By Professor Kyle Lee Hoehn

Journal articles

Hargett S; Lahiri S; Kowalski GM; Corley S; Nelson ME; Lackner C; Olzomer EM; Aleksovska I; Hearn BA; Shrestha R; Janitz M; Gorrell MD; Bruce CR; Wilkins M; Hoehn KL; Byrne FL, 2024, 'Bile acids mediate fructose-associated liver tumour growth in mice', Biochimica et Biophysica Acta - Molecular Basis of Disease, 1870, http://dx.doi.org/10.1016/j.bbadis.2024.167029

Beretta M; Dai Y; Olzomer EM; Vancuylenburg CS; Santiago-Rivera JA; Philp AM; Hargett SR; Li K; Shah DP; Chen SY; Alexopoulos SJ; Li C; Harris TE; Lee B; Wathier M; Cermak JM; Tucker SP; Turner N; Bayliss DA; Philp A; Byrne FL; Santos WL; Hoehn KL, 2024, 'Liver-Selective Imidazolopyrazine Mitochondrial Uncoupler SHD865 Reverses Adiposity and Glucose Intolerance in Mice', Diabetes, 73, pp. 374 - 384, http://dx.doi.org/10.2337/db23-0233

Chen SY; Telfser AJ; Olzomer EM; Vancuylenberg CS; Zhou M; Beretta M; Li C; Alexopoulos SJ; Turner N; Byrne FL; Santos WL; Hoehn KL, 2024, 'Beneficial effects of simultaneously targeting calorie intake and calorie efficiency in diet-induced obese mice', Clinical Science, 138, pp. 173 - 187, http://dx.doi.org/10.1042/CS20231016

Yau B; Naghiloo S; Diaz-Vegas A; Carr AV; Van Gerwen J; Needham EJ; Jevon D; Chen SY; Hoehn KL; Brandon AE; Macia L; Cooney GJ; Shortreed MR; Smith LM; Keller MP; Thorn P; Larance M; James DE; Humphrey SJ; Kebede MA, 2024, 'Erratum: Proteomic pathways to metabolic disease and type 2 diabetes in the pancreatic islet (iScience (2021) 24(10), (S2589004221010671), (10.1016/j.isci.2021.103099))', iScience, 27, http://dx.doi.org/10.1016/j.isci.2023.108707

Chen SY; Beretta M; Olzomer EM; Alexopoulos SJ; Shah DP; Byrne FL; Salamoun JM; Garcia CJ; Smith GC; Larance M; Philp A; Turner N; Santos WL; Cantley J; Hoehn KL, 2024, 'Head-to-head comparison of BAM15, semaglutide, rosiglitazone, NEN, and calorie restriction on metabolic physiology in female db/db mice', Biochimica et Biophysica Acta - Molecular Basis of Disease, 1870, http://dx.doi.org/10.1016/j.bbadis.2023.166908

Murray JH; Burgio AL; Beretta M; Hargett SR; Harris TE; Olzomer E; Grams RJ; Garcia CJ; Li C; Salamoun JM; Hoehn KL; Santos WL, 2023, 'Oxadiazolopyridine Derivatives as Efficacious Mitochondrial Uncouplers in the Prevention of Diet-Induced Obesity', Journal of Medicinal Chemistry, 66, pp. 3876 - 3895, http://dx.doi.org/10.1021/acs.jmedchem.2c01573

Takenaka K; Olzomer EM; Hoehn KL; Curry-Hyde A; Jun Chen B; Farrell R; Byrne FL; Janitz M, 2023, 'Investigation of circular RNA transcriptome in obesity-related endometrial cancer', Gene, 855, http://dx.doi.org/10.1016/j.gene.2022.147125

