By Professor Peter Gunning

Journal articles

Kumari R; Ven K; Chastney M; Kokate SB; Peränen J; Aaron J; Kogan K; Almeida-Souza L; Kremneva E; Poincloux R; Chew TL; Gunning PW; Ivaska J; Lappalainen P, 2024, 'Focal adhesions contain three specialized actin nanoscale layers', Nature Communications, 15, http://dx.doi.org/10.1038/s41467-024-46868-7

Xu T; Verhagen MP; Teeuwssen M; Sun W; Joosten R; Sacchetti A; Ewing-Graham PC; Jansen MPHM; Boere IA; Bryce NS; Zeng J; Treutlein HR; Hook J; Hardeman EC; Gunning PW; Fodde R, 2024, 'Tropomyosin1 isoforms underlie epithelial to mesenchymal plasticity, metastatic dissemination, and resistance to chemotherapy in high-grade serous ovarian cancer', Cell Death and Differentiation, 31, pp. 360 - 377, http://dx.doi.org/10.1038/s41418-024-01267-9

Mann Z; Lim F; Verma S; Nanavati BN; Davies JM; Begun J; Hardeman EC; Gunning PW; Subramanyam D; Yap AS; Duszyc K, 2023, 'Preexisting tissue mechanical hypertension at adherens junctions disrupts apoptotic extrusion in epithelia', Molecular Biology of the Cell, 35, http://dx.doi.org/10.1091/mbc.E23-08-0337

Zhao X; Alibhai D; Walsh TG; Tarassova N; Englert M; Birol SZ; Li Y; Williams CM; Neal CR; Burkard P; Cross SJ; Aitken EW; Waller AK; Beltrán JB; Gunning PW; Hardeman EC; Agbani EO; Nieswandt B; Hers I; Ghevaert C; Poole AW, 2023, 'Highly efficient platelet generation in lung vasculature reproduced by microfluidics', Nature Communications, 14, http://dx.doi.org/10.1038/s41467-023-39598-9

Wang D; Wang Y; Di X; Wang F; Wanninayaka A; Carnell M; Hardeman EC; Jin D; Gunning PW, 2023, 'Cortical tension drug screen links mitotic spindle integrity to Rho pathway', Current Biology, 33, pp. 4458 - 4469.e4, http://dx.doi.org/10.1016/j.cub.2023.09.022

Trevorrow P; Gunning P, 2022, 'An interview with Peter Gunning - School of Medical Sciences, UNSW Sydney, Australia', Cytoskeleton, 79, pp. 24 - 25, http://dx.doi.org/10.1002/cm.21715

Cagigas ML; Bryce NS; Ariotti N; Brayford S; Gunning PW; Hardeman EC, 2022, 'Correlative cryo-ET identifies actin/tropomyosin filaments that mediate cell–substrate adhesion in cancer cells and mechanosensitivity of cell proliferation', Nature Materials, 21, pp. 120 - 128, http://dx.doi.org/10.1038/s41563-021-01087-z

Hardeman EC; Heydecker M; Masedunskas A; Ebrahim S; Weigert R; Gunning PW, 2022, 'Intravital subcellular and single molecule imaging reveals multiple actin filament populations collaborate in the remodelling of the secretory granule membrane', Biophysical Journal, 121, pp. 297a - 298a, http://dx.doi.org/10.1016/j.bpj.2021.11.1268

Chaichim C; Tomanic T; Stefen H; Paric E; Gamaroff L; Suchowerska AK; Gunning PW; Ke YD; Fath T; Power J, 2021, 'Overexpression of tropomyosin isoform tpm3.1 does not alter synaptic function in hippocampal neurons', International Journal of Molecular Sciences, 22, http://dx.doi.org/10.3390/ijms22179303

Xu X; Wang Y; Bryce NS; Tang K; Meagher NS; Kang EY; Kelemen LE; Köbel M; Ramus SJ; Friedlander M; Ford CE; Hardeman EC; Gunning PW, 2021, 'Targeting the actin/tropomyosin cytoskeleton in epithelial ovarian cancer reveals multiple mechanisms of synergy with anti-microtubule agents', British Journal of Cancer, 125, pp. 265 - 276, http://dx.doi.org/10.1038/s41416-021-01420-y

