By Emeritus Professor William Ledger

Journal articles

Ledger W, 2019, 'Preimplantation genetic screening should be used in all in vitro fertilisation cycles in women over the age of 35 years: AGAINST: Pre-implantation genetic screening should not be used in all IVF cycles in women over the age of 35 years', BJOG: An International Journal of Obstetrics and Gynaecology, 126, pp. 1555, http://dx.doi.org/10.1111/1471-0528.15942

Anazodo A; Laws P; Logan S; Saunders C; Travaglia J; Gerstl B; Bradford N; Cohn R; Birdsall M; Barr R; Suzuki N; Takae S; Marinho R; Xiao S; Chen QH; Mahajan N; Patil M; Gunasheela D; Smith K; Sender L; Melo C; Almeida-Santos T; Salama M; Appiah L; Su I; Lane S; Woodruff TK; Pacey A; Anderson RA; Shenfield F; Sullivan E; Ledger W, 2019, 'The Development of an International Oncofertility Competency Framework: A Model to Increase Oncofertility Implementation', Oncologist, 24, pp. e1450 - e1459, http://dx.doi.org/10.1634/theoncologist.2019-0043

Chambers GM; Harrison C; Raymer J; Raymer AKP; Britt H; Chapman M; Ledger W; Norman RJ, 2019, 'Infertility management in women and men attending primary care - Patient characteristics, management actions and referrals', Human Reproduction, 34, pp. 2173 - 2183, http://dx.doi.org/10.1093/humrep/dez172

Costello M; Garad R; Hart R; Homer H; Johnson L; Jordan C; Mocanu E; Qiao J; Rombauts L; Teede HJ; Vanky E; Venetis C; Ledger W, 2019, 'A Review of First Line Infertility Treatments and Supporting Evidence in Women with Polycystic Ovary Syndrome', Medical sciences (Basel, Switzerland), 7, http://dx.doi.org/10.3390/medsci7090095

Fraison E; Crawford G; Casper G; Harris V; Ledger W, 2019, 'Pregnancy following diagnosis of premature ovarian insufficiency: a systematic review', Reproductive BioMedicine Online, 39, pp. 467 - 476, http://dx.doi.org/10.1016/j.rbmo.2019.04.019

Riepsamen AH; Chan K; Lien S; Sweeten P; Donoghoe MW; Walker G; Fraison EHJ; Stocker WA; Walton KL; Harrison CA; Ledger WL; Robertson DM; Gilchrist RB, 2019, 'Serum Concentrations of Oocyte-Secreted Factors BMP15 and GDF9 during IVF and in Women with Reproductive Pathologies', Endocrinology, 160, pp. 2298 - 2313, http://dx.doi.org/10.1210/en.2019-00264

Costello MF; Garad RM; Hart R; Homer H; Johnson L; Jordan C; Mocanu E; Qiao J; Rombauts L; Teede HJ; Vanky E; Venetis CA; Ledger WL, 2019, 'A Review of Second- and Third-line Infertility Treatments and Supporting Evidence in Women with Polycystic Ovary Syndrome', Medical sciences (Basel, Switzerland), 7, http://dx.doi.org/10.3390/medsci7070075

Anazodo A; Ledger W, 2019, 'Assessing and Supporting Adolescent Boys Having Fertility Preservation', In: Woodruff T., Shah D., Vitek W. (eds) Textbook of Oncofertility Research and Practice., pp. 507 - 512, http://dx.doi.org/10.1007/978-3-030-02868-8_53

Rodriguez Paris V; Solon-Biet S; Edwards M; Cox M; Ledger W; Gilchrist R; Simpson S; Handelsman D; Walters K, 2019, 'MON-231 Dietary Interventions Can Ameliorate Polycystic Ovary Syndrome (PCOS) Traits in a PCOS Mouse Model', Journal of the Endocrine Society, 3, http://dx.doi.org/10.1210/js.2019-mon-231

Aflatounian A; Edwards M; Gilchrist R; Bertoldo M; Ledger W; Handelsman D; Walters K, 2019, 'OR08-2 Androgen Receptor- Vs Estrogen Receptor-Mediated Actions in the Development of Distinct Clinical Polycystic Ovary Syndrome (PCOS) Phenotypes', Journal of the Endocrine Society, 3, http://dx.doi.org/10.1210/js.2019-or08-2

