Select Publications
Journal articles
2017, 'Identification of 153 new loci associated with heel bone mineral density and functional involvement of GPC6 in osteoporosis', Nature Genetics, 49, pp. 1468 - 1475, http://dx.doi.org/10.1038/ng.3949
,2017, 'Melphalan modifies the bone microenvironment by enhancing osteoclast formation', Oncotarget, 8, pp. 68047 - 68058, http://dx.doi.org/10.18632/oncotarget.19152
,2017, 'An essential physiological role for MCT8 in bone in male mice', Endocrinology, 158, pp. 3055 - 3066, http://dx.doi.org/10.1210/en.2017-00399
,2017, 'Inhibiting the osteocyte-specific protein sclerostin increases bone mass and fracture resistance in multiple myeloma', Blood, 129, pp. 3452 - 3464, http://dx.doi.org/10.1182/blood-2017-03-773341
,2017, 'Next generation mapping reveals novel large genomic rearrangements in prostate cancer', Oncotarget, 8, pp. 23588 - 23602, http://dx.doi.org/10.18632/oncotarget.15802
,2016, 'Mice with an N-Ethyl-N-Nitrosourea (ENU) induced Tyr209Asn mutation in natriuretic peptide receptor 3 (NPR3) provide a model for kyphosis associated with activation of the MAPK signaling pathway', PLoS ONE, 11, pp. e0167916, http://dx.doi.org/10.1371/journal.pone.0167916
,2016, 'Bone metastasis: The importance of the neighbourhood', Nature Reviews Cancer, 16, pp. 373 - 386, http://dx.doi.org/10.1038/nrc.2016.44
,2016, 'Anti-sclerostin treatment prevents multiple myeloma bone disease and reduces tumour burden', Bone Abstracts, http://dx.doi.org/10.1530/boneabs.5.cabs.oc3.4
,2016, 'Is circulating sclerostin an endocrine modulator of bone mass?', Bone Abstracts, http://dx.doi.org/10.1530/boneabs.5.oc2.5
,2016, 'Myeloma impairs mature osteoblast function but causes early expansion of osteo-progenitors: Temporal changes in bone physiology and gene expression in the KMS12BM model', British Journal of Haematology, 172, pp. 64 - 79, http://dx.doi.org/10.1111/bjh.13790
,2016, 'Prader-willi critical region, a non-translated, imprinted central regulator of bone mass: Possible role in skeletal abnormalities in Prader-Willi Syndrome', PLoS ONE, 11, pp. e0148155, http://dx.doi.org/10.1371/journal.pone.0148155
,2016, 'Rapid phenotyping of knockout mice to identify genetic determinants of bone strength', Journal of Endocrinology, 231, pp. 1 - 16, http://dx.doi.org/10.1530/JOE-16-0258
,2015, 'Osteoclasts control reactivation of dormant myeloma cells by remodelling the endosteal niche', Nature Communications, 6, http://dx.doi.org/10.1038/ncomms9983
,2015, 'The frequency of osteolytic bone metastasis is determined by conditions of the soil, not the number of seeds; evidence from in vivo models of breast and prostate cancer', Journal of Experimental and Clinical Cancer Research, 34, http://dx.doi.org/10.1186/s13046-015-0240-8
,2015, 'Thyrostimulin regulates osteoblastic bone formation during early skeletal development', Endocrinology, 156, pp. 3098 - 3113, http://dx.doi.org/10.1210/en.2014-1943
,2015, 'OPG-Fc inhibits ovariectomy-induced growth of disseminated breast cancer cells in bone', International Journal of Cancer, 137, pp. 968 - 977, http://dx.doi.org/10.1002/ijc.29439
,2015, 'Mitotic quiescence, but not unique "stemness," marks the phenotype of bone metastasis-initiating cells in prostate cancer', FASEB Journal, 29, pp. 3141 - 3150, http://dx.doi.org/10.1096/fj.14-266379
,2015, 'The forkhead transcription factor FOXP2 is required for regulation of p21waf1/cip1 in 143B osteosarcoma cell growth arrest', PLoS ONE, 10, http://dx.doi.org/10.1371/journal.pone.0128513
