By Scientia Professor Anthony D Kelleher

Journal articles

Bhaskaran K; Hamouda O; Sannes M; Boufassa F; Johnson AM; Lambert PC; Porter K; CASCADE Collaboration , 2008, 'Changes in the risk of death after HIV seroconversion compared with mortality in the general population.', JAMA, 300, pp. 51 - 59, http://dx.doi.org/10.1001/jama.300.1.51

Seddiki N; Kelleher AD, 2008, 'Regulatory T cells in HIV infection: Who's suppressing what?', Current Infectious Disease Reports, 10, pp. 252 - 258, http://dx.doi.org/10.1007/s11908-008-0041-8

Seddiki N; Kelleher AD, 2008, 'Regulatory T cells in HIV infection: Who's suppressing what?', Current HIV/AIDS Reports, 5, pp. 20 - 26, http://dx.doi.org/10.1007/s11904-008-0004-6

McElrath MJ; De Rosa SC; Moodie Z; Dubey S; Kierstead L; Janes H; Defawe OD; Carter DK; Hural J; Akondy R; Buchbinder SP; Robertson MN; Mehrotra DV; Self SG; Corey L; Shiver JW; Casimiro DR, 2008, 'HIV-1 vaccine-induced immunity in the test-of-concept Step Study: a case-cohort analysis', The Lancet, 372, pp. 1894 - 1905, http://dx.doi.org/10.1016/S0140-6736(08)61592-5

Santner-Nanan B; Seddiki N; Zhu E; Quent V; Kelleher AD; Fazekas de St Groth B; Nanan R, 2008, 'Accelerated age-dependent transition of human regulatory T cells to effector memory phenotype', International Immunology, 20, pp. 375 - 383, http://dx.doi.org/10.1093/intimm/dxm151

Suzuki K; Juelich T; Lim H; Ishida T; Watanebe T; Cooper DA; Rao S; Kelleher AD, 2008, 'Closed chromatin architecture is induced by an RNA duplex targeting the HIV-1 promoter region', The Journal of Biological Chemistry, 283, pp. 23353 - 23363

Kelleher AD; Purcell D, 2008, 'Controlling HIV infection HIV co-receptor gets the finger', Immunology and Cell Biology, 86, pp. 641 - 642

Mallon PW; Sedwell R; Rogers GJ; Nolan D; Unemori P; Hoy JF; Samaras K; Kelleher AD; Emery S; Cooper DA; Carr AD, 2008, 'Effect of Rosiglitazone on Peroxisome Proliferator-Activated Receptor gamma Gene Expression in Human Adipose Tissue Is Limited by Antiretroviral Drug-Induced Mitochondrial Dysfunction', Journal of Infectious Diseases, 198, pp. 1794 - 1803

Chessman D; Kostenko L; Lethborg T; Purcell A; Williamson N; Chen Z; Kjer-Nielsen L; Mifsud N; Tait B; Holdsworth R; Almeida C; Nolan D; Macdonalds W; Archbold J; Kelleher AD; Marriott D; Mallal SA; Bharadwaj M; Rossjohn J; McCluskey J, 2008, 'Human leukocyte antigen class I-restricted activation of CD8(+) T cells provides the immunogenetic basis of a systemic drug hypersensitivity', Immunity, 28, pp. 822 - 832, http://dx.doi.org/10.1016/j.immuni.2008.04.020

Mason R; De Rose R; Seddiki N; Kelleher AD; Kent SJ, 2008, 'Low pre-infection levels and loss of central memory CD4+T cells may predict rapid progression in SIV-infected pigtail macaques', Virology, 381, pp. 11 - 15

Brumme Z; Brumme C; Carlson J; Streeck H; John M; Eichbaum Q; Block B; Baker B; Kadie C; Markowitz M; Jessen H; Kelleher AD; Rosenberg E; Kaldor JM; Yuki Y; Carrington M; Allen TM; Mallal SA; Altfeld M; Heckerman D; Walker BD, 2008, 'Marked epitope- and allele- specific differences in rates of mutation in human immunodeficiency type 1 (HIV-1) Gag, Pol, and Nef cytotoxic T-lymphocyte epitopes in acute/early HIV-1 infection', Journal of Virology, 82, pp. 9216 - 9227

Lim H; Suzuki K; Cooper DA; Kelleher AD, 2008, 'Promoter-targeted siRNAs induce gene silencing of simian immunodeficiency virus (SIV) infection in vitro', Molecular Therapy, 16, pp. 565 - 570, http://dx.doi.org/10.1038/sj.mt.6300380

Seddiki N; Kelleher AD, 2008, 'Regulatory T cell abnormalities are associated with aberrant CD4+ T cell responses in patients with immune inflammatory syndrome (IRIS)', Clinical Immunology, 127, pp. S126 - S127, http://dx.doi.org/10.1016/j.ctim.2008.03.359

