By Dr Tristan Reekie

Journal articles

Stewart CD; White NG; Barrow RA; Reekie TA, 2024, 'Synthesis and spectroscopic investigation of substituted piperazine-2,5-dione derivatives', Tetrahedron, 153, http://dx.doi.org/10.1016/j.tet.2024.133838

Gimła M; Pyrczak-Felczykowska A; Malinowska M; Hać A; Narajczyk M; Bylińska I; Reekie TA; Herman-Antosiewicz A, 2023, 'The pyrazole derivative of usnic acid inhibits the proliferation of pancreatic cancer cells in vitro and in vivo', Cancer Cell International, 23, http://dx.doi.org/10.1186/s12935-023-03054-x

Gunawan GA; Gimła M; Gardiner MG; Herman-Antosiewicz A; Reekie TA, 2023, 'Divergent reactivity of usnic acid and evaluation of its derivatives for antiproliferative activity against cancer cells', Bioorganic and Medicinal Chemistry, 79, http://dx.doi.org/10.1016/j.bmc.2023.117157

Pyrczak-Felczykowska A; Reekie TA; Jąkalski M; Hać A; Malinowska M; Pawlik A; Ryś K; Guzow-Krzemińska B; Herman-Antosiewicz A, 2022, 'The Isoxazole Derivative of Usnic Acid Induces an ER Stress Response in Breast Cancer Cells that Leads to Paraptosis-like Cell Death', International Journal of Molecular Sciences, 23, pp. 1802, http://dx.doi.org/10.3390/ijms23031802

Sheikh Z; Bradbury P; Reekie TA; Pozzoli M; Robinson PD; Kassiou M; Young PM; Ong HX; Traini D, 2021, 'Tobramycin and Colistin display anti-inflammatory properties in CuFi-1 cystic fibrosis cell line', European Journal of Pharmacology, 902, pp. 174098, http://dx.doi.org/10.1016/j.ejphar.2021.174098

Chaney AM; Lopez-Picon FR; Serrière S; Wang R; Bochicchio D; Webb SD; Vandesquille M; Harte MK; Georgiadou C; Lawrence C; Busson J; Vercouillie J; Tauber C; Buron F; Routier S; Reekie T; Snellman A; Kassiou M; Rokka J; Davies KE; Rinne JO; Salih DA; Edwards FA; Orton LD; Williams SR; Chalon S; Boutin H, 2021, 'Prodromal neuroinflammatory, cholinergic and metabolite dysfunction detected by PET and MRS in the TgF344-AD transgenic rat model of AD: A collaborative multi-modal study', Theranostics, 11, pp. 6644 - 6667, http://dx.doi.org/10.7150/thno.56059

Sokias R; Werry EL; Alison Cheng HW; Lloyd JH; Sohler G; Danon JJ; Montgomery AP; Du JJ; Gao Q; Hibbs DE; Ittner LM; Reekie TA; Kassiou M, 2020, 'Tricyclic heterocycles display diverse sensitivity to the A147T TSPO polymorphism', European Journal of Medicinal Chemistry, 207, pp. 112725, http://dx.doi.org/10.1016/j.ejmech.2020.112725

Green D; Eyre H; Singh A; Taylor JT; Chu J; Jeys L; Sumathi V; Coonar A; Rassl D; Babur M; Forster D; Alzabin S; Ponthan F; McMahon A; Bigger B; Reekie T; Kassiou M; Williams K; Dalmay T; Fraser WD; Finegan KG, 2020, 'Targeting the MAPK7/MMP9 axis for metastasis in primary bone cancer', Oncogene, 39, pp. 5553 - 5569, http://dx.doi.org/10.1038/s41388-020-1379-0

Galletta M; Reekie TA; Nagalingam G; Bottomley AL; Harry EJ; Kassiou M; Triccas JA, 2020, 'Rapid antibacterial activity of cannabichromenic acid against methicillin-resistant staphylococcus aureus', Antibiotics, 9, pp. 1 - 11, http://dx.doi.org/10.3390/antibiotics9080523

