By Professor Beng Hock Chong

Journal articles

Leung HHL; Ahmadi Z; Lee B; Casey J; Ratnasingam S; McKenzie SE; Perdomo J; Chong BH, 2024, 'Antithrombotic efficacy and bleeding risks of vaccine-induced immune thrombotic thrombocytopenia treatments.', Blood Adv, 8, pp. 5744 - 5752, http://dx.doi.org/10.1182/bloodadvances.2024013883

Leung HHL; Perdomo J; Ahmadi Z; Chong BH, 2023, 'Determination of Antibody Activity by Platelet Aggregation', Bio-protocol, 13, pp. e4804, http://dx.doi.org/10.21769/BioProtoc.4804

Sidhu VS; Kelly TL; Pratt N; Graves SE; Buchbinder R; Adie S; Cashman K; Ackerman IN; Bastiras D; Brighton R; Burns AWR; Chong BH; Clavisi O; Cripps M; Dekkers M; De Steiger R; Dixon M; Ellis A; Griffith EC; Hale D; Hansen A; Harris A; Hau R; Horsley M; James D; Khorshid O; Kuo L; Lewis PL; Lieu D; Lorimer M; Macdessi SJ; McCombe P; McDougall C; Mulford J; Naylor JM; Page RS; Radovanovic J; Solomon M; Sorial R; Summersell P; Tran P; Walter WL; Webb S; Wilson C; Wysocki D; Harris IA, 2023, 'Effect of Aspirin vs Enoxaparin on 90-Day Mortality in Patients Undergoing Hip or Knee Arthroplasty: A Secondary Analysis of the CRISTAL Cluster Randomized Trial', JAMA Network Open, 6, pp. E2317838, http://dx.doi.org/10.1001/jamanetworkopen.2023.17838

Leung HHL; Perdomo J; Ahmadi Z; Zheng SS; Rashid FN; Enjeti A; Ting SB; Chong JJH; Chong BH, 2022, 'NETosis and thrombosis in vaccine-induced immune thrombotic thrombocytopenia', Nature Communications, 13, http://dx.doi.org/10.1038/s41467-022-32946-1

Zheng SS; Ahmadi Z; Leung HHL; Wong R; Yan F; Perdomo JS; Chong BH, 2022, 'Antiplatelet antibody predicts platelet desialylation and apoptosis in immune thrombocytopenia', Haematologica, 107, pp. 2195 - 2205, http://dx.doi.org/10.3324/haematol.2021.279751

Sidhu VS; Kelly TL; Pratt N; Graves SE; Buchbinder R; Adie S; Cashman K; Ackerman I; Bastiras D; Brighton R; Burns AWR; Chong BH; Clavisi O; Cripps M; Dekkers M; De Steiger R; Dixon M; Ellis A; Griffith EC; Hale D; Hansen A; Harris A; Hau R; Horsley M; James D; Khorshid O; Kuo L; Lewis P; Lieu D; Lorimer M; Macdessi S; McCombe P; McDougall C; Mulford J; Naylor JM; Page RS; Radovanovic J; Solomon M; Sorial R; Summersell P; Tran P; Walter WL; Webb S; Wilson C; Wysocki D; Harris IA, 2022, 'Effect of Aspirin vs Enoxaparin on Symptomatic Venous Thromboembolism in Patients Undergoing Hip or Knee Arthroplasty: The CRISTAL Randomized Trial', JAMA, 328, pp. 719 - 727, http://dx.doi.org/10.1001/jama.2022.13416

Choi PYI; Hsu D; Tran HA; Tan CW; Enjeti A; Chen VMY; Chong BH; Curnow J; Pepperell D; Bird R, 2022, 'Immune thrombocytopenia following vaccination during the COVID-19 pandemic', Haematologica, 107, pp. 1193 - 1196, http://dx.doi.org/10.3324/haematol.2021.279442

Chilingaryan Z; Deshmukh T; Leung HHL; Perdomo J; Emerson P; Kurup R; Chong BH; Chong JJH, 2022, 'Erythrocyte interaction with neutrophil extracellular traps in coronary artery thrombosis following myocardial infarction', Pathology, 54, pp. 87 - 94, http://dx.doi.org/10.1016/j.pathol.2021.05.099

