By Professor Murray David Norris

Journal articles

Lau DT; Flemming CL; Gherardi S; Perini G; Oberthuer A; Fischer M; Juraeva D; Brors B; Xue C; Norris MD; Marshall GM; Haber M; Fletcher JI; Ashton LJ, 2015, 'MYCN amplification confers enhanced folate dependence and methotrexate sensitivity in neuroblastoma', Oncotarget, 6, pp. 15510 - 15523, http://dx.doi.org/10.18632/oncotarget.3732

Dietrich PA; Yang C; Leung HHL; Lynch JR; Gonzales E; Liu B; Haber M; Norris MD; Wang J; Wang JY; Gonzales-Aloy E, 2014, 'GPR84 sustains aberrant β-catenin signaling in leukemic stem cells for maintenance of MLL leukemogenesis', Blood, 124, pp. 3284 - 3294, http://dx.doi.org/10.1182/blood-2013-10-532523

Cheung L; Flemming CL; Watt F; Masada N; Yu DMT; Huynh T; Conseil G; Tivnan A; Polinsky A; Gudkov AV; Munoz MA; Vishvanath A; Cooper DMF; Henderson MJ; Cole SPC; Fletcher JI; Haber M; Norris MD, 2014, 'High-throughput screening identifies Ceefourin 1 and Ceefourin 2 as highly selective inhibitors of multidrug resistance protein 4 (MRP4)', Biochemical Pharmacology, 91, pp. 97 - 108, http://dx.doi.org/10.1016/j.bcp.2014.05.023

Hedditch EL; Gao B; Russell AJ; Lu Y; Emmanuel C; Beesley J; Johnatty SE; Chen X; Harnett P; George J; Williams RT; Flemming C; Lambrechts D; Despierre E; Lambrechts S; Vergote I; Karlan B; Lester J; Orsulic S; Walsh C; Fasching P; Beckmann MW; Ekici AB; Hein A; Matsuo K; Hosono S; Nakanishi T; Yatabe Y; Pejovic T; Bean Y; Heitz F; Harter P; Du Bois A; Schwaab I; Hogdall E; Kjaer SK; Jensen A; Hogdall C; Lundvall L; Engelholm SA; Brown B; Flanagan J; Metcalf MD; Siddiqui N; Sellers T; Fridley B; Cunningham J; Schildkraut J; Iversen E; Weber RP; Berchuck A; Goode E; Bowtell DD; Chenevix-Trench G; Defazio A; Norris MD; Macgregor S; Haber M; Henderson MJ, 2014, 'ABCA transporter gene expression and poor outcome in epithelial ovarian cancer', Journal of the National Cancer Institute, 106, pp. dju149, http://dx.doi.org/10.1093/jnci/dju149

Gao B; Russell A; Beesley J; Chen XQ; Healey S; Henderson M; Wong M; Emmanuel C; Galletta L; Johnatty SE; Bowtell D; Haber M; Norris M; Harnett P; Chenevix-Trench G; Balleine RL; Defazio A; Gertig D; Green A; Webb P; Hung J; Moore S; Traficante N; Fereday S; Harrap K; Sadkowsky T; Pandeya N; Stuart-Harris R; Kirsten F; Rutovitz J; Clingan P; Glasgow A; Proietto A; Braye S; Otton G; Shannon J; Bonaventura T; Stewart J; Begbie S; Friedlander M; Bell D; Baron-Hay S; Ferrier A; Gard G; Nevell D; Pavlakis N; Valmadre S; Young B; Camaris C; Crouch R; Edwards L; Hacker N; Marsden D; Robertson G; Beale P; Beith J; Carter J; Dalrymple C; Hamilton A; Houghton R; Russell P; Links M; Grygiel J; Hill J; Brand A; Byth K; Jaworski R; Sharma R; Achen A; Wain G; Ward B; Papadimos D; Crandon A; Cummings M; Horwood K; Obermair A; Perrin L; Wyld D; Nicklin J; Davy M; Oehler MK; Hall C; Dodd T; Healy T; Pittman K; Henderson D; Miller J; Pierdes J; Blomfield P; Challis D; McIntosh R; Parker A; Brown B; Rome R; Allen D; Grant P; Hyde S; Laurie R; Robbie M; Healy D; Underhill C, 2014, 'Paclitaxel sensitivity in relation to ABCB1 expression, efflux and single nucleotide polymorphisms in ovarian cancer', Scientific Reports, 4, pp. 4669, http://dx.doi.org/10.1038/srep04669

