By Professor Christopher Carl Goodnow

Preprints

Gillman R; Dudka S; Samir J; Louie R; Goodnow C; Luciano F; Singh M; Field M, 2025, Detecting Somatic Mutations in Rare Clones using Single Cell Multi-Omics, http://dx.doi.org/10.1101/2025.10.30.685685

Voyer TL; Gervais A; Rosain J; Parent A; Cederholm A; Rinchai D; Bizien L; Hancioglu G; Philippot Q; Gueye MS; Luxman MR; Renkilaraj M; Ogishi M; Soudée C; Migaud M; Rozenberg F; Momenilandi M; Riller Q; Imberti L; Delmonte O; Müller G; Keller B; Orrego J; Gallego WA; Rubin T; Emiroglu M; Parvaneh N; Eriksson D; Aranda-Guillen M; Berrios DI; Vong L; Katelaris CH; Mustillo P; Rädler J; Bohlen J; Celik JB; Astudillo C; Winter S; Consortium CN-Κ; Guichard A; Béziat V; Bustamante J; Pan-Hammarström Q; Zhang Y; Rosen LB; Holland SM; Kenney H; Boztuğ K; Mahlaoui N; Latour S; Abraham R; Lougaris V; Hauck F; Sediva A; Atschekzei F; Poli MC; Slatter MA; Palterer B; Keller MD; Pinzon-Charry A; Sullivan A; Droney L; Suan D; Aladjidi N; Hie M; Lazaro E; Franco J; Keles S; Malphette M; Pasquet M; Maccari ME; Meinhardt A; Ikinciogullari A; Shahrooei M; Celmeli F; Frosk P; Goodnow CC; Gray PE; Belot A; Kuehn HS; Rosenzweig SD; Licciardi F; Servettaz A; Barlogis V; Guenno GL; Herrmann V-M; Kuijpers T; Ducoux G; Sarrot-Reynauld F; Schuetz C; Cunningham-Rundles C; Rieux-Laucat F; Tangye SG; Sobacchi C; Doffinger R; Warnatz K; Grimbacher B; Fieschi C; Berteloot L; Bryant V; Assant ST; Notarangelo LD; Su H; Neven B; Abel L; Zhang Q; Boisson B; Cobat A; Jouanguy E; Kampe O; Bastard P; Roifman C; Landegren N; Anderson MS; Casanova J-L; Puel A, 2023, Impaired thymic AIRE expression underlies autoantibodies against type I IFNs in humans with inborn errors of the alternative NF-kB pathway, http://dx.doi.org/10.22541/au.167330741.18394805/v1

Masle-Farquhar E; Peters TJ; Jackson KJ; Singh M; S. C; Suan D; Uzel G; Chua I; Leiding JW; Heiskanen K; Preece K; Kainulainen L; O’Sullivan M; Cooper MA; Seppänen MR; Mustjoki S; Brothers S; Vogel TP; Brink R; Tangye SG; Reed JH; Goodnow CC, 2021, Overactive STAT3 Drives Accumulation of Disease-Associated CD21 ^low B Cells, http://dx.doi.org/10.2139/ssrn.3996405

Masle-Farquhar E; Peters TJ; Miosge LA; Parish IA; Weigel C; Oakes CC; Reed JH; Goodnow CC, 2021, Uncontrolled CD21 ^low Age-Associated and B1 B Cell Accumulation Caused by Failure of an EGR2/3 Tolerance Checkpoint, http://dx.doi.org/10.2139/ssrn.3885243

Ho W-HJ; Law A; Masle-Farquhar E; Castillo L; Mawson A; O’Bryan M; Goodnow C; Ortega DG; Oakes S; Ormandy C, 2021, Activation of the viral sensor oligoadenylate synthetase 2 (Oas2) prevents pregnancy-driven mammary cancer metastases, http://dx.doi.org/10.21203/rs.3.rs-842107/v1

Zammit N; Siggs OM; Gray P; King C; Christ D; Goodnow CC; Grey S; Cowley M; Craig M; Dinger M; Ziegler J; Villanueva J; Cultrone D; Brink R, 2019, Phospho-tuning immunity through Denisovan, modern human and mouse TNFAIP3 gene variants, http://dx.doi.org/10.1101/589507

