By Professor Kyle Lee Hoehn

Journal articles

Fazakerley DJ; Chaudhuri R; Yang P; Maghzal GJ; Thomas KC; Krycer JR; Humphrey SJ; Parker BL; Fisher-Wellman KH; Meoli CC; Hoffman NJ; Diskin C; Burchfield JG; Cowley MJ; Kaplan W; Modrusan Z; Kolumam G; Yang JYH; Chen DL; Samocha-Bonet D; Greenfield JR; Hoehn KL; Stocker R; James DE; Chen D; Southwell Keely P, 2018, 'Mitochondrial CoQ deficiency is a common driver of mitochondrial oxidants and insulin resistance', eLife, 7, pp. e32111, http://dx.doi.org/10.7554/eLife.32111

Serasinghe MN; Gelles JD; Li K; Zhao L; Abbate F; Syku M; Mohammed JN; Badal B; Rangel CA; Hoehn KL; Celebi JT; Chipuk JE, 2018, 'Dual suppression of inner and outer mitochondrial membrane functions augments apoptotic responses to oncogenic MAPK inhibition', Cell Death and Disease, 9, pp. 29, http://dx.doi.org/10.1038/s41419-017-0044-1

Chen BJ; Byrne FL; Takenaka K; Modesitt SC; Olzomer EM; Mills JD; Farrell R; Hoehn KL; Janitz M, 2018, 'Analysis of the circular RNA transcriptome in endometrial cancer', Oncotarget, 9, pp. 5786 - 5796, http://dx.doi.org/10.18632/oncotarget.23534

Burchfield JG; Kebede MA; Meoli CC; Stöckli J; Whitworth PT; Wright AL; Hoffman NJ; Minard AY; Ma X; Krycer JR; Nelson ME; Tan SX; Yau B; Thomas KC; Wee NKY; Khor EC; Enriquez RF; Vissel B; Biden TJ; Baldock PA; Hoehn KL; Cantley J; Cooney GJ; James DE; Fazakerley DJ; Wright A, 2018, 'High dietary fat and sucrose results in an extensive and time-dependent deterioration in health of multiple physiological systems in mice', Journal of Biological Chemistry, 293, pp. 5731 - 5745, http://dx.doi.org/10.1074/jbc.RA117.000808

Meher AK; Serbulea V; Upchurch CM; Osinski V; Sahu S; Hargett S; Hoehn KL; Harris TE; Klibanov AL; McNamara CA; Leitinger N, 2018, 'Abstract 428: An Unexpected Role for ACC in Lipid Droplet Formation in Macrophages in Response to Acellular Adipocyte Fat', Arteriosclerosis, Thrombosis, and Vascular Biology, 38, http://dx.doi.org/10.1161/atvb.38.suppl_1.428

Krycer JR; Yugi K; Hirayama A; Fazakerley DJ; Quek LE; Scalzo R; Ohno S; Hodson MP; Ikeda S; Shoji F; Suzuki K; Domanova W; Parker BL; Nelson ME; Humphrey SJ; Turner N; Hoehn KL; Cooney GJ; Soga T; Kuroda S; James DE, 2017, 'Dynamic Metabolomics Reveals that Insulin Primes the Adipocyte for Glucose Metabolism', Cell Reports, 21, pp. 3536 - 3547, http://dx.doi.org/10.1016/j.celrep.2017.11.085

Chen BJ; Byrne FL; Takenaka K; Modesitt SC; Olzomer EM; Mills JD; Farrell R; Hoehn KL; Janitz M, 2017, 'Transcriptome landscape of long intergenic non-coding RNAs in endometrial cancer', Gynecologic Oncology, 147, pp. 654 - 662, http://dx.doi.org/10.1016/j.ygyno.2017.10.006

Gordon HM; Majithia N; MacDonald PE; Fox JEM; Sharma PR; Byrne FL; Hoehn KL; Evans-Molina C; Langman L; Brayman KL; Nunemaker CS, 2017, 'STEAP4 expression in human islets is associated with differences in body mass index, sex, HbA1c, and inflammation', Endocrine, 56, pp. 528 - 537, http://dx.doi.org/10.1007/s12020-017-1297-2