Burton C; Goodall R; Samri A; Autran B; Kelleher AD; Poli G; Pantaleo G; Gotch F; Imami N, 2008, 'Restoration of anti-tetanus toxoid responses in patients initiating highly active antiretroviral therapy with or without a boost immunization: an INITIO substudy', Clinical and Experimental Immunology, 152, pp. 252 - 257, http://dx.doi.org/10.1111/j.1365-2249.2008.03611.x

De Rose R; Mason RS; Loh L; Peut V; Smith MZ; Fernandez CS; Alcantara S; amarasena T; Reece J; Seddiki N; Kelleher AD; Zaunders J; Kent SJ, 2008, 'Safety, immunogenicity and efficacy of peptide-pulsed cellular immunotherapy in macaques.', Journal of Medical Primatology, 37, pp. 69 - 78

Streeck H; Van Bockel DJ; Kelleher AD, 2008, 'T-cell responses in primary HIV-1 infection. .', Current opinion in HIV & AIDS, 3, pp. 52 - 59

Venturi V; Chin HY; Asher TE; Ladell K; Scheinberg P; Bornstein E; van Bockel D; Kelleher AD; Douek DC; Price DA; Davenport MP, 2008, 'TCR beta-chain sharing in human CD8+ T cell responses to cytomegalovirus and EBV', Journal of Immunology, 181, pp. 7853 - 7862

Falster KA; Gelgor L; Shaik A; Zablotska Manos I; Prestage G; Grierson J; Thorpe R; Pitts M; Anderson JS; Chuah J; Mulhall BP; Petoumenos K; Kelleher AD; Law MG, 2008, 'Trends in antiretroviral treatment use and treatment response in three Australian states in the first decade of combination antiretroviral treatment', Sexual Health, 5, pp. 141 - 154

Lewin S; Murray JM; Solomon A; Wightman F; Cameron P; Purcell DJ; Zaunders J; Grey PA; Bloch M; Smith DE; Cooper DA; Kelleher AD, 2008, 'Virologic determinants of success after structured treatment interruptions in antiretrovirals in acute HIV-1 infection', JAIDS: Journal of Acquired Immune Deficiency Syndromes, 47, pp. 140 - 147

Zaunders J; Jing J; Leipold M; Maecker H; Kelleher AD; Koch I, 2007, 'Computationally efficient multidimensional analysis of complex flow cytometry data using second order polynomial histograms', Cytometry Part A, 89, pp. 44 - 58, http://dx.doi.org/10.1002/cyto.a.22704

Munier CM; Kelleher AD, 2007, 'Acutely dysregulated, chronically disabled by the enemy within: T-cell responses to HIV-1 infection', Immunology and Cell Biology, 85, pp. 6 - 15

Murray JM; Emery S; Kelleher AD; Law MG; Chen J; Hazuda DJ; Nguyen BT; Teppler H; Cooper DA, 2007, 'Antiretroviral therapy with the integrase inhibitor raltegravir alters decay kinetics of HIV, significantly reducing the second phase', AIDS, 21, pp. 2315 - 2321

Schneidewind A; Brockman M; Yang R; Adam RI; Li B; Le Gall S; Rinaldo C; Craggs SL; Allgaier RL; Power KA; Kuntzen T; Tung C; LaBute MX; Mueller SC; Harrer T; Mcmichael AJ; Goulder PJ; Aiken CM; Brander C; Kelleher AD; Allen TM, 2007, 'Escape from the Dominant HLA-B27-Restricted Cytotoxic T-Lymphocyte Response in Gag Is Associated with a Dramatic Reduction in Human Immunodeficiency Virus Type 1 Replication', Journal of Virology, 81, pp. 12382 - 12393

Emery S; Kelleher AD; Workman C; Puls R; Bloch MT; Baker D; Hoy JF; Ip S; Nalliah K; Ward L; Law MG; Cooper DA, 2007, 'Influence of IFN gamma co-expression on the safety and antiviral efficacy of recombinant fowlpox virus HIV therapeutic vaccines following interruption of antiretroviral therapy', Human Vaccines, 3, pp. 260 - 267

Lin BB; Gladden A; Altfeld M; Kaldor JM; Cooper DA; Kelleher AD; Allen TM, 2007, 'Rapid Reversion of Sequence Polymorphisms Dominates Early Human Immunodeficiency Virus Type 1 Evolution', Journal of Virology, 81, pp. 193 - 201