Chen SY; Beretta M; Olzomer EM; Shah DP; Wong DYH; Alexopoulos SJ; Aleksovska I; Salamoun JM; Garcia CJ; Cochran BJ; Rye KA; Smith GC; Byrne FL; Morris MJ; Santos WL; Cantley J; Hoehn KL, 2023, 'Targeting negative energy balance with calorie restriction and mitochondrial uncoupling in db/db mice', Molecular Metabolism, 69, http://dx.doi.org/10.1016/j.molmet.2023.101684

Veprik A; Denwood G; Liu D; Bany Bakar R; Morfin V; McHugh K; Tebeka NN; Vetterli L; Yonova-Doing E; Gribble F; Reimann F; Hoehn KL; Hemsley PA; Ahnfelt-Rønne J; Rorsman P; Zhang Q; de Wet H; Cantley J, 2022, 'Acetyl-CoA-carboxylase 1 (ACC1) plays a critical role in glucagon secretion', Communications Biology, 5, http://dx.doi.org/10.1038/s42003-022-03170-w

Yeudall S; Upchurch CM; Seegren PV; Pavelec CM; Greulich J; Lemke MC; Harris TE; Desai BN; Hoehn KL; Leitinger N, 2022, 'Macrophage acetyl-CoA carboxylase regulates acute inflammation through control of glucose and lipid metabolism', Science Advances, 8, http://dx.doi.org/10.1126/sciadv.abq1984

Dai Y; Santiago-Rivera JA; Hargett S; Salamoun JM; Hoehn KL; Santos WL, 2022, 'Conversion of oxadiazolo[3,4-b]pyrazines to imidazo[4,5-b]pyrazines via a tandem reduction-cyclization sequence generates new mitochondrial uncouplers', Bioorganic and Medicinal Chemistry Letters, 73, http://dx.doi.org/10.1016/j.bmcl.2022.128912

Chen SY; Olzomer EM; Beretta M; Cantley J; Nunemaker CS; Hoehn KL; Byrne FL, 2022, 'Investigating the Expression and Function of the Glucose Transporter GLUT6 in Obesity', International Journal of Molecular Sciences, 23, pp. 9798, http://dx.doi.org/10.3390/ijms23179798

Kaakoush NO; Olzomer EM; Kosasih M; Martin AR; Fargah F; Lambie N; Susic D; Hoehn KL; Farrell R; Byrne FL, 2022, 'Differences in the Active Endometrial Microbiota across Body Weight and Cancer in Humans and Mice', Cancers, 14, pp. 2141, http://dx.doi.org/10.3390/cancers14092141

Byrne FL; Olzomer EM; Lolies N; Hoehn KL; Wegner MS, 2022, 'Update on Glycosphingolipids Abundance in Hepatocellular Carcinoma', International Journal of Molecular Sciences, 23, pp. 4477, http://dx.doi.org/10.3390/ijms23094477

RODRIGUEZ PARIS V; ALEXOPOULOS SJ; HU Y; SHAH DP; AFLATOUNIAN A; EDWARDS MC; BERTOLDO MJ; GILCHRIST RB; HOEHN KL; WALTERS KA, 2022, 'Mitochondrial Uncoupler BAM15 Ameliorates Associated Metabolic PCOS Traits in a Hyperandrogenic PCOS Mouse Model', Fertility & Reproduction, 04, pp. 208 - 208, http://dx.doi.org/10.1142/s2661318222741194

Hoehn KL, 2021, 'How does obesity cause cancer?', Cancers, 13, http://dx.doi.org/10.3390/cancers13215330

Wegner MS; Schömel N; Olzomer EM; Trautmann S; Olesch C; Byrne FL; Brüne B; Gurke R; Ferreirós N; Weigert A; Geisslinger G; Hoehn KL, 2021, 'Increased glucosylceramide production leads to decreased cell energy metabolism and lowered tumor marker expression in non-cancerous liver cells', Cellular and Molecular Life Sciences, 78, pp. 7025 - 7041, http://dx.doi.org/10.1007/s00018-021-03958-9