Caruana BT; Hoehn KL, 2017, 'The race to find endometrial cancer biomarkers', Surgery for Obesity and Related Diseases, 13, pp. 869 - 870, http://dx.doi.org/10.1016/j.soard.2017.01.042

Nelson ME; Lahiri S; Chow JDY; Byrne FL; Hargett SR; Breen DS; Olzomer EM; Wu LE; Cooney GJ; Turner N; James DE; Slack-Davis JK; Lackner C; Caldwell SH; Hoehn KL, 2017, 'Inhibition of hepatic lipogenesis enhances liver tumorigenesis by increasing antioxidant defence and promoting cell survival', Nature Communications, 8, pp. 14689, http://dx.doi.org/10.1038/ncomms14689

Taddeo EP; Hargett SR; Lahiri S; Nelson ME; Liao JA; Li C; Slack-Davis JK; Tomsig JL; Lynch KR; Yan Z; Harris TE; Hoehn KL, 2017, 'Lysophosphatidic acid counteracts glucagon-induced hepatocyte glucose production via STAT3', Scientific Reports, 7, pp. 127, http://dx.doi.org/10.1038/s41598-017-00210-y

Laker RC; Taddeo EP; Akhtar YN; Zhang M; Hoehn KL; Yan Z, 2016, 'The mitochondrial permeability transition pore regulator cyclophilin D exhibits tissue-specific control of metabolic homeostasis', PLoS ONE, 11, pp. e0167910, http://dx.doi.org/10.1371/journal.pone.0167910

Takenaka K; Chen BJ; Modesitt SC; Byrne FL; Hoehn KL; Janitz M, 2016, 'The emerging role of long non-coding RNAs in endometrial cancer', Cancer Genetics, 209, pp. 445 - 455, http://dx.doi.org/10.1016/j.cancergen.2016.09.005

Biwer LA; Taddeo EP; Kenwood BM; Hoehn KL; Straub AC; Isakson BE, 2016, 'Two functionally distinct pools of eNOS in endothelium are facilitated by myoendothelial junction lipid composition', Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1861, pp. 671 - 679, http://dx.doi.org/10.1016/j.bbalip.2016.04.014

Narayanan S; Nieh AH; Kenwood BM; Davis CA; Tosello-Trampont AC; Elich TD; Breazeale SD; Ward E; Anderson RJ; Caldwell SH; Hoehn KL; Hahn YS, 2016, 'Distinct roles for intracellular and extracellular lipids in hepatitis C virus infection', PLoS ONE, 11, pp. e0156996, http://dx.doi.org/10.1371/journal.pone.0156996

Byrne FL; Hoehn KL, 2016, 'Subclassification of fatty liver by its pathogenesis: CIEFing is believing', Journal of Pathology, 239, pp. 3 - 5, http://dx.doi.org/10.1002/path.4702

Healy ME; Lahiri S; Hargett SR; Chow JDY; Byrne FL; Breen DS; Kenwood BM; Taddeo EP; Lackner C; Caldwell SH; Hoehn KL, 2016, 'Dietary sugar intake increases liver tumor incidence in female mice', Scientific Reports, 6, pp. 22292, http://dx.doi.org/10.1038/srep22292

Brandon AE; Stuart E; Leslie SJ; Hoehn KL; James DE; Kraegen EW; Turner N; Cooney GJ, 2016, 'Minimal impact of age and housing temperature on the metabolic phenotype of Acc2^-/- mice', Journal of Endocrinology, 228, pp. 127 - 134, http://dx.doi.org/10.1530/JOE-15-0444

Biwer L; Taddeo E; Hoehn K; Straub A; Isakson B, 2016, 'Lipid composition of the myoendothelial junction allows for compartmentalized eNOS function', The FASEB Journal, 30, http://dx.doi.org/10.1096/fasebj.30.1_supplement.727.9

Baker W; Paquette C; Byrne FL; Atkins KA; Shupnik M; Modesitt SC; Hoehn KL; Slack-Davis JK, 2016, 'Postmenopausal endometrial cancer patients have significantly higher expression of GLUT6 in the endometrium', Gynecologic Oncology, 141, pp. 175 - 176, http://dx.doi.org/10.1016/j.ygyno.2016.04.456