Streeck H; Lichterfeld M; Alter G; Meier A; Teigen N; Yassine-Diab B; Sidhu H; Little S; Kelleher AD; Routy J; Rosenberg E; Sekaly R; Walker BD; Altfeld M, 2007, 'Recognition of a defined region within p24 Gag by CD8(+) T cells during primary human immunodeficiency virus type I infection in individuals expressing protective HLA class I alleles', Journal of Virology, 81, pp. 7725 - 7731

Dyer W; Pett SL; Sullivan JS; Emery S; Cooper DA; Kelleher AD; Lloyd AR; Lewin S, 2007, 'Substantial improvements in performance indicators achieved in a peripheral blood mononuclear cell cryopreservation quality assurance program using single donor samples', Clinical and Vaccine Immunology, 14, pp. 52 - 59

Venturi V; Chin H; Asher T; Ladell K; Scheinberg P; Bornstein E; Van Bockel DJ; Kelleher AD; Douek DC; Price DA; Davenport MP, 2007, 'T cell receptor b-chain sharing in human CD8+ T cell responses to cytomegalovirus and Epstein-Barr virus', Journal of Immunology, 181, pp. 7853 - 7862

Samri A; Goodall RL; Burton C; Imami N; Pantaleo G; Kelleher AD; Poli G; Gotch F; Autran B, 2007, 'Three-year immune reconstitution in PI-sparing and PI-containing antiretroviral regimens in advanced HIV-1 disease', Antiviral Therapy, 12, pp. 553 - 558

Kaufmann D; Kavanagh D; Pereyra F; Zaunders J; Mackey E; Miura T; Palmer S; Brockman M; Rathod A; Piechocka-Trocha A; Baker B; Zhu B; Le Gall S; Waring M; Ahern R; Moss K; Kelleher AD; Coffin J; Freeman G; Rosenberg E; Walker BD, 2007, 'Upregulation of CTLA-4 by HIV-specific CD4(+) T cells correlates with disease progression and defines a reversible immune dysfunction', Nature Immunology, 8, pp. 1246 - 1254

van Bockel D; Price DA; Asher TE; Venturi V; Suzuki K; Warton K; Davenport MP; Cooper DA; Douek DC; Kelleher AD, 2007, 'Validation of RNA-based molecular clonotype analysis for virus-specific CD8+ T-cells in formaldehyde-fixed specimens isolated from peripheral blood', Journal of Immunological Methods, 326, pp. 127 - 138, http://dx.doi.org/10.1016/j.jim.2007.07.016

Hemelaar J; Gouws E; Ghys PD; Osmanov S, 2006, 'Global and regional distribution of HIV-1 genetic subtypes and recombinants in 2004.', AIDS, 20, pp. W13 - W23, http://dx.doi.org/10.1097/01.aids.0000247564.73009.bc

Hales GP; Birch C; Crowe S; Workman C; Hoy JF; Kelleher AD; Lincoln D; Lincoln D; Law MG; Emery S, 2006, 'A randomised trial comparing genotypic and virtual phenotypic interpretation of HIV drug resistance: The CREST study.', PLoS Clinical Trials, 1, pp. e18

Kelleher AD; Puls R; Bebbington M; Boyle D; Kent S; Kippax SC; Purcell D; Thomson S; Wand HC; Cooper DA; Emery S; Ffrench RA, 2006, 'A randomized, placebo-controlled phase I trial of DNA prime, recombinant fowlpox virus boost prophylactic vaccine for HIV-1', AIDS, 20, pp. 294 - 297

Zaunders J; Dyer W; Munier CM; Ip S; Liu J; Amyes E; Rawlinson WD; Rose RJ; Kent SJ; Sullivan JS; Cooper DA; Kelleher AD, 2006, 'CD127+CCR5+CD38+++CD4+ Th1 Effector Cells Are an Early Component of the Primary Immune Response to Vaccinia Virus and Precede Development of Interleukin-2+ Memory CD4+ T Cells', Journal of Virology, 80, pp. 10151 - 10161

Kelleher AD; Zaunders J, 2006, 'Decimated or missing in action:CD4+ T cells as targets and effectors in the pathogenesis of primary HIV infection. Curr HIV/AIDS Rep 2006;3(1):5-12.', Current HIV/AIDS Reports, 3, pp. 5 - 12

De Rose R; Sullivan MT; Dale CJ; Kelleher AD; Emery S; Cooper DA; Ramshaw I; Boyle D; Kent SJ, 2006, 'Dose-response relationship of DNA and recombinant fowlpox virus prime-boost HIV vaccines.', Human Vaccines, 2, pp. 134 - 136

Fazekos de St Groth B; Seddiki N; Santner-Nanan B; Martinson J; Zaunders J; Sasson SC; Landay A; Nanan R; Kelleher AD, 2006, 'Expression of IL-2 and IL-7 receptors discriminates between human regulatory and activated T-cells within CD45RA and CD45RO compartments', Clinical Immunology, 119, pp. S7 - S7