Yau B; Naghiloo S; Diaz-Vegas A; Carr AV; Van Gerwen J; Needham EJ; Jevon D; Chen SY; Hoehn KL; Brandon AE; Macia L; Cooney GJ; Shortreed MR; Smith LM; Keller MP; Thorn P; Larance M; James DE; Humphrey SJ; Kebede MA, 2021, 'Proteomic pathways to metabolic disease and type 2 diabetes in the pancreatic islet', iScience, 24, http://dx.doi.org/10.1016/j.isci.2021.103099

Zunica ERM; Axelrod CL; Cho E; Spielmann G; Davuluri G; Alexopoulos SJ; Beretta M; Hoehn KL; Dantas WS; Stadler K; King WT; Pergola K; Irving BA; Langohr IM; Yang S; Hoppel CL; Gilmore LA; Kirwan JP, 2021, 'Breast cancer growth and proliferation is suppressed by the mitochondrial targeted furazano[3,4-b]pyrazine BAM15', CANCER & METABOLISM, 9, http://dx.doi.org/10.1186/s40170-021-00274-5

Srivastava P; Gunawan C; Soeriyadi A; Amal R; Hoehn K; Marquis C, 2021, 'In vitrocoronal protein signatures and biological impact of silver nanoparticles synthesized with different natural polymers as capping agents', Nanoscale Advances, 3, pp. 4424 - 4439, http://dx.doi.org/10.1039/d0na01013h

Chen SY; Beretta M; Alexopoulos SJ; Shah DP; Olzomer EM; Hargett SR; Childress ES; Salamoun JM; Aleksovska I; Roseblade A; Cranfield C; Rawling T; Quinlan KGR; Morris MJ; Tucker SP; Santos WL; Hoehn KL, 2021, 'Mitochondrial uncoupler SHC517 reverses obesity in mice without affecting food intake', Metabolism: Clinical and Experimental, 117, http://dx.doi.org/10.1016/j.metabol.2021.154724

Knights AJ; Vohralik EJ; Houweling PJ; Stout ES; Norton LJ; Alexopoulos SJ; Yik JJ; Mat Jusoh H; Olzomer EM; Bell-Anderson KS; North KN; Hoehn KL; Crossley M; Quinlan KGR, 2020, 'Eosinophil function in adipose tissue is regulated by Krüppel-like factor 3 (KLF3)', Nature Communications, 11, http://dx.doi.org/10.1038/s41467-020-16758-9

Alexopoulos SJ; Chen SY; Brandon AE; Salamoun JM; Byrne FL; Garcia CJ; Beretta M; Olzomer EM; Shah DP; Philp AM; Hargett SR; Lawrence RT; Lee B; Sligar J; Carrive P; Tucker SP; Philp A; Lackner C; Turner N; Cooney GJ; Santos WL; Hoehn KL; Evans A, 2020, 'Mitochondrial uncoupler BAM15 reverses diet-induced obesity and insulin resistance in mice', Nature Communications, 11, pp. 2397, http://dx.doi.org/10.1038/s41467-020-16298-2

Schömel N; Gruber L; Alexopoulos SJ; Trautmann S; Olzomer EM; Byrne FL; Hoehn KL; Gurke R; Thomas D; Ferreirós N; Geisslinger G; Wegner MS, 2020, 'UGCG overexpression leads to increased glycolysis and increased oxidative phosphorylation of breast cancer cells', Scientific Reports, 10, pp. 8182, http://dx.doi.org/10.1038/s41598-020-65182-y

Märklin M; Tandler C; Kopp HG; Hoehn KL; Quintanilla-Martinez L; Borst O; Müller MR; Saur SJ, 2020, 'C-Cbl regulates c-MPL receptor trafficking and its internalization', Journal of Cellular and Molecular Medicine, 24, pp. 12491 - 12503, http://dx.doi.org/10.1111/jcmm.15785

