Select Publications


Goodnow C, 2007, Chair's Introduction,

Papathanasiou P; Goodnow CC, 2005, Connecting mammalian genome with phenome by ENU mouse mutagenesis: Gene combinations specifying the immune system,

Cornall RJ; Goodnow CC; Cyster JG, 1999, Regulation of B cell antigen receptor signaling by the Lyn/CD22/SHP1 pathway,

Healy JI; Goodnow CC, 1998, Positive versus negative signaling by lymphocyte antigen receptors,

Book Chapters

Goodnow CC; Christ D; Reed JH, 2018, 'Sequencing and affinity determination of antigen-specific B lymphocytes from peripheral blood', in Nevoltris D; Chames P (ed.), Antibody Engineering. Methods in Molecular Biology, Humana Press, New York, NY, pp. 287 - 309,

Goodnow C, 2007, 'Closing Remarks', in Decoding the Genomic Control of Immune Reactions, pp. 208 - 209,

Goodnow CC, 1997, 'Glimpses into the Balance Between Immunity and Self‐Tolerance', in Ciba Foundation Symposium 204 - The Molecular Basis of Cellular Defence Mechanisms, Wiley, pp. 190 - 207,

GOODNOW CC; MASON DY; JONES M; ADAMS E, 1993, 'Tolerant Autoreactive B Lymphocytes in the Follicular Mantle Zone Compartment: Substrates for Receptor Editing and Reform', in Molecular Mechanisms of Immunological Self-Recognition, Elsevier, pp. 25 - 36,

Davis MM; Goodnow C; Gascoigne NRJ; Lindsten T; Chien Y, 1986, 'Murine T-Cell Receptor Genes and the Problems of Cellular Recognition and Repertoire Selection', in Regulation of Immune Gene Expression, Humana Press, pp. 137 - 142,

Walker KZ; Boux HA; Hayden GE; Goodnow CC; Raison RL, 1985, 'A Monoclonal Antibody with Selectivity for Human Kappa Myeloma and Lymphoma Cells which has Potential as a Therapeutic Agent', in Microenvironments in the Lymphoid System, Springer Nature, pp. 833 - 841,

Journal articles

Masle-Farquhar E; Jackson KJL; Peters TJ; Al-Eryani G; Singh M; Payne KJ; Rao G; Avery DT; Apps G; Kingham J; Jara CJ; Skvortsova K; Swarbrick A; Ma CS; Suan D; Uzel G; Chua I; Leiding JW; Heiskanen K; Preece K; Kainulainen L; O'Sullivan M; Cooper MA; Seppänen MRJ; Mustjoki S; Brothers S; Vogel TP; Brink R; Tangye SG; Reed JH; Goodnow CC, 2022, 'STAT3 gain-of-function mutations connect leukemia with autoimmune disease by pathological NKG2Dhi CD8+ T cell dysregulation and accumulation', Immunity, vol. 55, pp. 2386 - 2404.e8,

Ho WHJ; Law AMK; Masle-Farquhar E; Castillo LE; Mawson A; O’Bryan MK; Goodnow CC; Gallego-Ortega D; Oakes SR; Ormandy CJ, 2022, 'Activation of the viral sensor oligoadenylate synthetase 2 (Oas2) prevents pregnancy-driven mammary cancer metastases', Breast Cancer Research, vol. 24, pp. 31,

Pelham SJ; Caldirola MS; Avery DT; Mackie J; Rao G; Gothe F; Peters TJ; Guerin A; Neumann D; Vokurkova D; Hwa V; Zhang W; Lyu SC; Chang I; Manohar M; Nadeau KC; Gaillard MI; Bezrodnik L; Iotova V; Zwirner NW; Gutierrez M; Al-Herz W; Goodnow CC; Vargas-Hernández A; Forbes Satter LR; Hambleton S; Deenick EK; Ma CS; Tangye SG, 2022, 'STAT5B restrains human B-cell differentiation to maintain humoral immune homeostasis', Journal of Allergy and Clinical Immunology, vol. 150, pp. 931 - 946,

Nüssing S; Miosge LA; Lee K; Olshansky M; Barugahare A; Roots CM; Sontani Y; Day EB; Koutsakos M; Kedzierska K; Goodnow CC; Russ BE; Daley SR; Turner SJ, 2022, 'SATB1 ensures appropriate transcriptional programs within naïve CD8+ T cells', Immunology and Cell Biology, vol. 100, pp. 636 - 652,