Heong V; Topp M; Rutkowski R; Ananda S; Wong S; Swisher E; Lindeman G; Haber M; Norris MD; Haluska P; Wakefield M; Bowtell D; Scott CL; Lindeman G, 2014, 'USE OF NOVEL PATIENT-DERIVED XENOGRAFTS AND MOLECULAR SUBTYPING TO IMPROVE PRECISION MEDICINE IN HIGH-GRADE SEROUS OVARIAN CANCER', EUROPEAN JOURNAL OF CANCER, 50, pp. E9 - E9, http://dx.doi.org/10.1016/j.ejca.2014.03.042

Tee EL; Ling D; Nelson C; Atmadibrata B; Dinger M; XU N; Mizukami T; Liu PY; Liu B; Cheung B; Pasquier E; Haber M; Norris MD; Suzuki T; Marshall GM; Liu T, 2014, 'The histone demethylase JMJD1A induces cell migration and invasion by up-regulating the expression of the long noncoding RNA MALAT1', Oncotarget, 5, pp. 1793 - 1804, http://dx.doi.org/10.18632/oncotarget.1785

Kim PY; Tan O; Diakiw SM; Carter D; Sekerye EO; Wasinger VC; Liu T; Kavallaris M; Norris MD; Haber M; Chesler L; Dolnikov A; Trahair TN; Cheung NK; Marshall GM; Cheung BB; Sekyere E, 2014, 'Identification of plasma Complement C3 as a potential biomarker for neuroblastoma using a quantitative proteomic approach', Journal of Proteomics, 96, pp. 1 - 12, http://dx.doi.org/10.1016/j.jprot.2013.10.032

Dorstyn L; Puccini J; Nikolic A; Shalini S; Wilson CH; Norris MD; Haber M; Kumar S, 2014, 'An unexpected role for caspase-2 in neuroblastoma', Cell Death and Disease, 5, pp. e1383 - e1383, http://dx.doi.org/10.1038/cddis.2014.342

Shahbazi J; Scarlett CJ; Norris MD; Liu B; Haber M; Tee AE; Carrier A; Biankin AV; London WB; Marshall GM; Lock RB; Liu T, 2014, 'Histone Deacetylase 2 and N-Myc reduce p53 protein phosphorylation at serine 46 by repressing gene transcription of tumor protein 53-induced nuclear protein 1', Oncotarget, 5, pp. 4257 - 4268, http://dx.doi.org/10.18632/oncotarget.1991

Saletta F; Wadham C; Ziegler DS; Marshall GM; Haber M; McCowage G; Norris MD; Byrne JA, 2014, 'Molecular profiling of childhood cancer: Biomarkers and novel therapies', Bba Clinical, 1, pp. 59 - 77, http://dx.doi.org/10.1016/j.bbacli.2014.06.003

Saletta F; Wadham C; Byrne J; Ziegler D; McCowage G; Haber M; Marshall G; Norris M, 2014, '421 Molecular profiling for factors predicting sensitivity or resistance to therapy in relapsed child cancer', European Journal of Cancer, 50, pp. 135, http://dx.doi.org/10.1016/s0959-8049(14)70547-7

Norris MD, 2014, 'Neuroblastoma: molecular targets and novel therapies', Pathology, 46, pp. S36 - S36, http://dx.doi.org/10.1097/01.pat.0000454208.74479.75

Dietrich PA; Norris MD; Wang JY, 2013, 'GPR84, a Proinflammatory Receptor, Sustains Wnt/β-Catenin Signaling In Leukemic Stem Cells For Maintenance Of MLL-AF9-Induced Leukemogenesis', Blood, 122, pp. 3781, http://dx.doi.org/10.1182/blood.v122.21.3781.3781

Karsa M; Dalla Pozza L; Venn NC; Law T; Shi R; Giles JE; Bahar AY; Cross S; Catchpoole D; Haber M; Marshall GM; Norris MD; Sutton R, 2013, 'Improving the Identification of High Risk Precursor B Acute Lymphoblastic Leukemia Patients with Earlier Quantification of Minimal Residual Disease', PLoS ONE, 8, pp. e76455, http://dx.doi.org/10.1371/journal.pone.0076455