Popp SK; Vecchio F; Brown DJ; Fukuda R; Suzuki Y; Takeda Y; Wakamatsu R; Sarma MA; Garrett J; Giovenzana A; Bosi E; Lafferty ARA; Brown KJ; Gardiner EE; Coupland LA; Thomas HE; Chong BH; Parish CR; Battaglia M; Petrelli A; Simeonovic CJ, 2022, 'Circulating platelet-neutrophil aggregates characterize the development of type 1 diabetes in humans and NOD mice', JCI Insight, 7, http://dx.doi.org/10.1172/jci.insight.153993

Pouplard C; Rollin J; Vayne C; Charuel N; Ahmadi Z; Alberio L; Azjenberg N; Althaus K; Bakchoul T; Chong B; Curtis BR; Faille D; Gomez FJ; Gresele P; Morel-Kopp MC; Mullier F; Nazy I; Smith JW; Greinacher A; Gruel Y, 2022, 'Multicentre evaluation of 5B9, a monoclonal anti-PF4/heparin IgG mimicking human HIT antibodies, as an internal quality control in HIT functional assays: Communication from the ISTH SSC Subcommittee on Platelet Immunology', Journal of Thrombosis and Haemostasis, 20, pp. 252 - 259, http://dx.doi.org/10.1111/jth.15560

Leung HHL; Perdomo J; Ahmadi Z; Yan F; McKenzie SE; Chong BH, 2021, 'Inhibition of NADPH oxidase blocks NETosis and reduces thrombosis in heparin-induced thrombocytopenia', Blood Advances, 5, pp. 5439 - 5451, http://dx.doi.org/10.1182/bloodadvances.2020003093

Kong H; Jiang Q; Su W; Luo Y; Ge H; Li L; Chong BH; Yang M, 2021, 'Effect of Thrombospondin-1 on Apoptosis of Human Megakaryocytic Leukemia Cells', BLOOD, 138, http://dx.doi.org/10.1182/blood-2021-149054

Yang M; Li L; Luo Y; Su W; Kong H; Chong BH; Ye J, 2021, 'PDGF-BB and Its Role in Megakaryopoiesis and Thrombocythemia', BLOOD, 138, http://dx.doi.org/10.1182/blood-2021-151850

Yang M; Su W; Yang L; Kong H; Wei H; Sun H; Chong BH; Li L, 2021, 'Anti-Apoptotic Effect of Angelica Polysaccharide (APS) on Cryopreservation of Platelets', Blood, 138, pp. 3250 - 3250, http://dx.doi.org/10.1182/blood-2021-151963

Chen H; Zhou M; Shu H; Su W; Yang L; Li L; Chong BH; Yang M, 2021, 'Tanshinone Iia Inhibits Megakaryopoiesis in Immune Vasculitis', Blood, 138, pp. 4288 - 4288, http://dx.doi.org/10.1182/blood-2021-152162

Merriman E; Chunilal S; Brighton T; Chen V; McRae S; Ockelford P; Curnow J; Tran H; Chong B; Smith M; Royle G; Crowther H; Slocombe A; Tran H, 2021, 'Two Weeks of Low Molecular Weight Heparin for Isolated Symptomatic Distal Vein Thrombosis (TWISTER study)', Thrombosis Research, 207, pp. 33 - 39, http://dx.doi.org/10.1016/j.thromres.2021.09.004

Zheng SS; Perdomo JS; Ahmadi Z; Chong BH, 2021, 'Indirect detection of anti-platelet antibodies in immune thrombocytopenia', Pathology, 53, pp. 759 - 762, http://dx.doi.org/10.1016/j.pathol.2020.12.006

Krilis M; Qi M; Ioannou Y; Zhang JY; Ahmadi Z; Wong JWH; Vlachoyiannopoulos PG; Moutsopoulos HM; Koike T; Sturgess AD; Chong BH; Krilis SA; Giannakopoulos B, 2021, 'Clinical relevance of nitrated beta 2-glycoprotein I in antiphospholipid syndrome: Implications for thrombosis risk', Journal of Autoimmunity, 122, http://dx.doi.org/10.1016/j.jaut.2021.102675

Yang M; Deng H; Yang L; Li L; Ye J; Cheng Y; Tan Y; Chong BH; Li Q, 2020, 'Coagulation Dysfunction and Hematological Changes in 633 Patients with COVID-19', Blood, 136, pp. 22 - 23, http://dx.doi.org/10.1182/blood-2020-140274

