By Emeritus Professor John Whitelock

Journal articles

Hayes AJ; Shu CC; Lord MS; Little CB; Whitelock JM; Melrose J, 2016, 'Pericellular colocalisation and interactive properties of type VI collagen and perlecan in the intervertebral disc', European Cells and Materials, 32, pp. 40 - 57, http://dx.doi.org/10.22203/eCM.v032a03

Farrugia BL; Chandrasekar K; Johnson L; Whitelock JM; Marks D; Irving D; Lord M, 2016, 'Perspectives on the use of biomaterials to store platelets for transfusion', Biointerphases: an open access journal for the biomaterials interface community, 11, pp. 029701 - 029701, http://dx.doi.org/10.1116/1.4952450

Melrose J; Shu C; Whitelock JM; Lord MS, 2016, 'The cartilage extracellular matrix as a transient developmental scaffold for growth plate maturation', Matrix Biology, 52-54, pp. 363 - 383, http://dx.doi.org/10.1016/j.matbio.2016.01.008

Shu CC; Jackson MT; Smith MM; Smith SM; Penm S; Lord MS; Whitelock JM; Little CB; Melrose J, 2016, 'Ablation of Perlecan Domain 1 Heparan Sulfate Reduces Progressive Cartilage Degradation, Synovitis, and Osteophyte Size in a Preclinical Model of Posttraumatic Osteoarthritis', Arthritis and Rheumatology, 68, pp. 868 - 879, http://dx.doi.org/10.1002/art.39529

Farrugia BL; Whitelock JM; O'Grady R; Caterson B; Lord MS, 2016, 'Mast Cells Produce a Unique Chondroitin Sulfate Epitope', Journal of Histochemistry and Cytochemistry: imaging the spectrum of cell biology, 64, pp. 85 - 98, http://dx.doi.org/10.1369/0022155415620649

Dos Santos M; Michopoulou A; André-Frei V; Boulesteix S; Guicher C; Dayan G; Whitelock J; Damour O; Rousselle P, 2016, 'Perlecan expression influences the keratin 15-positive cell population fate in the epidermis of aging skin', Aging, 8, pp. 751 - 768, http://dx.doi.org/10.18632/AGING.100928

Lord M; Chuang C; Rnjak‐Kovacina J; Cheng B; Lyons G; Whitelock J, 2016, 'Bioengineering Proteoglycan‐based Matrices For Blood Contacting Applications', The FASEB Journal, 30, http://dx.doi.org/10.1096/fasebj.30.1_supplement.622.2

Chuang CY-N; Degendorfer G; Kawasaki H; Hammer A; Yamakura F; Whitelock JM; Malle E; Davies MJ, 2016, 'Peroxynitrite Modifies Components of the Extracellular Matrix of Human Atherosclerotic Lesions', Free Radical Biology and Medicine, 100, pp. S139 - S139, http://dx.doi.org/10.1016/j.freeradbiomed.2016.10.364

Shawky MS; Ricciardelli C; Lord M; Whitelock J; Ferro V; Britt K; Thompson EW, 2015, 'Proteoglycans: Potential Agents in Mammographic Density and the Associated Breast Cancer Risk', Journal of Mammary Gland Biology and Neoplasia, 20, pp. 121 - 131, http://dx.doi.org/10.1007/s10911-015-9346-z

Farrugia BL; Lord MS; Melrose J; Whitelock JM, 2015, 'Can we produce heparin/heparan sulfate biomimetics using "mother-nature" as the gold standard?', Molecules, 20, pp. 4254 - 4276, http://dx.doi.org/10.3390/molecules20034254

Lord MS; Farrugia BL; Rnjak-Kovacina J; Whitelock JM, 2015, 'Current serological possibilities for the diagnosis of arthritis with special focus on proteins and proteoglycans from the extracellular matrix', Expert Review of Molecular Diagnostics, 15, pp. 77 - 95, http://dx.doi.org/10.1586/14737159.2015.979158