Langley DB; Schofield P; Nevoltris D; Jackson J; Jackson KJL; Peters TJ; Burk M; Matthews JM; Basten A; Goodnow CC; van Nunen S; Reed JH; Christ D, 2022, 'Genetic and structural basis of the human anti-α-galactosyl antibody response', Proceedings of the National Academy of Sciences of the United States of America, vol. 119, pp. e2123212119,

Yang R; Avery DT; Jackson KJL; Ogishi M; Benhsaien I; Du L; Ye X; Han J; Rosain J; Peel JN; Alyanakian MA; Neven B; Winter S; Puel A; Boisson B; Payne KJ; Wong M; Russell AJ; Mizoguchi Y; Okada S; Uzel G; Goodnow CC; Latour S; Bakkouri JE; Bousfiha A; Preece K; Gray PE; Keller B; Warnatz K; Boisson-Dupuis S; Abel L; Pan-Hammarström Q; Bustamante J; Ma CS; Casanova JL; Tangye SG, 2022, 'Human T-bet governs the generation of a distinct subset of CD11chighCD21low B cells', Science Immunology, vol. 7, pp. eabq3277,

Schulz SR; Hoffmann M; Roth E; Pracht K; Burnett DL; Mazigi O; Schuh W; Manger B; Mielenz D; Goodnow CC; Christ D; Pöhlmann S; Jäck HM, 2022, 'Augmented neutralization of SARS-CoV-2 Omicron variant by boost vaccination and monoclonal antibodies', European Journal of Immunology, vol. 52, pp. 970 - 977,

Aggarwal A; Stella AO; Walker G; Akerman A; Esneau C; Milogiannakis V; Burnett DL; McAllery S; Silva MR; Lu Y; Foster CSP; Brilot F; Pillay A; Van Hal S; Mathivanan V; Fichter C; Kindinger A; Hoppe AC; Munier ML; Amatayakul-Chantler S; Roth N; Coppola G; Symonds GP; Schofield P; Jackson J; Lenthall H; Henry JY; Mazigi O; Jäck HM; Davenport MP; Darley DR; Matthews GV; Khoury DS; Cromer D; Goodnow CC; Christ D; Robosa R; Starck DJ; Bartlett NW; Rawlinson WD; Kelleher AD; Turville SG, 2022, 'Platform for isolation and characterization of SARS-CoV-2 variants enables rapid characterization of Omicron in Australia', Nature Microbiology, vol. 7, pp. 896 - 908,

Masle-Farquhar E; Peters TJ; Miosge LA; Parish IA; Weigel C; Oakes CC; Reed JH; Goodnow CC, 2022, 'Uncontrolled CD21low age-associated and B1 B cell accumulation caused by failure of an EGR2/3 tolerance checkpoint', Cell Reports, vol. 38,

Burnett DL; Jackson KJL; Langley DB; Aggrawal A; Stella AO; Johansen MD; Balachandran H; Lenthall H; Rouet R; Walker G; Saunders BM; Singh M; Li H; Henry JY; Jackson J; Stewart AG; Witthauer F; Spence MA; Hansbro NG; Jackson C; Schofield P; Milthorpe C; Martinello M; Schulz SR; Roth E; Kelleher A; Emery S; Britton WJ; Rawlinson WD; Karl R; Schäfer S; Winkler TH; Brink R; Bull RA; Hansbro PM; Jäck HM; Turville S; Christ D; Goodnow CC, 2021, 'Immunizations with diverse sarbecovirus receptor-binding domains elicit SARS-CoV-2 neutralizing antibodies against a conserved site of vulnerability', Immunity, vol. 54, pp. 2908 - 2921.e6,

Wagle MV; Vervoort SJ; Kelly MJ; Van Der Byl W; Peters TJ; Martin BP; Martelotto LG; Nüssing S; Ramsbottom KM; Torpy JR; Knight D; Reading S; Thia K; Miosge LA; Howard DR; Gloury R; Gabriel SS; Utzschneider DT; Oliaro J; Powell JD; Luciani F; Trapani JA; Johnstone RW; Kallies A; Goodnow CC; Parish IA, 2021, 'Antigen-driven EGR2 expression is required for exhausted CD8+ T cell stability and maintenance', Nature Communications, vol. 12, pp. 2782,

