By Professor Irina Voineagu

Book Chapters

Nicholls L; Ramadas R; Voineagu I, 2014, 'From molecular pathways to ASD therapy: Insights from syndromic forms of autism', in Frontiers in Autism Research: New Horizons for Diagnosis and Treatment, pp. 23 - 46, http://dx.doi.org/10.1142/9789814602167_0002

Journal articles

Ha T; Morgan A; Bartos MN; Beatty K; Cogné B; Braun D; Gerber CB; Gaspar H; Kopps AM; Rieubland C; Hurst ACE; Amor DJ; Nizon M; Pasquier L; Pfundt R; Reis A; Siu VM; Tessarech M; Thompson ML; Vincent M; de Vries BBA; Walsh MB; Wechsler SB; Zweier C; Schnur RE; Guillen Sacoto MJ; Margot H; Masotto B; Palafoll MIV; Nawaz U; Voineagu I; Slavotinek A, 2024, 'De novo variants predicting haploinsufficiency for DIP2C are associated with expressive speech delay', American Journal of Medical Genetics, Part A, http://dx.doi.org/10.1002/ajmg.a.63559

Qian L; Sharpe LJ; Gokool A; Voineagu I; Brown AJ, 2023, 'Controlling an E3 ligase and its substrate: A function for MARCHF6 circRNA', Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1868, http://dx.doi.org/10.1016/j.bbalip.2022.159237

Li A; Wray N; Lister R; Voineagu I; Zeng J, 2023, '54. IDENTIFICATION OF CELL TYPES AND CELLULAR DYNAMICS GENETICALLY ASSOCIATED WITH BRAIN DISORDERS AND COGNITIVE TRAITS', European Neuropsychopharmacology, 75, pp. S85 - S85, http://dx.doi.org/10.1016/j.euroneuro.2023.08.160

Sutton GJ; Poppe D; Simmons RK; Walsh K; Nawaz U; Lister R; Gagnon-Bartsch JA; Voineagu I, 2022, 'Comprehensive evaluation of deconvolution methods for human brain gene expression', Nature Communications, 13, http://dx.doi.org/10.1038/s41467-022-28655-4

Wang J; Weatheritt R; Voineagu I, 2022, 'Alu-minating the Mechanisms Underlying Primate Cortex Evolution', Biological Psychiatry, 92, pp. 760 - 771, http://dx.doi.org/10.1016/j.biopsych.2022.04.021

Herring CA; Simmons RK; Freytag S; Poppe D; Moffet JJD; Pflueger J; Buckberry S; Vargas-Landin DB; Clément O; Echeverría EG; Sutton GJ; Alvarez-Franco A; Hou R; Pflueger C; McDonald K; Polo JM; Forrest ARR; Nowak AK; Voineagu I; Martelotto L; Lister R, 2022, 'Human prefrontal cortex gene regulatory dynamics from gestation to adulthood at single-cell resolution', Cell, 185, pp. 4428 - 4447.e28, http://dx.doi.org/10.1016/j.cell.2022.09.039

Dias KR; Carlston CM; Blok LER; De Hayr L; Nawaz U; Evans CA; Bayrak-Toydemir P; Htun S; Zhu Y; Ma A; Lynch SA; Moorwood C; Stals K; Ellard S; Bainbridge MN; Friedman J; Pappas JG; Rabin R; Nowak CB; Douglas J; Wilson TE; Guillen Sacoto MJ; Mullegama SV; Palculict TB; Kirk EP; Pinner JR; Edwards M; Montanari F; Graziano C; Pippucci T; Dingmann B; Glass I; Mefford HC; Shimoji T; Suzuki T; Yamakawa K; Streff H; Schaaf CP; Slavotinek AM; Voineagu I; Carey JC; Buckley MF; Schenck A; Harvey RJ; Roscioli T, 2022, 'De Novo ZMYND8 variants result in an autosomal dominant neurodevelopmental disorder with cardiac malformations', Genetics in Medicine, 24, pp. 1952 - 1966, http://dx.doi.org/10.1016/j.gim.2022.06.001

Koch FC; Sutton GJ; Voineagu I; Vafaee F, 2021, 'Supervised application of internal validation measures to benchmark dimensionality reduction methods in scRNA-seq data', Briefings in Bioinformatics, 22, http://dx.doi.org/10.1093/bib/bbab304

