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Conference Papers
, 2013, 'Abstract 3808: MYCN coordinately regulates the entire polyamine gene pathway to drive polyamine biosynthesis in neuroblastoma, with expression of every synthetic and catabolic polyamine pathway gene being highly prognostic of clinical outcome.', in Cancer Research, American Association for Cancer Research (AACR), pp. 3808 - 3808, http://dx.doi.org/10.1158/1538-7445.am2013-3808
, 2013, 'Abstract 5043: The facilitates chromatin transcription (FACT) protein complex promotes neuroblastoma tumor initiation.', in Cancer Research, American Association for Cancer Research (AACR), pp. 5043 - 5043, http://dx.doi.org/10.1158/1538-7445.am2013-5043
, 2012, 'Abstract 1834: Targeting ABC transporters in cancer through small molecule inhibitors', in Cancer Research, American Association for Cancer Research (AACR), pp. 1834 - 1834, http://dx.doi.org/10.1158/1538-7445.am2012-1834
, 2012, 'Abstract 789: GSTP1 expression is regulated by MycN and is a marker of poor outcome in childhood neuroblastoma', in Cancer Research, American Association for Cancer Research (AACR), pp. 789 - 789, http://dx.doi.org/10.1158/1538-7445.am2012-789
, 2011, 'Abstract 1660: Cholesterol efflux transporter gene expression predicts clinical outcome in serous ovarian cancer', in Cancer Research, American Association for Cancer Research (AACR), pp. 1660 - 1660, http://dx.doi.org/10.1158/1538-7445.am2011-1660
, 2011, 'Abstract 617: Small molecule that simultaneously inhibits Myc oncoprotein and activates HIF1A', in Cancer Research, American Association for Cancer Research (AACR), pp. 617 - 617, http://dx.doi.org/10.1158/1538-7445.am2011-617
, 2011, 'Abstract 954: ABCC/MRP multidrug transporters contribute to neuroblastoma biology, pathogenesis and clinical outcome, independently of any role in cytotoxic drug efflux', in Cancer Research, American Association for Cancer Research (AACR), pp. 954 - 954, http://dx.doi.org/10.1158/1538-7445.am2011-954
, 2011, 'Abstract LB-367: New evidence supports the potential use of methotrexate in children with MYCN -amplified neuroblastoma.', in Cancer Research, American Association for Cancer Research (AACR), pp. lb-367-lb-367, http://dx.doi.org/10.1158/1538-7445.am2011-lb-367
, 2010, 'Abstract 4869: Transcriptional upregulation of histone deacetylase 2 promotes Myc-induced oncogenic effects', in Cancer Research, American Association for Cancer Research (AACR), pp. 4869 - 4869, http://dx.doi.org/10.1158/1538-7445.am10-4869
, 2010, 'Abstract 888: Reduced folate carrier gene polymorphism (RFC 80G>A): Associations with clinical outcome in NMYC amplified neuroblastoma patients', in Cancer Research, American Association for Cancer Research (AACR), pp. 888 - 888, http://dx.doi.org/10.1158/1538-7445.am10-888
, 2009, 'A specific transcription signature of ABC transporter genes is dictated by Myc-family oncogenes: A powerful tool to predict clinical outcome', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000209701803375&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
, 2009, 'Dual Targeting of AMD1 and ODC1 potently inhibits neuroblastoma initiation in vitro and in vivo', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000209702803498&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
, 2009, 'Perinatal Myc signalling as a mechanism of embryonal cancer initiation', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000209702603052&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
, 2009, 'The role of N-Myc-induced HDAC2 over-expression in neuroblastoma', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000209701802056&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
, 2008, 'STABILIZATION OF THE MYCN ONCOPROTEIN AS A MECHANISM OF INITIATION AND PROGRESSION IN MEDULLOBLASTOMA RESULTING FROM SONIC HEDGEHOG PATHWAY ACTIVATION', in NEURO-ONCOLOGY, OXFORD UNIV PRESS INC, NV, Las Vegas, pp. 870 - 870, presented at 13th Annual Meeting of the Society-for-Neuro-Oncology (SNO), NV, Las Vegas, 20 November 2008 - 23 November 2008, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000259854500409&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
, 2008, 'Effective anti-colon cancer immunity induced through the targeting of the nuclear oncogene c-Myb by DNA vaccination in a mouse model', in ANNALS OF ONCOLOGY, OXFORD UNIV PRESS, SPAIN, Barcelona, pp. 77 - 77, presented at 10th World Congress on Gastrointestinal Cancer, SPAIN, Barcelona, 25 June 2008 - 28 June 2008, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000257951800259&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
