.07.017

Du X; Zadoorian A; Lukmantara IE; Qi Y; Brown AJ; Yang H, 2018, 'Oxysterol-binding protein–related protein 5 (ORP5) promotes cell proliferation by activation of MTORC1 signaling', Journal of Biological Chemistry, 293, pp. 3806 - 3818, http://dx.doi.org/10.1074/jbc.RA117.001558

Ghai R; Du X; Wang H; Dong J; Ferguson C; Brown AJ; Parton RG; Wu JW; Yang H, 2017, 'ORP5 and ORP8 bind phosphatidylinositol-4, 5-biphosphate (PtdIns(4,5)P 2) and regulate its level at the plasma membrane', Nature Communications, 8, http://dx.doi.org/10.1038/s41467-017-00861-5

Du X; Lukmantara I; Yang H, 2017, 'CRISPR/Cas9-mediated generation of niemann–pick C1 knockout cell line', , 1583, pp. 73 - 83, http://dx.doi.org/10.1007/978-1-4939-6875-6_7

Pagac M; Cooper DE; Qi Y; Lukmantara IE; Mak HY; Wu Z; Tian Y; Liu Z; Lei M; Du X; Ferguson C; Kotevski D; Sadowski P; Chen W; Boroda S; Harris TE; Liu G; Parton RG; Huang X; Coleman RA; Yang H, 2016, 'SEIPIN Regulates Lipid Droplet Expansion and Adipocyte Development by Modulating the Activity of Glycerol-3-phosphate Acyltransferase', Cell Reports, 17, pp. 1546 - 1559, http://dx.doi.org/10.1016/j.celrep.2016.10.037

Liu X; Xie B; Qi Y; Du X; Wang S; Zhang Y; Paxinos G; Yang H; Liang H, 2016, 'The expression of SEIPIN in the mouse central nervous system', Brain Structure and Function, 221, pp. 4111 - 4127, http://dx.doi.org/10.1007/s00429-015-1151-3

Wang M; Gao M; Liao J; Qi Y; Du X; Wang Y; Li L; Liu G; Yang H, 2016, 'Adipose tissue deficiency results in severe hyperlipidemia and atherosclerosis in the low-density lipoprotein receptor knockout mice', Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1861, pp. 410 - 418, http://dx.doi.org/10.1016/j.bbalip.2016.02.018

Qi Y; Kapterian TS; Du X; Ma Q; Fei W; Zhang Y; Huang X; Dawes IW; Yang H, 2016, 'CDP-diacylglycerol synthases regulate the growth of lipid droplets and adipocyte development', Journal of Lipid Research, 57, pp. 767 - 780, http://dx.doi.org/10.1194/jlr.M060574

Tuong ZK; Lau P; Du X; Condon ND; Goode JM; Oh TG; Yeo JC; Muscat GEO; Stow JL, 2016, 'RORα and 25-hydroxycholesterol crosstalk regulates lipid droplet homeostasis in macrophages', PLoS ONE, 11, http://dx.doi.org/10.1371/journal.pone.0147179

Du X; Zhang Y; Jo SR; Liu X; Qi Y; Osborne B; Byrne FL; Smith GC; Turner N; Hoehn KL; Brown AJ; Yang H, 2015, 'Akt activation increases cellular cholesterol by promoting the proteasomal degradation of Niemann-Pick C1', Biochemical Journal, 471, pp. 243 - 253, http://dx.doi.org/10.1042/BJ20150602

Chu B-B; Liao Y-C; Qi W; Xie C; Du X; Wang J; Yang H; Miao H-H; Li B-L; Song B-L, 2015, 'Cholesterol Transport through Lysosome-Peroxisome Membrane Contacts', Cell, 161, pp. 291 - 306, http://dx.doi.org/10.1016/j.cell.2015.02.019

Du X; Brown AJ; Yang H, 2015, 'Novel mechanisms of intracellular cholesterol transport: oxysterol-binding proteins and membrane contact sites', Current Opinion in Cell Biology, 35, pp. 37 - 42, http://dx.doi.org/10.1016/j.ceb.2015.04.002

Du X; Yang H, 2013, 'Endosomal cholesterol trafficking: protein factors at a glance.', ACTA Biochimica et Biophysica Sinica, 45, pp. 11 - 17, http://dx.doi.org/10.1093/abbs/gms095&#65279