Saur SJ; Märklin M; Ganser M; Hoehn K; David JE; Borst O; Kanz L; Kopp H-G; Mueller MR, 2015, 'C-Cbl Regulates c-Mpl Receptor Trafficking and Its Internalization', Blood, 126, pp. 2388 - 2388, http://dx.doi.org/10.1182/blood.v126.23.2388.2388

Chaudhuri R; Khoo PS; Tonks K; Junutula JR; Kolumam G; Modrusan Z; Samocha-Bonet D; Meoli CC; Hocking S; Fazakerley DJ; Stöckli J; Hoehn KL; Greenfield JR; Yang JYH; James DE; Milliken S; Goodnow C, 2015, 'Cross-species gene expression analysis identifies a novel set of genes implicated in human insulin sensitivity', npj Systems Biology and Applications, 1, pp. 15010, http://dx.doi.org/10.1038/npjsba.2015.10

Kenwood BM; Calderone JA; Taddeo EP; Hoehn KL; Santos WL, 2015, 'Structure-activity relationships of furazano[3,4-b]pyrazines as mitochondrial uncouplers', Bioorganic and Medicinal Chemistry Letters, 25, pp. 4858 - 4861, http://dx.doi.org/10.1016/j.bmcl.2015.06.040

Du X; Zhang Y; Jo SR; Liu X; Qi Y; Osborne B; Byrne FL; Smith GC; Turner N; Hoehn KL; Brown AJ; Yang H, 2015, 'Akt activation increases cellular cholesterol by promoting the proteasomal degradation of Niemann-Pick C1', Biochemical Journal, 471, pp. 243 - 253, http://dx.doi.org/10.1042/BJ20150602

Lee JE; Walsh MC; Hoehn KL; James DE; Wherry EJ; Choi Y, 2015, 'Acetyl CoA carboxylase 2 is dispensable for CD8+ T cell responses', PLoS ONE, 10, pp. e0137776, http://dx.doi.org/10.1371/journal.pone.0137776

Hargett SR; Walker NN; Hussain SS; Hoehn KL; Keller SR, 2015, 'Deletion of the rab GAP Tbc1d1 modifies glucose, lipid, and energy homeostasis in mice', American Journal of Physiology - Endocrinology and Metabolism, 309, pp. E233 - E245, http://dx.doi.org/10.1152/ajpendo.00007.2015

Modesitt SC; Hallowell PT; Slack-Davis JK; Michalek RD; Atkins KA; Kelley SL; Arapovic S; Shupnik MA; Hoehn K, 2015, 'Women at extreme risk for obesity-related carcinogenesis: Baseline endometrial pathology and impact of bariatric surgery on weight, metabolic profiles and quality of life', Gynecologic Oncology, 138, pp. 238 - 245, http://dx.doi.org/10.1016/j.ygyno.2015.05.015

Bajwa A; Rosin DL; Chroscicki P; Lee S; Dondeti K; Ye H; Kinsey GR; Stevens BK; Jobin K; Kenwood BM; Hoehn KL; Lynch KR; Okusa MD, 2015, 'Sphingosine 1-phosphate receptor-1 enhances mitochondrial function and reduces cisplatin-induced tubule injury', Journal of the American Society of Nephrology, 26, pp. 908 - 925, http://dx.doi.org/10.1681/ASN.2013121351

Healy ME; Chow JDY; Byrne FL; Breen DS; Leitinger N; Li C; Lackner C; Caldwell SH; Hoehn KL, 2015, 'Dietary effects on liver tumor burden in mice treated with the hepatocellular carcinogen diethylnitrosamine', Journal of Hepatology, 62, pp. 599 - 606, http://dx.doi.org/10.1016/j.jhep.2014.10.024

Kashatus JA; Nascimento A; Myers LJ; Sher A; Byrne FL; Hoehn KL; Counter CM; Kashatus DF, 2015, 'Erk2 phosphorylation of Drp1 promotes mitochondrial fission and MAPK-driven tumor growth', Molecular Cell, 57, pp. 537 - 551, http://dx.doi.org/10.1016/j.molcel.2015.01.002