Walsh K; Gokool A; Alinejad-Rokny H; Voineagu I, 2021, 'NeuroCirc: an integrative resource of circular RNA expression in the human brain', Bioinformatics, 37, pp. 3664 - 3666, http://dx.doi.org/10.1093/bioinformatics/btab230

Santos-Rodriguez G; Voineagu I; Weatheritt RJ, 2021, 'Evolutionary dynamics of circular rnas in primates', eLife, 10, http://dx.doi.org/10.7554/eLife.69148

Santos-Rodriguez G; Voineagu I; Weatheritt RJ, 2021, 'Evolutionary dynamics of circular RNAs in primates', , http://dx.doi.org/10.1101/2021.05.01.442284

Griesi-Oliveira K; Fogo MS; Pinto BGG; Alves AY; Suzuki AM; Morales AG; Ezquina S; Sosa OJ; Sutton GJ; Sunaga-Franze DY; Bueno AP; Seabra G; Sardinha L; Costa SS; Rosenberg C; Zachi EC; Sertie AL; Martins-de-Souza D; Reis EM; Voineagu I; Passos-Bueno MR, 2021, 'Transcriptome of iPSC-derived neuronal cells reveals a module of co-expressed genes consistently associated with autism spectrum disorder', Molecular Psychiatry, 26, pp. 1589 - 1605, http://dx.doi.org/10.1038/s41380-020-0669-9

Oldham Green N; Maniam J; Riese J; Morris MJ; Voineagu I, 2021, 'Transcriptomic signature of early life stress in male rat prefrontal cortex', Neurobiology of Stress, 14, http://dx.doi.org/10.1016/j.ynstr.2021.100316

Gokool A; Loy CT; Halliday GM; Voineagu I, 2020, 'Circular RNAs: The Brain Transcriptome Comes Full Circle', Trends in Neurosciences, 43, pp. 752 - 766, http://dx.doi.org/10.1016/j.tins.2020.07.007

Walsh K; Voineagu MA; Vafaee F; Voineagu I, 2020, 'TDAview: An online visualization tool for topological data analysis', Bioinformatics, 36, pp. 4805 - 4809, http://dx.doi.org/10.1093/bioinformatics/btaa600

Gokool A; Anwar F; Voineagu I, 2020, 'The Landscape of Circular RNA Expression in the Human Brain', Biological Psychiatry, 87, pp. 294 - 304, http://dx.doi.org/10.1016/j.biopsych.2019.07.029

Keidar L; Gerlitz G; Kshirsagar A; Tsoory M; Olender T; Wang X; Yang Y; Chen YS; Yang YG; Voineagu I; Reiner O, 2019, 'Interplay of LIS1 and MeCP2: Interactions and Implications With the Neurodevelopmental Disorders Lissencephaly and Rett Syndrome', Frontiers in Cellular Neuroscience, 13, http://dx.doi.org/10.3389/fncel.2019.00370

Gokoolparsadh A; Fang Z; Braidy N; Voineagu I, 2017, 'Topoisomerase I inhibition leads to length-dependent gene expression changes in human primary astrocytes', Genomics Data, 11, pp. 113 - 115, http://dx.doi.org/10.1016/j.gdata.2016.12.005

Gokoolparsadh A; Fang Z; Braidy N; Lin P; Pardy CJ; Eapen V; Clarke R; Voineagu I, 2017, 'Transcriptional response to mitochondrial protease IMMP2L knockdown in human primary astrocytes', Biochemical and Biophysical Research Communications, 482, pp. 1252 - 1258, http://dx.doi.org/10.1016/j.bbrc.2016.12.024

Gokoolparsadh A; Sutton GJ; Charamko A; Green NFO; Pardy CJ; Voineagu I, 2016, 'Searching for convergent pathways in autism spectrum disorders: insights from human brain transcriptome studies', Cellular and Molecular Life Sciences, 73, pp. 4517 - 4530, http://dx.doi.org/10.1007/s00018-016-2304-0

Won H; De La Torre-Ubieta L; Stein JL; Parikshak NN; Huang J; Opland CK; Gandal MJ; Sutton GJ; Hormozdiari F; Lu D; Lee C; Eskin E; Voineagu I; Ernst J; Geschwind DH, 2016, 'Chromosome conformation elucidates regulatory relationships in developing human brain', Nature, 538, pp. 523 - 527, http://dx.doi.org/10.1038/nature19847

