Select Publications
Journal articles
2014, '421 Molecular profiling for factors predicting sensitivity or resistance to therapy in relapsed child cancer', European Journal of Cancer, 50, pp. 135, http://dx.doi.org/10.1016/s0959-8049(14)70547-7
,2014, 'Neuroblastoma: molecular targets and novel therapies', Pathology, 46, pp. S36 - S36, http://dx.doi.org/10.1097/01.pat.0000454208.74479.75
,2013, 'GPR84, a Proinflammatory Receptor, Sustains Wnt/β-Catenin Signaling In Leukemic Stem Cells For Maintenance Of MLL-AF9-Induced Leukemogenesis', Blood, 122, pp. 3781, http://dx.doi.org/10.1182/blood.v122.21.3781.3781
,2013, 'Improving the Identification of High Risk Precursor B Acute Lymphoblastic Leukemia Patients with Earlier Quantification of Minimal Residual Disease', PLoS ONE, 8, pp. e76455, http://dx.doi.org/10.1371/journal.pone.0076455
,2013, 'High-risk childhood acute lymphoblastic leukemia in first remission treated with novel intensive chemotherapy and allogeneic transplantation', Leukemia, 27, pp. 1497 - 1503, http://dx.doi.org/10.1038/leu.2013.44
,2013, 'B-blockers increase response to chemotherapy via direct antitumour and anti-angiogenic mechanisms in neuroblastoma', British Journal of Cancer, 108, pp. 2485 - 2494, http://dx.doi.org/10.1038/bjc.2013.205
,2013, 'ABCB1 (MDR1) polymorphisms and ovarian cancer progression and survival: A comprehensive analysis from the Ovarian Cancer Association Consortium and the Cancer Genome Atlas', Gynecologic Oncology, 131, pp. 8 - 14, http://dx.doi.org/10.1016/j.ygyno.2013.07.107
,2013, 'Cell-based methods for the identification of Myc-inhibitory small molecules', Methods in Molecular Biology, 1012, pp. 255 - 264, http://dx.doi.org/10.1007/978-1-62703-429-6_18
,2013, 'Direct effects of Bmi1 on p53 protein stability inactivates oncoprotein stress responses in embryonal cancer precursor cells at tumor initiation', Oncogene, 32, pp. 3616 - 3626, http://dx.doi.org/10.1038/onc.2012.368
,2013, 'FBXW7 regulates glucocorticoid response in T-cell acute lymphoblastic leukaemia by targeting the glucocorticoid receptor for degradation', Leukemia, 27, pp. 1053 - 1062, http://dx.doi.org/10.1038/leu.2012.361
,2013, 'The histone deacetylase SIRT2 stabilizes Myc oncoproteins', Cell Death and Differentiation, 20, pp. 503 - 514, http://dx.doi.org/10.1038/cdd.2012.147
,2013, 'TRIM16 overexpression induces apoptosis through activation of caspase-2 in cancer cells', Apoptosis, 18, pp. 639 - 651, http://dx.doi.org/10.1007/s10495-013-0813-y
,2012, 'ABCC4/MRP4: a MYCN-regulated transporter and potential therapeutic target in neuroblastoma', FRONTIERS IN ONCOLOGY, 2, http://dx.doi.org/10.3389/fonc.2012.00178
,2012, 'Epigenetic Elimination of Mixed-Lineage Leukemia Leukemic Stem Cells by a Potent Small Molecule PRC2 Inhibitor.', Blood, 120, pp. 2456, http://dx.doi.org/10.1182/blood.v120.21.2456.2456
,2012, 'Abstract 68: Beyond GWAS: The prognostic significance of promoter DNA methylation in patients with neuroblastoma.', Cancer Epidemiology, Biomarkers & Prevention, 21, pp. 68 - 68, http://dx.doi.org/10.1158/1055-9965.gwas-68
,2012, 'Prognostic significance of promoter DNA methylation in patients with neuroblastoma', CANCER RESEARCH, 72, http://dx.doi.org/10.1158/1538-7445.AM2012-1425
,2012, 'Highly sensitive MRD tests for ALL based on the IKZF1 Delta 3-6 microdeletion', Leukemia, 26, pp. 1414 - 1416, http://dx.doi.org/10.1038/leu.2011.348