Vo SV; Banister SD; Freelander I; Werry EL; Reekie TA; Ittner LM; Kassiou M, 2020, 'Reversing binding sensitivity to A147T translocator protein', RSC Medicinal Chemistry, 11, pp. 511 - 517, http://dx.doi.org/10.1039/c9md00580c

Gillis A; Gondin AB; Kliewer A; Sanchez J; Lim HD; Alamein C; Manandhar P; Santiago M; Fritzwanker S; Schmiedel F; Katte TA; Reekie T; Grimsey NL; Kassiou M; Kellam B; Krasel C; Halls ML; Connor M; Lane JR; Schulz S; Christie MJ; Canals M, 2020, 'Low intrinsic efficacy for G protein activation can explain the improved side effect profiles of new opioid agonists', Science Signaling, 13, http://dx.doi.org/10.1126/scisignal.aaz3140

Pyrczak-Felczykowska A; Narlawar R; Pawlik A; Guzow-Krzemińska B; Artymiuk D; Hać A; Ryś K; Rendina LM; Reekie TA; Herman-Antosiewicz A; Kassiou M, 2020, 'Erratum: Synthesis of Usnic Acid Derivatives and Evaluation of Their Antiproliferative Activity against Cancer Cells (Journal of Natural Products (2019) 82:7 (1768-1778) DOI: 10.1021/acs.jnatprod.8b00980)', Journal of Natural Products, 83, pp. 563 - 564, http://dx.doi.org/10.1021/acs.jnatprod.0c00129

Moir M; Danon JJ; Reekie TA; Kassiou M, 2019, 'An overview of late-stage functionalization in today’s drug discovery', Expert Opinion on Drug Discovery, 14, pp. 1137 - 1149, http://dx.doi.org/10.1080/17460441.2019.1653850

Cheng HWA; Sokias R; Werry EL; Ittner LM; Reekie TA; Du J; Gao Q; Hibbs DE; Kassiou M, 2019, 'First Nondiscriminating Translocator Protein Ligands Produced from a Carbazole Scaffold', Journal of Medicinal Chemistry, 62, pp. 8235 - 8248, http://dx.doi.org/10.1021/acs.jmedchem.9b00980

Danon JJ; Reekie TA; Kassiou M, 2019, 'Challenges and Opportunities in Central Nervous System Drug Discovery', Trends in Chemistry, 1, pp. 612 - 624, http://dx.doi.org/10.1016/j.trechm.2019.04.009

Pyrczak-Felczykowska A; Narlawar R; Pawlik A; Guzow-Krzemińska B; Artymiuk D; Hać A; Ryś K; Rendina LM; Reekie TA; Herman-Antosiewicz A; Kassiou M, 2019, 'Synthesis of Usnic Acid Derivatives and Evaluation of Their Antiproliferative Activity against Cancer Cells', Journal of Natural Products, 82, pp. 1768 - 1778, http://dx.doi.org/10.1021/acs.jnatprod.8b00980

Longworth M; Reekie TA; Blakey K; Boyd R; Connor M; Kassiou M, 2019, 'New-generation azaindole-adamantyl-derived synthetic cannabinoids', Forensic Toxicology, 37, pp. 350 - 365, http://dx.doi.org/10.1007/s11419-019-00466-1

Reekie TA; Williams CM; Rendina LM; Kassiou M, 2019, 'Cubanes in Medicinal Chemistry', Journal of Medicinal Chemistry, 62, pp. 1078 - 1095, http://dx.doi.org/10.1021/acs.jmedchem.8b00888

Gulliver D; Werry E; Reekie TA; Katte TA; Jorgensen W; Kassiou M, 2019, 'Targeting the Oxytocin System: New Pharmacotherapeutic Approaches', Trends in Pharmacological Sciences, 40, pp. 22 - 37, http://dx.doi.org/10.1016/j.tips.2018.11.001

Reekie TA; Scott MP; Kassiou M, 2018, 'The evolving science of phytocannabinoids', Nature Reviews Chemistry, 2, pp. 0101, http://dx.doi.org/10.1038/S41570-017-0101

