By Emeritus Professor William Ledger

Journal articles

Ledger WL, 1999, 'Endometriosis and infertility: An integrated approach', International Journal of Gynecology and Obstetrics, 64, pp. 33 - 40, http://dx.doi.org/10.1016/s0020-7292(98)00240-9

Lau CP; Ledger WL; Groome NP; Barlow DH; Muttukrishna S, 1999, 'Dimeric inhibins and activin A in human follicular fluid and oocyte-cumulus culture medium', Human Reproduction, 14, pp. 2525 - 2530, http://dx.doi.org/10.1093/humrep/14.10.2525

Lashen H; Ledger W; Bernai AL; Barlow D, 1999, 'Extremes of body mass do not adversely affect the outcome of superovulation and in-vitro fertilization', Human Reproduction, 14, pp. 712 - 715, http://dx.doi.org/10.1093/humrep/14.3.712

Lockwood GM; Muttukrishna S; Groome NP; Ledger WL; Manek S, 1999, 'Immunohistochemical localisation of inhibin and activin subunits in normal and polycystic ovaries', JOURNAL OF PATHOLOGY, 187, pp. 29A - 29A, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000079173200116&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Ledger W, 1999, 'Infertility, but not fertility drug use, was a risk factor for borderline ovarian cancer in nulliparous women', Evidence-based Obstetrics and Gynecology, 1, pp. 67, http://dx.doi.org/10.1054/ebog.1999.0049

Lashen H; Ledger W; Remohi J; Pellicer A, 1999, 'Management of poor responders in IVF (multiple letters) [1]', Human Reproduction, 14, pp. 1919, http://dx.doi.org/10.1093/humrep/14.7.1919

Lashen H; Ledger W; Lopez-Bernal A; Barlow D, 1999, 'Poor responders to ovulation induction: Is proceeding to in-vitro fertilization worthwhile?', Human Reproduction, 14, pp. 964 - 969, http://dx.doi.org/10.1093/humrep/14.4.964

Al-Azemi M; Ledger WL; Lockwood GM; Barlow DH, 1999, 'Successful transvaginal ultrasound-guided ablation of a cervical pregnancy in a patient with simultaneous intrauterine pregnancy after in vitro fertilization and embryo transfer', Human Fertility, 2, pp. 67 - 69, http://dx.doi.org/10.1080/1464727992000198341

Lockwood GM; Groome NP; Muttukrishna S; Ledger WL, 1998, 'Inhibin b levels are prognostic of the perimenopausal transition in women with reduced ovarian reserve and regular cycles', International Journal of Fertility and Menopausal Studies, 43, pp. 217 - 218

Lashen H; Ledger W, 1998, 'Effects of agonist dose on in-vitro fertilization', HUMAN REPRODUCTION, 13, pp. 2973 - 2973, http://dx.doi.org/10.1093/humrep/13.10.2973

Lashen H; Ledger W; Bernal AL; Evans B; Barlow D, 1998, 'Superovulation with a high gonadotropin dose for in vitro fertilization: Is it effective?', JOURNAL OF ASSISTED REPRODUCTION AND GENETICS, 15, pp. 438 - 443, http://dx.doi.org/10.1007/BF02744938

Lashen H; Ledger W; Lopez-Bernal A; Barlow D, 1998, 'Proceeding to IVF in patients producing four follicles or less: is it worthwhile?', HUMAN REPRODUCTION, 13, pp. 51 - 52, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000075359300096&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Lashen H; Ledger W; Lopez-Bernal A; Barlow D, 1998, 'Total dose of gonadotrophin-releasing hormone agonist: factors affecting it and its effect on in-vitro fertilization outcome', HUMAN REPRODUCTION, 13, pp. 184 - 184, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000075359300346&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Lockwood GM; Muttukrishna S; Ledger WL, 1998, 'Inhibins and activins in human ovulation, conception and pregnancy', Human Reproduction Update, 4, pp. 284 - 295, http://dx.doi.org/10.1093/humupd/4.3.284

Bagratee JS; Lockwood G; López Bernal A; Barlow DH; Ledger WL, 1998, 'Comparison of highly purified FSH (Metrodin-high purity) with pergonal for IVF superovulation', Journal of Assisted Reproduction and Genetics, 15, pp. 65 - 69, http://dx.doi.org/10.1007/BF02766827

Lashen H; Ledger W; Alvarez C; Bernabeu R, 1998, 'Effects of agonist dose on in-vitro fertilization (multiple letters) [1]', Human Reproduction, 13, pp. 2973 - 2974, http://dx.doi.org/10.1093/humrep/13.10.2973-a

Manek S; Charles M; Ledger W, 1998, 'Endometrial cytology revisited - A comparative study of the Tao brush (IUMC endometrial sampler) and the pipelle biopsy as diagnostic tools', JOURNAL OF PATHOLOGY, 186, pp. 26A - 26A, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000075727500102&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Lockwood GM; Ledger WL; Barlow DH; Groome NP; Muttukrishna S, 1998, 'Identification of the source of inhibins at the time of conception provides a diagnostic role for them in very early pregnancy', American Journal of Reproductive Immunology, 40, pp. 303 - 308, http://dx.doi.org/10.1111/j.1600-0897.1998.tb00058.x

