By Scientia Professor Anthony D Kelleher

Journal articles

Brumme Z; Brumme C; Carlson J; Streeck H; John M; Eichbaum Q; Block B; Baker B; Kadie C; Markowitz M; Jessen H; Kelleher AD; Rosenberg E; Kaldor JM; Yuki Y; Carrington M; Allen TM; Mallal SA; Altfeld M; Heckerman D; Walker BD, 2008, 'Marked epitope- and allele- specific differences in rates of mutation in human immunodeficiency type 1 (HIV-1) Gag, Pol, and Nef cytotoxic T-lymphocyte epitopes in acute/early HIV-1 infection', Journal of Virology, 82, pp. 9216 - 9227

Lim H; Suzuki K; Cooper DA; Kelleher AD, 2008, 'Promoter-targeted siRNAs induce gene silencing of simian immunodeficiency virus (SIV) infection in vitro', Molecular Therapy, 16, pp. 565 - 570, http://dx.doi.org/10.1038/sj.mt.6300380

Seddiki N; Kelleher AD, 2008, 'Regulatory T cell abnormalities are associated with aberrant CD4+ T cell responses in patients with immune inflammatory syndrome (IRIS)', Clinical Immunology, 127, pp. S126 - S127, http://dx.doi.org/10.1016/j.ctim.2008.03.359

Burton C; Goodall R; Samri A; Autran B; Kelleher AD; Poli G; Pantaleo G; Gotch F; Imami N, 2008, 'Restoration of anti-tetanus toxoid responses in patients initiating highly active antiretroviral therapy with or without a boost immunization: an INITIO substudy', Clinical and Experimental Immunology, 152, pp. 252 - 257, http://dx.doi.org/10.1111/j.1365-2249.2008.03611.x

De Rose R; Mason RS; Loh L; Peut V; Smith MZ; Fernandez CS; Alcantara S; amarasena T; Reece J; Seddiki N; Kelleher AD; Zaunders J; Kent SJ, 2008, 'Safety, immunogenicity and efficacy of peptide-pulsed cellular immunotherapy in macaques.', Journal of Medical Primatology, 37, pp. 69 - 78

Streeck H; Van Bockel DJ; Kelleher AD, 2008, 'T-cell responses in primary HIV-1 infection. .', Current opinion in HIV & AIDS, 3, pp. 52 - 59

Venturi V; Chin HY; Asher TE; Ladell K; Scheinberg P; Bornstein E; van Bockel D; Kelleher AD; Douek DC; Price DA; Davenport MP, 2008, 'TCR beta-chain sharing in human CD8+ T cell responses to cytomegalovirus and EBV', Journal of Immunology, 181, pp. 7853 - 7862

Lewin S; Murray JM; Solomon A; Wightman F; Cameron P; Purcell DJ; Zaunders J; Grey PA; Bloch M; Smith DE; Cooper DA; Kelleher AD, 2008, 'Virologic determinants of success after structured treatment interruptions in antiretrovirals in acute HIV-1 infection', JAIDS: Journal of Acquired Immune Deficiency Syndromes, 47, pp. 140 - 147

Murray JM; Emery S; Kelleher AD; Law M; Chen J; Hazuda DJ; Nguyen BYT; Teppler H; Cooper DA, 2007, 'Antiretroviral therapy with the integrase inhibitor raltegravir alters decay kinetics of HIV, significantly reducing the second phase', AIDS, 21, pp. 2315 - 2321, http://dx.doi.org/10.1097/QAD.0b013e3282f12377

Zaunders J; Jing J; Leipold M; Maecker H; Kelleher AD; Koch I, 2007, 'Computationally efficient multidimensional analysis of complex flow cytometry data using second order polynomial histograms', Cytometry Part A, 89, pp. 44 - 58, http://dx.doi.org/10.1002/cyto.a.22704

Munier CM; Kelleher AD, 2007, 'Acutely dysregulated, chronically disabled by the enemy within: T-cell responses to HIV-1 infection', Immunology and Cell Biology, 85, pp. 6 - 15

