Select Publications
Books
2008, Preface
,Book Chapters
2015, 'The role of the actin cytoskeleton in cancer and its potential use as a therapeutic target', in The Cytoskeleton in Health and Disease, pp. 373 - 391, http://dx.doi.org/10.1007/978-1-4939-2904-7_16
,2012, 'Therapeutic Targeting of the Actin Cytoskeleton in Cancer', in Kavallaris M (ed.), Cytoskeleton and Human Disease, pp. 181 - 200, http://dx.doi.org/10.1007/978-1-61779-788-0_10
,2011, 'Tropomyosins in neuronal morphogenesis and development', in Abel Lajtha (ed.), Cytoskeleton of the Nervous System, Springer, USA, pp. 411 - 446
,2006, 'Protein Isoforms and Isozymes', in , Wiley, http://dx.doi.org/10.1038/npg.els.0005717
,1995, 'The cell cytoskeleton's functional requirement for localized mRNA', in Localized RNAs, Springer Publishing Company, New York, pp. 197 - 213
,1981, 'MECHANISM OF ACTION OF NERVE GROWTH FACTOR1', in Cellular Responses to Molecular Modulators, Elsevier, pp. 205 - 217, http://dx.doi.org/10.1016/b978-0-12-509380-4.50017-x
,Journal articles
2024, 'Focal adhesions contain three specialized actin nanoscale layers', Nature Communications, 15, http://dx.doi.org/10.1038/s41467-024-46868-7
,2024, 'Precision in situ cryogenic correlative light and electron microscopy of optogenetically positioned organelles', Journal of Cell Science, 137, http://dx.doi.org/10.1242/jcs.262163
,2024, 'Coordination of force-generating actin-based modules stabilizes and remodels membranes in vivo', Journal of Cell Biology, 223, http://dx.doi.org/10.1083/jcb.202401091
,2024, 'Tropomyosin1 isoforms underlie epithelial to mesenchymal plasticity, metastatic dissemination, and resistance to chemotherapy in high-grade serous ovarian cancer', Cell Death and Differentiation, 31, pp. 360 - 377, http://dx.doi.org/10.1038/s41418-024-01267-9
,2024, 'A truncation mutant of adenomatous polyposis coli impairs apical cell extrusion through elevated epithelial tissue tension', Cytoskeleton, http://dx.doi.org/10.1002/cm.21893
,2024, 'Single molecule visualization of tropomyosin isoform organization in the mammalian actin cytoskeleton', Cytoskeleton, http://dx.doi.org/10.1002/cm.21883
,2023, 'Preexisting tissue mechanical hypertension at adherens junctions disrupts apoptotic extrusion in epithelia', Molecular Biology of the Cell, 35, http://dx.doi.org/10.1091/mbc.E23-08-0337
,2023, 'Highly efficient platelet generation in lung vasculature reproduced by microfluidics', Nature Communications, 14, http://dx.doi.org/10.1038/s41467-023-39598-9
,2023, 'Cortical tension drug screen links mitotic spindle integrity to Rho pathway', Current Biology, 33, pp. 4458 - 4469.e4, http://dx.doi.org/10.1016/j.cub.2023.09.022
,2022, 'An interview with Peter Gunning - School of Medical Sciences, UNSW Sydney, Australia', Cytoskeleton, 79, pp. 24 - 25, http://dx.doi.org/10.1002/cm.21715
,2022, 'Correlative cryo-ET identifies actin/tropomyosin filaments that mediate cell–substrate adhesion in cancer cells and mechanosensitivity of cell proliferation', Nature Materials, 21, pp. 120 - 128, http://dx.doi.org/10.1038/s41563-021-01087-z
,2022, 'Intravital subcellular and single molecule imaging reveals multiple actin filament populations collaborate in the remodelling of the secretory granule membrane', Biophysical Journal, 121, pp. 297a - 298a, http://dx.doi.org/10.1016/j.bpj.2021.11.1268
,2021, 'Overexpression of tropomyosin isoform tpm3.1 does not alter synaptic function in hippocampal neurons', International Journal of Molecular Sciences, 22, http://dx.doi.org/10.3390/ijms22179303
,2021, 'Targeting the actin/tropomyosin cytoskeleton in epithelial ovarian cancer reveals multiple mechanisms of synergy with anti-microtubule agents', British Journal of Cancer, 125, pp. 265 - 276, http://dx.doi.org/10.1038/s41416-021-01420-y
,2021, 'A robust method for particulate detection of a genetic tag for 3D electron microscopy', eLife, 10, pp. e64630, http://dx.doi.org/10.7554/ELIFE.64630
,2021, 'Deletion of the actin‐associated tropomyosin tpm3 leads to reduced cell complexity in cultured hippocampal neurons—new insights into the role of the c‐terminal region of tpm3.1', Cells, 10, http://dx.doi.org/10.3390/cells10030715
,2020, 'Visualizing the in vitro assembly of tropomyosin/actin filaments using TIRF microscopy', Biophysical Reviews, 12, pp. 879 - 885, http://dx.doi.org/10.1007/s12551-020-00720-6
,2020, 'Drug targeting the actin cytoskeleton potentiates the cytotoxicity of low dose vincristine by abrogating actin-mediated repair of spindle defects', Molecular Cancer Research, 18, pp. 1074 - 1087, http://dx.doi.org/10.1158/1541-7786.MCR-19-1122
