By Professor Christopher John Ormandy

Journal articles

Kalyuga M; Gallego-Ortega D; Lee H; Roden DL; Cowley MJ; Caldon CE; Stone A; Allerdice SL; Valdes-Mora F; Rosalind launchbury R; Statham A; Armstrong NJ; Alles MC; Adelaide young A; Egger A; Au W; Piggin CL; Evans C; Ledger A; Brummer T; Oakes SR; Kaplan W; Gee JMW; Robert i nicholson RI; Sutherland RL; Swarbrick A; Naylor MJ; Clark SJ; Carroll JS; Ormandy CJ, 2012, 'ELF5 Suppresses Estrogen Sensitivity and Underpins the Acquisition of Antiestrogen Resistance in Luminal Breast Cancer', PLoS Biology, 10, pp. e1001461, http://dx.doi.org/10.1371/journal.pbio.1001461

Lee H; Ormandy CJ, 2012, 'Elf5, hormones and cell fate', Trends in Endocrinology and Metabolism, 23, pp. 292 - 298, http://dx.doi.org/10.1016/j.tem.2012.02.006

Lee H; Ormandy CJ, 2012, 'Interplay between progesterone and prolactin in mammary development and implications for breast cancer', Molecular and Cellular Endocrinology, 357, pp. 101 - 107, http://dx.doi.org/10.1016/j.mce.2011.09.020

Lo JCY; Jamsai D; O'connor A; Borg C; Clark B; Whisstock J; Field M; Adams V; Ishikawa T; Aitken R; Whittle B; Goodnow CC; Ormandy CJ; O'bryan M, 2012, 'RAB-Like 2 Has an Essential Role in Male Fertility, Sperm Intra-Flagellar Transport, and Tail Assembly', PLoS Genetics, 8, pp. e1002969, http://dx.doi.org/10.1371/journal.pgen.1002969

O'Toole S; Machalek DA; Shearer R; Millar E; Nair R; Schofield PR; McLeod D; Cooper CE; Mcneil CM; Mcfarland A; Nguyen A; Ormandy CJ; Qiu M; Rabinovich B; Martelotto L; Vu D; Hannigan GE; Musgrove EA; Christ DU; Sutherland RL; Watkins DJ; Swarbrick A, 2011, 'Hedgehog overexpression is associated with stromal interactions and predicts for poor outcome in breast cancer', Cancer research, 71, pp. 4002 - 4014, http://dx.doi.org/10.1158/0008-5472.CAN-10-3738

Lee HJ; Hinshelwood R; Bouras T; Gallego-Ortega D; Valdes-Mora F; Blazek K; Visvader JE; Clark SJ; Ormandy CJ, 2011, 'Lineage specific methylation of the Elf5 promoter in mammary epithelial cells', Stem Cells, 29, pp. 1611 - 1619, http://dx.doi.org/10.1002/stem.706

Jamsai D; Smith SJ; O'Connor AE; Merriner DJ; Borg C; Clark B; Adams V; Ormandy CJ; O'Bryan MK, 2010, '169. THE MECHANISM OF SPERMATID MATURATION - A LINK TO TUMOUR SUPPRESSION', Reproduction, Fertility and Development, 22, pp. 87 - 87, http://dx.doi.org/10.1071/srb10abs169

Bhandari M; Thomas A; Hussey DJ; Xin L; Jaya SP; Woods C; Schloithe AC; Mayne GC; Carati CJ; Toouli J; Ormandy CJ; Saccone GTP, 2010, 'Galanin mediates the pathogenesis of cerulein-induced acute pancreatitis in the mouse', Pancreas, 39, pp. 182 - 187, http://dx.doi.org/10.1097/MPA.0b013e3181bdc152

Zardawi SJ; Zardawi I; Mcneil CM; Millar E; Mcleod D; Morey AL; Crea P; Murphy NC; Pinese M; Lopez-Knowles E; Oakes SR; Ormandy CJ; Qiu MR; Hamilton A; Spillane AJ; Lee CS; Sutherland RL; Musgrove EA; O'Toole S, 2010, 'High Notch1 protein expression is an early event in breast cancer development and is associated with the HER-2 molecular subtype', Histopathology, 56, pp. 286 - 296, http://dx.doi.org/10.1111/j.1365-2559.2009.03475.x

Menzies KK; Lee HJ; Lefevre C; Ormandy CJ; Macmillan KL; Nicholas KR, 2010, 'Insulin, a key regulator of hormone responsive milk protein synthesis during lactogenesis in murine mammary explants', Functional and Integrative Genomics, 10, pp. 87 - 95, http://dx.doi.org/10.1007/s10142-009-0140-0