Lin P; Nicholls L; Assareh H; Fang Z; Amos TG; Edwards RJ; Assareh AA; Voineagu I, 2016, 'Transcriptome analysis of human brain tissue identifies reduced expression of complement complex C1Q Genes in Rett syndrome', BMC Genomics, 17, pp. 1 - 11, http://dx.doi.org/10.1186/s12864-016-2746-7

Pu Yao ; Peijie Lin ; Akira Gokoolparsadh ; Assareh AA; Mike W C Thang ; Voineagu , 2015, 'Coexpression networks identify brain region–specific enhancer RNAs in the human brain', Nature Neuroscience, 18, pp. 1168 - 1174, http://dx.doi.org/10.1038/nn.4063

Tian Y; Voineagu I; Paşca SP; Won H; Chandran V; Horvath S; Dolmetsch RE; Geschwind DH, 2014, 'Alteration in basal and depolarization induced transcriptional network in iPSC derived neurons from Timothy syndrome', Genome Medicine, 6, http://dx.doi.org/10.1186/s13073-014-0075-5

Fort A; Hashimoto K; Yamada D; Salimullah M; Keya CA; Saxena A; Bonetti A; Voineagu I; Bertin N; Kratz A; Noro Y; Wong CH; De Hoon M; Andersson R; Sandelin A; Suzuki H; Wei CL; Koseki H; Hasegawa Y; Forrest ARR; Carninci P, 2014, 'Deep transcriptome profiling of mammalian stem cells supports a regulatory role for retrotransposons in pluripotency maintenance', Nature Genetics, 46, pp. 558 - 566, http://dx.doi.org/10.1038/ng.2965

Voineagu I; Eapen V, 2013, 'Converging pathways in autism spectrum disorders: Interplay between synaptic dysfunction and immune responses', Frontiers in Human Neuroscience, 7, pp. 738, http://dx.doi.org/10.3389/fnhum.2013.00738

Miyauchi S; Voineagu I, 2013, 'Autism susceptibility genes and the transcriptional landscape of the human brain', , 113, pp. 303 - 318, http://dx.doi.org/10.1016/B978-0-12-418700-9.00010-1

Voineagu I; Yoo HJ, 2013, 'Current progress and challenges in the search for autism biomarkers', Disease Markers, 35, pp. 55 - 65, http://dx.doi.org/10.1155/2013/476276

Shah KA; Shishkin AA; Voineagu I; Pavlov YI; Shcherbakova PV; Mirkin SM, 2012, 'Role of DNA Polymerases in Repeat-Mediated Genome Instability', Cell Reports, 2, pp. 1088 - 1095, http://dx.doi.org/10.1016/j.celrep.2012.10.006

Luo R; Sanders SJ; Tian Y; Voineagu I; Huang N; Chu SH; Klei L; Cai C; Ou J; Lowe JK; Hurles ME; Devlin B; State MW; Geschwind DH, 2012, 'Genome-wide transcriptome profiling reveals the functional impact of rare de novo and recurrent CNVs in autism spectrum disorders', American Journal of Human Genetics, 91, pp. 38 - 55, http://dx.doi.org/10.1016/j.ajhg.2012.05.011

Voineagu I, 2012, 'Autism: From genetics to biomarkers', Disease Markers, 33, pp. 223 - 224, http://dx.doi.org/10.1155/2012/781390

Voineagu I; Huang L; Winden K; Lazaro M; Haan E; Nelson J; McGaughran J; Nguyen LS; Friend K; Hackett A; Field M; Gecz J; Geschwind D, 2012, 'CCDC22: A novel candidate gene for syndromic X-linked intellectual disability', Molecular Psychiatry, 17, pp. 4 - 7, http://dx.doi.org/10.1038/mp.2011.95

Voineagu I, 2012, 'Gene expression studies in autism: Moving from the genome to the transcriptome and beyond', Neurobiology of Disease, 45, pp. 69 - 75, http://dx.doi.org/10.1016/j.nbd.2011.07.017

Paşca SP; Portmann T; Voineagu I; Yazawa M; Shcheglovitov A; Paşca AM; Cord B; Palmer TD; Chikahisa S; Nishino S; Bernstein JA; Hallmayer J; Geschwind DH; Dolmetsch RE, 2011, 'Using iPSC-derived neurons to uncover cellular phenotypes associated with Timothy syndrome', Nature Medicine, 17, pp. 1657 - 1662, http://dx.doi.org/10.1038/nm.2576