Yang M; Li L; Zhou L; Zhang H; Yang L; Chong BH; Yang Y, 2020, 'Increased Circulating Proplatelets and Elevated Plasma TPO Levels: A Novel Pathological Mechanism of Cerebral Infarction', Blood, 136, pp. 9 - 9, http://dx.doi.org/10.1182/blood-2020-140287

Yang M; Liang E; Ye J; Chong BH; Li L, 2020, 'The Role of 5-HT on Proplatelet Formation and Thrombopoietin Production', Blood, 136, pp. 14 - 14, http://dx.doi.org/10.1182/blood-2020-140183

Li L; Wang J; Ye J; Yang L; Chong BH; Yang M, 2020, 'Thrombopoietin Protects Neural Cells and Endothelial Cells from Apoptosis Via PI3K/AKT Pathway', Blood, 136, pp. 8 - 9, http://dx.doi.org/10.1182/blood-2020-140262

Morgan RL; Ashoorion V; Cuker A; Begum H; Ross S; Martinez N; Chong BH; Linkins LA; Warkentin TE; Wiercioch W; Nieuwlaat R; Schünemann H; Santesso N, 2020, 'Management of heparin-induced thrombocytopenia: systematic reviews and meta-analyses', Blood Advances, 4, pp. 5184 - 5193, http://dx.doi.org/10.1182/BLOODADVANCES.2020002963

Chong BH, 2020, 'Evolving concepts of pathogenesis of heparin-induced thrombocytopenia: Diagnostic and therapeutic implications', International Journal of Laboratory Hematology, 42, pp. 25 - 32, http://dx.doi.org/10.1111/ijlh.13223

Li L; Yi C; Xia WJ; Huang B; Chen S; Zhong J; Fang X; Yang L; Xin H; Zheng SS; Chong BH; Fu Y; Chen C; Yang M, 2020, 'c-Mpl and TPO expression in the human central nervous system neurons inhibits neuronal apoptosis', Aging, 12, pp. 7397 - 7410, http://dx.doi.org/10.18632/AGING.103086

Zheng SS; Perdomo JS; Leung HHL; Yan F; Chong BH, 2020, 'Acquired Glanzmann thrombasthenia associated with platelet desialylation', Journal of Thrombosis and Haemostasis, 18, pp. 714 - 721, http://dx.doi.org/10.1111/jth.14722

Perdomo J; Leung HHL; Ahmadi Z; Yan F; Chong JJH; Passam FH; Chong BH, 2019, 'Neutrophil activation and NETosis are the major drivers of thrombosis in heparin-induced thrombocytopenia', Nature Communications, 10, pp. 1322, http://dx.doi.org/10.1038/s41467-019-09160-7

Zheng ZY; Yu XL; Dai TY; Yin LM; Zhao YN; Xu M; Zhuang HF; Chong BH; Gao RL, 2019, 'Panaxdiol Saponins Component Promotes Hematopoiesis and Modulates T Lymphocyte Dysregulation in Aplastic Anemia Model Mice', Chinese Journal of Integrative Medicine, 25, pp. 902 - 910, http://dx.doi.org/10.1007/s11655-019-3049-z

Yang M; Chen S; Li L; Xin H; Chong BH; Yang L, 2019, 'Analysis of a New Haematopoietic Stem/Progenitor Cells with Megakaryocyte Differentiation Potential', BLOOD, 134, http://dx.doi.org/10.1182/blood-2019-127851

Xu W-H; Li L; Yang L; Xin H; Chong BH; Yang M, 2019, 'Astragalus Polysaccharide Promotes Hematopoiesis in an Irradiated Mouse Model and Reduces Apoptosis of Hematopoietic Cells', BLOOD, 134, http://dx.doi.org/10.1182/blood-2019-131631

Li L; Yang L; Xin H; Chong BH; Yang M, 2019, 'Thrombopoietin Has Protective Effect in Neonatal Hypoxia-Ischemia Rat Model', BLOOD, 134, http://dx.doi.org/10.1182/blood-2019-131575

Sidhu VS; Graves SE; Buchbinder R; Naylor JM; Pratt NL; De Steiger RS; Chong BH; Ackerman IN; Adie S; Harris A; Hansen A; Cripps M; Lorimer M; Webb S; Clavisi O; Griffith EC; Anandan D; O'Donohue G; Kelly TL; Harris IA, 2019, 'CRISTAL: Protocol for a cluster randomised, crossover, non-inferiority trial of aspirin compared to low molecular weight heparin for venous thromboembolism prophylaxis in hip or knee arthroplasty, a registry nested study', BMJ Open, 9, pp. e031657, http://dx.doi.org/10.1136/bmjopen-2019-031657