Peters TJ; Buckley MJ; Chen Y; Smyth GK; Goodnow CC; Clark SJ, 2021, 'Calling differentially methylated regions from whole genome bisulphite sequencing with DMRcate', Nucleic Acids Research, vol. 49, pp. e109,

Zhang Z; Jara CJ; Singh M; Xu H; Goodnow CC; Jackson KJL; Reed JH, 2021, 'Human transitional and IgMlow mature naïve B cells preserve permissive B-cell receptors', Immunology and Cell Biology, vol. 99, pp. 865 - 878,

Russell AJ; Gray PE; Ziegler JB; Kim YJ; Smith S; Sewell WA; Goodnow CC, 2021, 'SAMD9L autoinflammatory or ataxia pancytopenia disease mutations activate cell-autonomous translational repression', Proceedings of the National Academy of Sciences of the United States of America, vol. 118,

Yabas M; Yazicioglu YF; Hoyne GF; Goodnow CC; Enders A, 2021, 'Loss of hnRNPLL-dependent splicing of Ptprc has no impact on B-cell development, activation and terminal differentiation into antibody-secreting cells', Immunology and Cell Biology, vol. 99, pp. 532 - 541,

Boast B; Miosge LA; Kuehn HS; Cho V; Athanasopoulos V; McNamara HA; Sontani Y; Mei Y; Howard D; Sutton HJ; Omari SA; Yu Z; Nasreen M; Daniel Andrews T; Cockburn IA; Goodnow CC; Rosenzweig SD; Enders A, 2021, 'A point mutation in IKAROS ZF1 causes a B cell deficiency in mice', Journal of Immunology, vol. 206, pp. 1505 - 1514,

Masle-Farquhar E; Russell A; Li Y; Zhu F; Rui L; Brink R; Goodnow CC, 2021, 'Loss-of-function of Fbxo10, encoding a post-translational regulator of BCL2 in lymphomas, has no discernible effect on BCL2 or B lymphocyte accumulation in mice', PLoS ONE, vol. 16, pp. e0237830,

Kayagaki N; Kornfeld OS; Lee BL; Stowe IB; O’Rourke K; Li Q; Sandoval W; Yan D; Kang J; Xu M; Zhang J; Lee WP; McKenzie BS; Ulas G; Payandeh J; Roose-Girma M; Modrusan Z; Reja R; Sagolla M; Webster JD; Cho V; Andrews TD; Morris LX; Miosge LA; Goodnow CC; Bertram EM; Dixit VM, 2021, 'NINJ1 mediates plasma membrane rupture during lytic cell death', Nature, vol. 591, pp. 131 - 136,

Goodnow CC, 2021, 'COVID-19, varying genetic resistance to viral disease and immune tolerance checkpoints', Immunology and Cell Biology, vol. 99, pp. 177 - 191,

Randall KL; Law HD; Ziolkowski AF; Wirasinha RC; Goodnow CC; Daley SR, 2021, 'DOCK8 deficiency diminishes thymic T-regulatory cell development but not thymic deletion', Clinical and Translational Immunology, vol. 10, pp. e1236,

Wirasinha RC; Davies AR; Srivastava M; Sheridan JM; Sng XYX; Delmonte OM; Dobbs K; Loh KL; Miosge LA; Lee CE; Chand R; Chan A; Yap JY; Keller MD; Chen K; Rossjohn J; la Gruta NL; Vinuesa CG; Reid HH; Lionakis MS; Notarangelo LD; Gray DHD; Goodnow CC; Cook MC; Daley SR, 2021, 'Nfkb2 variants reveal a p100-degradation threshold that defines autoimmune susceptibility', Journal of Experimental Medicine, vol. 218,

Rouet R; Mazigi O; Walker GJ; Langley DB; Sobti M; Schofield P; Lenthall H; Jackson J; Ubiparipovic S; Henry JY; Abayasingam A; Burnett D; Kelleher A; Brink R; Bull RA; Turville S; Stewart AG; Goodnow CC; Rawlinson WD; Christ D, 2021, 'Potent SARS-CoV-2 binding and neutralization through maturation of iconic SARS-CoV-1 antibodies', mAbs, vol. 13, pp. 1922134,

