By Professor Stuart Graham Tangye

Journal articles

Ma CS; Chew G; Simpson N; Priyadarshi A; Wong M; Grimbacher B; Fulcher DA; Tangye SG; Cook M, 2008, 'Deficiency of Th17 cells in hyper IgE syndrome due to mutations in STAT3', Journal of Experimental Medicine, 205, pp. 1551 - 1557

Chaganti S; Ma C; Bell A; Croom-Carter D; Hislop A; Tangye SG; Rickinson A, 2008, 'Epstein-Barr virus persistence in the absence of conventional memory B cells: IgM(+)IgD(+)CD27(+) B cells harbor the virus in X-linked lymphoproliferative disease patients', Blood, 112, pp. 672 - 679, http://dx.doi.org/10.1182/blood-2007-10-116269

Rosen DM; Cao W; Avery D; Tangye SG; Liu Y; Houchins J; Lanier L, 2008, 'Functional consequences of interactions between-human NKR-P1A and its ligand LLT1 expressed on activated dendritic cells and B cells', Journal of Immunology, 180, pp. 6508 - 6517

Avery D; Bryant V; Ma C; Malefyt R; Tangye SG, 2008, 'IL-21-induced isotype switching to IgG and IgA by human naive B cells is differentially regulated by IL-4', Journal of Immunology, 181, pp. 1767 - 1779

Deenick E; Tangye SG, 2008, 'Immunology: Helpful T cells are sticky', Nature, 455, pp. 745 - 746

Avery D; Ma C; Bryant V; Santner-Nanan B; Nanan R; Wong MB; Fulcher DA; Cook M; Tangye SG, 2008, 'STAT3 is required for IL-21-induced secretion of IgE from human naive B cells', Blood, 112, pp. 1784 - 1793

King CK; Tangye SG; MacKay CR, 2008, 'T follicular helper (T-FH) cells in normal and dysregulated immune responses', Annual Review of Immunology, 26, pp. 741 - 766, http://dx.doi.org/10.1146/annurev.immunol.26.021607.090344

Tangye SG; Avery DT; Bryant VL; Ma CS, 2007, 'Follicular CD4+T helper cells induce human B cells to undergo Ig isotype switching and differentiation to Ig-secreting cells through the production of IL-21', JOURNAL OF IMMUNOLOGY, 178, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000209758202295&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Mackay F; Groom JR; Tangye SG, 2007, 'An important role for B-cell activation factor and B cells in the pathogenesis of Sjogren`s syndrome', Current Opinion in Rheumatology, 19, pp. 406 - 413

Deenick E; Tangye SG, 2007, 'Autoimmunity IL-21: a new player in Th17-cell differentiation', Immunology and Cell Biology, 85, pp. 503 - 505

Bryant V; Ma C; Avery D; Li Y; Good K; Corcoran L; Malefyt R; Tangye SG, 2007, 'Cytokine-mediated regulation of human B cell differentiation into Ig-secreting cells: Predominant role of IL-21 produced by CXCR5(+) T follicular helper cells', Journal of Immunology, 179, pp. 8180 - 8190

Good K; Tangye SG, 2007, 'Decreased expression of Kruppel-like factors in memory B cells induces the rapid response typical of secondary antibody responses', Proceedings of the National Academy of Sciences of the United States of America, 104, pp. 13420 - 13425

Tangye SG; Good K, 2007, 'Human IgM(+)CD27(+) B cells: Memory B cells or `memory` B cells?', Journal of Immunology, 179, pp. 13 - 19

Ma C; Nichols K; Tangye SG, 2007, 'Regulation of cellular and humoral immune responses by the SLAM and SAP families of molecules', Annual Review of Immunology, 25, pp. 337 - 379

Hare NJ; Ma CS; Alvaro F; Nichols KE; Tangye SG, 2006, 'Missense mutations in SH2D1A identified in patients with X-linked lymphoproliferative disease differentially affect the expression and function of SAP', International Immunology, 18, pp. 1055 - 1065, http://dx.doi.org/10.1093/intimm/dxl039