Joseph J; Rabbolini D; Enjeti AK; Favaloro E; Kopp MC; McRae S; Pasalic L; Tan CW; Ward CM; Chong BH, 2019, 'Diagnosis and management of heparin-induced thrombocytopenia: a consensus statement from the Thrombosis and Haemostasis Society of Australia and New Zealand HIT Writing Group', Medical Journal of Australia, 210, pp. 509 - 516, http://dx.doi.org/10.5694/mja2.50213

Kuter DJ; Newland A; Chong BH; Rodeghiero F; Romero MT; Pabinger I; Chen Y; Wang K; Mehta B; Eisen M, 2019, 'Romiplostim in adult patients with newly diagnosed or persistent immune thrombocytopenia (ITP) for up to 1 year and in those with chronic ITP for more than 1 year: a subgroup analysis of integrated data from completed romiplostim studies', British Journal of Haematology, 185, pp. 503 - 513, http://dx.doi.org/10.1111/bjh.15803

Frey N; Jang JH; Szer J; Illés Á; Kim HJ; Ram R; Chong BH; Rowe JM; Borisenkova E; Liesveld J; Winer ES; Cherfi A; Aslanis V; Ghaznawi F; Strickland S, 2019, 'Eltrombopag treatment during induction chemotherapy for acute myeloid leukaemia: a randomised, double-blind, phase 2 study', The Lancet Haematology, 6, pp. e122 - e131, http://dx.doi.org/10.1016/S2352-3026(18)30231-X

Ahmadi Z; Perdomo J; Wong R; Chong BH, 2019, 'Drug-induced immune thrombocytopenia: Mapping of the drug binding site to the membrane-proximal region of platelet GPIX', Platelets, 30, pp. 251 - 255, http://dx.doi.org/10.1080/09537104.2017.1419556

Provan D; Arnold DM; Bussel JB; Chong BH; Cooper N; Gernsheimer T; Ghanima W; Godeau B; González-López TJ; Grainger J; Hou M; Kruse C; McDonald V; Michel M; Newland AC; Pavord S; Rodeghiero F; Scully M; Tomiyama Y; Wong RS; Zaja F; Kuter DJ, 2019, 'Updated international consensus report on the investigation and management of primary immune thrombocytopenia', Blood Advances, 3, pp. 3780 - 3817, http://dx.doi.org/10.1182/bloodadvances.2019000812

Cuker A; Arepally GM; Chong BH; Cines DB; Greinacher A; Gruel Y; Linkins LA; Rodner SB; Selleng S; Warkentin TE; Wex A; Mustafa RA; Morgan RL; Santesso N, 2018, 'American Society of Hematology 2018 guidelines for management of venous thromboembolism: Heparin-induced thrombocytopenia', Blood Advances, 2, pp. 3360 - 3392, http://dx.doi.org/10.1182/bloodadvances.2018024489

Spyropoulos AC; Ageno W; Albers GW; Elliott CG; Halperin JL; Hiatt WR; Maynard GA; Steg PG; Weitz JI; Suh E; Spiro TE; Barnathan ES; Raskob GE; Douketis J; Turpie AG; Schulman S; Kearon C; Linkins LA; Schellong S; Bauer K; Geerts W; Roberts R; Casais P; Gallus A; Karrasch J; Eichinger-Hasenauer S; Krivenchuk V; Hadzovic-Dzuvo A; Trbojevic S; Lopes R; Mincheva V; Carrier M; Dennis R; Tudoric N; Spinar J; Nielsen H; Marandi T; Shaburishvili T; Beyer-Westendorf J; Vardas P; Boda Z; Brenner B; Piovella F; Krievins D; Petrauskiene B; Dejanova-Ilijevska V; Virgen Carrillo LR; Middeldorp S; Castillo Leon RP; Torbicki A; Saraiva de Sousa M; Dorobantu M; Militaru C; Yavelov I; Vuckovic B; Reuter H; Basson M; Monreal M; Kucukoglu S; Parkhomenko A; Alikhan R; Rosenberg D; Yusen R; Khorana A; Tapson V; Pollack C; Hazelrigg M; Jure H; Alvarisqueta A; Cartasegna L; Hominal M; Cursack G; Alzogaray M; Maillo M; Parody M; Caccavo A; Dran RD; Muntaner JA; Casas M; Schmidberg J; Sarjanovich R; Gabito A; Garrido M; Amuchastegui M; Fernandez A; Loureyro J; Giumelli C; Heazlewood V; Colquhoun D; White H; Sabet A; Bowler S; Carroll P; Khalafallah A; Baker R; Hedger S; Simpson FG; Jackson D; Chong B; Siostrzonek P, 2018, 'Rivaroxaban for thromboprophylaxis after hospitalization for medical illness', New England Journal of Medicine, 379, pp. 1118 - 1127, http://dx.doi.org/10.1056/NEJMoa1805090