Bertoldo MJ; Caldwell ASL; Riepsamen AH; Lin D; Gonzalez MB; Robker RL; Ledger WL; Gilchrist RB; Handelsman DJ; Walters KA, 2019, 'A hyperandrogenic environment causes intrinsic defects that are detrimental to follicular dynamics in a PCOS mouse model', Endocrinology, 160, pp. 699 - 715, http://dx.doi.org/10.1210/en.2018-00966

Richani D; Constance K; Lien S; Agapiou D; Stocker WA; Hedger MP; Ledger WL; Thompson JG; Robertson DM; Mottershead DG; Walton KL; Harrison CA; Gilchrist RB, 2019, 'Cumulin and FSH cooperate to regulate inhibin B and activin B production by human granulosa-lutein cells in vitro', Endocrinology, 160, pp. 853 - 862, http://dx.doi.org/10.1210/en.2018-01026

Weddell S; Jones GL; Duffy S; Hogg C; Johnson S; Ledger W, 2019, 'Home ovulation test use and stress during subfertility evaluation: Subarm of a randomized controlled trial', Women's Health, 15, http://dx.doi.org/10.1177/1745506519838363

Crawford GE; Ledger WL, 2019, 'In vitro fertilisation/intracytoplasmic sperm injection beyond 2020', BJOG: An International Journal of Obstetrics and Gynaecology, 126, pp. 237 - 243, http://dx.doi.org/10.1111/1471-0528.15526

Hardy T; Ledger W; Scott H, 2019, '28. KARYOMAPPING USING WHOLE GENOME SEQUENCING DATA: PRECLINICAL VALIDATION OF A PERSONALISED APPROACH TO PGT-M', Reproductive BioMedicine Online, 39, pp. e43 - e44, http://dx.doi.org/10.1016/j.rbmo.2019.04.081

Walters KA; Gilchrist RB; Ledger WL; Teede HJ; Handelsman DJ; Campbell RE, 2018, 'New Perspectives on the Pathogenesis of PCOS: Neuroendocrine Origins', Trends in Endocrinology and Metabolism, 29, pp. 841 - 852, http://dx.doi.org/10.1016/j.tem.2018.08.005

Vogt KS; Hughes J; Wilkinson A; Mahmoodi N; Skull J; Wood H; McDougall S; Slade P; Greenfield DM; Pacey A; Ledger W; Jones GL, 2018, 'Preserving fertility in women with cancer (PreFer): Decision-making and patient-reported outcomes in women offered egg and embryo freezing prior to cancer treatment', Psycho-Oncology, 27, pp. 2725 - 2732, http://dx.doi.org/10.1002/pon.4866

Anazodo A; Paula L; Logan S; Saunders C; Travaglia J; Gerstl B; Bradford N; Cohn R; Birdsall M; Barr R; Suzuki N; Seido T; Marinho R; Xiao S; Qiang-Hua C; Mahajan N; Patil M; Gunasheela D; Smith K; Sender L; Melo C; Almeida-Santos T; Salama M; Appiah L; Su I; Lane S; Woodruff T; Pacey A; Anderson RA; Shenfield F; Ledger W; Sullivan E, 2018, 'How can we improve oncofertility care for patients? A systematic scoping review of current international practice and models of care.', Human Reproduction Update, 25, pp. 159 - 179, http://dx.doi.org/10.1093/humupd/dmy038

Ledger W, 2018, 'Preface – Vol. 53', Best Practice and Research: Clinical Obstetrics and Gynaecology, 53, pp. 1 - 2, http://dx.doi.org/10.1016/j.bpobgyn.2018.10.005

Deans R; Vancaillie T; Ledger W; Liu J; Abbott JA, 2018, 'Live birth rate and obstetric complications following the hysteroscopic management of intrauterine adhesions including Asherman syndrome', Human Reproduction, 33, pp. 1847 - 1853, http://dx.doi.org/10.1093/humrep/dey237

Bertoldo MJ; Walters KA; Ledger WL; Gilchrist RB; Mermillod P; Locatelli Y, 2018, 'In-vitro regulation of primordial follicle activation: challenges for fertility preservation strategies', Reproductive BioMedicine Online, 36, pp. 491 - 499, http://dx.doi.org/10.1016/j.rbmo.2018.01.014

Storr A; Venetis C; Cooke S; Kilani S; Ledger W, 2018, 'Time-lapse algorithms and morphological selection of day-5 embryos for transfer: a preclinical validation study', Fertility and Sterility, 109, pp. 276 - 283.e3, http://dx.doi.org/10.1016/j.fertnstert.2017.10.036

Ledger WL, 2017, 'The HFEA should be regulating add-on treatments for IVF/ICSI', BJOG: An International Journal of Obstetrics and Gynaecology, 124, pp. 1850, http://dx.doi.org/10.1111/1471-0528.14670