, 2008, 'Abstract 5832: Overexpression of ODC1 is associated with poor outcome in childhood neuroblastoma and represents an important therapeutic target', in Cancer Research, American Association for Cancer Research (AACR), pp. 5832 - 5832, http://dx.doi.org/10.1158/1538-7445.am2008-5832
, 2008, 'Full-length tissue transglutaminase is a resistance factor for cell differentiation in neuroblastoma', in European Journal of Cancer Supplements, Elsevier, pp. 94, http://dx.doi.org/10.1016/s1359-6349(08)71539-8
, 2008, 'The role of the estrogen-responsive B box protein (EBBP) in cancer cell cycle progression', in European Journal of Cancer Supplements, Elsevier, pp. 95, http://dx.doi.org/10.1016/s1359-6349(08)71542-8
, 2007, 'Expression of the multidrug transporter genes ABCC1/MRP1, ABCC3/MRP3, and ABCC4/MRP4 are powerful predictors of clinical outcome in childhood neuroblastoma', in JOURNAL OF CLINICAL ONCOLOGY, AMER SOC CLINICAL ONCOLOGY, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000455043702481&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
, 2006, 'Characterization of a novel regulator of the retinoid signal: The estrogen-responsive B box protein.', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000454608804357&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
, 2006, 'MYCN interacts with histone deacetylase to modulate target gene transcription', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000454608802468&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
, 2006, 'Neuroblastoma tumor initiation: MYCN mediated mechanisms of resistance to cell death', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000454606201380&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
, 2006, 'Polymorphisms of glutathione-S-transferase and N-acetyltransferase genes and response to treatment in childhood neuroblastoma', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000454606202297&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
, 2006, 'Selective Sensitization of murine tumors to chemotherapy by a novel class of non-toxic small molecule inhibitors of MRP1', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000454606201252&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
, 2006, '393 POSTER The multidrug transporter MRP4/ABCC4 is a powerful marker of poor prognosis in neuroblastoma and a target for therapeutic suppression', in European Journal of Cancer Supplements, Elsevier, pp. 121, http://dx.doi.org/10.1016/s1359-6349(06)70398-6
, 2005, 'Neuroblastoma tumour initiation-A MYCN mediated aberration in embryonic nervous system development', in MECHANISMS OF DEVELOPMENT, ELSEVIER SCIENCE BV, pp. S181 - S181, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000207524100690&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
, 2003, 'Early markers of the therapeutic index in children with acute lymphoblastic leukaemia predict outcome.', in BLOOD, AMER SOC HEMATOLOGY, CALIFORNIA, SAN DIEGO, pp. 879A - 879A, presented at 45th Annual Meeting of the American-Society-of-Hematology, CALIFORNIA, SAN DIEGO, 06 December 2003 - 09 December 2003, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000186536703271&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
, 2002, 'Acquired beta-tubulin mutations affecting microtubule stability and drug binding', in MOLECULAR BIOLOGY OF THE CELL, AMER SOC CELL BIOLOGY, CALIFORNIA, SAN FRANCISCO, pp. 463A - 463A, presented at 42nd Annual Meeting of the American-Society-for-Cell-Biology, CALIFORNIA, SAN FRANCISCO, 14 December 2002 - 18 December 2002, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000179569102604&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
, 2001, 'Novel biological characteristics and disparate vincristine responses of primary childhood acute lymphoblastic leukemia cells engrafted into non-obese diabetic/severe combined immunodeficient mice.', in BLOOD, AMER SOC HEMATOLOGY, pp. 309A - 310A, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000172134101312&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
, 1999, 'Is the 5T mutation in intron 8 of the cystic fibrosis gene associated with alcoholic pancreatitis?', in Gastroenterology, W B Saunders Co, Philadelphia, PA, USA, pp. 114 A466, presented at Digestive Disease Week and the 99th Annual Meeting of the American Gastroenterological Association, New Orleans, Louisiana, USA, 17 May 1999 - 20 May 1999
, 1988, 'THERAPY-INDUCED RESISTANCE TO BOTH METHOTREXATE AND SOME NATURAL PRODUCT DRUGS IN A HUMAN-LEUKEMIA LINE (LALW-2)', in PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, pp. 311 - 311, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1988N264701236&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
Conference Posters
, 2026, 'Abstract 3979: Targeting nicotinamide metabolism with NAMPT-inhibitor OT-82 potentiates venetoclax in preclinical models of pediatric and adult acute myeloid leukemia', Vol. 86, pp. 3979 - 3979, http://dx.doi.org/10.1158/1538-7445.am2026-3979