,2012, 'N-Myc Regulates Expression of the Detoxifying Enzyme Glutathione Transferase GSTP1, a Marker of Poor Outcome in Neuroblastoma', Cancer Research, 72, pp. 845 - 853, http://dx.doi.org/10.1158/0008-5472.CAN-11-1885
,2012, 'Polyamine pathway inhibition as a novel therapeutic approach to treating neuroblastoma', Frontiers in Oncology, 2, pp. 1 - 10, http://dx.doi.org/10.3389/fonc.2012.00162
,2012, 'Prognostic Significance of Promoter DNA Methylation in Patients with Childhood Neuroblastoma', Clinical Cancer Research, 18, pp. 5690 - 5700, http://dx.doi.org/10.1158/1078-0432.CCR-12-0294
,2012, 'The retinoid signalling molecule, TRIM16, is repressed during squamous cell carcinoma skin carcinogenesis in vivo and reduces skin cancer cell migration in vitro', Journal of Pathology, 226, pp. 451 - 462, http://dx.doi.org/10.1002/path.2986
,2011, 'ABCC Multidrug Transporters in Childhood Neuroblastoma: Clinical and Biological Effects Independent of Cytotoxic Drug Efflux', Journal of the National Cancer Institute, 103, pp. 1236 - 1251, http://dx.doi.org/10.1093/jnci/djr256
,2011, 'ABCC1 G2012T single nucleotide polymorphism is associated with patient outcome in primary neuroblastoma and altered stability of the ABCC1 gene transcript', Pharmacogenetics and Genomics, 21, pp. 270 - 279, http://dx.doi.org/10.1097/FPC.00b013e328343dd5f
,2011, 'c-MYC Oncoprotein Dictates Transcriptional Profiles of ATP-Binding Cassette Transporter Genes in Chronic Myelogenous Leukemia CD34(+) Hematopoietic Progenitor Cells', Molecular Cancer Research, 9, pp. 1054 - 1066, http://dx.doi.org/10.1158/1541-7786.MCR-10-0510
,2011, 'HLA-G polymorphisms, genetic susceptibility, and clinical outcome in chidlhood neuroblastoma', Tissue Antigens, 78, pp. 421 - 427, http://dx.doi.org/10.1111/j.1399-0039.2011.01781.x
,2011, 'SIRT1 promotes N-Myc oncogenesis through a positive feedback loop involving the effects of MKP3 and ERK on N-Myc protein stability', PLOS Genetics, 7, pp. e1 - e14, http://dx.doi.org/10.1371/journal.pgen.1002135
,2010, 'ABC transporters in cancer: more than just drug efflux pumps', Nature Reviews Cancer, 10, pp. 147 - 156, http://dx.doi.org/10.1038/nrc2789
,2010, 'Direct and Coordinate Regulation of ATP-binding Cassette Transporter Genes by Myc Factors Generates Specific Transcription Signatures That Significantly Affect the Chemoresistance Phenotype of Cancer Cells', The Journal of Biological Chemistry, 285, pp. 19532 - 19543, http://dx.doi.org/10.1074/jbc.M109.078584
,2010, 'Isolated testicular relapse after allo-SCT in boys with ALL: outcome without second transplant', Bone Marrow Transplantation, 45, pp. 397 - 399, http://dx.doi.org/10.1038/bmt.2009.138
,2010, 'Maternal folate and other vitamin supplementation during pregnancy and risk of acute lymphoblastic leukemia in the offspring', International Journal of Cancer, 126, pp. 2690 - 2699, http://dx.doi.org/10.1002/ijc.24969
,2010, 'miR-380-5p represses p53 to control cellular survival and is associated with poor outcome in MYCN-amplified neuroblastoma', Nature Medicine, 16, pp. 1134 - 1141, http://dx.doi.org/10.1038/nm.2227
,2010, 'Opposing Effects of Two Tissue Transglutaminase Protein Isoforms in Neuroblastoma Cell Differentiation', The Journal of Biological Chemistry, 285, pp. 3561 - 3567, http://dx.doi.org/10.1074/jbc.M109.053041
,2010, 'Transcriptional upregulation of histone deacetylase 2 promotes Myc-induced oncogenic effects', Oncogene, 29, pp. 5957 - 5968, http://dx.doi.org/10.1038/onc.2010.332
,2010, 'TRIM16 acts as a tumour suppressor by inhibitory effects on cytoplasmic vimentin and nuclear E2F1 in neuroblastoma cells', Oncogene, 29, pp. 6172 - 6183, http://dx.doi.org/10.1038/onc.2010.340