Voineagu I; Wang X; Johnston P; Lowe JK; Tian Y; Horvath S; Mill J; Cantor RM; Blencowe BJ; Geschwind DH, 2011, 'Transcriptomic analysis of autistic brain reveals convergent molecular pathology', Nature, 474, pp. 380 - 386, http://dx.doi.org/10.1038/nature10110

Shishkin AA; Voineagu I; Matera R; Cherng N; Chernet BT; Krasilnikova MM; Narayanan V; Lobachev KS; Mirkin SM, 2009, 'Large-Scale Expansions of Friedreich's Ataxia GAA Repeats in Yeast', Molecular Cell, 35, pp. 82 - 92, http://dx.doi.org/10.1016/j.molcel.2009.06.017

Voineagu I; Freudenreich CH; Mirkin SM, 2009, 'Checkpoint responses to unusual structures formed by DNA repeats', Molecular Carcinogenesis, 48, pp. 309 - 318, http://dx.doi.org/10.1002/mc.20512

Voineagu I; Surka CF; Shishkin AA; Krasilnikova MM; Mirkin SM, 2009, 'Replisome stalling and stabilization at CGG repeats, which are responsible for chromosomal fragility', Nature Structural and Molecular Biology, 16, pp. 226 - 228, http://dx.doi.org/10.1038/nsmb.1527

Voineagu I; Narayanan V; Lobachev KS; Mirkin SM, 2008, 'Replication stalling at unstable inverted repeats: Interplay between DNA hairpins and fork stabilizing proteins', Proceedings of the National Academy of Sciences of the United States of America, 105, pp. 9936 - 9941, http://dx.doi.org/10.1073/pnas.0804510105

Voineagu I; Lobachev K; Mirkin S, 2007, '67 REPLICATION OF DNA PALINDROMES AND CHROMOSOMAL INSTABILITY.', Journal of Investigative Medicine, 55, pp. S359.4 - S359, http://dx.doi.org/10.1136/jim-55-02-67

Voineagu I; Lobachev K; Mirkin S, 2007, 'Replication of Dna Palindromes and Chromosomal Instability', Journal of Investigative Medicine, 55, pp. 359 - 359, http://dx.doi.org/10.1177/108155890705500267

Conference Papers

Voineagu I; Gao F; Horvath S; Geschwind D, 2010, 'Identification of shared molecular pathways involved in autism by brain transcriptome profiling', in INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE, PERGAMON-ELSEVIER SCIENCE LTD, PORTUGAL, Estoril, pp. 706 - 706, presented at 18th Biennial Meeting of the International-Society-for-Developmental-Neuroscience, PORTUGAL, Estoril, 06 June 2010 - 09 June 2010, http://dx.doi.org/10.1016/j.ijdevneu.2010.07.187

Voineagu I; Lobachev K; Mirkin S, 2007, 'Replication of DNA palindromes and chromosomal instability.', in JOURNAL OF INVESTIGATIVE MEDICINE, B C DECKER INC, IL, Chicago, pp. S359 - S359, presented at Combined Annual Meeting of the Central-Society-for-Clinical-Research/Miswestern Section of the American-Federation-for-Medical-Research, IL, Chicago, 12 April 2007 - 13 April 2007, http://dx.doi.org/10.1097/00042871-200703010-00074

Working Papers

Voineagu M; Voineagu I; Shnier D, 2019, Persistent homology analysis of gene expression data in autism, http://dx.doi.org

Preprints

Sutton GJ; Poppe D; Simmons RK; Walsh K; Nawaz U; Lister R; Gagnon-Bartsch JA; Voineagu I, 2020, Comprehensive evaluation of deconvolution methods for human brain gene expression, , http://dx.doi.org/10.1101/2020.06.01.126839

Koch F; Sutton G; Voineagu I; Vafaee F, 2020, Supervised Application of Internal Validation Measures to Benchmark Dimensionality Reduction Methods in scRNA-seq Data, , http://dx.doi.org/10.1101/2020.10.29.361451

Gokoolparsadh A; Anwar F; Voineagu I, 2018, The Landscape Of Circular RNA Expression In The Human Brain, , http://dx.doi.org/10.1101/500991

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