Marshall GM; Dalla Pozza L; Sutton R; Ng A; De Groot-Kruseman HA; Van Der Velden VH; Venn NC; Van Den Berg H; De Bont ESJM; Maarten Egeler R; Hoogerbrugge PM; Kaspers GJL; Bierings MB; Van Der Schoot E; Van Dongen J; Law T; Cross S; Mueller H; De Haas V; Haber M; Révész T; Alvaro F; Suppiah R; Norris MD; Pieters R, 2013, 'High-risk childhood acute lymphoblastic leukemia in first remission treated with novel intensive chemotherapy and allogeneic transplantation', Leukemia, 27, pp. 1497 - 1503, http://dx.doi.org/10.1038/leu.2013.44

Pasquier E; Street J; Pouchy C; Carre M; Gifford AJ; Murray J; Norris MD; Trahair T; Andre N; Kavallaris M, 2013, 'B-blockers increase response to chemotherapy via direct antitumour and anti-angiogenic mechanisms in neuroblastoma', British Journal of Cancer, 108, pp. 2485 - 2494, http://dx.doi.org/10.1038/bjc.2013.205

Johnatty SE; Beesley J; Gao B; Chen X; Lu Y; Law MH; Henderson MJ; Russell AJ; Hedditch EL; Emmanuel C; Fereday S; Webb PM; Goode EL; Vierkant RA; Fridley BL; Cunningham JM; Fasching PA; Beckmann MW; Ekici AB; Hogdall E; Kjaer SK; Jensen A; Hogdall C; Brown R; Paul J; Lambrechts S; Despierre E; Vergote I; Lester J; Karlan BY; Heitz F; Du Bois A; Harter P; Schwaab I; Bean Y; Pejovic T; Levine DA; Goodman MT; Camey ME; Thompson PJ; Lurie G; Shildkraut J; Berchuck A; Terry KL; Cramer DW; Norris MD; Haber M; MacGregor S; DeFazio A; Chenevix-Trench G, 2013, 'ABCB1 (MDR1) polymorphisms and ovarian cancer progression and survival: A comprehensive analysis from the Ovarian Cancer Association Consortium and the Cancer Genome Atlas', Gynecologic Oncology, 131, pp. 8 - 14, http://dx.doi.org/10.1016/j.ygyno.2013.07.107

Burkhart CA; Haber M; Norris MD; Gudkov AV; Nikiforov MA, 2013, 'Cell-based methods for the identification of Myc-inhibitory small molecules', Methods in Molecular Biology, 1012, pp. 255 - 264, http://dx.doi.org/10.1007/978-1-62703-429-6_18

Sekyere E; Thomas WD; Keating J; Calao M; Cui HJ; Chen JB; Raif A; Jankowski K; Cheung B; Davies NP NP; Trahair TN; Liu T; Wainwright BJ; Ding HF; Marshall GM; Haber M; Norris M; Tan O; Chen B; van Bekkum M, 2013, 'Direct effects of Bmi1 on p53 protein stability inactivates oncoprotein stress responses in embryonal cancer precursor cells at tumor initiation', Oncogene, 32, pp. 3616 - 3626, http://dx.doi.org/10.1038/onc.2012.368

Malyukova A; Papa R; O'Brien R; Giles JE; Trahair TN; Pozza LD; Sutton R; Liu T; Haber M; Norris MD; Lock RB; Marshall GM; Giles J, 2013, 'FBXW7 regulates glucocorticoid response in T-cell acute lymphoblastic leukaemia by targeting the glucocorticoid receptor for degradation', Leukemia, 27, pp. 1053 - 1062, http://dx.doi.org/10.1038/leu.2012.361

Liu PY; Xu N; Malyukova A; Scarlett CJ; Sun YT; Zhang XD; Ling D; Su SP; Nelson CA; Chang DK; Koach J; Tee AE; Haber M; Norris MD; Rooman I; Toon C; Xue C; Cheung B; Kumar S; Marshall GM; Biankin AV; Liu T; Shih-Ping Su J; Toon CCW, 2013, 'The histone deacetylase SIRT2 stabilizes Myc oncoproteins', Cell Death and Differentiation, 20, pp. 503 - 514, http://dx.doi.org/10.1038/cdd.2012.147