Jackson N; Biddolph SC; Ledger W; Manek S, 1998, 'Inhibin expression in the normal and pre-eclamptic placental tissue', JOURNAL OF PATHOLOGY, 186, pp. 26A - 26A, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000075727500104&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Lockwood GM; Muttukrishna S; Groome NP; Matthews DR; Ledger WL, 1998, 'Mid-follicular phase pulses of inhibin B are absent in polycystic ovarian syndrome and are initiated by successful laparoscopic ovarian diathermy: A possible mechanism regulating emergence of the dominant follicle', Journal of Clinical Endocrinology and Metabolism, 83, pp. 1730 - 1735, http://dx.doi.org/10.1210/jcem.83.5.4756

LOCKWOOD G; MUTTUKRISHNA S; GROOME N; LEDGER W, 1998, 'Identification of the source of inhibins and activin at time of conception provides a diagnostic role for them in very early pregnancy', Journal of the Society for Gynecologic Investigation, 5, pp. 50A - 50A, http://dx.doi.org/10.1016/s1071-5576(97)86123-0

Lockwood GM; Muttukrishna S; Groome NP; Matthews DR; Ledger WL, 1998, 'Mid-Follicular Phase Pulses of Inhibin B Are Absent in Polycystic Ovarian Syndrome and Are Initiated by Successful Laparoscopic Ovarian Diathermy: A Possible Mechanism Regulating Emergence of the Dominant Follicle', The Journal of Clinical Endocrinology & Metabolism, 83, pp. 1730 - 1735, http://dx.doi.org/10.1210/jcem.83.5.4756

LOCKWOOD G; MUTTUKRISHNA S; GROOME N; LEDGER W, 1998, 'Mono-follicular development is mediated via inhihin B pulses', Journal of the Society for Gynecologic Investigation, 5, pp. 106A - 106A, http://dx.doi.org/10.1016/s1071-5576(97)86347-2

Muttukrishna S; Groome N; Ledger W, 1997, 'Gonadotropic control of secretion of dimeric inhibins and activin A by human granulosa-luteal cells in vitro', Journal of Assisted Reproduction and Genetics, 14, pp. 566 - 574, http://dx.doi.org/10.1023/A:1022524516824

Child TJ; Ledger WL; Barlow DH; Roest J; Van Heusden AM; Verhoeff A; Mous HVH; Zeilmaker GH, 1997, 'Number of embryos transferred and age of mother [3] (multiple letters)', Fertility and Sterility, 68, pp. 746 - 748

Child TJ; Ledger WL; Barlow DH, 1997, 'Number of embryos transferred and age of mother', FERTILITY AND STERILITY, 68, pp. 746 - 747, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1997YC50700035&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Lockwood GM; Muttukrishna S; Ledger W; Groome N; Dolfing J; Jansen CAM, 1997, 'Optimization of non-analogue IVF: a role for inhibin B in predicting patients liable to a premature LH surge or an inadequate response', HUMAN REPRODUCTION, 12, pp. P79 - P79, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1997YD97600312&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Lockwood GM; Muttukrishna S; Groome NP; Ledger WL, 1997, 'Source of inhibin and activin in early pregnancy', HUMAN REPRODUCTION, 12, pp. P226 - P226, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1997YD97600459&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Muttukrishna S; Knight PG; Groome NP; Redman CWG; Ledger WL, 1997, 'Activin A and inhibin A as possible endocrine markers for preeclampsia', Lancet, 349, pp. 1285 - 1288, http://dx.doi.org/10.1016/S0140-6736(96)09264-1

Birdsall M; Ledger W; Groome N; Abdalla H; Muttukrishna S, 1997, 'Inhibin A and Activin A in the First Trimester of Human Pregnancy', The Journal of Clinical Endocrinology & Metabolism, 82, pp. 1557 - 1560, http://dx.doi.org/10.1210/jcem.82.5.3934

Birdsall M; Ledger W; Groome N; Abdalla H; Muttukrishna S, 1997, 'Inhibin A and activin A in the first trimester of human pregnancy', Journal of Clinical Endocrinology and Metabolism, 82, pp. 1557 - 1560, http://dx.doi.org/10.1210/jcem.82.5.3934

Lockwood GM; Ledger WL; Barlow DH; Groome NP; Muttukrishna S, 1997, 'Measurement of inhibin and activin in early human pregnancy: Demonstration of fetoplacental origin and role in prediction of early- pregnancy outcome', Biology of Reproduction, 57, pp. 1490 - 1494, http://dx.doi.org/10.1095/biolreprod57.6.1490

Lockwood GM; Muttukrishna S; Groome NP; Ledger WL, 1997, 'Predicting the unpredictable: Inhibin B is prognostic of unexpected over and under response to gonadotrophin stimulation in IVF treatment cycles.', FERTILITY AND STERILITY, pp. O183 - O183, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1997XY16000182&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Child TJ; Watson NR; Ledger WL, 1997, 'Sequential bilateral adnexal torsion after a single cycle of gonadotropin ovulation induction with intrauterine insemination', Fertility and Sterility, 67, pp. 573 - 575, http://dx.doi.org/10.1016/S0015-0282(97)80090-8