Seddiki N; Santner-Nanan B; Tangye SG; Alexander SI; Solomon M; Lee S; Nanan R; Fazekas De Saint Groth B, 2006, 'Persistence of naive CD45RA⁺ regulatory T cells in adult life', Blood, 107, pp. 2830 - 2838, http://dx.doi.org/10.1182/blood-2005-06-2403

Cuss AK; Avery DT; Cannons JL; Yu LJ; Nichols KE; Shaw PJ; Tangye SG, 2006, 'Expansion of functionally immature transitional B cells is associated with human-immunodeficient states characterized by impaired humoral immunity', Journal of Immunology, 176, pp. 1506 - 1516, http://dx.doi.org/10.4049/jimmunol.176.3.1506

Ma CS; Pittaluga S; Avery DT; Hare NJ; Maric I; Klion AD; Nichols KE; Tangye SG, 2006, 'Selective generation of functional somatically mutated IgM ⁺CD27⁺, but not Ig isotype-switched, memory B cells in X-linked lymphoproliferative disease', Journal of Clinical Investigation, 116, pp. 322 - 333, http://dx.doi.org/10.1007/0-387-34403-9_44

Tangye S; Mackay F, 2006, 'B Cells and Autoimmunity', , pp. 139 - 156, http://dx.doi.org/10.1016/B978-012595961-2/50014-7

Tangye SG; Bryant V; Cuss A; Good K, 2006, 'BAFF, APRIL and human B cell disorders', Seminars in Immunology, 18, pp. 305 - 317

Liu SM; Xavier R; Good K; Newton R; Sisavanh M; Zimmer S; Deng C; Silva D; Frost M; Tangye SG; Rolph MS; Mackay C; Chtanova T, 2006, 'Immune cell transcriptome datasets reveal novel leukocyte subset-specific genes and genes associated with allergic processes', Journal of Allergy and Clinical Immunology, 118, pp. 496 - 503

Good K; Bryant V; Tangye SG, 2006, 'Kinetics of human B cell behavior and amplification of proliferative responses following stimulation with IL-21', Journal of Immunology, 177, pp. 5236 - 5247

Gu C; Tangye SG; Sun XF; Luo Y; Lin Z; Wu J, 2006, 'The X-linked lymphoproliferative disease gene product SAP associates with PAK-interacting exchange factor and participates in T cell activation', Proceedings of the National Academy of Sciences of the United States of America, 103, pp. 14447 - 14452

Dupré L; Andolfi G; Tangye SG; Clementi R; Locatelli F; Aricò M; Aiuti A; Roncarolo MG, 2005, 'SAP controls the cytolytic activity of CD8⁺ T cells against EBV-infected cells', Blood, 105, pp. 4383 - 4389, http://dx.doi.org/10.1182/blood-2004-08-3269

Avery DT; Ellyard JI; Mackay F; Corcoran LM; Hodgkin PD; Tangye SG, 2005, 'Erratum: Increased expression of CD27 on activated human memory B cells correlates with their commitment to the plasma cell lineage (Journal of Immunology (2005) 174 (4034-4042))', Journal of Immunology, 174, pp. 5885, http://dx.doi.org/10.4049/jimmunol.174.9.5885

Avery DT; Ellyard JI; Mackay F; Corcoran LM; Hodgkin PD; Tangye SG, 2005, 'Increased expression of CD27 on activated human memory B cells correlates with their commitment to the plasma cell lineage (vol 174, pg 4034, 2005)', JOURNAL OF IMMUNOLOGY, 174, pp. 5885 - 5885, http://dx.doi.org/10.4049/jimmunol.174.9.5885

Ma CS; Hare NJ; Nichols KE; Dupré L; Andolfi G; Roncarolo M-G; Adelstein S; Hodgkin PD; Tangye SG, 2005, 'Impaired humoral immunity in X-linked lymphoproliferative disease is associated with defective IL-10 production by CD4+ T cells', Journal of Clinical Investigation, 115, pp. 1049 - 1059, http://dx.doi.org/10.1172/jci23139

