By Professor Joseph Powell

Preprints

Neavin D; Nguyen Q; Daniszewski MS; Liang HH; Chiu HS; Senabouth A; Lukowski SW; Crombie DE; Lidgerwood GE; Hernández D; Vickers JC; Cook AL; Palpant NJ; Pébay A; Hewitt AW; Powell JE, 2020, Single cell eQTL analysis identifies cell type-specific genetic control of gene expression in fibroblasts and reprogrammed induced pluripotent stem cells, http://dx.doi.org/10.1101/2020.06.21.163766

Engel JA; Lee HJ; Williams CG; Kuns R; Olver S; Lansink LIM; Soon MSF; Andersen SB; Powell JE; Svensson V; Teichmann SA; Hill GR; Varelias A; Koyama M; Haque A, 2020, Single-cell transcriptomics of allo-reactive CD4⁺T cells over time reveals divergent fates during gut GVHD, http://dx.doi.org/10.1101/2020.03.08.978239

Cobos FA; Alquicira-Hernandez J; Powell J; Mestdagh P; De Preter K, 2020, Comprehensive benchmarking of computational deconvolution of transcriptomics data, http://dx.doi.org/10.1101/2020.01.10.897116

Lidgerwood GE; Senabouth A; Smith-Anttila CJA; Gnanasambandapillai V; Kaczorowski DC; Amann-Zalcenstein D; Fletcher EL; Naik SH; Hewitt AW; Powell JE; Pébay A, 2019, Transcriptomic Profiling of Human Pluripotent Stem Cell-Derived Retinal Pigment Epithelium Over Time, http://dx.doi.org/10.1101/842328

van der Wijst MGP; de Vries DH; Groot HE; Trynka G; Hon C-C; Nawijn MC; Idaghdour Y; van der Harst P; Ye CJ; Powell J; Theis FJ; Mahfouz A; Heinig M; Franke L, 2019, Single-cell eQTLGen Consortium: a personalized understanding of disease, http://dx.doi.org/10.48550/arxiv.1909.12550

Xu J; Falconer C; Nguyen Q; Crawford J; McKinnon BD; Mortlock S; Pébay A; Hewitt AW; Senabouth A; Andersen S; Palpant N; Chiu HS; Montgomery GW; Powell J; Coin L, 2019, Genotype-free demultiplexing of pooled single-cell RNA-seq, http://dx.doi.org/10.1101/570614

Senabouth A; Andersen S; Shi Q; Shi L; Liu P; Jiang F; Zhang W; Wing K; Daniszewski M; Lukowski SW; Hung SSC; Nguyen Q; Fink L; Beckhouse A; Jiang H; Pébay A; Hewitt AW; Powell JE, 2019, Comparative performance of the BGI and Illumina sequencing technology for single-cell RNA-sequencing, http://dx.doi.org/10.1101/552588

Wang H; Zhang F; Zeng J; Wu Y; Kemper KE; Xue A; Zhang M; Powell JE; Goddard ME; Wray NR; Visscher PM; McRae AF; Yang J, 2019, Genotype-by-environment interactions inferred from genetic effects on phenotypic variability in the UK Biobank, http://dx.doi.org/10.1101/519538

Võsa U; Claringbould A; Westra H-J; Bonder MJ; Deelen P; Zeng B; Kirsten H; Saha A; Kreuzhuber R; Kasela S; Pervjakova N; Alvaes I; Fave M-J; Agbessi M; Christiansen M; Jansen R; Seppälä I; Tong L; Teumer A; Schramm K; Hemani G; Verlouw J; Yaghootkar H; Sönmez R; Brown A; Kukushkina V; Kalnapenkis A; Rüeger S; Porcu E; Kronberg-Guzman J; Kettunen J; Powell J; Lee B; Zhang F; Arindrarto W; Beutner F; Brugge H; Dmitreva J; Elansary M; Fairfax BP; Georges M; Heijmans BT; Kähönen M; Kim Y; Knight JC; Kovacs P; Krohn K; Li S; Loeffler M; Marigorta UM; Mei H; Momozawa Y; Müller-Nurasyid M; Nauck M; Nivard M; Penninx B; Pritchard J; Raitakari O; Rotzchke O; Slagboom EP; Stehouwer CDA; Stumvoll M; Sullivan P; Hoen PACT; Thiery J; Tönjes A; van Dongen J; van Iterson M; Veldink J; Völker U; Wijmenga C; Swertz M; Andiappan A; Montgomery GW; Ripatti S; Perola M; Kutalik Z; Dermitzakis E; Bergmann S; Frayling T; van Meurs J; Prokisch H; Ahsan H; Pierce B; Lehtimäki T; Boomsma D; Psaty BM; Gharib SA; Awadalla P; Milani L; Ouwehand W; Downes K; Stegle O; Battle A; Yang J; Visscher PM; Scholz M; Gibson G; Esko T; Franke L, 2018, Unraveling the polygenic architecture of complex traits using blood eQTL metaanalysis, http://dx.doi.org/10.1101/447367

Lukowski SW; Lo CY; Sharov A; Nguyen QH; Fang L; Hung SSC; Zhu L; Zhang T; Nguyen T; Senabouth A; Jabbari JS; Welby E; Sowden JC; Waugh HS; Mackey A; Pollock G; Lamb TD; Wang P-Y; Hewitt AW; Gillies M; Powell JE; Wong RCB, 2018, Generation of human neural retina transcriptome atlas by single cell RNA sequencing, http://dx.doi.org/10.1101/425223

Alquicira-Hernández J; Sathe A; Ji HP; Nguyen Q; Powell JE, 2018, scPred: Cell type prediction at single-cell resolution, http://dx.doi.org/10.1101/369538