Schramek D; Leibbrandt A; Sigl V; Kenner L; Pospisilik JA; Lee HJ; Hanada R; Joshi PA; Aliprantis A; Glimcher L; Pasparakis M; Khokha R; Ormandy CJ; Widschwendter M; Schett G; Penninger JM, 2010, 'Osteoclast differentiation factor RANKL controls development of progestin-driven mammary cancer', Nature, 468, pp. 98 - 102

Chan C; Liu X; Ensslin MA; Dillehay DL; Ormandy CJ; Sohn P; Serra R; Ye K, 2010, 'PIKE-A is required for prolactin-mediated STAT5a activation in mammary gland development', European Molecular Biology Organization, 29, pp. 956 - 968, http://dx.doi.org/10.1038/emboj.2009.406

Alles MC; Gardiner-Garden M; Nott DJ; Foekens J; Wang Y; Sutherland RL; Musgrove EA; Ormandy CJ, 2009, 'Meta-analysis and gene set enrichment relative to ER status reveal elevated activity of MYC and E2F in the `Basal` breast cancer subgroup', PLoS One, 4

Musgrove EA; Sergio CM; Anderson LR; Inman CK; Mcneil CM; Alles MC; Gardiner-Garden M; Ormandy CJ; Butt A; Sutherland RL, 2008, 'Identification of downstream targets of estrogen and c-myc in breast cancer cells', , pp. 445 - 451

Musgrove EA; Sergio CM; Loi S; Inman CK; Anderson LR; Alles MC; Pinese M; Caldon CE; Schutte J; Gardiner-Garden M; Ormandy CJ; McArthur G; Butt A; Sutherland RL, 2008, 'Identification of functional networks of estrogen-and c-Myc-responsive genes and their relationship to response to tamoxifen therapy in breast cancer', PLoS One, 3, pp. 2987 - 2995

Hilton HN; Stanford PM; Harris J; Oakes SR; Kaplan W; Daly RJ; Ormandy CJ, 2008, 'KIBRA interacts with discoidin domain receptor 1 to modulate collagen-induced signalling', Biochimica et Biophysica ACTA - Molecular Cell Research, 1783, pp. 383 - 393, http://dx.doi.org/10.1016/j.bbamcr.2007.12.007

Oakes SR; Rogers R; Naylor MJ; Ormandy CJ, 2008, 'Prolactin regulation of mammary gland development', Journal of Mammary Gland Biology and Neoplasia, 13, pp. 13 - 28, http://dx.doi.org/10.1007/s10911-008-9069-5

Oakes SR; Naylor MJ; Asselin-Labat M; Blazek K; Gardiner-Garden M; Hilton HN; Kazlauskas M; Pritchard M; Chodosh L; Pfeffer P; Lindeman GJ; Visvader J; Ormandy CJ, 2008, 'The Ets transcription factor Elf5 specifies mammary alveolar cell fate', Genes and Development, 22, pp. 581 - 586, http://dx.doi.org/10.1101/gad.1614608

Ramanathan P; Martin I; Gardiner-Garden M; Thomson P; Taylor R; Ormandy CJ; Moran C; Williamson P, 2008, 'Transcriptome analysis identifies pathways associated with enhanced maternal performance in QSi5 mice', BMC Genomics, 9, pp. 1 - 13, http://dx.doi.org/10.1186/1471-2164-9-197

Naylor MJ; Ormandy CJ, 2007, 'Gata-3 and mammary cell fate', Breast Cancer Research, 9

Oakes SR; Robertson FG; Kench JG; Gardiner-Garden M; Wand MP; Green JE; Ormandy CJ, 2007, 'Loss of mammary epithelial prolactin receptor delays tumor formation by reducing cell proliferation in low-grade preinvasive lesions', Oncogene, 26, pp. 543 - 553

McNeil CM; Sergio CM; Anderson LR; Inman CK; Eggleton SA; Murphy NC; Millar EKA; Crea P; Kench JG; Alles MC; Gardiner-Garden M; Ormandy CJ; Butt AJ; Henshall SM; Musgrove EA; Sutherland RL, 2006, 'c-Myc overexpression and endocrine resistance in breast cancer', Journal of Steroid Biochemistry and Molecular Biology, 102, pp. 147 - 155, http://dx.doi.org/10.1016/j.jsbmb.2006.09.028

Mcneil CM; Anderson LR; Inman CK; Eggleton SA; Murphy NC; Millar E; Crea P; Kench JG; Alles MC; Gardiner-Garden M; Ormandy CJ; Butt A; Henshall SM; Musgrove EA; Sutherland RL; Sergio CM, 2006, 'c-Myc overexpression and endocrine resistance in breast cancer', Journal of Steroid Biochemistry and Molecular Biology, 18, pp. 284 - 289

