Select Publications

Journal articles

Indurthi DC; Qudah T; Liao VW; Ahring PK; Lewis TM; Balle T; Chebib M; Absalom NL, 2019, 'Revisiting autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) mutations in the nicotinic acetylcholine receptor reveal an increase in efficacy regardless of stochiometry', Pharmacological Research, 139, pp. 215 - 227, http://dx.doi.org/10.1016/j.phrs.2018.11.031

Polly P; Thai T; Yang JL; Luo A; Herbert C; Jones N; Lewis T; Vickery R; Richardson A; Schibeci S, 2018, 'The teacher-student journey: Program-wide teamwork skills development and evaluation in the medical sciences', International Journal of Assessment and Evaluation, 24, pp. 1 - 24, http://dx.doi.org/10.18848/2327-7920/cgp/v24i04/1-24

Goulton CS; Watanabe M; Cheung DL; Wang KW; Oba T; Khoshaba A; Lai D; Inada H; Eto K; Nakamura K; Power JM; Lewis TM; Housley GD; Wake H; Nabekura J; Moorhouse AJ, 2018, 'Conditional Upregulation of KCC2 selectively enhances neuronal inhibition during seizures', , http://dx.doi.org/10.1101/253831

Duncan T; Lowe A; Sidhu K; Sachdev P; Lewis T; Lin RCY; Sytnyk V; Valenzuela M, 2017, 'Replicable Expansion and Differentiation of Neural Precursors from Adult Canine Skin.', Stem Cell Reports, 9, pp. 557 - 570, http://dx.doi.org/10.1016/j.stemcr.2017.07.008

Lewis TM; Indurthi DC; Ahring PK; Balle T; Chebib M; Absalom NL, 2016, 'Ligand Binding at the α4-α4 Agonist-Binding Site of the α4β2 nAChR Triggers Receptor Activation through a Pre-Activated Conformational State', PLoS One, 11, pp. e0161154 - e0161154, http://dx.doi.org/10.1371/journal.pone.0161154

Carland JE; Yamamoto I; Hanrahan JR; Abdel-Halim H; Lewis TM; Absalom N; Chebib M, 2015, 'A Hydrophobic Area of the GABA ρ1 Receptor Containing Phenylalanine 124 Influences Both Receptor Activation and Deactivation', Journal of Molecular Neuroscience, 55, pp. 305 - 313, http://dx.doi.org/10.1007/s12031-014-0322-7

Absalom NL; Quek G; Lewis TM; Qudah T; Von Arenstorff I; Ambrus JI; Harpsøe K; Karim N; Balle T; McLeod MD; Chebib M, 2013, 'Covalent trapping of methyllycaconitine at the α4-α4 interface of the α4α2 nicotinic acetylcholine receptor: Antagonist binding site and mode of receptor inhibition revealed', Journal of Biological Chemistry, 288, pp. 26521 - 26532, http://dx.doi.org/10.1074/jbc.M113.475053

Barry PH; Lewis TM; Moorhouse AJ, 2013, 'An optimised 3 M KCl salt-bridge technique used to measure and validate theoretical liquid junction potential values in patch-clamping and electrophysiology', European Biophysics Journal, 42, pp. 631 - 646, http://dx.doi.org/10.1007/s00249-013-0911-3

Huang SH; Lewis TM; Lummis SCR; Thompson AJ; Chebib M; Johnston GAR; Duke RK, 2012, 'Mixed antagonistic effects of the ginkgolides at recombinant human ρ1 GABAC receptors', Neuropharmacology, 63, pp. 1127 - 1139, http://dx.doi.org/10.1016/j.neuropharm.2012.06.067

Cederholm JME; Absalom NL; Sugiharto S; Griffith R; Schofield PR; Lewis TM, 2010, 'Conformational changes in extracellular loop 2 associated with signal transduction in the glycine receptor', Journal of Neurochemistry, 115, pp. 1245 - 1255, http://dx.doi.org/10.1111/j.1471-4159.2010.07021.x

Sugiharto S; Carland JE; Lewis TM; Moorhouse AJ; Barry PH, 2010, 'External divalent cations increase anion-cation permeability ratio in glycine receptor channels', Pflugers Archiv - European Journal of Physiology, 460, pp. 131 - 152, http://dx.doi.org/10.1007/s00424-010-0792-6

Barry PH; Sugiharto S; Lewis TM; Moorhouse AJ, 2010, 'Further analysis of counterion permeation through anion-selective glycine receptor channels.', Channels, 4, pp. 142 - 149, http://www.landesbioscience.com/journals/channels/article/11020

Carland JE; cooper MA; Sugiharto S; Jeong H; Lewis TM; Barry PH; Peters JA; Lambert J; Moorhouse AJ, 2009, 'Characterization of the effects of charged residues in the intracellular loop on ion permeation in α1 glycine receptor channels', The Journal of Biological Chemistry, 284, pp. 2023 - 2030, http://dx.doi.org/10.1074/jbc.M806618200

Cederholm JME; Schofield PR; Lewis TM, 2009, 'Gating mechanisms in Cys-loop receptors', European Biophysics Journal, 39, pp. 37 - 49, http://dx.doi.org/10.1007/s00249-009-0452-y

Absalom NL; Schofield PR; Lewis TM, 2009, 'Pore structure of the Cys-loop ligand-gated ion channels', Neurochemical Research, 34, pp. 1805 - 1815