Flynn MC; Kraakman MJ; Tikellis C; Lee MKS; Hanssen NMJ; Kammoun HL; Pickering RJ; Dragoljevic D; Al-Sharea A; Barrett TJ; Hortle F; Byrne FL; Olzomer E; McCarthy DA; Schalkwijk CG; Forbes JM; Hoehn K; Makowski L; Lancaster GI; El-Osta A; Fisher EA; Goldberg IJ; Cooper ME; Nagareddy PR; Thomas MC; Murphy AJ, 2020, 'Transient Intermittent Hyperglycemia Accelerates Atherosclerosis by Promoting Myelopoiesis', Circulation Research, 127, pp. 877 - 892, http://dx.doi.org/10.1161/CIRCRESAHA.120.316653

Axelrod CL; King WT; Davuluri G; Noland RC; Hall J; Hull M; Dantas WS; Zunica ERM; Alexopoulos SJ; Hoehn KL; Langohr I; Stadler K; Doyle H; Schmidt E; Nieuwoudt S; Fitzgerald K; Pergola K; Fujioka H; Mey JT; Fealy C; Mulya A; Beyl R; Hoppel CL; Kirwan JP, 2020, 'BAM15-mediated mitochondrial uncoupling protects against obesity and improves glycemic control', EMBO Molecular Medicine, 12, http://dx.doi.org/10.15252/emmm.202012088

Salamoun JM; Garcia CJ; Hargett SR; Murray JH; Chen SY; Beretta M; Alexopoulos SJ; Shah DP; Olzomer EM; Tucker SP; Hoehn KL; Santos WL, 2020, '6-Amino[1,2,5]oxadiazolo[3,4- b]pyrazin-5-ol Derivatives as Efficacious Mitochondrial Uncouplers in STAM Mouse Model of Nonalcoholic Steatohepatitis', Journal of Medicinal Chemistry, 63, pp. 6203 - 6224, http://dx.doi.org/10.1021/acs.jmedchem.0c00542

Murray JH; Hargett S; Hoehn KL; Santos WL, 2020, 'Anilinopyrazines as potential mitochondrial uncouplers', Bioorganic and Medicinal Chemistry Letters, 30, http://dx.doi.org/10.1016/j.bmcl.2020.127057

Childress ES; Salamoun JM; Hargett SR; Alexopoulos SJ; Chen SY; Shah DP; Santiago-Rivera J; Garcia CJ; Dai Y; Tucker SP; Hoehn KL; Santos WL, 2020, 'Oxadiazolo[3,4- b]pyrazine-5,6-diamine Derivatives as Mitochondrial Uncouplers for the Potential Treatment of Nonalcoholic Steatohepatitis', Journal of Medicinal Chemistry, 63, pp. 2511 - 2526, http://dx.doi.org/10.1021/acs.jmedchem.9b01440

Byrne FL; Olzomer EM; Marriott GR; Quek LE; Katen A; Su J; Nelson ME; Hart-Smith G; Larance M; Sebesfi VF; Cuff J; Martyn GE; Childress E; Alexopoulos SJ; Poon IK; Faux MC; Burgess AW; Reid G; McCarroll JA; Santos WL; Quinlan KG; Turner N; Fazakerley DJ; Kumar N; Hoehn KL, 2020, 'Phenotypic screen for oxygen consumption rate identifies an anti-cancer naphthoquinone that induces mitochondrial oxidative stress', Redox Biology, 28, pp. 101374, http://dx.doi.org/10.1016/j.redox.2019.101374

Schömel N; Hancock SE; Gruber L; Olzomer EM; Byrne FL; Shah D; Hoehn KL; Turner N; Grösch S; Geisslinger G; Wegner MS, 2019, 'UGCG influences glutamine metabolism of breast cancer cells', Scientific Reports, 9, pp. 15665, http://dx.doi.org/10.1038/s41598-019-52169-7