Chuang CY; Degendorfer G; Hammer A; Whitelock JM; Malle E; Davies MJ, 2015, 'The Potent Inflammatory Oxidant, Peroxynitrite, Modifies the Extracellular Matrix of Human Atherosclerotic Lesions', Free Radical Biology and Medicine, 87, pp. S145 - S146, http://dx.doi.org/10.1016/j.freeradbiomed.2015.10.374

Lord MS; Whitelock JM; Simmons A; Williams RL; Milthorpe BK, 2014, 'Fibrinogen adsorption and platelet adhesion to silica surfaces with stochastic nanotopography', Biointerphases, 9, pp. 041002, http://dx.doi.org/10.1116/1.4900993

Chuang CY; Degendorfer G; Hammer A; Whitelock JM; Malle E; Davies MJ, 2014, 'Oxidation modifies the structure and function of the extracellular matrix generated by human coronary artery endothelial cells', Biochemical Journal, 459, pp. 313 - 322, http://dx.doi.org/10.1042/BJ20131471

Chui A; Murthi P; Gunatillake T; Brennecke SP; Ignjatovic V; Monagle PT; Whitelock JM; Said JM, 2014, 'Altered decorin leads to disrupted endothelial cell function: A possible mechanism in the pathogenesis of fetal growth restriction?', Placenta, 35, pp. 596 - 605, http://dx.doi.org/10.1016/j.placenta.2014.05.009

, 2014, 'Bioengineered heparin: Is there a future for this form of the successful therapeutic?', Bioengineered, 5, pp. 222 - 226, http://dx.doi.org/10.4161/bioe.29388

Baljinnyam E; Umemura M; Chuang C; De Lorenzo MS; Iwatsubo M; Chen S; Goydos JS; Ishikawa Y; Whitelock JM; Iwatsubo K, 2014, 'Epac1 increases migration of endothelial cells and melanoma cells via FGF2-mediated paracrine signaling', Pigment Cell and Melanoma Research, 27, pp. 611 - 620, http://dx.doi.org/10.1111/pcmr.12250

Lord MS; Tsoi BM; Farrugia BL; Simon Ting SR; Baker S; Wiesmann WP; Whitelock JM, 2014, 'Synthesis and characterization of water soluble biomimetic chitosans for bone and cartilage tissue regeneration', Journal of Materials Chemistry B, 20, pp. 6517 - 6526, http://dx.doi.org/10.1039/c4tb00531g

Lord MS; Chuang CY; Melrose J; Davies MJ; Iozzo RV; Whitelock JM, 2014, 'The role of vascular-derived perlecan in modulating cell adhesion, proliferation and growth factor signaling', Matrix Biology, 35, pp. 112 - 122, http://dx.doi.org/10.1016/j.matbio.2014.01.016

Lord MS; Jung MS; Cheng B; Whitelock JM, 2014, 'Transcriptional complexity of the HSPG2 gene in the human mast cell line, HMC-1', Matrix Biology, 35, pp. 123 - 131, http://dx.doi.org/10.1016/j.matbio.2013.12.005

Farrugia BL; Whitelock JM; Jung M; O'Grady RL; McGrath B; McCarthy SJ; Lord MS, 2014, 'The localisation of inflammatory cells and expression of associated proteoglycans in response to implanted chitosan', Biomaterials, 35, pp. 1462 - 1477, http://dx.doi.org/10.1016/j.biomaterials.2013.10.068

Chuang CY; Degendorfer G; Hammer A; Malle E; Kawasaki H; Yamakura F; Whitelock JM; Davies MJ, 2013, 'Peroxynitrite-mediated damage in the artery wall and its consequences', FREE RADICAL BIOLOGY AND MEDICINE, 65, pp. S6 - S6, http://dx.doi.org/10.1016/j.freeradbiomed.2013.08.117

Gunatillake T; Chui A; Murthi P; Ignjatovic V; Monagle P; Whitelock J; Brennecke S; Said J, 2013, 'The functional effect of Syndecan 1 deficiency in BeWo cells and its implications in fetal growth restriction', Placenta, 34, pp. A67 - A67, http://dx.doi.org/10.1016/j.placenta.2013.06.201

