By Dr Siiri Iismaa

Journal articles

Iismaa SE; Li M; Kesteven S; Wu J; Chan AY; Holman SR; Calvert JW; Haq AU; Nicks AM; Naqvi N; Husain A; Feneley MP; Graham RM, 2018, 'Cardiac hypertrophy limits infarct expansion after myocardial infarction in mice', Scientific Reports, 8, pp. 6114, http://dx.doi.org/10.1038/s41598-018-24525-6

Iismaa SE; Kaidonis X; Nicks AM; Bogush N; Kikuchi K; Naqvi N; Harvey RP; Husain A; Graham RM, 2018, 'Comparative regenerative mechanisms across different mammalian tissues', npj Regenerative Medicine, 3, pp. 6, http://dx.doi.org/10.1038/s41536-018-0044-5

Mižíková I; Pfeffer T; Nardiello C; Surate Solaligue DE; Steenbock H; Tatsukawa H; Silva DM; Vadász I; Herold S; Pease RJ; Iismaa SE; Hitomi K; Seeger W; Brinckmann J; Morty RE, 2018, 'Targeting transglutaminase 2 partially restores extracellular matrix structure but not alveolar architecture in experimental bronchopulmonary dysplasia', FEBS Journal, 285, pp. 3056 - 3076, http://dx.doi.org/10.1111/febs.14596

Coleman JLJ; Mouat MA; Wu J; Jancovski N; Bassi JK; Chan AY; Humphreys DT; Mrad N; Yu ZY; Ngo T; Iismaa S; Dos Remedios CG; Feneley MP; Allen AM; Graham RM; Smith NJ, 2018, 'Orphan receptor GPR37L1 contributes to the sexual dimorphism of central cardiovascular control', Biology of Sex Differences, 9, pp. 14, http://dx.doi.org/10.1186/s13293-018-0173-y

Iismaa SE, 2016, 'The prostate-specific protein, transglutaminase 4 (TG4), is an autoantigen associated with male subfertility', Annals of Translational Medicine, 4, http://dx.doi.org/10.21037/atm.2016.10.02

Naqvi N; Singh R; Iismaa SE; Li M; Calvert JW; Martin DIK; Harvey RP; Graham RM; Husain A, 2015, 'Cardiomyocytes Replicate and their Numbers Increase in Young Hearts', Cell, 163, pp. 783 - 784, http://dx.doi.org/10.1016/j.cell.2015.10.038

Cannon L; Yu ZY; Marciniec T; Waardenberg AJ; Iismaa SE; Nikolova-Krstevski V; Neist E; Ohanian M; Qiu MR; Rainer S; Harvey RP; Feneley MP; Graham RM; Fatkin D, 2015, 'Irreversible triggers for hypertrophic cardiomyopathy are established in the early postnatal period', Journal of the American College of Cardiology, 65, pp. 560 - 569, http://dx.doi.org/10.1016/j.jacc.2014.10.069

Li M; Iismaa SE; Naqvi N; Nicks A; Husain A; Graham RM, 2014, 'Thyroid hormone action in postnatal heart development', Stem Cell Research, 13, pp. 582 - 591, http://dx.doi.org/10.1016/j.scr.2014.07.001

Yu ZY; Tan JC; McMahon AC; Iismaa SE; Xiao H; Kesteven SH; Reichelt ME; Mohl MC; Smith NJ; Fatkin D; Allen D; Head SI; Graham RM; Feneley MP, 2014, 'RhoA/ROCK signaling and pleiotropic α1A-adrenergic receptor regulation of cardiac contractility', PLoS ONE, 9, pp. e99024, http://dx.doi.org/10.1371/journal.pone.0099024

Naqvi N; Li M; Calvert JW; Tejada T; Lambert JP; Wu J; Kesteven SH; Holman SR; Matsuda T; Lovelock JD; Howard WW; Iismaa SE; Chan AY; Crawford BH; Wagner MB; Martin DIK; Lefer DJ; Graham RM; Husain A, 2014, 'A proliferative burst during preadolescence establishes the final cardiomyocyte number', Cell, 157, pp. 795 - 807, http://dx.doi.org/10.1016/j.cell.2014.03.035

Lismaa SE; Aplin M; Holman S; Yiu T; Jackson K; Burchfield JG; Mitchell CJ; O'Reilly L; Davenport A; Cantley J; Schmitz-Peiffer C; Biden TJ; Cooney GJ; Graham RM, 2013, 'Glucose Homeostasis in Mice Is Transglutaminase 2 Independent', PLoS One, 8, pp. Article numbere63346, http://dx.doi.org/10.1371/journal.pone.0063346