Muttukrishna S; Child TJ; Groome NP; Ledger WL, 1997, 'Source of circulating levels of inhibin A, pro alpha C-containing inhibins and activin A in early pregnancy', Human Reproduction, 12, pp. 1089 - 1093, http://dx.doi.org/10.1093/humrep/12.5.1089

Lashen H; Ledger W; Bernal A; Evans B; Barlow D, 1997, 'Superovulation with a high gonadotrophin dose for in vitro fertilization.', FERTILITY AND STERILITY, pp. O128 - O128, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1997XY16000127&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Lashen H; Ledger W; Bernal A; Evans B; Barlow D, 1997, 'O-128 Superovulation with a high gonadotrophin dose for in vitro fertilization', Fertility and Sterility, 68, pp. S64 - S64, http://dx.doi.org/10.1016/s0015-0282(97)90760-3

Lockwood GM; Muttukrishna S; Groome NP; Ledger WL, 1997, 'O-183 Predicting the unpredictable: Inhibin B is prognostic of unexpected over and under response to gonadotrophin stimulation in IVF treatment cycles', Fertility and Sterility, 68, pp. S90 - S91, http://dx.doi.org/10.1016/s0015-0282(97)90815-3

Lockwood GM; Muttukrishna S; Ledger W; Groome N; Dolfing J; Jansen CAM, 1997, 'P-079. Optimization of non-analogue IVF: a role for inhibin B in predicting patients liable to a premature LH surge or an inadequate response', Human Reproduction, 12, pp. 157 - 158, http://dx.doi.org/10.1093/humrep/12.suppl_2.157-a

Lockwood GM; Muttukrishna S; Groome NP; Ledger WL, 1997, 'P-226. Source of inhibin and activin in early pregnancy', Human Reproduction, 12, pp. 225 - 225, http://dx.doi.org/10.1093/humrep/12.suppl_2.225

Lashen H; Ledger W; Davies WAR; Smith R, 1996, 'Oocyte release in luteinized unruptured follicles with a second dose of human chorionic gonadotrophin', Middle East Fertility Society Journal, 1, pp. 226 - 229

Birdsall MA; Lockwood GM; Ledger WL; Johnson PM; Chamley LW, 1996, 'Antiphospholipid antibodies in women having in-vitro fertilization', Human Reproduction, 11, pp. 1185 - 1189, http://dx.doi.org/10.1093/oxfordjournals.humrep.a019352

Lockwood GM; Muttukrishna S; Groome NP; Knight PG; Ledger WL, 1996, 'Circulating inhibins and activin A during GnRH-analogue down-regulation and ovarian hyperstimulation with recombinant FSH for in-vitro fertilization-embryo transfer', Clinical Endocrinology, 45, pp. 741 - 748, http://dx.doi.org/10.1046/j.1365-2265.1996.8510861.x

Todd BS; Ledger WL, 1995, 'A computer-based flowcharting system for clinical protocols', Medical Informatics, 20, pp. 177 - 198

Lockwood GM; Ledger WL; Barlow DH, 1995, 'Successful pregnancy outcome in a renal transplant patient following in-vitro fertilization', Human Reproduction, 10, pp. 1528 - 1530, http://dx.doi.org/10.1093/HUMREP/10.6.1528

Todd BS; Ledger WL, 1995, 'A computer-based flowcharting system for clinical protocols', Informatics for Health and Social Care, 20, pp. 177 - 198, http://dx.doi.org/10.3109/14639239508995004

Mahmud G; Lopez Bernal A; Yudkin P; Ledger W; Barlow DH, 1995, 'A controlled assessment of the in vitro fertilization performance of British women of indian origin compared with white women', Fertility and Sterility, 64, pp. 103 - 106, http://dx.doi.org/10.1016/s0015-0282(16)57663-8

Clark AM; Ledger W; Galletly C; Tomlinson L; Blaney F; Wang X; Norman RJ, 1995, 'Weight loss results in significant improvement in pregnancy and ovulation rates in anovulatory obese women', Human Reproduction, 10, pp. 2705 - 2712, http://dx.doi.org/10.1093/oxfordjournals.humrep.a135772

ANGELL RR; XIAN J; KEITH J; LEDGER W; BAIRD DT, 1994, '1ST MEIOTIC DIVISION ABNORMALITIES IN HUMAN OOCYTES - MECHANISM OF TRISOMY FORMATION', CYTOGENETICS AND CELL GENETICS, 65, pp. 194 - 202, http://dx.doi.org/10.1159/000133631

Ledger WL; Sweeting VM; Chatterjee S, 1994, 'Rapid diagnosis of early ectopic pregnancy in an emergency gynaecology service-are measurements of progesterone, intact and free β human chorionic gonadotrophin helpful?', Human Reproduction, 9, pp. 157 - 160, http://dx.doi.org/10.1093/oxfordjournals.humrep.a138307

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