Parish IA; Stamp LA; Lorenzo AMD; Fowler SM; Sontani Y; Miosge LA; Howard DR; Goodnow CC; Young HM; Furness JB, A novel mutation in the nucleoporin NUP35 causes murine degenerative colonic smooth muscle myopathy, http://dx.doi.org/10.1101/036582

Rizzetto S; Koppstein DN; Samir J; Singh M; Reed JH; Cai CH; Lloyd AR; Eltahla AA; Goodnow CC; Luciani F, B-cell receptor reconstruction from single-cell RNA-seq with VDJPuzzle, http://dx.doi.org/10.1101/181156

Rouet R; Henry JY; Johansen MD; Sobti M; Balachandran H; Langley DB; Walker G; Lenthall H; Jackson J; Ubiparipovic S; Mazigi O; Schofield P; Burnett DL; Brown SHJ; Martinello M; Hudson B; Gilroy N; Post JJ; Kelleher A; Jäck H-M; Goodnow CC; Turville SG; Rawlinson WD; Bull RA; Stewart AG; Hansbro PM; Christ D, Broadly neutralizing SARS-CoV-2 antibodies through epitope-based selection from convalescent patients, http://dx.doi.org/10.1101/2022.10.19.512954

Boast B; Helian K; Andrews TD; Li X; Cho V; Closa A; Sutton HJ; Reed JH; Bergmann H; Roots CM; Yabas M; Barthel N; Omari SA; Young C; Miosge LA; Eyras E; Nutt SL; Hein N; Hannan KM; Cockburn IA; Goodnow CC; Enders A, Dysregulation of PAX5 causes uncommitted B cell development and tumorigenesis in mice, http://dx.doi.org/10.1101/2021.01.29.428877

Zammit NW; Gray PE; Siggs OM; Yap JY; Russell A; Cultrone D; Warren J; Walters SN; Brink R; Zahra D; Burnett DL; Gayevskiy V; Minoche AE; Ziegler JB; Craig ME; Wong M; Benitez-Aguirre P; Teo J; Cowley MJ; Dinger ME; Tangye SG; Burke C; Phan TG; Goodnow CC; Grey ST, Environmental and genetic disease modifiers of haploinsufficiency of A20, http://dx.doi.org/10.1101/2022.03.19.485004

Singh M; Louie RHY; Samir J; Field MA; Milthorpe C; Aldiriki T; Mackie J; Roper E; Faulks M; Jackson KJL; Calcino A; Hardy MY; Blombery P; Amos TG; Deveson IW; Read SA; Shek D; Guerin A; S C; Tangye SG; Di Sabatino A; Lenti MV; Pasini A; Ciccocioppo R; Ahlenstiel G; Suan D; Tye-Din JA; Goodnow CC; Luciani F, Expanded T cell clones with lymphoma driver somatic mutations in refractory celiac disease, http://dx.doi.org/10.1101/2024.03.17.24304320

Singh M; Al-Eryani G; Carswell S; Ferguson JM; Blackburn J; Barton K; Roden D; Luciani F; Phan T; Junankar S; Jackson K; Goodnow CC; Smith MA; Swarbrick A, High-throughput targeted long-read single cell sequencing reveals the clonal and transcriptional landscape of lymphocytes, http://dx.doi.org/10.1101/424945

Al-Eryani G; Bartonicek N; Chan C-L; Anderson A; Harvey K; Wu SZ; Roden D; Wang T; Reeves J; Yeung BZ; Masle-Farquhar E; Goodnow CC; Ma C; Phan TG; Lundeberg J; Junankar S; Swarbrick A, Integration of single-cell RNA and protein data identifies novel clinically-relevant lymphocyte phenotypes in breast cancers, http://dx.doi.org/10.1101/2022.05.31.494081

Masle-Farquhar E; Russell A; Li Y; Zhu F; Rui L; Brink R; Goodnow CC, Loss-of-function of Fbxo10, encoding a post-translational regulator of BCL2 in lymphomas, has no discernible effect on BCL2 or B lymphocyte accumulation in mice, http://dx.doi.org/10.1101/2020.08.05.237545

Bryant D; Smith L; Rogers-Broadway KR; Karydis L; Woo J; Blunt MD; Forconi F; Stevenson FK; Goodnow C; Russell A; Humberg P; Packham G; Steele AJ; Strefford JC, Network analysis reveals a major role for 14q32 cluster miRNAs in determining transcriptional differences between IGHV-mutated and unmutated CLL, http://dx.doi.org/10.1101/2022.04.26.487675