Tong L; Png E; AiHua H; Yong SS; Yeo HL; Riau A; Mendoz E; Charausia SS; Lim CT; Yiu TW; Iismaa SE, 2013, 'Molecular mechanism of transglutaminase-2 in corneal epithelial migration and adhesion', Biochimica et Biophysica ACTA - Molecular Cell Research, 1833, pp. 1304 - 1315, http://dx.doi.org/10.1016/j.bbamcr.2013.02.030

Yu Z; Tan J; McMahon A; Iismaa S; Xiao X; Kesteven S; Reichelt M; Mohl M; Dai Y; Sketchley A; Yang L; Gong H; Fatkin D; Allen D; Head S; Graham R; Feneley M, 2013, 'Studies of a Mouse Model of Cardiac α1A-Adrenergic Receptor Overexpression Provide Evidence For a Critical Role of RhoA/ROCK Signalling in Cardiac Contractility', Heart, Lung and Circulation, 22, pp. S59 - S59, http://dx.doi.org/10.1016/j.hlc.2013.05.143

Iismaa SE; Aplin M; Yiu T-W; Wu J; Du X-J; Graham RM, 2012, '877 TransglutaminAse 2 is cardioprotective following MyoCardal INFARCTION, but plays no role in cardiac hyPERtrophy', Journal of Hypertension, 30, pp. e256 - e256, http://dx.doi.org/10.1097/01.hjh.0000420443.49005.96

Zhao X; Park J; Ho D; Gao S; Yan L; Ge H; Iismaa S; Lin L; Tian B; Vatner DE; Graham RM; Vatner SF, 2012, 'Cardiomyocyte overexpression of the á 1A-adrenergic receptor in the rat phenocopies second but not first window preconditioning', American Journal of Physiology - Heart and Circulatory Physiology, 302, pp. H1614 - H1624, http://dx.doi.org/10.1152/ajpheart.01072.2011

Liu T; Marshall G; Iismaa S; Liu P; Xu N, 2012, 'Enhancing the anticancer effect of the histone deacetylase inhibitor by activating transglutaminase', European Journal of Cancer, 48, pp. 3278 - 3287, http://dx.doi.org/10.1016/j.ejca.2012.02.067

Iismaa SE; Basso M; Berlin J; Xia L; Sleiman SF; Kuo T; Haskew-Layton R; Kim E; Antonyak MA; Cerione RA; Willis D; Cho S, 2012, 'Transglutaminase 2 Inhibition Protects against Oxidative Stress-Induced Neuronal Death Downstream of Pathological ERK Activation', Journal of Neuroscience, 32, pp. 11157 - 11157, http://dx.doi.org/10.1523/JNEUROSCI.2552-12.2012

Basso M; Berlin J; Xia L; Sleiman SF; Ko B; Haskew-Layton R; Kim E; Antonyak MA; Cerione RA; Iismaa SE; Willis D; Cho S; Ratan R, 2012, 'Transglutaminase inhibition protects against oxidative stress-induced neuronal death downstream of pathological ERK activation', Journal of Neuroscience, 32, pp. 6561 - 6569, http://dx.doi.org/10.1523/JNEUROSCI.3353-11.2012

Fatkin D; Mohl M; Iismaa SE; Xiao XH; Friedrich O; Wagner ; Nikolova-Krstevski ; Wu J; Yu ZY; Feneley MP; Allen ; Graham RM, 2011, 'Regulation of murine cardiac contractility by activation of alpha(1A)-adrenergic receptor-operated Ca(2+) entry', Cardiovascular Research, 91, pp. 310 - 319

Wouters MA; Iismaa S; Fan SW; Haworth NL; Haworth , 2011, 'Thiol-based redox signalling: Rust never sleeps', International Journal of Biochemistry and Cell Biology, 43, pp. 1079 - 1085, http://dx.doi.org/10.1016/j.biocel.2011.04.002

Olsen K; Iismaa SE; Sapinoro R; Kottman RM; Kulkarni AA; Johnson G, 2011, 'Transglutaminase 2 and its role in pulmonary fibrosis', American Journal of Respiratory and Critical Care Medicine, 184, pp. 699 - 707