Kim PY; Rahmanto AS; Tan O; Norris MD; Haber M; Marshall GM; Cheung BB; Suryo Rahmanto A, 2013, 'TRIM16 overexpression induces apoptosis through activation of caspase-2 in cancer cells', Apoptosis, 18, pp. 639 - 651, http://dx.doi.org/10.1007/s10495-013-0813-y

Huynh T; Norris MD; Haber M; Henderson MJ, 2012, 'ABCC4/MRP4: a MYCN-regulated transporter and potential therapeutic target in neuroblastoma', FRONTIERS IN ONCOLOGY, 2, http://dx.doi.org/10.3389/fonc.2012.00178

Wang JY; Sprod O; Haber M; Norris MD, 2012, 'Epigenetic Elimination of Mixed-Lineage Leukemia Leukemic Stem Cells by a Potent Small Molecule PRC2 Inhibitor.', Blood, 120, pp. 2456, http://dx.doi.org/10.1182/blood.v120.21.2456.2456

Lau DT; Hesson LB; Norris MD; Marshall G; Haber M; Ashton LJ, 2012, 'Abstract 68: Beyond GWAS: The prognostic significance of promoter DNA methylation in patients with neuroblastoma.', Cancer Epidemiology, Biomarkers & Prevention, 21, pp. 68 - 68, http://dx.doi.org/10.1158/1055-9965.gwas-68

Lau DT; Hesson LB; Norris MD; Haber M; Marshall GM; Ashton LJ, 2012, 'Prognostic significance of promoter DNA methylation in patients with neuroblastoma', CANCER RESEARCH, 72, http://dx.doi.org/10.1158/1538-7445.AM2012-1425

Venn NC; Van der velden VHJ; De bie M; Waanders E; Giles JE; Law T; Kuiper RP; de Haas V; Mullighan CG; Haber M; Marshall GM; Norris MD; Van dongen JJM; Sutton R; Giles J; Law T, 2012, 'Highly sensitive MRD tests for ALL based on the IKZF1 Delta 3-6 microdeletion', Leukemia, 26, pp. 1414 - 1416, http://dx.doi.org/10.1038/leu.2011.348

Fletcher JI; Gherardi S; Murray J; Burkhart C; Russell A; Valli E; Smith J; Oberthuer A; Ashton LJ; London WB; Marshall GM; Norris MD; Perini G; Haber M, 2012, 'N-Myc Regulates Expression of the Detoxifying Enzyme Glutathione Transferase GSTP1, a Marker of Poor Outcome in Neuroblastoma', Cancer Research, 72, pp. 845 - 853, http://dx.doi.org/10.1158/0008-5472.CAN-11-1885

Gamble LD; Hogarty MD; Liu X; Ziegler DS; Marshall GM; Norris MD; Haber M; Gamble L, 2012, 'Polyamine pathway inhibition as a novel therapeutic approach to treating neuroblastoma', Frontiers in Oncology, 2, pp. 1 - 10, http://dx.doi.org/10.3389/fonc.2012.00162

Lau DT; Hesson L; Norris MD; Marshall GM; Haber M; Ashton LJ, 2012, 'Prognostic Significance of Promoter DNA Methylation in Patients with Childhood Neuroblastoma', Clinical Cancer Research, 18, pp. 5690 - 5700, http://dx.doi.org/10.1158/1078-0432.CCR-12-0294

Cheung BB; Koach J; Tan O; Kim P; Bell J; D'andreti C; Sutton S; Malyukova A; Sekyere E; Norris MD; Haber M; Kavallaris M; Cunningham AM; Proby C; Leigh I; Wilmott J; Cooper C; Halliday GM; Scolyer RA; Marshall GM, 2012, 'The retinoid signalling molecule, TRIM16, is repressed during squamous cell carcinoma skin carcinogenesis in vivo and reduces skin cancer cell migration in vitro', Journal of Pathology, 226, pp. 451 - 462, http://dx.doi.org/10.1002/path.2986