Rae J; Ferguson C; Ariotti N; Webb RI; Cheng HH; Mead JL; Riches JD; Hunter DJB; Martel N; Baltos J; Christopoulos A; Bryce NS; Cagigas ML; Fonseka S; Sayre ME; Hardeman EC; Gunning PW; Gambin Y; Hall TE; Parton RG; Lastra Cagigas M, 2021, 'A robust method for particulate detection of a genetic tag for 3D electron microscopy', eLife, 10, pp. e64630, http://dx.doi.org/10.7554/ELIFE.64630

Tomanić T; Martin C; Stefen H; Parić E; Gunning P; Fath T, 2021, 'Deletion of the actin‐associated tropomyosin tpm3 leads to reduced cell complexity in cultured hippocampal neurons—new insights into the role of the c‐terminal region of tpm3.1', Cells, 10, http://dx.doi.org/10.3390/cells10030715

Janco M; Dedova I; Bryce NS; Hardeman EC; Gunning PW, 2020, 'Visualizing the in vitro assembly of tropomyosin/actin filaments using TIRF microscopy', Biophysical Reviews, 12, pp. 879 - 885, http://dx.doi.org/10.1007/s12551-020-00720-6

Wang Y; Stear JH; Swain A; Xu X; Bryce NS; Carnell M; Alieva IB; Dugina VB; Cripe TP; Stehn J; Hardeman EC; Gunning PW, 2020, 'Drug targeting the actin cytoskeleton potentiates the cytotoxicity of low dose vincristine by abrogating actin-mediated repair of spindle defects', Molecular Cancer Research, 18, pp. 1074 - 1087, http://dx.doi.org/10.1158/1541-7786.MCR-19-1122

Hardeman EC; Bryce NS; Gunning PW, 2020, 'Impact of the actin cytoskeleton on cell development and function mediated via tropomyosin isoforms', Seminars in Cell and Developmental Biology, 102, pp. 122 - 131, http://dx.doi.org/10.1016/j.semcdb.2019.10.004

Abouelezz A; Stefen H; Segerstråle M; Micinski D; Minkeviciene R; Lahti L; Hardeman EC; Gunning PW; Hoogenraad CC; Taira T; Fath T; Hotulainen P, 2020, 'Tropomyosin Tpm3.1 Is Required to Maintain the Structure and Function of the Axon Initial Segment', iScience, 23, pp. 101053, http://dx.doi.org/10.1016/j.isci.2020.101053

Kumari R; Jiu Y; Carman PJ; Tojkander S; Kogan K; Varjosalo M; Gunning PW; Dominguez R; Lappalainen P, 2020, 'Tropomodulins Control the Balance between Protrusive and Contractile Structures by Stabilizing Actin-Tropomyosin Filaments', Current Biology, 30, pp. 767 - 778.e5, http://dx.doi.org/10.1016/j.cub.2019.12.049

Manstein DJ; Meiring JCM; Hardeman EC; Gunning PW, 2020, 'Actin–tropomyosin distribution in non-muscle cells', Journal of Muscle Research and Cell Motility, 41, pp. 11 - 22, http://dx.doi.org/10.1007/s10974-019-09514-0

Hardeman EC; Gunning PW, 2020, 'Life and death agendas of actin filaments', Nature Materials, 19, pp. 135 - 136, http://dx.doi.org/10.1038/s41563-019-0583-1

Rae J; Ferguson C; Ariotti N; Webb R; Cheng H-H; Mead J; Riches J; Hunter DJB; Martel N; Baltos J; Christopoulos A; Bryce N; Cagigas ML; Fonseka S; Hardeman E; Gunning P; Gambin Y; Hall T; Parton R, 2020, 'APEX-Gold: A genetically-encoded particulate marker for robust 3D electron microscopy', , http://dx.doi.org/10.1101/2020.10.06.328831