Oakes SR; Hilton HN; Ormandy CJ, 2006, 'Key stages in mammary gland development - The alveolar switch: coordinating the proliferative cues and cell fate decisions that drive the formation of lobuloalveoli from ductal epithelium', Breast Cancer Research, 8

Craven AJ; Nixon AJ; Ashby MG; Ormandy CJ; Blazek K; Wilkins RJ; Pearson AJ, 2006, 'Prolactin delays hair regrowth in mice', Journal of Endocrinology, 191, pp. 415 - 425

Harris J; Stanford PM; Sutherland K; Oakes SR; Naylor MJ; Robertson F; Blazek K; Kazlauskas M; Hilton HN; Wittlin S; Alexander WS; Lindeman GJ; Visvader J; Ormandy CJ, 2006, 'Socs2 and Elf5 mediate prolactin-induced mammary gland development', Molecular Endocrinology, 20, pp. 1177 - 1187

Ormandy C; Goffin V, 2005, 'Cancer', Drug Discovery Today: Disease Models, 2, http://dx.doi.org/10.1016/j.ddmod.2005.05.022

Menzies KK; Macmillan KL; Nicholas KR; Lefevre C; Ormandy C, 2005, '281. The role of insulin in milk protein synthesis', Reproduction, Fertility and Development, 17, pp. 117 - 117, http://dx.doi.org/10.1071/srb05abs281

Zhou J; Chehab R; Tkalcevic J; Naylor MJ; Harris J; Wilson T; Tsao S; Tellis I; Zavarsek S; Xu D; Lapinskas E; Visvader J; Lindeman GJ; Thomas R; Ormandy CJ; Hertzog P; Kola I; Pritchard M, 2005, 'Elf5 is essential for early embryogenesis and mammary gland development during pregnancy and lactation', European Molecular Biology Organization, 24, pp. 635 - 644

Nilsson L; Binart N; Bohlooly-Y M; Bramnert M; Egecioglu E; Kindblom J; Kelly PA; Kopchick J; Ormandy CJ; Ling C; Billig H, 2005, 'Prolactin and growth hormone regulate adiponectin secretion and receptor expression in adipose tissue', Biochemical and Biophysical Research Communications, 331, pp. 1120 - 1126, http://www.sciencedirect.com/science/article/B6WBK-4FYGBBM-1/2/53f2f3ba0a766cd5714b305e659026fd

Ormandy CJ, 2005, 'Review of: Oncogenic transformation of human mammary epithelial cells by autocrine human growth hormone', Breast Cancer Online, 8, http://dx.doi.org/10.1017/s1470903105004475

Naylor MJ; Oakes SR; Gardiner-Garden M; Harris J; Blazek K; Ho TW; Li F; Wynick D; Walker AM; Ormandy CJ, 2005, 'Transcriptional changes underlying the secretory activation phase of mammary gland development', Molecular Endocrinology, 19, pp. 1868 - 1883

Saunders DN; Hird SL; Withington SL; Dunwoodie SL; Henderson MJ; Biben C; Sutherland RL; Ormandy CJ; Watts CKW, 2004, 'Erratum: Edd, the murine ortholog of the hyperplastic discs (hyd) gene, is essential for yolk sac vascularization and chorioallantoic fusion (Molecular and Cellular Biology (2004) 24: 16 (7225-7234))', Molecular and Cellular Biology, 24, pp. 9262, http://dx.doi.org/10.1128/MCB.24.20.9262.2004

Saunders DN; Hird S; Withington SL; Dunwoodie SL; Henderson M; Biben C; Sutherland RL; Ormandy CJ; Watts CK, 2004, 'Edd, the murine hyperplastic disc gene, is essential for yolk sac vascularization and chorioallantoic fusion', Molecular and Cellular Biology, 24, pp. 7225 - 7234, http://dx.doi.org/10.1128/MCB.24.16.7225-7234.2004

Cooney GJ; Lyons RJ; Crew A; Jensen T; Molero JC; Mitchell CJ; Biden TJ; Ormandy CJ; James DE; Daly et A, 2004, 'Improved glucose homeostasis and enhanced insulin signalling in Grb14-deficient mice', EMBO Journal, 23, pp. 582 - 593, http://www.sciencedirect.com/science/article/B6WVB-4C6S53N-1D7/2/8969638193550a0dce7725a099aba822

Harris J; Stanford PM; Oakes SR; Ormandy CJ, 2004, 'Prolactin and the prolactin receptor: new targets of an old hormone', Annals of Medicine, 36, pp. 414 - 425, http://www.sciencedirect.com/science/article/B6WVB-4DPTTDJ-115/2/64c9f2829ad0aa962efbb9ba7f7f6f0c

