Select Publications
Journal articles
2024, 'Patterns and Clinical Implications of Hemorrhagic Transformation After Thrombolysis in Acute Ischemic Stroke: Results From the ENCHANTED Study.', Neurology, 103, pp. e210020, http://dx.doi.org/10.1212/WNL.0000000000210020
,2024, 'What is the carbon footprint of academic clinical trials? A study of hotspots in 10 trials', BMJ Open, 14, pp. e088600, http://dx.doi.org/10.1136/bmjopen-2024-088600
,2024, 'Twenty-Four-Hour Post-Thrombolysis NIHSS Score As the Strongest Prognostic Predictor After Acute Ischemic Stroke: ENCHANTED Study', Journal of the American Heart Association, 13, http://dx.doi.org/10.1161/JAHA.124.036109
,2024, 'Risk of recurrent stroke and dementia following acute stroke by changes in kidney function: results from the Perindopril Protection Against Recurrent Stroke Study', Journal of Hypertension, 42, pp. 1313 - 1321, http://dx.doi.org/10.1097/HJH.0000000000003711
,2024, 'Decentralized clinical trials for medications to reduce the risk of dementia: Consensus report and guidance', Alzheimer's and Dementia, 20, pp. 4625 - 4634, http://dx.doi.org/10.1002/alz.13891
,2024, 'Intensive Blood Pressure Lowering and Renal Function in Ischemic Stroke Patients: Secondary Analysis of the ENCHANTED Trial', Cerebrovascular Diseases, http://dx.doi.org/10.1159/000536275
,2024, 'Optimum Baseline Clinical Severity Scale Cut Points for Prognosticating Intracerebral Hemorrhage: INTERACT Studies', Stroke, 55, pp. 139 - 145, http://dx.doi.org/10.1161/STROKEAHA.123.044538
,2024, 'Predictors of Early versus Delayed Neurological Deterioration after Thrombolysis for Ischemic Stroke', Cerebrovascular Diseases, http://dx.doi.org/10.1159/000539322
,2024, 'Statistical Analysis Plan for the INTEnsive Ambulance-Delivered Blood Pressure Reduction in Hyper-ACute Stroke Trial', Cerebrovascular Diseases, http://dx.doi.org/10.1159/000539503
,2023, 'Update on the INTEnsive ambulance-delivered blood pressure Reduction in hyper-ACute stroke Trial (INTERACT4): progress and baseline features in 2053 participants', Trials, 24, pp. 817, http://dx.doi.org/10.1186/s13063-023-07861-5
,2023, 'The third Intensive Care Bundle with Blood Pressure Reduction in Acute Cerebral Haemorrhage Trial (INTERACT3): an international, stepped wedge cluster randomised controlled trial', The Lancet, 402, pp. 27 - 40, http://dx.doi.org/10.1016/S0140-6736(23)00806-1
,2023, 'Trials in intracerebral haemorrhage: a path to success?', The Lancet Neurology, 22, pp. 542 - 543, http://dx.doi.org/10.1016/S1474-4422(23)00201-6
,2023, 'Incidence and outcomes for stroke in Ulaanbaatar, Mongolia, during 2019–21: a prospective population-based study', The Lancet Global Health, 11, pp. e942 - e952, http://dx.doi.org/10.1016/S2214-109X(23)00130-4
,2023, 'Baseline brain imaging signs in patients with ischaemic stroke by the presence of atrial fibrillation: the ENCHANTED trial', Journal of Neurology, 270, pp. 2567 - 2575, http://dx.doi.org/10.1007/s00415-023-11580-x
,2023, 'Statistical Analysis Plan for the INTEnsive Care Bundle with Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial: A Stepped-Wedge Cluster Randomized Controlled Trial', Cerebrovascular Diseases, 52, pp. 251 - 254, http://dx.doi.org/10.1159/000526384
,2023, 'Cost-Effectiveness of Low-Dose Compared to Standard-Dose Alteplase for Acute Ischemic Stroke in China: A Within-Trial Economic Evaluation of the ENCHANTED Study', Cerebrovascular Diseases, 52, pp. 145 - 152, http://dx.doi.org/10.1159/000525869
,2023, 'Effects of intensive blood pressure lowering on cerebral ischaemia in thrombolysed patients: insights from the ENCHANTED trial', eClinicalMedicine, 57, pp. 101849, http://dx.doi.org/10.1016/j.eclinm.2023.101849
