By Professor Peter Gunning

Preprints

Mann Z; Verma S; Chen O; Dunbabin P; Ju RJ; Hu C; Lim Kam Sian TCC; Hardeman EC; Gunning PW; Daly RJ; Duszyc K; Poole K; Yap AS, 2026, The way less obvious: PIEZO1 supports apoptotic cell extrusion by optimizing tissue mechanical tension for homeostasis, http://dx.doi.org/10.64898/2026.06.01.729446

Heydecker M; Chen D; Masedunskas A; Mikolaj M; Narayan K; Chen J; Vishwasrao H; Meckel T; Hardeman E; Gunning P; Weigert R, 2026, Intravital single-molecule imaging reveals cytoskeletal turnover as a driver of membrane remodeling in live animals., http://dx.doi.org/10.64898/2026.02.25.708035

Heydecker M; Shitara A; Chen D; Tran D; Masedunskas A; Tora M; Ebrahim S; Appaduray MA; Galeano Niño JL; Bhardwaj A; Narayan K; Hardeman EC; Gunning PW; Weigert R, 2023, Spatial and Temporal Coordination of Force-generating Actin-based Modules Drives Membrane Remodeling In Vivo., http://dx.doi.org/10.1101/2023.12.04.569944

Abouelezz A; Stefen H; Segerstråle M; Micinski D; Minkeviciene R; Hardeman EC; Gunning PW; Hoogenraad CC; Taira T; Fath T; Hotulainen P, 2019, Tropomyosin Tpm3.1 is Required to Maintain the Structure and Function of the Axon Initial Segment, http://dx.doi.org/10.2139/ssrn.3448139

Latham SL; O’Donnell YE; Girgis-Cook O; Clearwater MS; Bryce NS; Mok ET; Lynn SA; Ni J; Alfred S; Leong H; Quek L-E; Murphy KJ; Pantarelli C; Dragutinovic I; Naeini MM; Thiel C; Cadell A; Phimmachanh M; Sharma R; Millar E; Han JZ; Hastings JF; Köhler M; Brummer T; Young A; O’Toole S; Oakes SR; Hardeman E; Lock J; Kolch W; Taft MH; Nobis M; Goldstein L; Timpson P; Parker BL; Holst J; Gunning PW; Cox TR; Morris JC; Croucher DR, A selective inhibitor of oncogenic JNK signalling perturbs metastatic outgrowth of triple-negative breast cancer through metabolic blockade, http://dx.doi.org/10.1101/2025.04.16.649243

Gan WJ; Giri R; Begun J; Abud HE; Hardeman EC; Gunning PW; Yap AS; Noordstra I, A truncation mutant of adenomatous polyposis coli (APC) impairs apical cell extrusion through elevated epithelial tissue tension, http://dx.doi.org/10.1101/2024.03.06.583801

Rae J; Ferguson C; Ariotti N; Webb RI; Cheng H-H; Mead JL; Riches J; Hunter DJB; Martel N; Baltos J; Christopoulos A; Bryce NS; Cagigas ML; Fonseka S; Hardeman EC; Gunning PW; Gambin Y; Hall T; Parton RG, APEX-Gold: A genetically-encoded particulate marker for robust 3D electron microscopy, http://dx.doi.org/10.1101/2020.10.06.328831

Zhao X; Alibhai D; Walsh T; Tarassova N; Englert M; Birol S; Li Y; Williams C; Neal C; Burkard P; Aitken E; Waller A; Ballester-Beltran J; Gunning P; Hardeman E; Agbani E; Nieswandt B; Hers I; Ghevaert C; Poole A, Highly efficient platelet generation in lung vasculature reproduced by microfluidics, http://dx.doi.org/10.21203/rs.3.rs-2306404/v1

Genoud S; Chaichim C; Porto RR; Tomanic T; Stefen H; Paric E; Sarkar S; Yoo D; Gao W; Hardeman EC; Gunning PW; Karl T; Power J; Fath T, Knock-out of Tpm4.2/actin filaments alters neuronal signaling, neurite outgrowth and behavioral phenotypes in mice, http://dx.doi.org/10.1101/2025.04.10.648285

Zhao X; Alibhai D; Walsh TG; Tarassova N; Birol SZ; Williams CM; Neil CR; Aitken EW; Waller AK; Ballester-Beltran J; Gunning PW; Hardeman EC; Agbani EO; Hers I; Ghevaert C; Poole AW, Platelet generation from circulating megakaryocytes is triggered in the lung vasculature, http://dx.doi.org/10.1101/2021.11.01.466743

Zhao X; Alibhai D; Walsh T; Tarassova N; Birol S; Williams C; Neil C; Aitken E; Waller A; Ballester-Beltran J; Gunning P; Hardeman E; Agbani E; Hers I; Ghevaert C; Poole A, Platelet generation from circulating megakaryocytes is triggered in the lung vasculature, http://dx.doi.org/10.21203/rs.3.rs-690639/v1

Mann Z; Lim F; Verma S; Nanavati BN; Davies JM; Begun J; Hardeman EC; Gunning PW; Subramanyam D; Yap AS; Duszyc K, Pre-existing tissue mechanical hypertension at adherens junctions disrupts apoptotic extrusion in epithelia, http://dx.doi.org/10.1101/2023.08.31.555652

Redpath GMI; Rae J; Yao Y; Ruan J; Cagigas ML; Whan R; Hardeman EC; Gunning PW; Ananthanarayanan V; Parton RG; Ariotti N, Precision Super-Resolution Cryo-Correlative Light and Electron Microscopy for Rapid <i>in situ</i> Structural Analyses of Optogenetically-Positioned Organelles, http://dx.doi.org/10.2139/ssrn.4309027

Redpath GMI; Rae J; Yao Y; Ruan J; Cagigas ML; Whan R; Hardeman EC; Gunning PW; Ananthanarayanan V; Parton RG; Ariotti NA, Precision super-resolution cryo-correlative light and electron microscopy for rapid in situ structural analyses of optogenetically-positioned organelles, http://dx.doi.org/10.1101/2022.11.22.516823

Kumari R; Ven K; Chastney M; Peränen J; Aaron J; Almeida-Souza L; Kremneva E; Poincloux R; Chew T-L; Gunning PW; Ivaska J; Lappalainen P, Specialized actin nanoscale layers control focal adhesion turnover, http://dx.doi.org/10.1101/2023.02.15.528622

Abouelezz A; Stefen H; Segerstråle M; Micinski D; Minkeviciene R; Hardeman EC; Gunning PW; Hoogenraad CC; Taira T; Fath T; Hotulainen P, Tropomyosin Tpm3.1 is required to maintain the structure and function of the axon initial segment, http://dx.doi.org/10.1101/711614

Kokkinos J; Sharbeen G; Ignacio RMC; Pandzic E; Youkhana J; Boyer C; Haghighi KS; Gunawarman M; Goldstein D; Gebski V; Pajic M; Pitiyarachchi O; Davis ME; Schulstad G; Arkell OSM; Kopecky C; Gonzales-Aloy E; Erkan M; Morton JP; Kavallaris M; Gunning PW; Hardeman EC; Johns A; Gill AJ; Whan RM; Mawson A; Initiative APCG; McCarroll JA; Phillips PA, βIII-Tubulin is a Brake on Extrinsic Cell-Death in Pancreatic Cancer, http://dx.doi.org/10.1101/2022.09.29.510034

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