Boast B; Helian K; Andrews D; Li X; Cho V; Closa A; Sutton H; Reed J; Bergmann H; Roots C; Yabas M; Barthel N; Omari S; Young C; Miosge L; Eyras E; Nutt S; Hein N; Hannan K; Cockburn I; Goodnow C; Enders A, 2021, 'Dysregulation of PAX5 causes uncommitted B cell development and tumorigenesis in mice', ,

Burnett DL; Schofield P; Langley DB; Jackson J; Bourne K; Wilson E; Porebski BT; Buckle AM; Brink R; Goodnow CC; Christ D, 2020, 'Conformational diversity facilitates antibody mutation trajectories and discrimination between foreign and self-antigens', Proceedings of the National Academy of Sciences of the United States of America, vol. 117, pp. 22341 - 22350,

Masle-Farquhar E; Payne K; Singh M; Rao G; Al-Eryani G; Jara C; Jackson K; Brink RA; Tangye S; Reed J; Goodnow CC, 2020, 'The effects of germline STAT3-activating mutations from autoimmunity and lymphoid malignancy on mouse and human T cells', The Journal of Immunology, vol. 204, pp. 142.35 - 142.35,

Singh M; Jackson KJL; Wang JJ; Schofield P; Field MA; Koppstein D; Peters TJ; Burnett DL; Rizzetto S; Nevoltris D; Masle-Farquhar E; Faulks ML; Russell A; Gokal D; Hanioka A; Horikawa K; Colella AD; Chataway TK; Blackburn J; Mercer TR; Langley DB; Goodall DM; Jefferis R; Gangadharan Komala M; Kelleher AD; Suan D; Rischmueller M; Christ D; Brink R; Luciani F; Gordon TP; Goodnow CC; Reed JH, 2020, 'Lymphoma Driver Mutations in the Pathogenic Evolution of an Iconic Human Autoantibody', Cell, vol. 180, pp. 878 - 894.e19,

Lau A; Avery DT; Jackson K; Lenthall H; Volpi S; Brigden H; Russell AJ; Bier J; Reed JH; Smart JM; Cole T; Choo S; Gray PE; Berglund LJ; Hsu P; Wong M; O'Sullivan M; Boztug K; Meyts I; Uzel G; Notarangelo LD; Brink R; Goodnow CC; Tangye SG; Deenick EK, 2020, 'Activated PI3Kd breaches multiple B cell tolerance checkpoints and causes autoantibody production', Journal of Experimental Medicine, vol. 217,

Stirzaker C; Skvortsova K; Masle-Farquhar E; Goodnow C; Clark SJ, 2020, 'Epigenetic changes during tumour development – Functional epigenetics study', Pathology, vol. 52, pp. S29 - S29,

Rouet R; Mazigi O; Walker G; Langley D; Sobti M; Schofield P; Lenthall H; Jackson J; Ubiparipovic S; Henry J; Abayasingam A; Burnett D; Kelleher A; Brink R; Bull R; Turville S; Stewart A; Goodnow C; Rawlinson W; Christ D, 2020, 'Potent SARS-CoV-2 binding and neutralization through maturation of iconic SARS-CoV-1 antibodies', ,

Wirasinha RC; Chan A; Yap JY; Hu DY; Teh CE; Gray DHD; Goodnow CC; Daley SR, 2019, 'Deletion of self-reactive CCR7– thymocytes in the absence of MHC expression on thymic epithelial cells', Cell Death and Differentiation, vol. 26, pp. 2727 - 2739,

Singh M; Al-Eryani G; Carswell S; Ferguson JM; Blackburn J; Barton K; Roden D; Luciani F; Giang Phan T; Junankar S; Jackson K; Goodnow CC; Smith MA; Swarbrick A, 2019, 'High-throughput targeted long-read single cell sequencing reveals the clonal and transcriptional landscape of lymphocytes', Nature Communications, vol. 10, pp. 3120,

Burnett DL; Reed JH; Christ D; Goodnow CC, 2019, 'Clonal redemption and clonal anergy as mechanisms to balance B cell tolerance and immunity', Immunological Reviews, vol. 292, pp. 61 - 75,