Ma CS; Hare NJ; Nichols KE; Dupré L; Andolfi G; Roncarolo MG; Adelstein S; Hodgkin PD; Tangye SG, 2005, 'Impaired humoral immunity in X-linked lymphoproliferative disease is associated with defective IL-10 production by CD4⁺ T cells', Journal of Clinical Investigation, 115, pp. 1049 - 1059, http://dx.doi.org/10.1172/JCI200523139

Nichols KE; Hom J; Gong SY; Ganguly A; Ma CS; Cannons JL; Tangye SG; Schwartzberg PL; Koretzky GA; Stein PL, 2005, 'Regulation of NKT cell development by SAP, the protein defective in XLP', Nature Medicine, 11, pp. 340 - 345, http://dx.doi.org/10.1038/nm1189

Nichols KE; Ma CS; Cannons JL; Schwartzberg PL; Tangye SG, 2005, 'Molecular and cellular pathogenesis of X-linked lymphoproliferative disease', Immunological Reviews, 203, pp. 180 - 199, http://dx.doi.org/10.1111/j.0105-2896.2005.00230.x

Nichols KE; Hom J; Ganguly A; Ma CS; Tangye SG; Cannons JL; Schwartzberg PL; Koretzky GA; Stein PL, 2004, 'Regulation of NKT Cell Development by Sap, the Adaptor Mutated in X-Linked Lymphoproliferative Disease.', Blood, 104, pp. 317 - 317, http://dx.doi.org/10.1182/blood.v104.11.317.317

Tangye SG; Hodgkin PD, 2004, 'Divide and conquer: The importance of cell division in regulating B-cell responses', Immunology, 112, pp. 509 - 520, http://dx.doi.org/10.1111/j.1365-2567.2004.01950.x

Ellyard JI; Avery DT; Phan TG; Hare NJ; Hodgkin PD; Tangye SG, 2004, 'Antigen-selected, immunoglobulin-secreting cells persist in human spleen and bone marrow', Blood, 103, pp. 3805 - 3812, http://dx.doi.org/10.1182/blood-2003-09-3109

Avery DT; Kalled SL; Ellyard JI; Ambrose C; Bixler SA; Thien M; Brink R; Mackay F; Hodgkin PD; Tangye SG, 2004, 'BAFF selectively enhances the survival of plasmablasts generated from human memory B cells', Journal of Clinical Investigation, 113, pp. 1069 - 1069, http://dx.doi.org/10.1172/jci18025e1

Avery DT; Kalled SL; Ellyard JI; Ambrose C; Bixler SA; Thien M; Brink R; Mackay F; Hodgkin PD; Tangye SG, 2004, 'Erratum: BAFF selectively enhances the survival of plasmablasts generated from human memory B cells (Journal of Clinical Investigation (2003) 112 (286-297) doi:10.1172/JCI200318025)', Journal of Clinical Investigation, 113, pp. 1069, http://dx.doi.org/10.1172/JCI200318025C

Ma CS; Hodgkin PD; Tangye SG, 2004, 'Automatic generation of lymphocyte heterogeneity: Division-dependent changes in the expression of CD27, CCR7 and CD45 by activated human naive CD4⁺ T cells are independently regulated', Immunology and Cell Biology, 82, pp. 67 - 74, http://dx.doi.org/10.1046/j.0818-9641.2003.01206.x

Hasbold J; Corcoran LM; Tarlinton DM; Tangye SG; Hodgkin PD, 2004, 'Evidence from the generation of immunoglobulin G-secreting cells that stochastic mechanisms regulate lymphocyte differentiation', Nature Immunology, 5, pp. 55 - 63, http://dx.doi.org/10.1038/ni1016

Tangye SG; Nichols KE; Hare NJ; Van de Weerdt BCM, 2003, 'Functional requirements for interactions between CD84 and Src homology 2 domain-containing proteins and their contribution to human T cell activation', Journal of Immunology, 171, pp. 2485 - 2495, http://dx.doi.org/10.4049/jimmunol.171.5.2485