Meiring JCM; Bryce NS; Niño JLG; Gabriel A; Tay SS; Hardeman EC; Biro M; Gunning PW, 2019, 'Tropomyosin concentration but not formin nucleators mDia1 and mDia3 determines the level of tropomyosin incorporation into actin filaments', Scientific Reports, 9, pp. 6504, http://dx.doi.org/10.1038/s41598-019-42977-2

Bryce NS; Failes TW; Stehn JR; Baker K; Zahler S; Arzhaeva Y; Bischof L; Lyons C; Dedova I; Arndt GM; Gaus K; Goult BT; Hardeman EC; Gunning PW; Lock JG; Arndt G, 2019, 'High-Content Imaging of Unbiased Chemical Perturbations Reveals that the Phenotypic Plasticity of the Actin Cytoskeleton Is Constrained', Cell Systems, 9, pp. 496 - 507.e5, http://dx.doi.org/10.1016/j.cels.2019.09.002

Janco M; Rynkiewicz MJ; Li L; Hook J; Eiffe E; Ghosh A; Böcking T; Lehman WJ; Hardeman EC; Gunning PW, 2019, 'Molecular integration of the anti-tropomyosin compound ATM-3507 into the coiled coil overlap region of the cancer-associated Tpm3.1', Scientific reports, 9, pp. 11262, http://dx.doi.org/10.1038/s41598-019-47592-9

Bryce NS; Hardeman EC; Gunning PW; Lock JG, 2019, 'Chemical biology approaches targeting the actin cytoskeleton through phenotypic screening', Current Opinion in Chemical Biology, 51, pp. 40 - 47, http://dx.doi.org/10.1016/j.cbpa.2019.02.013

Meiring JCM; Bryce NS; Cagigas ML; Benda A; Whan RM; Ariotti N; Parton RG; Stear JH; Hardeman EC; Gunning PW; Lastra Cagigas M, 2019, 'Colocation of Tpm3.1 and myosin IIa heads defines a discrete subdomain in stress fibres', Journal of Cell Science, 132, pp. jcs228916, http://dx.doi.org/10.1242/jcs.228916

Ebrahim S; Chen D; Weiss M; Malec L; Ng Y; Rebustini I; Krystofiak E; Hu L; Liu J; Masedunskas A; Hardeman E; Gunning P; Kachar B; Weigert R, 2019, 'Dynamic polyhedral actomyosin lattices remodel micron-scale curved membranes during exocytosis in live mice', Nature Cell Biology, 21, pp. 933 - 939, http://dx.doi.org/10.1038/s41556-019-0365-7

Kim TH; Ly C; Christodoulides A; Nowell CJ; Gunning PW; Sloan EK; Rowat AC, 2019, 'Stress hormone signaling through β-adrenergic receptors regulates macrophage mechanotype and function', FASEB Journal, 33, pp. 3997 - 4006, http://dx.doi.org/10.1096/fj.201801429RR

Sao K; Jones TM; Doyle AD; Maity D; Schevzov G; Chen Y; Gunning PW; Petrie RJ, 2019, 'Myosin II governs intracellular pressure and traction by distinct tropomyosin-dependent mechanisms', Molecular Biology of the Cell, 30, pp. 1170 - 1181, http://dx.doi.org/10.1091/mbc.E18-06-0355

Kee AJ; Chagan J; Chan JY; Bryce NS; Lucas CA; Zeng J; Hook J; Treutlein H; Laybutt DR; Stehn JR; Gunning PW; Hardeman EC, 2018, 'On-target action of anti-tropomyosin drugs regulates glucose metabolism', Scientific Reports, 8, pp. 4604, http://dx.doi.org/10.1038/s41598-018-22946-x

Meiring JCM; Bryce NS; Wang Y; Taft MH; Manstein DJ; Liu Lau S; Stear J; Hardeman EC; Gunning PW, 2018, 'Co-polymers of Actin and Tropomyosin Account for a Major Fraction of the Human Actin Cytoskeleton', Current Biology, 28, pp. 2331 - 2337.e5, http://dx.doi.org/10.1016/j.cub.2018.05.053