,2020, 'Impact of the actin cytoskeleton on cell development and function mediated via tropomyosin isoforms', Seminars in Cell and Developmental Biology, 102, pp. 122 - 131, http://dx.doi.org/10.1016/j.semcdb.2019.10.004
,2020, 'Tropomyosin Tpm3.1 Is Required to Maintain the Structure and Function of the Axon Initial Segment', iScience, 23, pp. 101053, http://dx.doi.org/10.1016/j.isci.2020.101053
,2020, 'Tropomodulins Control the Balance between Protrusive and Contractile Structures by Stabilizing Actin-Tropomyosin Filaments', Current Biology, 30, pp. 767 - 778.e5, http://dx.doi.org/10.1016/j.cub.2019.12.049
,2020, 'Actin–tropomyosin distribution in non-muscle cells', Journal of Muscle Research and Cell Motility, 41, pp. 11 - 22, http://dx.doi.org/10.1007/s10974-019-09514-0
,2020, 'Life and death agendas of actin filaments', Nature Materials, 19, pp. 135 - 136, http://dx.doi.org/10.1038/s41563-019-0583-1
,2020, 'APEX-Gold: A genetically-encoded particulate marker for robust 3D electron microscopy', , http://dx.doi.org/10.1101/2020.10.06.328831
,2019, 'Tropomyosin concentration but not formin nucleators mDia1 and mDia3 determines the level of tropomyosin incorporation into actin filaments', Scientific Reports, 9, pp. 6504, http://dx.doi.org/10.1038/s41598-019-42977-2
,2019, 'High-Content Imaging of Unbiased Chemical Perturbations Reveals that the Phenotypic Plasticity of the Actin Cytoskeleton Is Constrained', Cell Systems, 9, pp. 496 - 507.e5, http://dx.doi.org/10.1016/j.cels.2019.09.002
,2019, 'Molecular integration of the anti-tropomyosin compound ATM-3507 into the coiled coil overlap region of the cancer-associated Tpm3.1', Scientific reports, 9, pp. 11262, http://dx.doi.org/10.1038/s41598-019-47592-9
,2019, 'Chemical biology approaches targeting the actin cytoskeleton through phenotypic screening', Current Opinion in Chemical Biology, 51, pp. 40 - 47, http://dx.doi.org/10.1016/j.cbpa.2019.02.013
,2019, 'Colocation of Tpm3.1 and myosin IIa heads defines a discrete subdomain in stress fibres', Journal of Cell Science, 132, pp. jcs228916, http://dx.doi.org/10.1242/jcs.228916
,2019, 'Dynamic polyhedral actomyosin lattices remodel micron-scale curved membranes during exocytosis in live mice', Nature Cell Biology, 21, pp. 933 - 939, http://dx.doi.org/10.1038/s41556-019-0365-7
,2019, 'Stress hormone signaling through β-adrenergic receptors regulates macrophage mechanotype and function', FASEB Journal, 33, pp. 3997 - 4006, http://dx.doi.org/10.1096/fj.201801429RR
,2019, 'Myosin II governs intracellular pressure and traction by distinct tropomyosin-dependent mechanisms', Molecular Biology of the Cell, 30, pp. 1170 - 1181, http://dx.doi.org/10.1091/mbc.E18-06-0355
,2018, 'On-target action of anti-tropomyosin drugs regulates glucose metabolism', Scientific Reports, 8, pp. 4604, http://dx.doi.org/10.1038/s41598-018-22946-x
,2018, 'Co-polymers of Actin and Tropomyosin Account for a Major Fraction of the Human Actin Cytoskeleton', Current Biology, 28, pp. 2331 - 2337.e5, http://dx.doi.org/10.1016/j.cub.2018.05.053
,2018, 'Tropomyosin isoforms have specific effects on the transcriptome of undifferentiated and differentiated B35 neuroblastoma cells', FEBS Open Bio, 8, pp. 570 - 583, http://dx.doi.org/10.1002/2211-5463.12386
,2018, 'Tropomyosin-directed tuning of myosin motor function: Insights from mutagenesis', Cytoskeleton, 75, pp. 147 - 149, http://dx.doi.org/10.1002/cm.21441
,2018, 'Parallel assembly of actin and tropomyosin, but not myosin II, during de novo actin filament formation in live mice', Journal of Cell Science, 131, pp. jcs212654, http://dx.doi.org/10.1242/jcs.212654
,2018, 'Fundamental differences', eLife, 7, pp. e34477, http://dx.doi.org/10.7554/eLife.34477
,2017, 'Developmental profiling of tropomyosin expression in mouse brain reveals Tpm4.2 as the major post-synaptic tropomyosin in the mature brain', Frontiers in Cellular Neuroscience, 11, pp. 421, http://dx.doi.org/10.3389/fncel.2017.00421
,2017, 'Phosphomimetic S3D cofilin binds but only weakly severs actin filaments', Journal of Biological Chemistry, 292, pp. 19565 - 19579, http://dx.doi.org/10.1074/jbc.M117.808378
,2017, 'A RhoA-FRET Biosensor Mouse for Intravital Imaging in Normal Tissue Homeostasis and Disease Contexts', Cell Reports, 21, pp. 274 - 288, http://dx.doi.org/10.1016/j.celrep.2017.09.022
,2017, 'ER/Golgi trafficking is facilitated by unbranched actin filaments containing Tpm4.2', Cytoskeleton, 74, pp. 379 - 389, http://dx.doi.org/10.1002/cm.21405
,2017, 'Identification of cancer-targeted tropomyosin inhibitors and their synergy with microtubule drugs', Molecular Cancer Therapeutics, 16, pp. 1555 - 1565, http://dx.doi.org/10.1158/1535-7163.MCT-16-0873
,