Schneidewind A; Brockman M; Yang R; Adam RI; Li B; Le Gall S; Rinaldo C; Craggs SL; Allgaier RL; Power KA; Kuntzen T; Tung C; LaBute MX; Mueller SC; Harrer T; Mcmichael AJ; Goulder PJ; Aiken CM; Brander C; Kelleher AD; Allen TM, 2007, 'Escape from the Dominant HLA-B27-Restricted Cytotoxic T-Lymphocyte Response in Gag Is Associated with a Dramatic Reduction in Human Immunodeficiency Virus Type 1 Replication', Journal of Virology, 81, pp. 12382 - 12393

Emery S; Kelleher AD; Workman C; Puls R; Bloch MT; Baker D; Hoy JF; Ip S; Nalliah K; Ward L; Law MG; Cooper DA, 2007, 'Influence of IFN gamma co-expression on the safety and antiviral efficacy of recombinant fowlpox virus HIV therapeutic vaccines following interruption of antiretroviral therapy', Human Vaccines, 3, pp. 260 - 267

Lin BB; Gladden A; Altfeld M; Kaldor JM; Cooper DA; Kelleher AD; Allen TM, 2007, 'Rapid Reversion of Sequence Polymorphisms Dominates Early Human Immunodeficiency Virus Type 1 Evolution', Journal of Virology, 81, pp. 193 - 201

Streeck H; Lichterfeld M; Alter G; Meier A; Teigen N; Yassine-Diab B; Sidhu H; Little S; Kelleher AD; Routy J; Rosenberg E; Sekaly R; Walker BD; Altfeld M, 2007, 'Recognition of a defined region within p24 Gag by CD8(+) T cells during primary human immunodeficiency virus type I infection in individuals expressing protective HLA class I alleles', Journal of Virology, 81, pp. 7725 - 7731

Dyer W; Pett SL; Sullivan JS; Emery S; Cooper DA; Kelleher AD; Lloyd AR; Lewin S, 2007, 'Substantial improvements in performance indicators achieved in a peripheral blood mononuclear cell cryopreservation quality assurance program using single donor samples', Clinical and Vaccine Immunology, 14, pp. 52 - 59

Venturi V; Chin H; Asher T; Ladell K; Scheinberg P; Bornstein E; Van Bockel DJ; Kelleher AD; Douek DC; Price DA; Davenport MP, 2007, 'T cell receptor b-chain sharing in human CD8+ T cell responses to cytomegalovirus and Epstein-Barr virus', Journal of Immunology, 181, pp. 7853 - 7862

Samri A; Goodall RL; Burton C; Imami N; Pantaleo G; Kelleher AD; Poli G; Gotch F; Autran B, 2007, 'Three-year immune reconstitution in PI-sparing and PI-containing antiretroviral regimens in advanced HIV-1 disease', Antiviral Therapy, 12, pp. 553 - 558

Kaufmann D; Kavanagh D; Pereyra F; Zaunders J; Mackey E; Miura T; Palmer S; Brockman M; Rathod A; Piechocka-Trocha A; Baker B; Zhu B; Le Gall S; Waring M; Ahern R; Moss K; Kelleher AD; Coffin J; Freeman G; Rosenberg E; Walker BD, 2007, 'Upregulation of CTLA-4 by HIV-specific CD4(+) T cells correlates with disease progression and defines a reversible immune dysfunction', Nature Immunology, 8, pp. 1246 - 1254

van Bockel D; Price DA; Asher TE; Venturi V; Suzuki K; Warton K; Davenport MP; Cooper DA; Douek DC; Kelleher AD, 2007, 'Validation of RNA-based molecular clonotype analysis for virus-specific CD8+ T-cells in formaldehyde-fixed specimens isolated from peripheral blood', Journal of Immunological Methods, 326, pp. 127 - 138, http://dx.doi.org/10.1016/j.jim.2007.07.016

Hemelaar J; Gouws E; Ghys PD; Osmanov S, 2006, 'Global and regional distribution of HIV-1 genetic subtypes and recombinants in 2004', AIDS, 20, pp. w13 - w23, http://dx.doi.org/10.1097/01.aids.0000247564.73009.bc

Kelleher AD; Zaunders JJ, 2006, 'Decimated or missing in action: CD4+ T cells as targets and effectors in the pathogenesis of primary HIV infection', Current HIV AIDS Reports, 3, pp. 5 - 12, http://dx.doi.org/10.1007/s11904-006-0002-5