,2009, 'DUAL TARGETING OF AMD1 AND ODC1 POTENTLY INHIBITS NEUROBLASTOMA INITIATION IN THE TH-MYCN MOUSE MODEL', PEDIATRIC BLOOD & CANCER, 52, pp. 731 - 731, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000264515600128&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
,2009, 'ATP7A is a novel target of retinoic acid receptor beta(2) in neuroblastoma cells', British Journal of Cancer, 100, pp. 96 - 105, http://dx.doi.org/10.1038/sj.bjc.6604833
,2009, 'Clinical significance of minimal residual disease at day 15 and at the end of therapy in childhood acute lymphoblastic leukaemia', British Journal of Haematology, 146, pp. 292 - 299, http://dx.doi.org/10.1111/j.1365-2141.2009.07744.x
,2009, 'Determining the repertoire of IGH gene rearrangements to develop molecular markers for minimal residual disease in B-lineage acute lymphoblastic leukemia', Journal of Molecular Diagnostics, 11, pp. 194 - 200, http://dx.doi.org/10.2353/jmoldx.2009.080047
,2009, 'Optimization of the antitumor efficacy of a synthetic mitochondrial toxin by increasing the residence time in the cytosol', Journal of Medicinal Chemistry, 52, pp. 6209 - 6216, http://dx.doi.org/10.1021/jm9008339
,2009, 'Over-expression of clusterin is a resistance factor to the anti-cancer effect of histone deacetylase inhibitors', European Journal of Cancer, 45, pp. 1846 - 1854, http://dx.doi.org/10.1016/j.ejca.2009.03.002
,2009, 'Patched1 deletion increases N-Myc protein stability as a mechanism of medulloblastoma initiation and progression', Oncogene, 28, pp. 1605 - 1615, http://dx.doi.org/10.1038/onc.2009.3
,2009, 'Reduced folate carrier and methylenetetrahydrofolate reductase gene polymorphisms: associations with clinical outcome in childhood acute lymphoblastic leukemia', Leukemia, 23, pp. 1348 - 1351, http://dx.doi.org/10.1038/leu.2009.67
,2009, 'Sensitive and specific measurement of minimal residual disease in acute lymphoblastic leukemia', Journal of Molecular Diagnostics, 11, pp. 201 - 210, http://dx.doi.org/10.2353/jmoldx.2009.080048
,2009, 'Small-Molecule Multidrug Resistance-Associated Protein 1 Inhibitor Reversan Increases the Therapeutic Index of Chemotherapy in Mouse Models of Neuroblastoma', Cancer research, 69, pp. 6573 - 6580, http://dx.doi.org/10.1158/0008-5472.CAN-09-1075
,2009, 'The cyclin-dependent kinase inhibitor, p21WAF1, promotes angiogenesis by repressing gene transcription of thioredoxin-binding protein 2 in cancer cells', Carcinogenesis, 30, pp. 1865 - 1871, http://dx.doi.org/10.1093/carcin/bgp225
,2009, 'The estrogen-responsive B box protein (EBBP) restores retinoid sensitivity in retinoid-resistant cancer cells via effects on histone acetylation', Cancer Letters, 277, pp. 82 - 90, http://dx.doi.org/10.1016/j.canlet.2008.11.030
,2008, 'A xenograft model of infant leukaemia reveals a complex MLL translocation', British Journal of Haematology, 140, pp. 716 - 719, http://dx.doi.org/10.1111/j.1365-2141.2007.06966.x
,2008, 'Improving minimal residual disease detection in precursor B-ALL based on immunoglobulin-j and heavy-chain gene rearrangements', Leukemia, 22, pp. 2265 - 2267
,2008, 'Induction of T cell-mediated immunity using a c-Myb DNA vaccine in a mouse model of colon cancer', Cancer Immunology and Immunotherapy, 57, pp. 1635 - 1645
,2008, 'Mechanism of relapse in pediatric acute lymphoblastic leukemia', Cell Cycle, 7, pp. 1315 - 1320
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