Kayagaki N; Kornfeld O; Lee B; Stowe I; O'Rourke K; Li Q; Sandoval W; Yan D; Xu M; Ulas G; Payandeh J; Roose-Girma M; Modrusan Z; Reja R; Sagolla M; Webster J; Cho V; Andrews T; Morris L; Miosge L; Goodnow C; Bertram E; Dixit V, NINJ1 mediates plasma membrane rupture during lytic cell death, http://dx.doi.org/10.21203/rs.3.rs-62714/v1

Masle-Farquhar E; Peters T; Jackson KJ; Singh M; S C; Suan D; Uzel G; Chua I; Leiding JW; Heiskanen K; Preece K; Kainulainen L; O’Sullivan M; Cooper MA; Seppänen MR; Mustjoki S; Brothers S; Vogel TP; Brink R; Tangye SG; Reed JH; Goodnow CC, Overactive STAT3 drives accumulation of disease-associated CD21low B cells, http://dx.doi.org/10.1101/2021.12.20.473595

Rouet R; Mazigi O; Walker GJ; Langley DB; Sobti M; Schofield P; Lenthall H; Jackson J; Ubiparipovic S; Henry JY; Abayasingam A; Burnett D; Kelleher A; Brink R; Bull RA; Turville S; Stewart AG; Goodnow CC; Rawlinson WD; Christ D, Potent SARS-CoV-2 binding and neutralization through maturation of iconic SARS-CoV-1 antibodies, http://dx.doi.org/10.1101/2020.12.14.422791

Al-Eryani G; Van Der Leij S; Masle-Farquhar E; Chan C-L; Harvey K; Wu SZ; Roden D; Wang T; Reeves J; Yeung BZ; Goodnow CC; Ma CS; Perou CM; Hacohen N; Al'Khafaji AM; Nilsson M; Lundeberg J; Batten M; Junankar S; Swarbrick A, Proteotranscriptomic Dissection of Breast Cancer T Cell States Identifies CD103+ Tfh-derived Cytotoxic Cells Linked to Immunotherapy Response, http://dx.doi.org/10.21203/rs.3.rs-8394722/v1

Young C; Singh M; Jackson KJ; Field MA; Peters TJ; Angioletti-Uberti S; Frenkel D; Ravishankar S; Gupta M; Wang JJ; Agapiou D; Faulks ML; Al-Eryani G; Luciani F; Gordon TP; Reed JH; Danta M; Carr A; Kelleher AD; Dore GJ; Matthews G; Brink R; Bull RA; Suan D; Goodnow CC, Self-reactive B cells traverse a perfect storm of somatic mutagenesis to cause a virus-induced autoimmune disease, http://dx.doi.org/10.1101/2024.01.07.574561

Li M; Safavi A; Samir J; Louie R; Roohparvar Basmenj E; Bonomi M; Adikari T; Gloss B; Xing J; Jackson K; Calcino A; Suan D; Vaira V; Milthorpe C; Hardy M; Masle-Farquhar E; Read S; Field M; Elli L; Lenti MV; Di Sabatino A; Ciccocioppo R; Tye-Din JA; Ahlenstiel G; Goodnow CC; Singh M; Luciani F, Single-cell multi-omics maps clonal IEL expansion and epithelial remodelling in refractory coeliac disease, http://dx.doi.org/10.64898/2026.08.30.747985

Masle-Farquhar E; Jackson KJL; Peters TJ; Al-Eryani G; Singh M; Payne KJ; Rao G; Apps G; Kingham J; Jara CJ; Skvortsova K; Swarbrick A; S. C; Suan D; Uzel G; Chua I; Leiding JW; Heiskanen K; Preece K; Kainulainen L; O’Sullivan M; Cooper MA; Seppänen MRJ; Mustjoki S; Brothers S; Vogel TP; Brink R; Tangye SG; Reed JH; Goodnow CC, STAT3 gain-of-function mutations connect leukemia with autoimmune disease by pathological dysregulation of NKG2Dhi CD8 killer T cells, http://dx.doi.org/10.1101/2022.02.11.480027

Masle-Farquhar E; Peters TJ; Miosge LA; Parish IA; Weigel C; Oakes CC; Reed JH; Goodnow CC, Uncontrolled CD21low age-associated and B1 B cell accumulation caused by failure of an EGR2/3 tolerance checkpoint, http://dx.doi.org/10.1101/2021.07.01.450650

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