Jones G; Hughes J; Mahmoodi N; Smith E; Skull J; Ledger W, 2017, 'What factors hinder the decision-making process for women with cancer and contemplating fertility preservation treatment?', Human Reproduction Update, 23, pp. 433 - 457, http://dx.doi.org/10.1093/humupd/dmx009

McCredie S; Ledger W; Venetis CA, 2017, 'Anti-Müllerian hormone kinetics in pregnancy and post-partum: a systematic review', Reproductive BioMedicine Online, 34, pp. 522 - 533, http://dx.doi.org/10.1016/j.rbmo.2017.02.005

Rodgers RJ; Reid GD; Koch J; Deans R; Ledger WL; Friedlander M; Gilchrist RB; Walters KA; Abbott JA, 2017, 'The safety and efficacy of controlled ovarian hyperstimulation for fertility preservation in women with early breast cancer: A systematic review', Human Reproduction, 32, pp. 1033 - 1045, http://dx.doi.org/10.1093/humrep/dex027

Patanwala IY; Lamvu G; Ledger WJ; Witzeman K; Marvel R; Rapkin A; Bongiovanni AM; Feranec J; Witkin SS, 2017, 'Catechol-O-methyltransferase gene polymorphism and vulvar pain in women with vulvodynia', American Journal of Obstetrics and Gynecology, 216, pp. 395.e1 - 395.e6, http://dx.doi.org/10.1016/j.ajog.2016.10.020

Ledger WL, 2017, 'A history of mental illness, but not of conception with assisted reproductive technology, puts patients at increased risk of severe postnatal depression', BJOG: An International Journal of Obstetrics and Gynaecology, 124, pp. 443, http://dx.doi.org/10.1111/1471-0528.13792

Storr A; Venetis CA; Cooke S; Kilani S; Ledger W, 2017, 'Inter-observer and intra-observer agreement between embryologists during selection of a single Day 5 embryo for transfer: A multicenter study', Human Reproduction, 32, pp. 307 - 314, http://dx.doi.org/10.1093/humrep/dew330

Nasioudis D; Linhares IM; Ledger WJ; Witkin SS, 2017, 'Bacterial vaginosis: a critical analysis of current knowledge', BJOG: An International Journal of Obstetrics and Gynaecology, 124, pp. 61 - 69, http://dx.doi.org/10.1111/1471-0528.14209

Chambers GM; Wand H; Macaldowie A; Chapman MG; Farquhar CM; Bowman M; Molloy D; Ledger W, 2016, 'Population trends and live birth rates associated with common ART treatment strategies', Human Reproduction, 31, pp. 2632 - 2641, http://dx.doi.org/10.1093/humrep/dew232

Anazodo AC; Stern CJ; Mclachlan RI; Gerstl B; Agresta F; Cohn RJ; Jayasinghe Y; Wakefield CE; Daly G; Chan D; Gilbert L; Kemertzis M; Orme LM; Wand H; Viney R; Gillam L; Deans R; Jetti M; Wu J; Chapman M; Ledger W; Sullivan EA, 2016, 'A study protocol for the australasian oncofertility registry: Monitoring referral patterns and the uptake, quality, and complications of fertility preservation strategies in Australia and New Zealand', Journal of Adolescent and Young Adult Oncology, 5, pp. 215 - 225, http://dx.doi.org/10.1089/jayao.2015.0062

Anazodo AC; Gerstl B; Stern CJ; Mclachlan RI; Agresta F; Jayasinghe Y; Cohn RJ; Wakefield CE; Chapman M; Ledger W; Sullivan EA, 2016, 'Utilizing the experience of consumers in consultation to develop the australasian oncofertility consortium charter', Journal of Adolescent and Young Adult Oncology, 5, pp. 232 - 239, http://dx.doi.org/10.1089/jayao.2015.0056

McCullough K; Ledger W, 2016, 'Anti-Müllerian hormone is all you need: An assisted reproductive technology perspective in diagnosing polycystic ovary syndrome', Women's Health, 12, pp. 263 - 265, http://dx.doi.org/10.2217/whe-2016-0005

Wang X; Gook DA; Walters KA; Anazodo A; Ledger WL; Gilchrist RB, 2016, 'Improving fertility preservation for girls and women by coupling oocyte in vitro maturation with existing strategies', Women's Health, 12, pp. 275 - 278, http://dx.doi.org/10.2217/whe-2016-0019