Chui A; Gunatillake T; Murthi P; Ignjatovic V; Monagle P; Whitelock J; Brennecke S; Said J, 2013, 'Unfractionated heparin reverses the increased thrombin generation associated with decorin deficiency in fetal growth restriction', Placenta, 34, pp. A25 - A26, http://dx.doi.org/10.1016/j.placenta.2013.06.078

Jin C; Ekwall AKH; Bylund JE; Bjorkman L; Estrella RP; Whitelock J; Eisler T; Bokarewa MI; Karlsson NG, 2012, 'Human synovial lubricin expresses sialyl Lewis x determinant and has L-selectin ligand activity', The Journal of Biological Chemistry, 287, pp. 35922 - 35933, http://dx.doi.org/10.1074/jbc.M112.363119

Lord MS; Estrella RP; Chuang CY; Youssef P; Karlsson NG; Flannery CR; Whitelock J, 2012, 'Not all lubricin isoforms are substituted with a glycosaminoglycan chain', Connective Tissue Research, 53, pp. 132 - 141, http://dx.doi.org/10.3109/03008207.2011.614364

Cheng JY; Whitelock J; Poole-Warren LA, 2012, 'Syndecan-4 is associated with betá-cells in the pancreas and the MIN6 beta-cell line', Histochemistry and Cell Biology, 138, pp. 933 - 944, http://dx.doi.org/10.1007/s00418-012-1004-6

Goyal A; Pal N; Concannon M; Paul M; Doran M; Poluzzi C; Sekiguchi K; Whitelock J; Neill T; Iozzo R, 2011, 'Endorepellin, the angiostatic module of perlecan, interacts with both the á2â1 integrin and vascular endothelial growth factor receptor 2 (VEGFR2): A dual receptor antagonism', The Journal of Biological Chemistry, 286, pp. 25947 - 25962, http://dx.doi.org/10.1074/jbc.M111.243626

Whitelock J; Melrose J, 2011, 'Heparan sulfate proteoglycans in healthy and diseased systems', Wiley Interdisciplinary Reviews: Systems Biology and Medicine, 3, pp. 739 - 751, http://dx.doi.org/10.1002/wsbm.149

Cheng JY; Raghunath M; Whitelock J; Poole-Warren LA, 2011, 'Matrix components and scaffolds for sustained islet function', Tissue Engineering Part B: Reviews, 17, pp. 235 - 247, http://dx.doi.org/10.1089/ten.teb.2011.0004

Kennett EC; Chuang CY; Degendorfer G; Whitelock J; Davies MJ, 2011, 'Mechanisms and consequences of oxidative damage to extracellular matrix', Biochemical Society Transactions, 39, pp. 1279 - 1287, http://dx.doi.org/10.1042/BST0391279

Ellis AL; Pan W; Yang G; Jones K; Chuang C; Whitelock JM; DeCarlo AA, 2010, 'Similarity of Recombinant Human Perlecan Domain 1 by Alternative Expression Systems Bioactive Heterogenous Recombinant Human Perlecan D1', BMC Biotechnology, 10, http://dx.doi.org/10.1186/1472-6750-10-66

Estrella RP; Whitelock JM; Packer NH; Karlsson NG, 2010, 'The glycosylation of human synovial lubricin: Implications for its role in inflammation', Biochemical Journal, 429, pp. 359 - 367, http://dx.doi.org/10.1042/BJ20100360

Kennett EC; Rees MD; Malle E; Hammer A; Whitelock JM; Davies MJ, 2010, 'Peroxynitrite modifies the structure and function of the extracellular matrix proteoglycan perlecan by reaction with both the protein core and the heparan sulfate chains', Free Radical Biology and Medicine, 49, pp. 282 - 293, http://dx.doi.org/10.1016/j.freeradbiomed.2010.04.018

Parsi MK; Adams JRJ; Whitelock J; Gibson MA, 2010, 'LTBP-2 has multiple heparin/heparan sulfate binding sites', Matrix Biology, 29, pp. 393 - 401