Sugiharto S; Lewis TM; Moorhouse AJ; Schofield PR; Barry PH, 2008, 'Anion-cation permeability correlates with hydrated counterion size in glycine receptor channels', Biophysical Journal, 95, pp. 4698 - 4715, http://dx.doi.org/10.1529/biophysj.107.125690

Qu W; Moorhouse AJ; Chandra M; Pierce KD; Lewis TM; Barry PH, 2006, 'A single P-loop glutamate point mutation to either lysine or arginine switches the cation-anion selectivity of the CNGA2 channel', Journal of General Physiology, 127, pp. 375 - 389

Absalom N; Lewis T; Schofield P, 2005, 'Channel gating in the LGIC receptor superfamily – insights into the signal', Physiology News, pp. 27 - 28, http://dx.doi.org/10.36866/pn.57.27

Qu W; Moorhouse AJ; Lewis TM; Pierce KD; Barry PH, 2005, 'Mutation of the pore glutamate affects both cytoplasmic and external dequalinium block in the rat olfactory CNGA2 channel', European Biophysics Journal with Biophysics Letters, 34, pp. 442 - 453

Morris R, 2004, 'In vivo somatic delivery of plasmid DNA and retrograde transport to obtain cell-specific gene expression in the central nervous system', Journal of Neurochemistry, 90, pp. 1445 - 1452

Absalom NL; Lewis TM; Schofield PR, 2004, 'Mechanisms of channel gating of the ligand-gated ion channelsuperfamily inferred from protein structure', Experimental Physiology, 89, pp. 145 - 153

Lewis TM; Schofield PR; McClellan AM, 2003, 'Kinetic determinants of agonist potency at the recombinant human glycine receptor', The Journal of Physiology, 549, pp. 361 - 374

Absalom NL; Lewis TM; Kaplan W; Pierce KD; Schofield PR, 2003, 'Role of charged residues in coupling ligand binding and channel activation in the extracellular domain of the clycine receptor', The Journal of Biological Chemistry, 278, pp. 50151 - 50157

Rees MI; Lewis TM; Kwok JB; Mortier GR; Govaert P; Snell RG; Schofield PR; Owen MJ, 2002, 'Hyperekplexia associated with compound heterozygote mutations in the β-subunit of the human inhibitory glycine receptor (GLRB).', Human Molecular Genetics, 11, pp. 853 - 860, http://dx.doi.org/10.1093/hmg/11.7.853

Rees MI; Lewis TM; Vafa B; Ferrie C; Corry P; Muntoni F; Jungbluth H; Stephenson JB; Kerr M; Snell RG; Schofield PR; Owen MJ, 2001, 'Compound heterozygosity and nonsense mutations in the α1-subunit of the inhibitory glycine receptor in hyperekplexia', Human Genetics, 109, pp. 267 - 270, http://dx.doi.org/10.1007/s004390100569

Rees MI; Lewis TM; Mortier G; Snell RG; Schofield PR; Owen MJ, 2000, 'A transient hyperekplexia phenotype associated with compound heterozygote mutations in the human beta-subunit of the inhibitory glycine receptor (GLRB).', AMERICAN JOURNAL OF HUMAN GENETICS, 67, pp. 391 - 391, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000089400702194&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Vafa B; Lewis TM; Cunningham AM; Jacques P; Lynch JP; Schofield PR, 1999, 'Identification of a new ligand binding domain in the alpha1 subunit of the inhibitory glycine receptor', Journal of Neurochemistry, pp. 2158 - 2166

Lewis TM; Schofield PR, 1999, 'Structure-function relationships of the human glycine receptor: Insights from hyperekplexia mutations', Annals of the New York Academy of Sciences, pp. 681 - 684

Lewis TM; Sivilotti LG; Colquhoun D; Gardiner RM; Schoepfer R; Rees M, 1998, 'Properties of human glycine receptors containing the hyperekplexia mutation α1 (K276E), expressed in Xenopus oocytes', Journal of Physiology, 507, pp. 25 - 40, http://dx.doi.org/10.1111/j.1469-7793.1998.025bu.x

Lewis TM; Harkness PC; Sivilotti LG; Colquhoun D; Millar NS, 1997, 'The ion channel properties of a rat recombinant neuronal nicotinic receptor are dependent on the host cell type', Journal of Physiology, 505, pp. 299 - 306, http://dx.doi.org/10.1111/j.1469-7793.1997.299bb.x

Sivilotti LG; McNeil DK; Lewis TM; Nassar MA; Schoepfer R; Colquhoun D, 1997, 'Recombinant nicotinic receptors, expressed in Xenopus oocytes, do not resemble native rat sympathetic ganglion receptors in single-channel behaviour', Journal of Physiology, 500, pp. 123 - 138, http://dx.doi.org/10.1113/jphysiol.1997.sp022004

Lewis TM; Roberts ML; Bretag AH, 1994, 'Immunolabelling for VDAC, the mitochondrial voltage-dependent anion channel, on sarcoplasmic reticulum from amphibian skeletal muscle', Neuroscience Letters, 181, pp. 83 - 86, http://dx.doi.org/10.1016/0304-3940(94)90565-7

Lewis TM; Dulhunty AF; Junankar PR; Stanhope C, 1992, 'Ultrastructure of sarcoballs on the surface of skinned amphibian skeletal muscle fibres', Journal of Muscle Research and Cell Motility, 13, pp. 640 - 653, http://dx.doi.org/10.1007/BF01738254


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