Mohl M; Xiao X-H; Prosser H; Iismaa S; Feneley M; Graham R, 2010, 'Involvement of a Novel a1A-Adrenergic Receptor-Coupled Signaling Pathway in Cardiac Contractility', FASEB JOURNAL, 24, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000208675506325&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Zhao X; Vatner DE; Park M; Yan L; IIsmaa S; Graham R; Vatner SF, 2010, 'Transgenic Rats with Cardiac Overexpression of alpha1A Adrenergic Receptors are protected from Myocardial Ischemia by a Nitric Oxide Mechanism', FASEB JOURNAL, 24, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000208675500791&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

McConoughey S; Basso SJ; Nietsetskaya Z; Sleiman SF; Smirnova T; Langley B; Mahishi L; Cooper AJ; Antonyak MA; Cerione RA; Li B; Starkov A; Chaturvedi R; Beale M; Coppola G; Geschwind D; Ryu H; Li XR; Iismaa SE; Pallos J; Pasternack R; Hils M; Fan J; Raymond LA; Marsh JL; Thompson LM; Ratan R, 2010, 'Inhibition of transglutaminase 2 mitigates transcriptional dysregulation in models of Huntington disease', EMBO Journal, 2, pp. 349 - 370

Liu T, 2010, 'Opposing Effects of Two Tissue Transglutaminase Protein Isoforms in Neuroblastoma Cell Differentiation', The Journal of Biological Chemistry, 285, pp. 3561 - 3567, http://dx.doi.org/10.1074/jbc.M109.053041

Tatsukawa H; Fukaya Y; Frampton G; Martinez-Fuentes A; Suzuki K; Kuo T; Nagatsuma K; Shimokado K; Okuno M; Wu J; Iismaa SE; Matsuura T; Tsukamoto H; Zern M; Graham RM; Kojima S, 2009, 'Role of Transglutaminase 2 in Liver Injury via Cross-linking and Silencing of Transcription Factor Sp1', Gastroenterology, 136, pp. 1783 - 1795, http://dx.doi.org/10.1053/j.gastro.2009.01.007

Iismaa SE; Mearns BM; Lorand L; Graham RM, 2009, 'Transglutaminases and disease: Lessons from genetically engineered mouse models and inherited disorders', Physiological Reviews, 89, pp. 991 - 1023

Begg GE; Holman SR; Stokes PH; Matthews JM; Graham RM; Iismaa SE, 2006, 'Mutation of a critical arginine in the GTP-binding site of transglutaminase 2 disinhibits intracellular cross-linking activity', JOURNAL OF BIOLOGICAL CHEMISTRY, 281, pp. 12603 - 12609, http://dx.doi.org/10.1074/jbc.M600146200

Iismaa S; Begg G; Graham RM, 2006, 'Cross-linking transglutaminases with G protein-coupled receptor signaling.', Science S Stke, 353, pp. pe34, http://dx.doi.org/10.1126/stke.3532006pe34

Begg G; Carrington L; Stokes P; Matthews JM; Wouters MA; Husain A; Lorand L; Iismaa SE; Graham RM, 2006, 'Mechanism of allosteric regulation of transglutaminase 2 by GTP', Proceedings of the National Academy of Sciences of the United States of America, 103, pp. 19683 - 19688

Begg G; Holman S; Stokes P; Matthews J; Graham RM; Iismaa SE; Holman , 2006, 'Mutation of a critical arginine in the GTP-binding site of transglutaminase 2 disinhibits intracellular cross-linking activity', The Journal of Biological Chemistry, 281, pp. 12603 - 12609, http://dx.doi.org/10.1074/jbc.M600146200

Begg G; Iismaa S; Carrington L; Holman S; Graham RM; Holman , 2005, 'Allosteric inactivation of transglutaminase 2 by GTP involves stabilisation of a conformational substate and formation of a critical Cys/Tyr H-bond', Biophysical Journal, 88, pp. 15A - 15A

Begg G; Iismaa SE; Carrington L; Holman S; Husain A; Graham RM; Holman , 2005, 'Allosteric regulation of the transamidase activity of transglutaminase 2 by guanine nucleotide', FEBS Journal, 272, pp. 408 - 408

Krasnikov B; Ratan R; Gibson G; Iismaa SE; Cooper A, 2005, 'Transglutaminase activity in non-synaptosomal mouse brain and liver mitochondria', Journal of Neurochemistry, 94, pp. 41 - 41