Robertson DM; Gilchrist RB; Ledger WL; Baerwald A, 2016, 'Random start or emergency IVF/in vitro maturation: A new rapid approach to fertility preservation', Women's Health, 12, pp. 339 - 349, http://dx.doi.org/10.2217/whe-2015-0001

Lim HJ; Ledger W, 2016, 'Targeted therapy in ovarian cancer', Women's Health, 12, pp. 363 - 378, http://dx.doi.org/10.2217/whe.16.4

Jones GL; Jacques RM; Thompson J; Wood HJ; Hughes J; Ledger W; Alazzam M; Radley SC; Tidy JA, 2016, 'The impact of surgery for vulval cancer upon health-related quality of life and pelvic floor outcomes during the first year of treatment: a longitudinal, mixed methods study', Psycho-Oncology, pp. 656 - 662, http://dx.doi.org/10.1002/pon.3992

Ledger W; Johnson MH, 2016, 'One plus one equals two: Why fetal reduction is always a second-best solution', Reproductive BioMedicine Online, 32, pp. 467 - 468, http://dx.doi.org/10.1016/j.rbmo.2016.03.002

Ledger WL; Turner MJ, 2016, 'Implementation of the findings of a national enquiry into the misdiagnosis of miscarriage in the Republic of Ireland: impact on quality of clinical care', Fertility and sterility, 105, pp. 417 - 422, http://dx.doi.org/10.1016/j.fertnstert.2015.11.002

Ledger WL; Turner MJ, 2016, 'Implementation of the findings of a national enquiry into the misdiagnosis of miscarriage in the Republic of Ireland: impact on quality of clinical care', Fertility and Sterility, 105, pp. 417 - 422, http://dx.doi.org/10.1016/j.fertnstert.2015.11.002

Ledger W, 2016, 'A history of mental illness, but not of conception with assisted reproductive technology, puts patients at increased risk of severe postnatal depression', BJOG: An International Journal of Obstetrics and Gynaecology, http://dx.doi.org/10.1111/1471-0528.13792

Ledger WL, 2016, 'Superfertility is more prevalent in obese women with recurrent early pregnancy miscarriage', BJOG: An International Journal of Obstetrics and Gynaecology, 123, pp. 223, http://dx.doi.org/10.1111/1471-0528.13815

Jones G; Carlton J; Weddell S; Johnson S; Ledger WL, 2015, 'Women's experiences of ovulation testing: A qualitative analysis', Reproductive Health, 12, http://dx.doi.org/10.1186/s12978-015-0103-y

Beghini J; Linhares IM; Giraldo PC; Ledger WJ; Witkin SS, 2015, 'Differential expression of lactic acid isomers, extracellular matrix metalloproteinase inducer, and matrix metalloproteinase-8 in vaginal fluid from women with vaginal disorders', BJOG: An International Journal of Obstetrics and Gynaecology, 122, pp. 1580 - 1585, http://dx.doi.org/10.1111/1471-0528.13072

Ledger W, 2015, 'Letter to the editor', Journal of Assisted Reproduction and Genetics, 32, pp. 1161, http://dx.doi.org/10.1007/s10815-015-0526-y

Storr A; Venetis CA; Cooke S; Susetio D; Kilani S; Ledger W, 2015, 'Morphokinetic parameters using time-lapse technology and day 5 embryo quality: a prospective cohort study', Journal of Assisted Reproduction and Genetics, 32, pp. 1151 - 1160, http://dx.doi.org/10.1007/s10815-015-0534-y

Coughlan C; Clarke H; Cutting R; Saxton J; Waite S; Ledger W; Li T; Pacey AA, 2015, 'Sperm DNA fragmentation, recurrent implantation failure and recurrent miscarriage', Asian Journal of Andrology, 17, pp. 681 - 685, http://dx.doi.org/10.4103/1008-682X.144946

Riepsamen A; Wu L; Lau L; Listijono D; Ledger W; Sinclair DA; Homer H, 2015, 'Erratum: Nicotinamide impairs entry into and exit from meiosis I in mouse oocytes (PLoS ONE (2015) 10:5 (e0126194) DOI:10.1371/journal.pone.0126194)', PLoS ONE, 10, pp. e0126194, http://dx.doi.org/10.1371/journal.pone.0126194

Riepsamen A; Wu L; Lau L; Listijono D; Ledger W; Sinclair D; Homer H, 2015, 'Nicotinamide impairs entry into and exit from meiosis I in mouse oocytes', PLoS ONE, 10, pp. e0130058, http://dx.doi.org/10.1371/journal.pone.0130058

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