Stefen H; Suchowerska AK; Chen BJ; Brettle M; Kuschelewski J; Gunning PW; Janitz M; Fath T, 2018, 'Tropomyosin isoforms have specific effects on the transcriptome of undifferentiated and differentiated B35 neuroblastoma cells', FEBS Open Bio, 8, pp. 570 - 583, http://dx.doi.org/10.1002/2211-5463.12386

Gunning PW; Hardeman EC, 2018, 'Tropomyosin-directed tuning of myosin motor function: Insights from mutagenesis', Cytoskeleton, 75, pp. 147 - 149, http://dx.doi.org/10.1002/cm.21441

Masedunskas A; Appaduray MA; Lucas CA; Cagigas ML; Heydecker M; Holliday M; Meiring JCM; Hook J; Kee A; White M; Thomas P; Zhang Y; Adelstein RS; Meckel T; Böcking T; Weigert R; Bryce NS; Gunning PW; Hardeman EC; Lastra Cagigas M, 2018, 'Parallel assembly of actin and tropomyosin, but not myosin II, during de novo actin filament formation in live mice', Journal of Cell Science, 131, pp. jcs212654, http://dx.doi.org/10.1242/jcs.212654

Gunning PW; Hardeman EC, 2018, 'Fundamental differences', eLife, 7, pp. e34477, http://dx.doi.org/10.7554/eLife.34477

Suchowerska AK; Fok S; Stefen H; Gunning PW; Hardeman EC; Power J; Fath T, 2017, 'Developmental profiling of tropomyosin expression in mouse brain reveals Tpm4.2 as the major post-synaptic tropomyosin in the mature brain', Frontiers in Cellular Neuroscience, 11, pp. 421, http://dx.doi.org/10.3389/fncel.2017.00421

Austin Elam W; Cao W; Kang H; Huehn A; Hocky GM; Prochniewicz E; Schramm AC; Negrón K; Garcia J; Bonello TT; Gunning PW; Thomas DD; Voth GA; Sindelar CV; De La Cruz EM, 2017, 'Phosphomimetic S3D cofilin binds but only weakly severs actin filaments', Journal of Biological Chemistry, 292, pp. 19565 - 19579, http://dx.doi.org/10.1074/jbc.M117.808378

Nobis M; Herrmann D; Warren SC; Kadir S; Leung W; Killen M; Magenau A; Stevenson D; Lucas MC; Reischmann N; Vennin C; Conway JRW; Boulghourjian A; Zaratzian A; Law AM; Gallego-Ortega D; Ormandy CJ; Walters SN; Grey ST; Bailey J; Chtanova T; Quinn JMW; Baldock PA; Croucher PI; Schwarz JP; Mrowinska A; Zhang L; Herzog H; Masedunskas A; Hardeman EC; Gunning PW; del Monte-Nieto G; Harvey RP; Samuel MS; Pajic M; McGhee EJ; Johnsson AKE; Sansom OJ; Welch HCE; Morton JP; Strathdee D; Anderson KI; Timpson P; del Monte Nieto G, 2017, 'A RhoA-FRET Biosensor Mouse for Intravital Imaging in Normal Tissue Homeostasis and Disease Contexts', Cell Reports, 21, pp. 274 - 288, http://dx.doi.org/10.1016/j.celrep.2017.09.022

Kee AJ; Bryce NS; Yang L; Polishchuk E; Schevzov G; Weigert R; Polishchuk R; Gunning PW; Hardeman EC, 2017, 'ER/Golgi trafficking is facilitated by unbranched actin filaments containing Tpm4.2', Cytoskeleton, 74, pp. 379 - 389, http://dx.doi.org/10.1002/cm.21405