Henderson M; Haber M; Porro A; Munoz M; Xue C; Murray JE; Flemming C; Smith J; Fletcher JI; Gherardi S; Kwek C; Russell AJ; Valli E; London WB; Buxton AB; Ashton LJ; Sartorelli AC; Cohn SL; Schwab M; Marshall GM; Perini G; Norris MD; Kwek C-K, 2011, 'ABCC Multidrug Transporters in Childhood Neuroblastoma: Clinical and Biological Effects Independent of Cytotoxic Drug Efflux', Journal of the National Cancer Institute, 103, pp. 1236 - 1251, http://dx.doi.org/10.1093/jnci/djr256

Pajic M; Murray JE; Marshall GM; Cole SPC; Norris MD; Haber M, 2011, 'ABCC1 G2012T single nucleotide polymorphism is associated with patient outcome in primary neuroblastoma and altered stability of the ABCC1 gene transcript', Pharmacogenetics and Genomics, 21, pp. 270 - 279, http://dx.doi.org/10.1097/FPC.00b013e328343dd5f

Porro A; Iraci N; Soverini S; Diolaiti D; Gherardi S; Terragna C; Durante S; Valli E; Kalebic T; Bernardoni R; Perrod C; Haber M; Norris MD; Baccarani M; Martinelli G; Perini G, 2011, 'c-MYC Oncoprotein Dictates Transcriptional Profiles of ATP-Binding Cassette Transporter Genes in Chronic Myelogenous Leukemia CD34(+) Hematopoietic Progenitor Cells', Molecular Cancer Research, 9, pp. 1054 - 1066, http://dx.doi.org/10.1158/1541-7786.MCR-10-0510

Lau DTT; Norris MD; Marshall GM; Haber M; Ashton LJ, 2011, 'HLA-G polymorphisms, genetic susceptibility, and clinical outcome in chidlhood neuroblastoma', Tissue Antigens, 78, pp. 421 - 427, http://dx.doi.org/10.1111/j.1399-0039.2011.01781.x

Marshall GM; Liu PY; Gherardi S; Scarlett CJ; Bedalov A; Xu N; Iraci N; Valli E; Ling D; Thomas W; Van bekkum M; Sekyere E; Jankowski K; Trahair T; Mackenzie K; Haber M; Norris MD; Biankin AV; Perini G; Liu T, 2011, 'SIRT1 promotes N-Myc oncogenesis through a positive feedback loop involving the effects of MKP3 and ERK on N-Myc protein stability', PLOS Genetics, 7, pp. e1 - e14, http://dx.doi.org/10.1371/journal.pgen.1002135

Fletcher JI; Haber M; Henderson M; Norris MD, 2010, 'ABC transporters in cancer: more than just drug efflux pumps', Nature Reviews Cancer, 10, pp. 147 - 156, http://dx.doi.org/10.1038/nrc2789

Porro A; Haber M; Diolaiti D; Iraci N; Henderson M; Gherardi S; Valli E; Munoz M; Xue C; Flemming C; Schwab M; Wong JH; Marshall GM; Della valle G; Norris MD; Perini G, 2010, 'Direct and Coordinate Regulation of ATP-binding Cassette Transporter Genes by Myc Factors Generates Specific Transcription Signatures That Significantly Affect the Chemoresistance Phenotype of Cancer Cells', The Journal of Biological Chemistry, 285, pp. 19532 - 19543, http://dx.doi.org/10.1074/jbc.M109.078584

Bhadri V; McGregor MR; Venn NC; Hackenberg N; Russell SJ; Norris MD; Haber M; Sutton R; Marshall GM, 2010, 'Isolated testicular relapse after allo-SCT in boys with ALL: outcome without second transplant', Bone Marrow Transplantation, 45, pp. 397 - 399, http://dx.doi.org/10.1038/bmt.2009.138

Milne E; Royle JA; Miller M; Bower C; de klerk NH; Bailey HD; Van brockxmeer F; Attia J; Scott RJ; Norris MD; Haber M; Thompson JR; Fritschi L; Marshall GM; Armstrong B, 2010, 'Maternal folate and other vitamin supplementation during pregnancy and risk of acute lymphoblastic leukemia in the offspring', International Journal of Cancer, 126, pp. 2690 - 2699, http://dx.doi.org/10.1002/ijc.24969