Seddiki N; Santner-Nanan B; Martinson J; Zaunders J; Sasson SC; Landay A; Solomon MJ; Selby W; Alexander S; Nanan R; Kelleher AD; Fazekas de St Groth B; Solomon M, 2006, 'Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells', Journal of Experimental Medicine, 203, pp. 1693 - 1700, http://dx.doi.org/10.1084/jem.20060468

Barbour J; Hecht FM; Little S; Markowitz M; Daar E; Kelleher AD; Routy J; Campbell T; Rosenberg E; Segal M; Weidler J; Grant R, 2006, 'Greater CD4 T-cell gains after one year of antiretroviral therapy are associated with lower HIV-1 pol replication capacity.', AIDS, 20, pp. 2123 - 2125

Sasson SC; Zaunders J; Zanetti G; King E; Merlin K; Smith DE; Stanley K; Cooper DA; Kelleher AD, 2006, 'Increased plasma interleukin-7 level correlates with decreased CD127 and increased CD132 extracellular expression on T cell subsets in patients with HIV-1 infection', Journal of Infectious Diseases, 193, pp. 505 - 514

Zaunders J; Ip S; Munier CM; Munier M; Kaufmann D; Suzuki K; Brereton C; Seddiki N; Sasson SC; Koelsch KK; Landay A; Grey PA; Finlayson R; Kaldor JM; Rosenberg E; Walker BD; Fazekas de St Groth B; Cooper DA; Kelleher AD, 2006, 'Infection of CD127(+) (Interleukin-7 receptor+) CD4+ cells and overexpression of CTLA-4 are linked to loss of antigen-specific CD4 T cells during primary human immunodeficiency virus type 1 infection', Journal of Virology, 80, pp. 10162 - 10172

Carlin S; Moore JJ; Zaunders J; Kelleher AD; Ma DD, 2006, 'T lineage differentiation in vitro of adult Haematopoietic Stem Cells', CYTOMETRY PART A, 69A, pp. 399 - 400

Sasson SC; Zaunders J; Kelleher AD, 2006, 'The IL-7/IL-7 receptor axis: understanding its central role in T-cell homeostatis and the challenges facing its utilization as a novel therapy. 2006;7:1571-1582.', Current Drug Targets, 7, pp. 1571 - 1582

Bloch MT; Smith DE; Quan D; Kaldor JM; Zaunders J; Petoumenos K; Irvine K; Law MG; Grey PA; Finlayson R; Mcfarlane R; Kelleher AD; Carr AD; Cooper DA, 2006, 'The role of hydroxyurea in enhancing the virologic control achieved through structured treatment interruption in primary HIV infection: Final results from a randomized clinical trial (Pulse)', JAIDS: Journal of Acquired Immune Deficiency Syndromes, 42, pp. 192 - 202

Ammaranond P; Zaunders J; Satchell C; Van Bockel DJ; Cooper DA; Kelleher AD, 2005, 'A new variant cytotoxic T lymphocyte escape mutation in HLA-B27-positive individuals infected with HIV type 1', AIDS Research and Human Retroviruses, 21, pp. 395 - 397

Zaunders J; Munier M; Kaufmann D; Ip S; Grey PA; Smith DE; Ramacciotti TP; Quan D; Finlayson RJ; Kaldor JM; Rosenberg E; Walker BD; Cooper DA; Kelleher AD, 2005, 'Early proliferation of CCR5(+) CD38(+++) antigen-specific CD4(+) Th1 effector cells during primary HIV-1 infection', Blood, 106, pp. 1660 - 1667

Sedwell R; Mallon PW; Duarte NL; Zaunders J; Kelleher AD; Cooper DA; Carr AD, 2005, 'Impaired mitochondrial function induced by NRTIs is only detectable in the monocyte (CD14(+)) subset of human PBMC', Antiviral Therapy, 10, pp. L44 - L45

Mallon PW; Unemori P; Sedwell R; Morey AL; Rafferty M; Williams KM; Chisholm DJ; Samaras K; Emery S; Kelleher AD; Cooper DA; Carr AD, 2005, 'In vivo, nucleoside reverse-transcriptase inhibitors alter expression of both mitochondrial and lipid metabolism genes in the absence of depletion of mitochondrial DNA', Journal of Infectious Diseases, 191, pp. 1686 - 1696

Mallon PW; Sedwell R; Unemori P; Kelleher AD; Cooper DA; Carr AD, 2005, 'Methodological considerations in human studies of gene expression in HIV-associated lipodystrophy', Antiviral Therapy, 10, pp. M101 - M108

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