De Smit E; Lukowski SW; Anderson L; Senabouth A; Dauyey K; Song S; Wyse B; Wheeler L; Chen CY; Cao K; Yuen AWT; Shuey N; Clarke L; Sanchez IL; Hung SSC; Pébay A; Mackey DA; Brown MA; Hewitt AW; Powell JE, 2018, Longitudinal expression profiling of CD4+ and CD8+ cells in patients with active to quiescent Giant Cell Arteritis, http://dx.doi.org/10.1101/243493

Nguyen QH; Lukowski SW; Chiu HS; Friedman CE; Senabouth A; Crowhurst L; Bruxmer TJC; Christ AN; Palpant NJ; Powell JE, 2017, Determining cell fate specification and genetic contribution to cardiac disease risk in hiPSC-derived cardiomyocytes at single cell resolution, http://dx.doi.org/10.1101/229336

Senabouth A; Lukowski SW; Alquicira Hernandez J; Andersen S; Mei X; Nguyen QH; Powell JE, 2017, ascend: R package for analysis of single cell RNA-seq data, http://dx.doi.org/10.1101/207704

Daniszewski M; Senabouth A; Nguyen Q; Crombie DE; Lukowski SW; Kulkarni T; Zack DJ; Pébay A; Powell JE; Hewitt AW, 2017, Single Cell RNA Sequencing of stem cell-derived retinal ganglion cells, http://dx.doi.org/10.1101/191395

McRae AF; Marioni RE; Shah S; Yang J; Powell JE; Harris SE; Gibson J; Henders AK; Bowdler L; Painter JN; Murphy L; Martin NG; Starr JM; Wray NR; Deary IJ; Visscher PM; Montgomery GW, 2017, Identification of 55,000 Replicated DNA Methylation QTL, http://dx.doi.org/10.1101/166710

Zeng J; de Vlaming R; Wu Y; Robinson MR; Lloyd-Jones L; Yengo L; Yap C; Xue A; Sidorenko J; McRae AF; Powell JE; Montgomery GW; Metspalu A; Esko T; Gibson G; Wray NR; Visscher PM; Yang J, 2017, Widespread signatures of negative selection in the genetic architecture of human complex traits, http://dx.doi.org/10.1101/145755

Nguyen QH; Lukowski SW; Chiu HS; Senabouth A; Bruxner TJC; Christ AN; Palpant NJ; Powell JE, 2017, Single-cell RNA-seq of human induced pluripotent stem cells reveals cellular heterogeneity and cell state transitions between subpopulations, http://dx.doi.org/10.1101/119255

Friedman C; Nguyen Q; Lukowski S; Chiu HS; Helfer A; Miklas J; Suo SS; Jackie Han J-D; Osteil P; Peng G; Jing N; Baillie G; Senabouth A; Christ A; Bruxner T; Murry C; Wong E; Ding J; Wang Y; Hudson J; Ruohola-Baker H; Bar-Joseph Z; Tam P; Powell J; Palpant N, 2017, Analysis of cardiac differentiation at single cell resolution reveals a requirement of hypertrophic signaling for HOPX transcription, http://dx.doi.org/10.1101/229294

Wong E; Chenoweth S; Blows M; Powell J, 2017, Evidence for stabilizing selection at pleiotropic loci for human complex traits, http://dx.doi.org/10.1101/126888

Zeng B; Lloyd-Jones LR; Holloway A; Marigorta UM; Metspalu A; Montgomery GW; Esko T; Brigham KL; Quyyumi AA; Idaghdour Y; Yang J; Visscher PM; Powell JE; Gibson G, 2016, Constraints on eQTL fine mapping in the presence of multi-site local regulation of gene expression, http://dx.doi.org/10.1101/084293

Hung SSC; Chrysostomou V; Li F; Lim JKH; Wang J-H; Powell JE; Tu L; Daniszewski M; Lo C; Wong RC; Crowston JG; Pébay A; King AE; Bui BV; Liu G-S; Hewitt AW, 2016, AAV-mediated CRISPR/Cas gene editing of retinal cellsin vivo, http://dx.doi.org/10.1101/039156

Tuong ZK; Lukowski SW; Nguyen QH; Chandra J; Zhou C; Gillinder K; Bashaw AA; Ferdinand JR; Stewart BJ; Teoh SM; Hanson SJ; Devitt K; Clatworthy MR; Powell JE; Frazer IH, A Model of Impaired Langerhans Cell Maturation Associated With HPV Induced Epithelial Hyperplasia, http://dx.doi.org/10.2139/ssrn.3889711

Friedman CE; Nguyen Q; Lukowski SW; Helfer A; Chiu HS; Voges HK; Suo Suo S; Jackie Han J-D; Osteil P; Peng G; Jing N; Baillie GJ; Senabouth A; Christ AN; Bruxner TJ; Murry CE; Wong ES; Ding J; Wang Y; Hudson J; Bar-Joseph Z; Tam PPL; Powell JE; Palpant NJ, Cardiac Directed Differentiation Using Small Molecule WNT Modulation at Single-Cell Resolution, http://dx.doi.org/10.2139/ssrn.3155757

Daniszewski M; Nguyen Q; Chy H; Singh V; Crombie D; Kulkarni T; Liang H; Lidgerwood G; Hernnndez D; Conquest A; Rooney L; Chevalier S; Andersen S; Senabouth A; Vickers J; Mackey D; Craig J; Laslett A; Hewitt A; Powell JE; PPbay A, Single Cell Profiling Identifies Key Pathways Expressed by iPSCs Cultured in Different Commercial Media, http://dx.doi.org/10.2139/ssrn.3188388

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