Serasinghe MN; Wieder SY; Renault TT; Elkholi R; Asciolla JJ; Yao JL; Jabado O; Hoehn K; Kageyama Y; Sesaki H; Chipuk JE, 2015, 'Mitochondrial division is requisite to RAS-induced transformation and targeted by oncogenic MAPK pathway inhibitors', Molecular Cell, 57, pp. 521 - 536, http://dx.doi.org/10.1016/j.molcel.2015.01.003

Cronk SM; Kelly-Goss MR; Ray HC; Mendel TA; Hoehn KL; Bruce AC; Dey BK; Guendel AM; Tavakol DN; Herman IM; Peirce SM; Yates PA, 2015, 'Adipose-derived stem cells from diabetic mice show impaired vascular stabilization in a murine model of diabetic retinopathy', Stem Cells Translational Medicine, 4, pp. 459 - 467, http://dx.doi.org/10.5966/sctm.2014-0108

Modesitt SC; Hallowell PT; Hoehn KL; Slack-Davis JK; Kelley SL; Arapovic S; Shupnik M, 2015, 'Changes in metabolic profiles before and after bariatric surgery in high risk morbidly obese women: Obesity-related carcinogenesis is not all about hormones', Gynecologic Oncology, 137, pp. 26 - 26, http://dx.doi.org/10.1016/j.ygyno.2015.01.060

Laker R; Taddeo E; Zhang M; Hoehn K; Yan Z, 2015, 'The Mitochondrial Permeability Transition Pore Regulator Cyclophilin D Exhibits Tissue‐Specific Control of Metabolic Homeostasis', The FASEB Journal, 29, http://dx.doi.org/10.1096/fasebj.29.1_supplement.1036.14

Byrne FL; Poon IKH; Modesitt SC; Tomsig JL; Chow JDY; Healy ME; Baker WD; Atkins KA; Lancaster JM; Marchion DC; Moley KH; Ravichandran KS; Slack-Davis JK; Hoehn KL, 2014, 'Metabolic vulnerabilities in endometrial cancer', Cancer Research, 74, pp. 5832 - 5845, http://dx.doi.org/10.1158/0008-5472.CAN-14-0254

Narayanan S; Hoehn K; Kenwood B; Nieh A; Tosello-Trampont A; Davis C; Caldwell S; Hahn Y, 2014, 'Altered lipid metabolism influences course of hepatitis C virus infection and hepatocyte cytokine production', JOURNAL OF IMMUNOLOGY, 192, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000209765005005&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Bupp MG; Litvin S; Edwards R; Mihalcoe B; Byrne F; Hoehn K; Anoff J, 2014, 'The forkhead transcription factor, Foxo1, may coordinate naive CD8+T cell homeostasis with energy availability in mice.', JOURNAL OF IMMUNOLOGY, 192, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000209765005135&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Laker RC; Xu P; Ryall KA; Sujkowski A; Kenwood BM; Chain KH; Zhang M; Royal MA; Hoehn KL; Driscoll M; Adler PN; Wessells RJ; Saucerman JJ; Yan Z, 2014, 'A novel mitotimer reporter gene for mitochondrial content, structure, stress, and damage in vivo', Journal of Biological Chemistry, 289, pp. 12005 - 12015, http://dx.doi.org/10.1074/jbc.M113.530527

Lee JE; Walsh MC; Hoehn KL; James DE; Wherry EJ; Choi Y, 2014, 'Regulator of fatty acid metabolism, acetyl coenzyme a carboxylase 1, controls T cell immunity', Journal of Immunology, 192, pp. 3190 - 3199, http://dx.doi.org/10.4049/jimmunol.1302985

Laker RC; Lillard TS; Okutsu M; Zhang M; Hoehn KL; Connelly JJ; Yan Z, 2014, 'Exercise prevents maternal high-fat diet-induced hypermethylation of the Pgc-1α gene and age-dependent metabolic dysfunction in the offspring', Diabetes, 63, pp. 1605 - 1611, http://dx.doi.org/10.2337/db13-1614

Chow JDY; Lawrence RT; Healy ME; Dominy JE; Liao JA; Breen DS; Byrne FL; Kenwood BM; Lackner C; Okutsu S; Mas VR; Caldwell SH; Tomsig JL; Cooney GJ; Puigserver PB; Turner N; James DE; Villén J; Hoehn KL, 2014, 'Genetic inhibition of hepatic acetyl-CoA carboxylase activity increases liver fat and alters global protein acetylation', Molecular Metabolism, 3, pp. 419 - 431, http://dx.doi.org/10.1016/j.molmet.2014.02.004