Avery DT; Kalled SL; Ellyard JI; Ambrose C; Bixler SA; Thien M; Brink R; Mackay F; Hodgkin PD; Tangye SG, 2003, 'BAFF selectively enhances the survival of plasmablasts generated from human memory B cells', Journal of Clinical Investigation, 112, pp. 286 - 297, http://dx.doi.org/10.1172/jci200318025

Tangye SG; Avery DT; Deenick EK; Hodgkin PD, 2003, 'Intrinsic differences in the proliferation of naive and memory human B cells as a mechanism for enhanced secondary immune responses', Journal of Immunology, 170, pp. 686 - 694, http://dx.doi.org/10.4049/jimmunol.170.2.686

Tangye SG; Avery DT; Hodgkin PD, 2003, 'A division-linked mechanism for the rapid generation of Ig-secreting cells from human memory B cells', Journal of Immunology, 170, pp. 261 - 269, http://dx.doi.org/10.4049/jimmunol.170.1.261

Avery DT; Kalled SL; Ellyard JI; Ambrose C; Bixler SA; Thien M; Brink R; MacKay F; Hodgkin PD; Tangye SG, 2003, 'BAFF selectively enhances the survival of plasmablasts generated from human memory B cells', Journal of Clinical Investigation, 112, pp. 286 - 297, http://dx.doi.org/10.1172/JCI18025

Tangye SG; Ferguson A; Avery DT; Ma CS; Hodgkin PD, 2002, 'Isotype switching by human B cells is division-associated and regulated by cytokines', Journal of Immunology, 169, pp. 4298 - 4306, http://dx.doi.org/10.4049/jimmunol.169.8.4298

Tangye SG; Van De Weerdt BCM; Avery DT; Hodgkin PD, 2002, 'CD84 is up-regulated on a major population of human memory B cells and recruits the SH2 domain containing proteins SAP and EAT-2', European Journal of Immunology, 32, pp. 1640 - 1649, http://dx.doi.org/10.1002/1521-4141(200206)32:6<1640::AID-IMMU1640>3.0.CO;2-S

Weston KM; Tangye SG; Dunn RD; Smith A; Morris MB; Raison RL, 2001, 'IgM expressed by leukemic CD5⁺ B cells binds mouse immunoglobulin light chain', Journal of Molecular Recognition, 14, pp. 245 - 253, http://dx.doi.org/10.1002/jmr.539

Baker JE; Majeti R; Tangye SG; Weiss A, 2001, 'Protein tyrosine phosphatase CD148-mediated inhibition of T-cell receptor signal transduction is associated with reduced LAT and phospholipase Cγ1 phosphorylation', Molecular and Cellular Biology, 21, pp. 2393 - 2403, http://dx.doi.org/10.1128/MCB.21.7.2393-2403.2001

Tangye SG; Cherwinski H; Lanier LL; Phillips JH, 2000, '2B4-mediated activation of human natural killer cells', Molecular Immunology, 37, pp. 493 - 501, http://dx.doi.org/10.1016/S0161-5890(00)00076-6

Tangye SG; Phillips JH; Lanier LL; Nichols KE, 2000, 'Cutting edge: Functional requirement for SAP in 2B4-mediated activation of human natural killer cells as revealed by the X-linked lymphoproliferative syndrome', Journal of Immunology, 165, pp. 2932 - 2936, http://dx.doi.org/10.4049/jimmunol.165.6.2932

Tangye SG; Phillips JH; Lanier LL, 2000, 'The CD2-subset of the Ig superfamily of cell surface molecules: Receptor-ligand pairs expressed by NK cells and other immune cells', Seminars in Immunology, 12, pp. 149 - 157, http://dx.doi.org/10.1006/smim.2000.0217

Castro AG; Hauser TM; Cocks BG; Abrams J; Zurawski S; Churakova T; Zonin F; Robinson D; Tangye SG; Aversa G; Nichols KE; De Vries JE; Lanier LL; O'Garra A, 1999, 'Molecular and functional characterization of mouse signaling lymphocytic activation molecule (SLAM): Differential expression and responsiveness in Th1 and Th2 cells', Journal of Immunology, 163, pp. 5860 - 5870

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