Swarbrick A; Woods SL; Shaw A; Balakrishnan A; Phua Y; Nguyen A; Chanthery Y; Lim L; Ashton LJ; Judson RL; Blelloch R; Huskey N; Haber M; Norris MD; Lengyel P; Hackett CS; Preiss T; Chetcuti A; Sullivan CS; Marcusson EG; Weiss W; L''Etoile N; Goga A, 2010, 'miR-380-5p represses p53 to control cellular survival and is associated with poor outcome in MYCN-amplified neuroblastoma', Nature Medicine, 16, pp. 1134 - 1141, http://dx.doi.org/10.1038/nm.2227

Liu T, 2010, 'Opposing Effects of Two Tissue Transglutaminase Protein Isoforms in Neuroblastoma Cell Differentiation', The Journal of Biological Chemistry, 285, pp. 3561 - 3567, http://dx.doi.org/10.1074/jbc.M109.053041

Marshall GM; Gherardi S; Xu N; Neiron Z; Trahair TN; Scarlett CJ; Chang DK; Liu PY; Jankowski K; Iraci N; Haber M; Norris MD; Keating J; Sekyere E; Jonquieres G; Biankin AV; Stossi F; Katzenellenbogen BS; Perini G; Liu T, 2010, 'Transcriptional upregulation of histone deacetylase 2 promotes Myc-induced oncogenic effects', Oncogene, 29, pp. 5957 - 5968, http://dx.doi.org/10.1038/onc.2010.332

Liu T; Bell J; Koach J; Malyukova A; Thomas W; Sekyere E; Cunningham A; Norris M; Haber M; Kavallaris M; Cheung B-B; Kim P; Tan O; marshall G, 2010, 'TRIM16 acts as a tumour suppressor by inhibitory effects on cytoplasmic vimentin and nuclear E2F1 in neuroblastoma cells', Oncogene, 29, pp. 6172 - 6183, http://dx.doi.org/10.1038/onc.2010.340

Evageliou N; Vu A; Liu X; Barr R; Hayes C; Norris M; Marshall G; Haber M; Gilmour S; Hogarty M, 2009, 'DUAL TARGETING OF AMD1 AND ODC1 POTENTLY INHIBITS NEUROBLASTOMA INITIATION IN THE TH-MYCN MOUSE MODEL', PEDIATRIC BLOOD & CANCER, 52, pp. 731 - 731, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000264515600128&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Bohlken A; Cheung B; Bell J; Koach J; Smith S; Sekyere E; Thomas WD; Norris MD; Haber M; Lovejoy DB; Richardson DR; Marshall GM, 2009, 'ATP7A is a novel target of retinoic acid receptor beta(2) in neuroblastoma cells', British Journal of Cancer, 100, pp. 96 - 105, http://dx.doi.org/10.1038/sj.bjc.6604833

Sutton R; Venn NC; Tolisano J; Bahar AY; Giles JE; Ashton LJ; Teague L; Rigutto G; Waters K; Marshall GM; Haber M; Norris MD; Giles J, 2009, 'Clinical significance of minimal residual disease at day 15 and at the end of therapy in childhood acute lymphoblastic leukaemia', British Journal of Haematology, 146, pp. 292 - 299, http://dx.doi.org/10.1111/j.1365-2141.2009.07744.x

Brisco MJ; Latham S; Sutton R; Hughes E; Wilczek V; Van Zanten K; Budgen B; Malec M; Sykes PJ; Kuss BJ; Waters K; Venn NC; Giles J; Haber M; Norris MD; Marshall GM; Morley AA; Bahar ; Giles J, 2009, 'Determining the repertoire of IGH gene rearrangements to develop molecular markers for minimal residual disease in B-lineage acute lymphoblastic leukemia', Journal of Molecular Diagnostics, 11, pp. 194 - 200, http://dx.doi.org/10.2353/jmoldx.2009.080047

Dilda P; Decollogne SM; Weerakoon L; Norris MD; Haber M; Allen JD; Hogg PJ, 2009, 'Optimization of the antitumor efficacy of a synthetic mitochondrial toxin by increasing the residence time in the cytosol', Journal of Medicinal Chemistry, 52, pp. 6209 - 6216, http://dx.doi.org/10.1021/jm9008339

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