Musgrove EA; Davison EA; Ormandy CJ, 2004, 'Role of the CDK Inhibitor p27 (Kip1) in Mammary Development and Carcinogenesis: Insights from Knockout Mice', Journal of Mammary Gland Biology and Neoplasia, 9, pp. 55 - 66, http://www.sciencedirect.com/science/article/B6WVB-4C82RMK-3D1/2/72b5e4398e846ea1a8f5ab7fa97d561a

Ormandy CJ; Musgrove EA; Hui R; Daly RJ; Sutherland RL, 2003, 'Cyclin D1, EMS1 and 11q13 amplication in breast cancer', Breast Cancer Research and Treatment, 78, pp. 323 - 335

Hovey RC; Harris J; Hadsell DL; Lee A; Ormandy CJ; Vonderhaar BK, 2003, 'Local insulin-like growth factor-II mediates prolactin-induced mammary gland development', Molecular Endocrinology, 17, pp. 460 - 471

Naylor MJ; Lockerfeer JA; Horseman NJ; Ormandy CJ, 2003, 'Prolactin regulates mammary epithelial cell proliferation via autocrine/paracrine mechanism', Endocrine, 20, pp. 111 - 114

Robertson F; Harris J; Naylor MJ; Oakes S; Kindblom J; Dillner K; Wennbo H; Tornell J; Kelly PA; Green J; Ormandy CJ, 2003, 'Prostate development and carcinogenesis in prolactin receptor knockout mice', Endocrinology, 144, pp. 3196 - 3205

Kindblom J; Dillner K; Sahlin L; Robertson F; Ormandy CJ; Tornell J; Wennbo H, 2003, 'Prostate hyperplasia in a transgenic mouse with prostate-specific expression of prolactin', Endocrinology, 144, pp. 2269 - 2278

Davison EA; Lee CM; Naylor MJ; Oakes SR; Sutherland RL; Henninghausen L; Ormandy CJ; Musgrove EA, 2003, 'The Cyclin-Dependent Kinase inhibitor p27 (Kip1) regulates both DNA synthesis and apoptosis in mammary epithelium but is not required for its functional development during pregnancy.', Molecular Endocrinology, 17, pp. 2436 - 2447

Naylor MJ; Ginsburg E; Iismaa T; Vonderhaar BK; Wynick D; Ormandy CJ, 2003, 'The neuropeptide galanin augments lobuloalveolar development', The Journal of Biological Chemistry, 278, pp. 29145 - 29152

Gass S; Harris J; Ormandy CJ; Brisken C, 2003, 'Using gene expression arrays to elucidate transcriptional profiles underlying prolactin function', Journal of Mammary Gland Biology and Neoplasia, 8, pp. 269 - 285

Grimm SL; Seagroves TN; Kabotyanski EB; Hovey RC; Vonderhaar BK; Lydon JP; Miyoshi K; Hennighausen L; Ormandy CJ; Lee AV; Stull MA; Wood TL; Rosen JM, 2002, 'Disruption of steroid and prolactin receptor patterning in the mammary gland correlates with a block in lobuloalveolar development', Molecular Endocrinology, 16, pp. 2675 - 2691, http://dx.doi.org/10.1210/me.2002-0239

Kelly PA; Bachelot A; Kedzia C; Hennighausen L; Ormandy CJ; Kopchick JJ; Binart N, 2002, 'The role of prolactin and growth hormone in mammary gland development', Molecular and Cellular Endocrinology, 197, pp. 127 - 131, http://dx.doi.org/10.1016/S0303-7207(02)00286-1

Naylor MJ; Ormandy CJ, 2002, 'Mouse strain-specific patterns of mammary epithelial ductal side branching are elicited by stromal factors', Developmental Dynamics, 225, pp. 100 - 105, http://dx.doi.org/10.1002/dvdy.10133

Sainsbury A; Schwarzer C; Couzens M; Jenkins A; Oakes SR; Ormandy CJ; Herzog H, 2002, 'Y4 receptor knockout rescues fertility in ob/ob mice', Genes and Development, 16, pp. 1077 - 1088, http://dx.doi.org/10.1101/gad.979102

Craven AJ; Ormandy CJ; Robertson FG; Wilkins RJ; Kelly PA; Nixon AJ; Pearson AJ, 2001, 'Prolactin Signaling Influences the Timing Mechanism of the Hair Follicle: Analysis of Hair Growth Cycles in Prolactin Receptor Knockout Mice*', Endocrinology, 142, pp. 2533 - 2539, http://dx.doi.org/10.1210/endo.142.6.8179

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