Xu Y; Mak HY; Lukmantara I; Li YE; Hoehn KL; Huang X; Du X; Yang H, 2019, 'CDP-DAG synthase 1 and 2 regulate lipid droplet growth through distinct mechanisms', Journal of Biological Chemistry, 294, pp. 16740 - 16755, http://dx.doi.org/10.1074/jbc.RA119.009992

Caruana BT; Byrne FL; Knights AJ; Quinlan KGR; Hoehn KL, 2019, 'Characterization of glucose transporter 6 in lipopolysaccharide-induced bone marrow-derived macrophage function', Journal of Immunology, 202, pp. 1826 - 1832, http://dx.doi.org/10.4049/jimmunol.1801063

Huo Y; Buckton LK; Bennett JL; Smith EC; Byrne FL; Hoehn KL; Rahimi MN; McAlpine SR, 2019, 'Delivering bioactive cyclic peptides that target Hsp90 as prodrugs', Journal of Enzyme Inhibition and Medicinal Chemistry, 34, pp. 728 - 739, http://dx.doi.org/10.1080/14756366.2019.1580276

Cantley J; Davenport A; Vetterli L; Nemes NJ; Whitworth PT; Boslem E; Thai LM; Mellett N; Meikle PJ; Hoehn KL; James DE; Biden TJ, 2019, 'Disruption of beta cell acetyl-CoA carboxylase-1 in mice impairs insulin secretion and beta cell mass', Diabetologia, 62, pp. 99 - 111, http://dx.doi.org/10.1007/s00125-018-4743-7

Gemta LF; Siska PJ; Nelson ME; Gao X; Liu X; Locasale JW; Yagita H; Slingluff CL; Hoehn KL; Rathmell JC; Bullock TNJ, 2019, 'Impaired enolase 1 glycolytic activity restrains effector functions of tumor-infiltrating CD8⁺ T cells', Science Immunology, 4, http://dx.doi.org/10.1126/sciimmunol.aap9520

Jiménez de Oya N; Esler WP; Huard K; El-Kattan AF; Karamanlidis G; Blázquez AB; Ramos-Ibeas P; Escribano-Romero E; Louloudes-Lázaro A; Casas J; Sobrino F; Hoehn K; James DE; Gutiérrez-Adán A; Saiz JC; Martín-Acebes MA, 2019, 'Targeting host metabolism by inhibition of acetyl-Coenzyme A carboxylase reduces flavivirus infection in mouse models', Emerging Microbes and Infections, 8, pp. 624 - 636, http://dx.doi.org/10.1080/22221751.2019.1604084

Podwika S; Gabel A; Slack-Davis J; Shupnik M; Hoehn K; Modesitt SC, 2019, 'Physical Activity, Nutrition and Hormone Levels of Postmenopausal Women With and Without Endometrial Cancer [40R]', Obstetrics & Gynecology, 133, pp. 202S - 202S, http://dx.doi.org/10.1097/01.aog.0000559153.05084.de

Turner N; Lim XY; Toop HD; Osborne B; Brandon AE; Taylor EN; Fiveash CE; Govindaraju H; Teo JD; McEwen HP; Couttas TA; Butler SM; Das A; Kowalski GM; Bruce CR; Hoehn KL; Fath T; Schmitz-Peiffer C; Cooney GJ; Montgomery MK; Morris JC; Don AS; Brandon A, 2018, 'A selective inhibitor of ceramide synthase 1 reveals a novel role in fat metabolism', Nature Communications, 9, pp. 3165, http://dx.doi.org/10.1038/s41467-018-05613-7

Chaudhuri R; Krycer JR; Fazakerley DJ; Fisher-Wellman KH; Su Z; Hoehn KL; Yang JYH; Kuncic Z; Vafaee F; James DE, 2018, 'The transcriptional response to oxidative stress is part of, but not sufficient for, insulin resistance in adipocytes', Scientific Reports, 8, pp. 1774, http://dx.doi.org/10.1038/s41598-018-20104-x