Coughlin JM; Yang T; Rebman AW; Bechtold KT; Du Y; Mathews WB; Lesniak WG; Mihm EA; Frey SM; Marshall ES; Rosenthal HB; Reekie TA; Kassiou M; Dannals RF; Soloski MJ; Aucott JN; Pomper MG, 2018, 'Imaging glial activation in patients with post-treatment Lyme disease symptoms: A pilot study using [ ¹¹ C]DPA-713 PET', Journal of Neuroinflammation, 15, pp. 346, http://dx.doi.org/10.1186/s12974-018-1381-4

Zhou Q; Reekie TA; Abbassi RH; Indurthi Venkata D; Font JS; Ryan RM; Munoz L; Kassiou M, 2018, 'Synthesis and in vitro evaluation of diverse heterocyclic diphenolic compounds as inhibitors of DYRK1A', Bioorganic and Medicinal Chemistry, 26, pp. 5852 - 5869, http://dx.doi.org/10.1016/j.bmc.2018.10.034

Hagens MHJ; Golla SV; Wijburg MT; Yaqub M; Heijtel D; Steenwijk MD; Schober P; Brevé JJP; Schuit RC; Reekie TA; Kassiou M; Van Dam AM; Windhorst AD; Killestein J; Barkhof F; Van Berckel BNM; Lammertsma AA, 2018, 'In vivo assessment of neuroinflammation in progressive multiple sclerosis: A proof of concept study with [¹⁸F]DPA714 PET', Journal of Neuroinflammation, 15, pp. 314, http://dx.doi.org/10.1186/s12974-018-1352-9

Ryan P; Patel B; Makwana V; Jadhav HR; Kiefel M; Davey A; Reekie TA; Rudrawar S; Kassiou M, 2018, 'Peptides, Peptidomimetics, and Carbohydrate-Peptide Conjugates as Amyloidogenic Aggregation Inhibitors for Alzheimer's Disease', ACS Chemical Neuroscience, 9, pp. 1530 - 1551, http://dx.doi.org/10.1021/acschemneuro.8b00185

Callis TB; Reekie TA; O'Brien-Brown J; Wong ECN; Werry EL; Elias N; Jorgensen WT; Tsanaktsidis J; Rendina LM; Kassiou M, 2018, 'The role of polycyclic frameworks in modulating P2X7 receptor function', Tetrahedron, 74, pp. 1207 - 1219, http://dx.doi.org/10.1016/j.tet.2017.10.075

Jorgensen WT; Gulliver DW; Katte TA; Werry EL; Reekie TA; Connor M; Kassiou M, 2018, 'Conformationally rigid derivatives of WAY-267,464: Synthesis and pharmacology at the human oxytocin and vasopressin-1a receptors', European Journal of Medicinal Chemistry, 143, pp. 1644 - 1656, http://dx.doi.org/10.1016/j.ejmech.2017.10.059

Zhou Q; Reekie TA; Abbassi RH; Venkata DI; Font JS; Ryan RM; Rendina LM; Munoz L; Kassiou M, 2018, 'Flexible Analogues of Azaindole DYRK1A Inhibitors Elicit Cytotoxicity in Glioblastoma Cells', Australian Journal of Chemistry, 71, pp. 789 - 797, http://dx.doi.org/10.1071/CH18251

Reekie TA; Sekita M; Urner LM; Bauroth S; Ruhlmann L; Gisselbrecht JP; Boudon C; Trapp N; Clark T; Guldi DM; Diederich F, 2017, 'Porphyrin Donor and Tunable Push–Pull Acceptor Conjugates—Experimental Investigation of Marcus Theory', Chemistry - A European Journal, 23, pp. 6357 - 6369, http://dx.doi.org/10.1002/chem.201700043

Zhou Q; Phoa AF; Abbassi RH; Hoque M; Reekie TA; Font JS; Ryan RM; Stringer BW; Day BW; Johns TG; Munoz L; Kassiou M, 2017, 'Structural Optimization and Pharmacological Evaluation of Inhibitors Targeting Dual-Specificity Tyrosine Phosphorylation-Regulated Kinases (DYRK) and CDC-like kinases (CLK) in Glioblastoma', Journal of Medicinal Chemistry, 60, pp. 2052 - 2070, http://dx.doi.org/10.1021/acs.jmedchem.6b01840