, 2025, 'Inhibition of nicotinamide metabolism by the novel NAMPT inhibitor OT-82 potentiates venetoclax in paediatric and adult acute myeloid leukaemia models', Vol. 146, pp. 3282, http://dx.doi.org/10.1182/blood-2025-3282
, 2018, 'PO-405 Repositioning existing drugs as novel therapeutics for high-risk paediatric leukaemia', Vol. 3, pp. a181, http://dx.doi.org/10.1136/esmoopen-2018-eacr25.431
Conference Presentations
, 2014, 'Abstract 5138: Histone deacetylase 2 and N-Myc reduce p53 protein phosphorylation at serine 46 by repressing gene transcription of tumor protein 53-induced nuclear protein 1', http://dx.doi.org/10.1158/1538-7445.am2014-5138
Conference Abstracts
, 2025, 'Abstract B079: The glycogen synthase kinase-3β inhibitor 9-ING-41 in combination with chemoimmunotherapy provides long-term survival in the Th-MYCN mouse model', in Molecular Cancer Therapeutics, American Association for Cancer Research (AACR), Vol. 24, pp. b079 - b079, http://dx.doi.org/10.1158/1535-7163.targ-25-b079
, 2024, 'Abstract C018: Spatial profiling of tumor associated cells expressing endoplasmic reticulum stress proteins predicts poor outcomes in pancreatic cancer patients', in Cancer Research, American Association for Cancer Research (AACR), Vol. 84, pp. c018 - c018, http://dx.doi.org/10.1158/1538-7445.panca2023-c018
, 2024, '24 (PB012): Runx1t1 is an epigenetic regulator essential for MYCN-driven neuroblastoma tumorigenesis', in European Journal of Cancer, Elsevier, Vol. 211, pp. 114552, http://dx.doi.org/10.1016/j.ejca.2024.114552
, 2021, 'Targeting chromatin potently inhibits leukemia progression in MLL-rearranged leukemia models', in ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY, WILEY, Vol. 17, pp. 15 - 15
, 2021, 'HGG-09. TARGETING FACILITATES CHROMATIN TRANSCRIPTION (FACT) AS A NOVEL STRATEGY THAT ENHANCES RESPONSE TO HISTONE DEACETYLASE (HDAC) INHIBITION IN DIPG', in Neuro-Oncology, Oxford University Press (OUP), Vol. 23, pp. i18 - i19, http://dx.doi.org/10.1093/neuonc/noab090.075
, 2021, 'RARE-02. POLYAMINE PATHWAY INHIBITION IS A POTENT NOVEL THERAPEUTIC STRATEGY AGAINST DIFFUSE INTRINSIC PONTINE GLIOMA', in Neuro-Oncology, Oxford University Press (OUP), Vol. 23, pp. i40 - i41, http://dx.doi.org/10.1093/neuonc/noab090.163
, 2020, 'DIPG-15. POLYAMINE PATHWAY INHIBITION IS A POTENT NOVEL THERAPEUTIC STRATEGY AGAINST DIFFUSE INTRINSIC PONTINE GLIOMA', in Neuro-Oncology, Oxford University Press (OUP), Vol. 22, pp. iii289 - iii290, http://dx.doi.org/10.1093/neuonc/noaa222.065
, 2020, 'DIPG-16. COMBINATION OF ARGININE DEPLETION AND POLYAMINE INHIBITION AS AN ANTICANCER STRATEGY FOR DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG)', in Neuro-Oncology, Oxford University Press (OUP), Vol. 22, pp. iii290 - iii290, http://dx.doi.org/10.1093/neuonc/noaa222.066
, 2020, 'DIPG-27. TARGETING FACILITATES CHROMATIN TRANSCRIPTION (FACT) AS A NOVEL STRATEGY FOR DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG) THAT ENHANCES RESPONSE TO HISTONE DEACETYLASE (HDAC) INHIBITION', in Neuro-Oncology, Oxford University Press (OUP), Vol. 22, pp. iii292 - iii292, http://dx.doi.org/10.1093/neuonc/noaa222.076
, 2020, 'DIPG-75. PRECISION MEDICINE FOR PAEDIATRIC HIGH-GRADE DIFFUSE MIDLINE GLIOMAS - RESULTS FROM THE ZERO CHILDHOOD CANCER COMPREHENSIVE PRECISION MEDICINE PROGRAM', in Neuro-Oncology, Oxford University Press (OUP), Vol. 22, pp. iii302 - iii302, http://dx.doi.org/10.1093/neuonc/noaa222.117
, 2020, 'COMBINATION OF ARGININE DEPLETION AND POLYAMINE INHIBITION AS AN ANTICANCER STRATEGY FOR DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG)', in NEURO-ONCOLOGY, OXFORD UNIV PRESS INC, Vol. 22, pp. 290 - 290, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000606080100067&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
, 2020, 'Abstract SY09-02: Zero Childhood Cancer: A comprehensive precision medicine platform for children with high-risk cancer in Australia', in Cancer Research, American Association for Cancer Research (AACR), Vol. 80, pp. sy09-02-sy09-02, http://dx.doi.org/10.1158/1538-7445.am2020-sy09-02
, 2020, 'Abstract A35: P-Glycoprotein is a resistance mechanism for conventional induction chemotherapy but not ALK inhibitors in high-risk neuroblastoma', in Cancer Research, American Association for Cancer Research (AACR), Vol. 80, pp. a35 - a35, http://dx.doi.org/10.1158/1538-7445.pedca19-a35
, 2020, 'Abstract A52: Zero Childhood Cancer (ZERO): A comprehensive precision medicine platform for children with high-risk cancer', in Cancer Research, American Association for Cancer Research (AACR), Vol. 80, pp. a52 - a52, http://dx.doi.org/10.1158/1538-7445.pedca19-a52