,2015, 'N-ethyl-N-nitrosourea (ENU) induced mutations within the Klotho gene lead to ectopic calcification and reduced lifespan in mouse models', PLoS ONE, 10, http://dx.doi.org/10.1371/journal.pone.0122650
,2015, 'Bone turnover markers and prostate cancer: Not just a measure of bone disease?', European Urology, 68, pp. 51 - 52, http://dx.doi.org/10.1016/j.eururo.2014.10.041
,2015, 'Real-Time Intravital Imaging Establishes Tumor-Associated Macrophages as the Extraskeletal Target of Bisphosphonate Action in Cancer', Cancer Discovery, 5, pp. 35 - 42, http://dx.doi.org/10.1158/2159-8290.CD-14-0621
,2014, 'Prostate cancer cells preferentially home to osteoblast-rich areas in the early stages of bone metastasis: Evidence from in vivo models', Journal of Bone and Mineral Research, 29, pp. 2688 - 2696, http://dx.doi.org/10.1002/jbmr.2300
,2014, 'Castration-induced bone loss triggers growth of disseminated prostate cancer cells in bone', Endocrine-Related Cancer, 21, pp. 769 - 781, http://dx.doi.org/10.1530/ERC-14-0199
,2014, 'The bone marrow stromal compartment in multiple myeloma patients retains capability for osteogenic differentiation in vitro: Defining the stromal defect in myeloma', British Journal of Haematology, 167, pp. 194 - 206, http://dx.doi.org/10.1111/bjh.13020
,2014, 'Thyroid hormone receptor α mutation causes a severe and thyroxine-resistant skeletal dysplasia in female mice', Endocrinology (United States), 155, pp. 3699 - 3712, http://dx.doi.org/10.1210/en.2013-2156
,2014, 'Zoledronic acid has differential antitumor activity in the pre- and postmenopausal bone microenvironment in vivo', Clinical Cancer Research, 20, pp. 2922 - 2932, http://dx.doi.org/10.1158/1078-0432.CCR-13-1246
,2014, 'An N-ethyl-n-nitrosourea induced corticotropin-releasing hormone promoter mutation provides a mouse model for endogenous glucocorticoid excess', Endocrinology, 155, pp. 908 - 922, http://dx.doi.org/10.1210/en.2013-1247
,2014, 'TR[alpha] mutation causes a severe and thyroxine-resistant skeletal dysplasia', Endocrine Abstracts, http://dx.doi.org/10.1530/endoabs.34.oc4.3
,2014, 'Signaling Between Tumor Cells and the Host Bone Marrow Microenvironment', Calcified Tissue International, 94, pp. 125 - 139, http://dx.doi.org/10.1007/s00223-013-9794-7
,2013, 'A novel antagonist of the canonical Wnt-signalling pathway, Sostdc1, is expressed in experimental models of myeloma and suppresses bone formation', Bone Abstracts, http://dx.doi.org/10.1530/boneabs.1.pp159
,2013, 'Effect of the HDAC inhibitor vorinostat on the osteogenic differentiation of mesenchymal stem cells in vitro and bone formation in vivo', Acta Pharmacologica Sinica, 34, pp. 699 - 709, http://dx.doi.org/10.1038/aps.2012.182
,2013, 'An N-ethyl-N-nitrosourea induced Corticotrophin releasing hormone promoter mutation provides a mouse model of Cushing's syndrome', Endocrine Abstracts, pp. 1 - 1, http://dx.doi.org/10.1530/endoabs.31.oc2.6
,2012, 'Bone Mineral Content and Density.', Curr Protoc Mouse Biol, 2, pp. 365 - 400, http://dx.doi.org/10.1002/9780470942390.mo120124
,2012, 'Impaired osteogenic differentiation of mesenchymal stem cells derived from multiple myeloma patients is associated with a blockade in the deactivation of the Notch signaling pathway', Leukemia, 26, pp. 2546 - 2549, http://dx.doi.org/10.1038/leu.2012.126