Sridharan S; Lepelletier FX; Trigg W; Banister S; Reekie T; Kassiou M; Gerhard A; Hinz R; Boutin H, 2017, 'Comparative Evaluation of Three TSPO PET Radiotracers in a LPS-Induced Model of Mild Neuroinflammation in Rats', Molecular Imaging and Biology, 19, pp. 77 - 89, http://dx.doi.org/10.1007/s11307-016-0984-3

Sokias R; Werry EL; Chua SW; Reekie TA; Munoz L; Wong ECN; Ittner LM; Kassiou M, 2017, 'Determination and reduction of translocator protein (TSPO) ligand rs6971 discrimination', MedChemComm, 8, pp. 202 - 210, http://dx.doi.org/10.1039/c6md00523c

O'Brien-Brown J; Jackson A; Reekie TA; Barron ML; Werry EL; Schiavini P; McDonnell M; Munoz L; Wilkinson S; Noll B; Wang S; Kassiou M, 2017, 'Discovery and pharmacological evaluation of a novel series of adamantyl cyanoguanidines as P2X7 receptor antagonists', European Journal of Medicinal Chemistry, 130, pp. 433 - 439, http://dx.doi.org/10.1016/j.ejmech.2017.02.060

Katte TA; Reekie TA; Werry EL; Jorgensen WT; Boyd R; Wong ECN; Gulliver DW; Connor M; Kassiou M, 2017, 'Investigation of pyrazolo-sulfonamides as putative small molecule oxytocin receptor agonists', European Journal of Medicinal Chemistry, 136, pp. 330 - 333, http://dx.doi.org/10.1016/j.ejmech.2017.05.013

Reekie TA; Gisselbrecht JP; Boudon C; Trapp N; Diederich F, 2017, 'Metal-acetylide addition to tetracyanoethylene', Tetrahedron Letters, 58, pp. 2414 - 2416, http://dx.doi.org/10.1016/j.tetlet.2017.05.009

Wong ECN; Reekie TA; Werry EL; O'Brien-Brown J; Bowyer SL; Kassiou M, 2017, 'Pharmacological evaluation of a novel series of urea, thiourea and guanidine derivatives as P2X7 receptor antagonists', Bioorganic and Medicinal Chemistry Letters, 27, pp. 2439 - 2442, http://dx.doi.org/10.1016/j.bmcl.2017.04.005

Reekie TA; Wilkinson SM; Law V; Hibbs DE; Ong JA; Kassiou M, 2017, 'Rapid access to N-(indol-2-yl)amides and N-(indol-3-yl)amides as unexplored pharmacophores', Organic and Biomolecular Chemistry, 15, pp. 576 - 580, http://dx.doi.org/10.1039/c6ob02622b

Moir M; Chua SW; Reekie T; Martin AD; Ittner A; Ittner LM; Kassiou M, 2017, 'Ring-opened aminothienopyridazines as novel tau aggregation inhibitors', MedChemComm, 8, pp. 1275 - 1282, http://dx.doi.org/10.1039/c6md00306k

Katte TA; Reekie TA; Jorgensen WT; Kassiou M, 2016, 'The Formation of Seven-Membered Heterocycles under Mild Pictet-Spengler Conditions: A Route to Pyrazolo[3,4]benzodiazepines', Journal of Organic Chemistry, 81, pp. 4883 - 4889, http://dx.doi.org/10.1021/acs.joc.6b00710

Reekie TA; Donckele EJ; Manenti G; Püntener S; Trapp N; Diederich F, 2016, 'A Three-Step Synthesis of Tetrasubstituted NH-Pyrroles', Organic Letters, 18, pp. 2252 - 2255, http://dx.doi.org/10.1021/acs.orglett.6b00890

Donckele EJ; Reekie TA; Trapp N; Diederich F, 2016, 'Penta-2,4-dien-1-ones by Formal [3+2] Cycloaddition–Rearrangement of Electron-Deficient Diethyl 2-(Dicyanomethylene)malonate with Alk­ynes', European Journal of Organic Chemistry, 2016, pp. 716 - 724, http://dx.doi.org/10.1002/ejoc.201501473