Currier MA; Stehn JR; Swain A; Chen D; Hook J; Eiffe E; Heaton A; Brown D; Nartker BA; Eaves DW; Kloss N; Treutlein H; Zeng J; Alieva IB; Dugina VB; Hardeman EC; Gunning PW; Cripe TP, 2017, 'Identification of cancer-targeted tropomyosin inhibitors and their synergy with microtubule drugs', Molecular Cancer Therapeutics, 16, pp. 1555 - 1565, http://dx.doi.org/10.1158/1535-7163.MCT-16-0873

Desouza-Armstrong M; Gunning PW; Stehn JR, 2017, 'Tumor suppressor tropomyosin Tpm2.1 regulates sensitivity to apoptosis beyond anoikis characterized by changes in the levels of intrinsic apoptosis proteins', Cytoskeleton, 74, pp. 233 - 248, http://dx.doi.org/10.1002/cm.21367

Gateva G; Kremneva E; Reindl T; Kotila T; Kogan K; Gressin L; Gunning PW; Manstein DJ; Michelot A; Lappalainen P, 2017, 'Tropomyosin Isoforms Specify Functionally Distinct Actin Filament Populations In Vitro', Current Biology, 27, pp. 705 - 713, http://dx.doi.org/10.1016/j.cub.2017.01.018

Pleines I; Woods J; Chappaz S; Kew V; Foad N; Ballester-Beltrán J; Aurbach K; Lincetto C; Lane RM; Schevzov G; Alexander WS; Hilton DJ; Astle WJ; Downes K; Nurden P; Westbury SK; Mumford AD; Obaji SG; Collins PW; BioResource N; Delerue F; Ittner LM; Bryce NS; Holliday M; Lucas CA; Hardeman EC; Ouwehand WH; Gunning PW; Turro E; Tijssen MR; Kile BT, 2017, 'Mutations in tropomyosin 4 underlie a rare form of human macrothrombocytopenia', Journal of Clinical Investigation, 127, pp. 814 - 829, http://dx.doi.org/10.1172/JCI86154

Gunning PW; Hardeman EC, 2017, 'Tropomyosins', Current Biology, 27, pp. R8 - R13, http://dx.doi.org/10.1016/j.cub.2016.11.033

Jeong SY; Lim SY; Schevzov G; Gunning PW; Helfman DM, 2017, 'Loss of Tpm4.1 leads to disruption of cell-cell adhesions and invasive behavior in breast epithelial cells via increased Rac1 signaling', Oncotarget, 8, pp. 33544 - 33559, http://dx.doi.org/10.18632/oncotarget.16825

Kee AJ; Bryce NS; Yang L; Polishchuk E; Schevzov G; Weigert R; Polishchuk R; Gunning PW; Hardeman EC, 2017, 'Cover Image, Volume 74, Issue 10', Cytoskeleton, 74, http://dx.doi.org/10.1002/cm.21413

Desouza‐Armstrong M; Gunning PW; Stehn JR, 2017, 'Cover Image, Volume 74, Issue 6', Cytoskeleton, 74, http://dx.doi.org/10.1002/cm.21376

Desouza‐Armstrong M; Gunning PW; Stehn JR, 2017, 'Cover Image, Volume 74, Issue 6', Cytoskeleton, 74, http://dx.doi.org/10.1002/cm.21375

Nicovich PR; Janco M; Sobey T; Gajwani M; Obeidy P; Whan R; Gaus K; Gunning PW; Coster ACF; Böcking T, 2016, 'Effect of surface chemistry on tropomyosin binding to actin filaments on surfaces', Cytoskeleton, 73, pp. 729 - 738, http://dx.doi.org/10.1002/cm.21342

Appaduray MA; Masedunskas A; Bryce NS; Lucas CA; Warren SC; Timpson P; Stear JH; Gunning PW; Hardeman EC, 2016, 'Recruitment kinetics of tropomyosin tpm3.1 to actin filament bundles in the cytoskeleton is independent of actin filament kinetics', PLoS ONE, 11, pp. e0168203, http://dx.doi.org/10.1371/journal.pone.0168203

Gunning P; Shivashankar GV, 2016, 'Letter from the editors', BioArchitecture, 6, pp. 105, http://dx.doi.org/10.1080/19490992.2016.1291050

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