Kenwood BM; Weaver JL; Bajwa A; Poon IK; Byrne FL; Murrow BA; Calderone JA; Huang L; Divakaruni AS; Tomsig JL; Okabe K; Lo RH; Cameron Coleman G; Columbus L; Yan Z; Saucerman JJ; Smith JS; Holmes JW; Lynch KR; Ravichandran KS; Uchiyama S; Santos WL; Rogers GW; Okusa MD; Bayliss DA; Hoehn KL, 2014, 'Identification of a novel mitochondrial uncoupler that does not depolarize the plasma membrane', Molecular Metabolism, 3, pp. 114 - 123, http://dx.doi.org/10.1016/j.molmet.2013.11.005

Taddeo EP; Laker RC; Breen DS; Akhtar YN; Kenwood BM; Liao JA; Zhang M; Fazakerley DJ; Tomsig JL; Harris TE; Keller SR; Chow JD; Lynch KR; Chokki M; Molkentin JD; Turner N; James DE; Yan Z; Hoehn KL, 2014, 'Opening of the mitochondrial permeability transition pore links mitochondrial dysfunction to insulin resistance in skeletal muscle', Molecular Metabolism, 3, pp. 124 - 134, http://dx.doi.org/10.1016/j.molmet.2013.11.003

Lira VA; Okutsu M; Zhang M; Greene NP; Laker RC; Breen DS; Hoehn KL; Yan Z, 2013, 'Autophagy is required for exercise training-induced skeletal muscle adaptation and improvement of physical performance', FASEB Journal, 27, pp. 4184 - 4193, http://dx.doi.org/10.1096/fj.13-228486

Caldwell S; Hoehn KL; Hahn YS, 2013, 'The strange and critical intersection of hepatitis C and lipoprotein metabolism: "C-zing" the oil', Hepatology, 57, pp. 1684 - 1687, http://dx.doi.org/10.1002/hep.26091

Cantley J; Whitworth PT; Davenport A; Hoehn KL; James DE; Biden TJ, 2013, 'Acetyl-CoA carboxylase-1 is a critical regulator of beta cell size and proliferation', DIABETIC MEDICINE, 30, pp. 8 - 9, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000316263400049&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Kenwood BM; Weaver JL; Byrne FL; Murrow BA; Tomsig JL; Cameron Coleman G; Yan Z; Lynch KR; Bayliss DA; Hoehn KL; Bajwa A; Huang L; Okusa MD; Poon IK; Ravichandran KS; Divakaruni AS; Saucerman JJ; Smith JS; Holmes JW; Rogers GW; Lo RH; Columbus L; Okabe K; Uchiyama S; Calderone JA; Santos WL, 2013, 'Identification of a novel mitochondrial uncoupler that does not depolarize the plasma membrane', Molecular Metabolism, http://dx.doi.org/10.1016/j.molmet.2013.11.005

Cleasby ME; Hoehn KL; Patel SA; Lawrence RT; Sawbridge L; Talbot NA; Turner N; Cooney GJ; Whitehead JP; Kraegen EW, 2012, 'Overexpression of the adiponectin receptor AdipoR1 in rat skeletal muscle amplifies local insulin sensitivity', DIABETOLOGIA, 55, pp. S244 - S245, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000208826501338&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Hoehn KL; Turner N; Cooney GJ; James DE, 2012, 'Phenotypic discrepancies in acetyl-CoA carboxylase 2-deficient mice (Journal of Biological Chemistry (2012) 287, (15801))', Journal of Biological Chemistry, 287, pp. 20468, http://dx.doi.org/10.1074/jbc.A112.356915

Modesitt SC; Hsu JY; Chowbina SR; Lawrence RT; Hoehn KL, 2012, 'Not all fat is equal: Differential gene expression and potential therapeutic targets in subcutaneous adipose, visceral adipose, and endometrium of obese women with and without endometrial cancer', International Journal of Gynecological Cancer, 22, pp. 732 - 741, http://dx.doi.org/10.1097/IGC.0b013e3182510496

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