Knights AJ; Vohralik EJ; Hoehn KL; Crossley M; Quinlan KGR, 2018, 'Defining Eosinophil Function in Adiposity and Weight Loss', BioEssays, 40, http://dx.doi.org/10.1002/bies.201800098

Byrne FL; Hargett SR; Lahiri S; Roy RJ; Berr SS; Caldwell SH; Hoehn KL, 2018, 'Serial MRI imaging reveals minimal impact of ketogenic diet on established liver tumor growth', Cancers, 10, pp. 312, http://dx.doi.org/10.3390/cancers10090312

Byrne FL; Olzomer EM; Brink R; Hoehn KL, 2018, 'Knockout of glucose transporter GLUT6 has minimal effects on whole body metabolic physiology in mice', American Journal of Physiology - Endocrinology and Metabolism, 315, pp. E286 - E293, http://dx.doi.org/10.1152/ajpendo.00082.2018

Childress ES; Alexopoulos SJ; Hoehn KL; Santos WL, 2018, 'Small Molecule Mitochondrial Uncouplers and Their Therapeutic Potential', Journal of Medicinal Chemistry, 61, pp. 4641 - 4655, http://dx.doi.org/10.1021/acs.jmedchem.7b01182

Fazakerley DJ; Chaudhuri R; Yang P; Maghzal GJ; Thomas KC; Krycer JR; Humphrey SJ; Parker BL; Fisher-Wellman KH; Meoli CC; Hoffman NJ; Diskin C; Burchfield JG; Cowley MJ; Kaplan W; Modrusan Z; Kolumam G; Yang JYH; Chen DL; Samocha-Bonet D; Greenfield JR; Hoehn KL; Stocker R; James DE; Chen D; Southwell Keely P, 2018, 'Mitochondrial CoQ deficiency is a common driver of mitochondrial oxidants and insulin resistance', eLife, 7, pp. e32111, http://dx.doi.org/10.7554/eLife.32111

Serasinghe MN; Gelles JD; Li K; Zhao L; Abbate F; Syku M; Mohammed JN; Badal B; Rangel CA; Hoehn KL; Celebi JT; Chipuk JE, 2018, 'Dual suppression of inner and outer mitochondrial membrane functions augments apoptotic responses to oncogenic MAPK inhibition', Cell Death and Disease, 9, pp. 29, http://dx.doi.org/10.1038/s41419-017-0044-1

Chen BJ; Byrne FL; Takenaka K; Modesitt SC; Olzomer EM; Mills JD; Farrell R; Hoehn KL; Janitz M, 2018, 'Analysis of the circular RNA transcriptome in endometrial cancer', Oncotarget, 9, pp. 5786 - 5796, http://dx.doi.org/10.18632/oncotarget.23534

Burchfield JG; Kebede MA; Meoli CC; Stöckli J; Whitworth PT; Wright AL; Hoffman NJ; Minard AY; Ma X; Krycer JR; Nelson ME; Tan SX; Yau B; Thomas KC; Wee NKY; Khor EC; Enriquez RF; Vissel B; Biden TJ; Baldock PA; Hoehn KL; Cantley J; Cooney GJ; James DE; Fazakerley DJ; Wright A, 2018, 'High dietary fat and sucrose results in an extensive and time-dependent deterioration in health of multiple physiological systems in mice', Journal of Biological Chemistry, 293, pp. 5731 - 5745, http://dx.doi.org/10.1074/jbc.RA117.000808

Meher AK; Serbulea V; Upchurch CM; Osinski V; Sahu S; Hargett S; Hoehn KL; Harris TE; Klibanov AL; McNamara CA; Leitinger N, 2018, 'Abstract 428: An Unexpected Role for ACC in Lipid Droplet Formation in Macrophages in Response to Acellular Adipocyte Fat', Arteriosclerosis, Thrombosis, and Vascular Biology, 38, http://dx.doi.org/10.1161/atvb.38.suppl_1.428

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