Kennett EC; Rees MD; Mallee E; Hammer A; Whitelock J; Davies MJ, 2010, 'Peroxynitrite modifies the structure and function of the extracellular matrix', Free Radical Biology and Medicine, 49, pp. 282 - 293

Ellis AL; Ellis AL; Yang G; Jones K; Chuang CY; Whitelock J; DeCarlo AA, 2010, 'Similarity of Recombinant Human Perlecan', BMC Biotechnology, pp. 1 - 12

Estrella RP; Whitelock J; Packer NH; Karlsson NG, 2010, 'The glycosylation of human synovial lubricin:', Biochemical Journal, 429, pp. 359 - 367

Dawson PA; Choyce A; Chuang CY; Whitelock J; Markovich D; Leggatt GR, 2009, 'Enhanced tumor growth in the NaS1 sulfate transporter null mouse', Cancer Science, 101, pp. 369 - 373, http://dx.doi.org/10.1111/j.1349-7006.2009.01399.x

Rees M; Bottle S; Fairfull-Smith K; Malle E; Whitelock J; Davies MJ, 2009, 'Inhibition of myeloperoxidase-mediated hypochlorous acid production by nitroxides', Biochemical Journal, 421, pp. 79 - 86, http://dx.doi.org/10.1042/bj20090309

Rees MD; Whitelock J; Malle E; Chuang CY; Iozzo R; Nilasaroya A; Davies MJ, 2009, 'Myeloperoxidase-derived oxidants selectively disrupt the protein core of the heparan sulfate proteoglycan perlecan', Matrix Biology, pp. 1 - 11

Zoeller J; Whitelock J; Iozzo R, 2009, 'Perlecan regulates developmental angiogenesis by modulating the VEGF-VEGFR2 axis', Matrix Biology, 28, pp. 284 - 291, http://dx.doi.org/10.1016/j.matbio.2009.04.010

Wilson R; Whitelock J; Bateman J, 2009, 'Proteomics makes progress in cartilage and arthritis research', Matrix Biology, 28, pp. 121 - 128, http://dx.doi.org/10.1016/j.matbio.2009.01.004

Lord MS; Yu W; Cheng B; Simmons A; Poole-Warren LA; Whitelock J, 2009, 'The modulation of platelet and endothelial cell adhesion to vascular graft materials by perlecan', Biomaterials, 30, pp. 4898 - 4906, http://dx.doi.org/10.1016/j.biomaterials.2009.05.063

Smith S; Whitelock J; Iozzo R; Little C; Melrose J, 2009, 'Topographical variation in the distributions of versican, aggrecan and perlecan in the foetal human spine reflects their diverse functional roles in spinal development', Histochemistry and Cell Biology, 132, pp. 491 - 503, http://dx.doi.org/10.1007/s00418-009-0623-z

Zoeller J; McQuillan A; Whitelock J; Ho SY; Iozzo R, 2008, 'A central function for perlecan in skeletal muscle and cardiovascular development', Journal of Cell Biology, 181, pp. 381 - 394

Martens P; Grant M; Nilasaroya A; Whitelock J; Poole-Warren LA, 2008, 'Characterisation of redox initiators for producing poly (vinyl alcohol)hydrogels', Macromolecular Symposia, 266, pp. 59 - 62, http://dx.doi.org/10.1002/masy.200850611

Davies NP; Roubin R; Whitelock J, 2008, 'Characterization and purification of glycosaminoglycans from crude biological samples', Journal of Agricultural and Food Chemistry, 56, pp. 343 - 348, http://dx.doi.org/10.1021/jf072624v

Whitelock J; Melrose J; Iozzo R, 2008, 'Diverse cell signalling events modulated by perlecan', Biochemistry, 47, pp. 11174 - 11183

Rees M; Kennett E; Whitelock J; Davies MJ, 2008, 'Oxidative damage to extracellular matrix and its role in human pathologies', Free Radical Biology and Medicine, 44, pp. 1973 - 2001, http://dx.doi.org/10.1016/j.freeradbiomed.2008.03.016

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