Cai H; Cho EA; Li Y; Sockler J; Parish CR; Chong BH; Edwards J; Dodds TJ; Ferguson PM; Wilmott JS; Scolyer RA; Halliday GM; Khachigian LM, 2018, 'Melanoma protective antitumor immunity activated by catalytic DNA', Oncogene, 37, pp. 5115 - 5126, http://dx.doi.org/10.1038/s41388-018-0306-0

Lee KH; Cavanaugh L; Leung H; Yan F; Ahmadi Z; Chong BH; Passam F, 2018, 'Quantification of NETs-associated markers by flow cytometry and serum assays in patients with thrombosis and sepsis', International Journal of Laboratory Hematology, 40, pp. 392 - 399, http://dx.doi.org/10.1111/ijlh.12800

Sun X; Zhao YN; Qian S; Gao RL; Yin LM; Wang LP; Chong BH; Zhang SZ, 2018, 'Ginseng-Derived Panaxadiol Saponins Promote Hematopoiesis Recovery in Cyclophosphamide-Induced Myelosuppressive Mice: Potential Novel Treatment of Chemotherapy-Induced Cytopenias', Chinese Journal of Integrative Medicine, 24, pp. 200 - 206, http://dx.doi.org/10.1007/s11655-017-2754-8

Perdomo J; Yan F; Leung HHL; Chong BH, 2017, 'Megakaryocyte Differentiation and Platelet Formation from Human Cord Blood-derived CD34⁺ Cells', Journal of Visualized Experiments, http://dx.doi.org/10.3791/56420-v

Perdomo JS; Yan F; Leung HH; Chong BH, 2017, 'Megakaryocyte Differentiation and Platelet Formation from Human Cord Blood-derived CD34+ Cells', Journal of Visualized Experiments, 2017, http://dx.doi.org/10.3791/56420

Cines DB; Wasser J; Rodeghiero F; Chong BH; Steurer M; Provan D; Lyons R; Garcia-Chavez J; Carpenter N; Wang X; Eisen M, 2017, 'Safety and efficacy of romiplostim in splenectomized and nonsplenectomized patients with primary immune thrombocytopenia', Haematologica, 102, pp. 1342 - 1351, http://dx.doi.org/10.3324/haematol.2016.161968

Yang M; Liang E; Mao L; Li C; Chong BH, 2016, 'Notoginsenoside R1 Has Thrombopoietic Effect in Irradiated Mice', Blood, 128, pp. 4932 - 4932, http://dx.doi.org/10.1182/blood.v128.22.4932.4932

Li Xia Z; Mo Y; Jie Yu Y; Chong BH, 2016, 'PDGFR Inhibitor Imatinib May be a Potent Drug in Treating Essential Thrombocythemia', Blood, 128, pp. 5470 - 5470, http://dx.doi.org/10.1182/blood.v128.22.5470.5470

Yang M; Ye J; Liang E; Li C; Chong BH, 2016, 'The Ex-Vivo Expansion of Megakaryocytic Progenitors from Hematopoietic Stem Cells for Thrombocytopenia in NOD/SCID Mice', Blood, 128, pp. 3746 - 3746, http://dx.doi.org/10.1182/blood.v128.22.3746.3746

Yang M; Liu L; Liang E; Chong BH; Li C, 2016, 'Thrombopoietin Has Neural Protective Effect in a Neonatal Rat Model of Hypoxic-Ischemic Brain Damage', Blood, 128, pp. 5059 - 5059, http://dx.doi.org/10.1182/blood.v128.22.5059.5059

Yang M; Liang E; Mao L; Chong BH; Li C, 2016, 'Thrombospondin-1 Induces Apoptosis in Megakaryocytic Leukemia Via CD36 and Caspase-3 Signaling', Blood, 128, pp. 5209 - 5209, http://dx.doi.org/10.1182/blood.v128.22.5209.5209

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