,2012, 'Erratum: Inhibiting activin-A signaling stimulates bone formation and prevents cancer-induced bone destruction in vivo', Journal of Bone and Mineral Research, 27, pp. 2038 - 2038, http://dx.doi.org/10.1002/jbmr.1704
,2012, 'Erratum: Inhibiting activin-A signaling stimulates bone formation and prevents cancer-induced bone destruction in vivo (Journal of Bone and Mineral Research (2010) 25:12 (2633-2646) DOI:10.1002/jbmr.142)', Journal of Bone and Mineral Research, 27, pp. 2036 - 2037, http://dx.doi.org/10.1002/jbmr.1705
,2012, 'Significant deterioration in nanomechanical quality occurs through incomplete extrafibrillar mineralization in rachitic bone: Evidence from in-situ synchrotron X-ray scattering and backscattered electron imaging', Journal of Bone and Mineral Research, 27, pp. 876 - 890, http://dx.doi.org/10.1002/jbmr.1495
,2012, 'A mouse model for spondyloepiphyseal dysplasia congenita with secondary osteoarthritis due to a Col2a1 mutation', Journal of Bone and Mineral Research, 27, pp. 413 - 428, http://dx.doi.org/10.1002/jbmr.547
,2012, 'A mouse model of early-onset renal failure due to a xanthine dehydrogenase nonsense mutation', PLoS One, 7, pp. e45217, http://dx.doi.org/10.1371/journal.pone.0045217
,2012, 'A mouse with an N-Ethyl-N-Nitrosourea (ENU) induced Trp589Arg Galnt3 mutation represents a model for hyperphosphataemic familial tumoural calcinosis', PLoS One, 7, pp. e43205, http://dx.doi.org/10.1371/journal.pone.0043205
,2012, 'A soluble bone morphogenetic protein type IA receptor increases bone mass and bone strength', Proceedings of the National Academy of Sciences of the United States of America, 109, pp. 12207 - 12212, http://dx.doi.org/10.1073/pnas.1204929109
,2012, 'Mice lacking the calcineurin inhibitor Rcan2 have an isolated defect of osteoblast function', Endocrinology, 153, pp. 3537 - 3548, http://dx.doi.org/10.1210/en.2011-1814
,2012, 'Rapid-throughput skeletal phenotyping of 100 knockout mice identifies 9 new genes that determine bone strength', PLoS Genetics, 8, pp. e1002858, http://dx.doi.org/10.1371/journal.pgen.1002858
,2012, 'Soluble rank ligand produced by myeloma cells causes generalised bone loss in multiple myeloma', PLoS One, 7, pp. e41127, http://dx.doi.org/10.1371/journal.pone.0041127
,2012, 'Targeting tumour-initiating cells with TRAIL based combination therapy ensures complete and lasting eradication of multiple myeloma tumours in vivo', PLoS One, 7, pp. e35830, http://dx.doi.org/10.1371/journal.pone.0035830
,2011, 'Bisphosphonates in preclinical bone oncology', Bone, 49, pp. 66 - 70, http://dx.doi.org/10.1016/j.bone.2010.11.017
,2011, 'Glycogen synthase kinase-3α/β inhibition promotes in vivo amplification of endogenous mesenchymal progenitors with osteogenic and adipogenic potential and their differentiation to the osteogenic lineage', Journal of Bone and Mineral Research, 26, pp. 811 - 821, http://dx.doi.org/10.1002/jbmr.266
,2011, 'Hedgehog signalling is required for perichondral osteoblast differentiation in zebrafish', Mechanisms of Development, 128, pp. 141 - 152, http://dx.doi.org/10.1016/j.mod.2010.11.006
,2011, 'Tumor-host cell interactions in the bone disease of myeloma', Bone, 48, pp. 121 - 128, http://dx.doi.org/10.1016/j.bone.2010.06.029
,2011, 'Deregulation of the bone marrow stromal compartment occurs early in multiple myeloma and precedes osteolytic bone disease', Bone, 48, pp. S253 - S254, http://dx.doi.org/10.1016/j.bone.2011.03.619
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