Zammit NW; Siggs OM; Gray PE; Horikawa K; Langley DB; Walters SN; Daley SR; Loetsch C; Warren J; Yap JY; Cultrone D; Russell A; Malle EK; Villanueva JE; Cowley MJ; Gayevskiy V; Dinger ME; Brink R; Zahra D; Chaudhri G; Karupiah G; Whittle B; Roots C; Bertram E; Yamada M; Jeelall Y; Enders A; Clifton BE; Mabbitt PD; Jackson CJ; Watson SR; Jenne CN; Lanier LL; Wiltshire T; Spitzer MH; Nolan GP; Schmitz F; Aderem A; Porebski BT; Buckle AM; Abbott DW; Ziegler JB; Craig ME; Benitez-Aguirre P; Teo J; Tangye SG; King C; Wong M; Cox MP; Phung W; Tang J; Sandoval W; Wertz IE; Christ D; Goodnow CC; Grey ST, 2019, 'Denisovan, modern human and mouse TNFAIP3 alleles tune A20 phosphorylation and immunity', Nature Immunology, vol. 20, pp. 1299 - 1310,

Policheni A; Horikawa K; Milla L; Kofler J; Bouillet P; Belz GT; O'Reilly LA; Goodnow CC; Strasser A; Gray DHD, 2019, 'CARD11 is dispensable for homeostatic responses and suppressive activity of peripherally induced FOXP3+ regulatory T cells', Immunology and Cell Biology, vol. 97, pp. 740 - 752,

Siggs OM; Russell A; Singh-Grewal D; Wong M; Chan P; Craig ME; O'Loughlin T; Stormon M; Goodnow CC, 2019, 'Preponderance of CTLA4 Variation Associated With Autosomal Dominant Immune Dysregulation in the MYPPPY Motif', Frontiers in Immunology, vol. 10, pp. 1544,

Moran I; Avery DT; Payne K; Lenthall H; Davies EG; Burns S; Ip W; Oleastro MM; Reisli I; Guner S; Keles S; Notarangelo L; Deenick EK; Goodnow CC; Zahra D; Brink R; Wong M; Tangye SG; Ma CS; Phan TG, 2019, 'B cell–intrinsic requirement for STK4 in humoral immunity in mice and human subjects', Journal of Allergy and Clinical Immunology, vol. 143, pp. 2302 - 2305,

Kayagaki N; Lee BL; Stowe IB; Kornfeld OS; O'Rourke K; Mirrashidi KM; Haley B; Watanabe C; Roose-Girma M; Modrusan Z; Kummerfeld S; Reja R; Zhang Y; Cho V; Daniel Andrews T; Morris LX; Goodnow CC; Bertram EM; Dixit VM, 2019, 'IRF2 transcriptionally induces GSDMD expression for pyroptosis', Science Signaling, vol. 12,

Skvortsova K; Masle-Farquhar E; Luu PL; Song JZ; Qu W; Zotenko E; Gould CM; Du Q; Peters TJ; Colino-Sanguino Y; Pidsley R; Nair SS; Khoury A; Smith GC; Miosge LA; Reed JH; Kench JG; Rubin MA; Horvath L; Bogdanovic O; Lim SM; Polo JM; Goodnow CC; Stirzaker C; Clark SJ, 2019, 'DNA Hypermethylation Encroachment at CpG Island Borders in Cancer Is Predisposed by H3K4 Monomethylation Patterns', Cancer Cell, vol. 35, pp. 297 - 314.e8,

Koay HF; Su S; Amann-Zalcenstein D; Daley SR; Comerford I; Miosge L; Whyte CE; Konstantinov IE; D'Udekem Y; Baldwin T; Hickey PF; Berzins SP; Mak JYW; Sontani Y; Roots CM; Sidwell T; Kallies A; Chen Z; Nüssing S; Kedzierska K; Mackay LK; McColl SR; Deenick EK; Fairlie DP; McCluskey J; Goodnow CC; Ritchie ME; Belz GT; Naik SH; Pellicci DG; Godfrey DI, 2019, 'A divergent transcriptional landscape underpins the development and functional branching of MAIT cells', Science Immunology, vol. 4,

Zammit N; Siggs OM; Gray P; King C; Christ D; Goodnow CC; Grey S, 2019, 'Phospho-tuning immunity through Denisovan, modern human and mouse TNFAIP3 gene variants', bioRxiv,

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