Jorgensen WT; Gulliver DW; Werry EL; Reekie T; Connor M; Kassiou M, 2016, 'Flexible analogues of WAY-267,464: Synthesis and pharmacology at the human oxytocin and vasopressin 1a receptors', European Journal of Medicinal Chemistry, 108, pp. 730 - 740, http://dx.doi.org/10.1016/j.ejmech.2015.11.050

Conroy T; Manohar M; Gong Y; Wilkinson SM; Webster M; Lieberman BP; Banister SD; Reekie TA; Mach RH; Rendina LM; Kassiou M, 2016, 'A systematic exploration of the effects of flexibility and basicity on sigma (σ) receptor binding in a series of substituted diamines', Organic and Biomolecular Chemistry, 14, pp. 9388 - 9405, http://dx.doi.org/10.1039/c6ob00615a

Reekie TA; Donckele EJ; Manenti G; Puentener S; Trapp N; Diederich F, 2016, 'ChemInform Abstract: A Three‐Step Synthesis of Tetrasubstituted NH‐Pyrroles.', ChemInform, 47, http://dx.doi.org/10.1002/chin.201637091

Donckele EJ; Reekie TA; Trapp N; Diederich F, 2016, 'ChemInform Abstract: Penta‐2,4‐dien‐1‐ones by Formal [3 + 2] Cycloaddition‐Rearrangement of Electron‐Deficient Diethyl 2‐(Dicyanomethylene)malonate with Alkynes.', ChemInform, 47, http://dx.doi.org/10.1002/chin.201625063

Katte TA; Reekie TA; Jorgensen WT; Kassiou M, 2016, 'ChemInform Abstract: The Formation of Seven‐Membered Heterocycles under Mild Pictet—Spengler Conditions: A Route to Pyrazolo[3,4]benzodiazepines.', ChemInform, 47, http://dx.doi.org/10.1002/chin.201642188

Reekie TA; Donckele EJ; Ruhlmann L; Boudon C; Trapp N; Diederich F, 2015, 'Ester-Substituted Electron-Poor Alkenes for Cycloaddition-Retroelectrocyclization (CA-RE) and Related Reactions', European Journal of Organic Chemistry, 2015, pp. 7264 - 7275, http://dx.doi.org/10.1002/ejoc.201501085

Hicks C; Ramos L; Reekie TA; Narlawar R; Kassiou M; McGregor IS, 2015, 'WAY 267,464, a non-peptide oxytocin receptor agonist, impairs social recognition memory in rats through a vasopressin 1A receptor antagonist action', Psychopharmacology, 232, pp. 2659 - 2667, http://dx.doi.org/10.1007/s00213-015-3902-5

Beinat C; Reekie T; Banister SD; O'Brien-Brown J; Xie T; Olson TT; Xiao Y; Harvey A; O'Connor S; Coles C; Grishin A; Kolesik P; Tsanaktsidis J; Kassiou M, 2015, 'Structure-activity relationship studies of SEN12333 analogues: Determination of the optimal requirements for binding affinities at α7 nAChRs through incorporation of known structural motifs', European Journal of Medicinal Chemistry, 95, pp. 277 - 301, http://dx.doi.org/10.1016/j.ejmech.2015.03.025

Beels MT; Biaggio I; Reekie T; Chiu M; Diederich F, 2015, 'Two-photon absorption and spectroscopy of the lowest two-photon transition in small donor-acceptor-substituted organic molecules', Physical Review A - Atomic, Molecular, and Optical Physics, 91, http://dx.doi.org/10.1103/PhysRevA.91.043818

Banwell MG; Jones MT; Reekie TA; Schwartz BD; Tan SH; White LV, 2014, 'ChemInform Abstract: RANEY® Cobalt — An Underutilised Reagent for the Selective Cleavage of C—X and N—O Bonds', ChemInform, 45, http://dx.doi.org/10.1002/chin.201445264

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