,2023, 'Increasing burden of stroke in China: A systematic review and meta-analysis of prevalence, incidence, mortality, and case fatality', International Journal of Stroke, 18, pp. 259 - 267, http://dx.doi.org/10.1177/17474930221135983
,2022, 'Revisiting the Adiposity Paradox for the Risk of Stroke Subtypes', JAMA Network Open, 5, pp. E2246621, http://dx.doi.org/10.1001/jamanetworkopen.2022.46621
,2022, 'Intensive blood pressure control after endovascular thrombectomy for acute ischaemic stroke (ENCHANTED2/MT): a multicentre, open-label, blinded-endpoint, randomised controlled trial', The Lancet, 400, pp. 1585 - 1596, http://dx.doi.org/10.1016/S0140-6736(22)01882-7
,2022, 'The association between functional status and physical pain with depressive symptoms after a stroke event: A cross-sectional analysis of the China Health and Retirement Longitudinal Study 2018', Frontiers in Psychiatry, 13, pp. 927856, http://dx.doi.org/10.3389/fpsyt.2022.927856
,2022, 'Process Evaluation of an Implementation Trial: Design, Rationale, and Early Lessons Learnt From an International Cluster Clinical Trial in Intracerebral Hemorrhage', Frontiers in Medicine, 9, pp. 813749, http://dx.doi.org/10.3389/fmed.2022.813749
,2022, 'Thrombolysis outcomes according to arterial characteristics of acute ischemic stroke by alteplase dose and blood pressure target', International Journal of Stroke, 17, pp. 566 - 575, http://dx.doi.org/10.1177/17474930211025436
,2022, 'Implementing a Goal-Directed Care Bundle after Acute Intracerebral Haemorrhage: Process Evaluation for the Third INTEnsive Care Bundle with Blood Pressure Reduction in Acute Cerebral Haemorrhage Trial Study in China', Cerebrovascular Diseases, 51, pp. 373 - 383, http://dx.doi.org/10.1159/000520669
,2022, 'Associations of Early Systolic Blood Pressure Control and Outcome after Thrombolysis-Eligible Acute Ischemic Stroke: Results from the ENCHANTED Study', Stroke, 29, pp. 779 - 787, http://dx.doi.org/10.1161/STROKEAHA.121.034580
,2022, 'The second randomized controlled ENhanced Control of Hypertension ANd Thrombectomy strokE stuDy (ENCHANTED2): Protocol and progress', International Journal of Stroke, 18, http://dx.doi.org/10.1177/17474930221120345
,2021, 'Early decompressive hemicraniectomy in thrombolyzed acute ischemic stroke patients from the international ENCHANTED trial', Scientific Reports, 11, pp. 16495, http://dx.doi.org/10.1038/s41598-021-96087-z
,2021, 'INTEnsive ambulance-delivered blood pressure Reduction in hyper-ACute stroke Trial (INTERACT4): study protocol for a randomized controlled trial', Trials, 22, pp. 1 - 14, http://dx.doi.org/10.1186/s13063-021-05860-y
,2021, 'INTEnsive care bundle with blood pressure reduction in acute cerebral hemorrhage trial (INTERACT3): study protocol for a pragmatic stepped-wedge cluster-randomized controlled trial', Trials, 22, pp. 1 - 14, http://dx.doi.org/10.1186/s13063-021-05881-7
,2021, 'Disparities between Asian and Non-Asian Thrombolyzed Acute Ischemic Stroke Patients in the Enhanced Control of Hypertension and Thrombolysis Stroke Trial', Cerebrovascular Diseases, 50, pp. 560 - 566, http://dx.doi.org/10.1159/000516487
,2021, 'Low-Dose vs Standard-Dose Alteplase in Acute Lacunar Ischemic Stroke: The ENCHANTED Trial', Neurology, 96, pp. E1512 - E1526, http://dx.doi.org/10.1212/WNL.0000000000011598
,2021, 'Intensive versus guideline-recommended blood pressure reduction in acute lacunar stroke with intravenous thrombolysis therapy: The ENCHANTED trial', European Journal of Neurology, 28, pp. 783 - 793, http://dx.doi.org/10.1111/ene.14598
,2021, 'Low Dose versus Standard Dose Alteplase in Acute Lacunar Ischemic Stroke.', STROKE, 52, http://dx.doi.org/10.1161/str.52.suppl_1.MP3