Du X; Kazim AS; Dawes IW; Brown AJ; Yang H, 2013, 'The AAA ATPase VPS4/SKD1 regulates endosomal cholesterol trafficking independently of ESCRT-III.', Traffic, 14, pp. 107 - 119, http://dx.doi.org/10.1111/tra.12015

Ta MT; Kapterian T; Fei W; Du X; Brown AJ; Dawes IW; Yang H, 2012, 'Accumulation of squalene is associated with the clustering of lipid droplets.', FEBS Journal, 279, pp. 4231 - 4244, http://dx.doi.org/10.1111/febs.12015

Du X; Kazim A; Brown AJ; Yang H, 2012, 'An essential role of Hrs/Vps27 in endosomal cholesterol trafficking', Cell Reports, 1, pp. 29 - 35

Du XR; Kumar J; Ferguson C; Schulz TA; Ong YS; Hong W; Prinz WA; Parton RG; Brown AJ; Yang H, 2011, 'A role for oxysterol-binding protein-related protein 5 in endosomal cholesterol trafficking', Journal of Cell Biology, 192, pp. 121 - 135, http://dx.doi.org/10.1083/jcb.201004142

Fei W; Li H; Shui G; Kapterian TS; Bielby C; Du X; Brown AJ; Li P; Wenk M; Liu P; Yang H, 2011, 'Molecular characterization of seipin and its mutants: implications for seipin in triacylglycerol synthesis.', Journal of Lipid Research, 52, pp. 2136 - 2147, http://www.ncbi.nlm.nih.gov/pubmed/21957196

Fei W; Du XR; Yang H, 2011, 'Seipin, adipogenesis and lipid droplets.', Trends in Endocrinology and Metabolism, 22, pp. 204 - 210, http://www.ncbi.nlm.nih.gov/pubmed/21497513

Du X; Yang H, 2011, 'Sterol-binding proteins and endosomal cholesterol transport', Frontiers in Biology, 6, pp. 190 - 196

Sharpe LJ; Du X; Brown AJ, 2008, 'Approaches to investigate the role of signaling in ER-to-golgi transport', Methods in Molecular Biology, 457, pp. 215 - 225, http://dx.doi.org/10.1007/978-1-59745-261-8_16

Fei W; Shui G; Gaeta BA; Du XR; Kuerschner L; Liu P; Brown AJ; Wenk M; Parton R; Yang H, 2008, 'Fld1p, a functional homologue of human seipin, regulates the size of lipid droplets in yeast', Journal of Cell Biology, 180, pp. 473 - 482, http://dx.doi.org/10.1083/icb.200711136

Du XR; Kristiana I; Wong J; Brown AJ, 2006, 'Involvement of Akt in ER-to-Golgi transport of SCAP/SREBP: A link between a key cell proliferative pathway and membrane synthesis', Molecular Biology of the Cell, 17, pp. 2735 - 2745

Du XR; Pham Y; Brown AJ, 2004, 'Effects of 25-hydroxycholesterol on cholesterol esterification andsterol regulatory element-binding protein processing are dissociable -Implications for cholesterol movement to the regulatory pool in theendoplasmic reticulum', The Journal of Biological Chemistry, 279, pp. 47010 - 47016

Yan R; Qian H; Lukmantara I; Gao M; Du X; Yan N; Yang H, 'Human SEIPIN Binds Anionic Phospholipids', Dev. Cell, 47, pp. 248 - 256

Preprints

Wu J; Gao M; Wu X; Liu Y; Du X; Liang Y; Ma C; Li P; Chen F-J; Yang H, 2024, PI(4)P recruits CIDE proteins to promote the formation of unilocular lipid droplets during adipogenesis and hepatic steatosis, http://dx.doi.org/10.1101/2024.08.22.609036

Coates H; Olzomer E; Du X; Farrell R; Yang H; Byrne F; Brown A, 2022, Hypoxia truncates and constitutively activates the key cholesterol synthesis enzyme squalene monooxygenase, http://dx.doi.org/10.1101/2022.08.18.504470

Amanda Tan RP; Kozlova I; Su F; Sah S; Keable R; Hagan W; Bustamante S; Du X; Osborne B; Turner N; Clemens K; Begg D; Phelps E; Yang H; Leshchyns’ka I; Sytnyk V, 2022, Neuronal growth regulator 1 (NEGR1) promotes synaptic targeting of glutamic acid decarboxylase 65 (GAD65), http://dx.doi.org/10.1101/2022.02.08.479601

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