Krasnikov B; Kim SY; McConoughey S; Ryu H; Xu H; Stavrovskaya I; Iismaa S; Mearns BM; Ratan R; Blass J; Gibson G; Cooper A, 2005, 'Transglutaminase activity is present in highly purified nonsynaptosomal mouse brain and liver mitochondria', Biochemistry, 44, pp. 7830 - 7843

Iismaa SE; Graham RM, 2003, 'Dissecting cardiac hypertrophy and signalling pathways: evidence for an interaction between multifunctional G proteins and prostanoids', Corc Res, 92, pp. 1059 - 1061

Iismaa SE; Holman S; Wouters MA; Lorand L; Graham RM; Husain A; Holman , 2003, 'Evolutionary specialization of a tryptophan indole group for transition-state stabilization by eukaryotic transglutaminases', Proceedings of the National Academy of Sciences of the United States of America, 22, pp. 12636 - 12641

Murthy SN; Iismaa SE; Begg G; Freymann DM; Graham RM; Lorand L, 2002, 'Conserved tryptophan in the core domain of transglutaminase is essential for catalytic activity.', Proceedings of the National Academy of Sciences of the United States of America, 99, pp. 2738 - 2742

Mearns BM; Nanda N; Michalicek J; Iismaa SE; Graham RM, 2002, 'Impaired wound healing and altered fibroblast cytoskeletal dynamics in Gh knockout mice.', Minerva Biotecnologica, 14, pp. 218

Iismaa SE, 2002, 'Structure and function of tissue transglutaminase.', Minerva Biotecnologica, 14, pp. 113 - 119

Nanda N; Iismaa SE; Owens WA; Husain A; Mackay F; Graham RM, 2001, 'Targeted inactivation of Gh/tissue transglutaminase II', The Journal of Biological Chemistry, pp. 20673 - 20678

Nanda N; Iismaa SE; Owens WA; Husain A; Mackay F; Graham RM, 2001, 'Targeted inactivation of Gh/Transglutaminase II', The Journal of Biological Chemistry, pp. 20673 - 20678

Iismaa S; Wu M; Nanda N; Church WB; Graham RM, 2000, 'GTP binding and signaling by Gh/transglutaminase II involves distinct residues in a unique GTP-binding pocket.', The Journal of Biological Chemistry, 275, pp. 18259 - 18265

Nanda N; Iismaa SE; Copeland NG; Gilbert DM; Jenkins NA; Graham RM; Sutrave P, 1999, 'Organisation and chromosomal mapping of mouse Gh/tissue transglutaminase gene (Tgm2)', Archives of Biochemistry and Biophysics, 366, pp. 151 - 156

Harrison C; Raftery MJ; Walsh J; Alewood P; Iismaa S; Thliveris S; Geczy C, 1999, 'Oxidation regulates the inflammatory properties of the murine S100 protein S100A8', The Journal of Biological Chemistry, 274, pp. 8561 - 8569

Yen T; Harrison CA; Devery JM; Leong S; Iismaa SE; Yoshimura T; Geczy CL, 1997, 'Induction of the S100 Chemotactic Protein, CP-10, in Murine Microvascular Endothelial Cells by Proinflammatory Stimuli', Blood, 90, pp. 4812 - 4821, http://dx.doi.org/10.1182/blood.v90.12.4812

Yen T; Harrison C; Devery JM; Leong S; Iismaa S; Yoshimura T; Geczy C, 1997, 'Induction of the S100 chemotactic protein CP10, in murine microvascular endothelial cells by proinflammatory stimuli', Blood, 90, pp. 4812 - 4821

Iismaa S; Chung L; Wu M; Teller DC; Yee VC; Graham RM, 1997, 'The core domain of the tissue transglutaminase, Gh, hydrolyzes GTP and ATP', Biochemistry, 36, pp. 11655 - 11664

Chen S; Lin F; Iismaa S; Lee KN; Birckbichler PJ; Graham RM, 1996, 'α1-adrenergic receptor signaling via G(h) is subtype specific and independent of its transglutaminase activity', Journal of Biological Chemistry, 271, pp. 32385 - 32391, http://dx.doi.org/10.1074/jbc.271.50.32385

Chen S; Lin F; Iismaa SE; Lee K; Birckbichler PJ; Graham RM, 1996, 'Alpha1-Adrenergic receptor signalling via Gh is subtype-specific and independent of its transglutaminase activity', The Journal of Biological Chemistry, 271, pp. 32385 - 32391

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