,2021, 'Associations of an Abnormal Physiological Score With Outcomes in Acute Intracerebral Hemorrhage: INTERACT2 Study', Stroke, 52, pp. 722 - 725, http://dx.doi.org/10.1161/STROKEAHA.120.030435
,2021, 'Validation of the simplified modified Rankin scale for stroke trials: Experience from the ENCHANTED alteplase-dose arm', International Journal of Stroke, 16, pp. 222 - 228, http://dx.doi.org/10.1177/1747493019897858
,2020, 'Brain imaging abnormalities and outcome after acute ischaemic stroke: The ENCHANTED trial', Journal of Neurology, Neurosurgery and Psychiatry, 91, pp. 1290 - 1296, http://dx.doi.org/10.1136/jnnp-2020-323015
,2020, 'Combined utility of blood glucose and white blood cell in predicting outcome after acute ischemic stroke: The ENCHANTED trial', Clinical Neurology and Neurosurgery, 198, http://dx.doi.org/10.1016/j.clineuro.2020.106254
,2020, 'Brain Imaging Signs and Health-Related Quality of Life after Acute Ischemic Stroke: Analysis of ENCHANTED Alteplase Dose Arm', Cerebrovascular Diseases, 49, pp. 427 - 436, http://dx.doi.org/10.1159/000509226
,2020, 'Utility-Weighted Modified Rankin Scale Scores for the Assessment of Stroke Outcome: Pooled Analysis of 20 000+ Patients', Stroke, 51, pp. 2411 - 2417, http://dx.doi.org/10.1161/STROKEAHA.119.028523
,2020, 'Ethnicity and Other Determinants of Quality of Functional Outcome in Acute Ischemic Stroke: The ENCHANTED Trial', Stroke, 51, pp. 588 - 593, http://dx.doi.org/10.1161/STROKEAHA.119.027639
,2020, 'Thrombolysis Outcomes in Acute Ischemic Stroke by Fluid-Attenuated Inversion Recovery Hyperintense Arteries', Stroke, 51, pp. 2240 - 2243, http://dx.doi.org/10.1161/STROKEAHA.119.028550
,2020, 'Abstract TMP15: Asian versus Non-Asian, Differences in Characteristics, Management & Outcomes in the Enchanted Trial', Stroke, 51, http://dx.doi.org/10.1161/str.51.suppl_1.tmp15
,2019, 'Intensive blood pressure reduction with intravenous thrombolysis therapy for acute ischaemic stroke (ENCHANTED): an international, randomised, open-label, blinded-endpoint, phase 3 trial', The Lancet, 393, pp. 877 - 888, http://dx.doi.org/10.1016/S0140-6736(19)30038-8
,2019, 'Abstract TP362: Comparison of the Simplified Modified Rankin Scale Questionnaire With Conventional Neurological Scales in the Dose Arm of the Enchanted Study', Stroke, 50, http://dx.doi.org/10.1161/str.50.suppl_1.tp362
,2018, 'Statistical analysis plan for evaluating different intensities of blood pressure control in the ENhanced Control of Hypertension And Thrombolysis strokE stuDy.', International Journal of Stroke, pp. 1 - 4, http://dx.doi.org/10.1177/1747493018806170
,2017, 'Characteristics, management and response to alteplase in China versus non-China participants of the ENCHANTED trial', Stroke and Vascular Neurology, 2, pp. 53 - 58, http://dx.doi.org/10.1136/svn-2017-000085
,2017, 'Intracerebral hemorrhage location and outcome among INTERACT2 participants', Neurology, 88, pp. 1408 - 1414, http://dx.doi.org/10.1212/WNL.0000000000003771
,2017, 'Associations with health-related quality of life after intracerebral haemorrhage: Pooled analysis of INTERACT studies', Journal of Neurology, Neurosurgery and Psychiatry, 88, pp. 70 - 75, http://dx.doi.org/10.1136/jnnp-2016-314414
,2016, 'Low-dose versus standard-dose intravenous alteplase in acute ischemic stroke', New England Journal of Medicine, 374, pp. 2313 - 2323, http://dx.doi.org/10.1056/NEJMoa1515510
,2016, 'White blood cell count and clinical outcomes after intracerebral hemorrhage: The INTERACT2 trial', Journal of the Neurological Sciences, 361, pp. 112 - 116, http://dx.doi.org/10.1016/j.jns.2015.12.033
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