Hales GP; Birch C; Crowe S; Workman C; Hoy JF; Kelleher AD; Lincoln D; Lincoln D; Law MG; Emery S, 2006, 'A randomised trial comparing genotypic and virtual phenotypic interpretation of HIV drug resistance: The CREST study.', PLoS Clinical Trials, 1, pp. e18

Kelleher AD; Puls R; Bebbington M; Boyle D; Kent S; Kippax SC; Purcell D; Thomson S; Wand HC; Cooper DA; Emery S; Ffrench RA, 2006, 'A randomized, placebo-controlled phase I trial of DNA prime, recombinant fowlpox virus boost prophylactic vaccine for HIV-1', AIDS, 20, pp. 294 - 297

Zaunders J; Dyer W; Munier CM; Ip S; Liu J; Amyes E; Rawlinson WD; Rose RJ; Kent SJ; Sullivan JS; Cooper DA; Kelleher AD, 2006, 'CD127+CCR5+CD38+++CD4+ Th1 Effector Cells Are an Early Component of the Primary Immune Response to Vaccinia Virus and Precede Development of Interleukin-2+ Memory CD4+ T Cells', Journal of Virology, 80, pp. 10151 - 10161

De Rose R; Sullivan MT; Dale CJ; Kelleher AD; Emery S; Cooper DA; Ramshaw I; Boyle D; Kent SJ, 2006, 'Dose-response relationship of DNA and recombinant fowlpox virus prime-boost HIV vaccines.', Human Vaccines, 2, pp. 134 - 136

Fazekos de St Groth B; Seddiki N; Santner-Nanan B; Martinson J; Zaunders J; Sasson SC; Landay A; Nanan R; Kelleher AD, 2006, 'Expression of IL-2 and IL-7 receptors discriminates between human regulatory and activated T-cells within CD45RA and CD45RO compartments', Clinical Immunology, 119, pp. S7 - S7

Seddiki N; Santner-Nanan B; Martinson J; Zaunders J; Sasson SC; Landay A; Solomon MJ; Selby W; Alexander S; Nanan R; Kelleher AD; Fazekas de St Groth B; Solomon M, 2006, 'Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells', Journal of Experimental Medicine, 203, pp. 1693 - 1700, http://dx.doi.org/10.1084/jem.20060468

Barbour J; Hecht FM; Little S; Markowitz M; Daar E; Kelleher AD; Routy J; Campbell T; Rosenberg E; Segal M; Weidler J; Grant R, 2006, 'Greater CD4 T-cell gains after one year of antiretroviral therapy are associated with lower HIV-1 pol replication capacity.', AIDS, 20, pp. 2123 - 2125

Sasson SC; Zaunders J; Zanetti G; King E; Merlin K; Smith DE; Stanley K; Cooper DA; Kelleher AD, 2006, 'Increased plasma interleukin-7 level correlates with decreased CD127 and increased CD132 extracellular expression on T cell subsets in patients with HIV-1 infection', Journal of Infectious Diseases, 193, pp. 505 - 514

Zaunders J; Ip S; Munier CM; Munier M; Kaufmann D; Suzuki K; Brereton C; Seddiki N; Sasson SC; Koelsch KK; Landay A; Grey PA; Finlayson R; Kaldor JM; Rosenberg E; Walker BD; Fazekas de St Groth B; Cooper DA; Kelleher AD, 2006, 'Infection of CD127(+) (Interleukin-7 receptor+) CD4+ cells and overexpression of CTLA-4 are linked to loss of antigen-specific CD4 T cells during primary human immunodeficiency virus type 1 infection', Journal of Virology, 80, pp. 10162 - 10172

Carlin S; Moore JJ; Zaunders J; Kelleher AD; Ma DD, 2006, 'T lineage differentiation in vitro of adult Haematopoietic Stem Cells', CYTOMETRY PART A, 69A, pp. 399 - 400

Sasson SC; Zaunders J; Kelleher AD, 2006, 'The IL-7/IL-7 receptor axis: understanding its central role in T-cell homeostatis and the challenges facing its utilization as a novel therapy. 2006;7:1571-1582.', Current Drug Targets, 7, pp. 1571 - 1582

Bloch MT; Smith DE; Quan D; Kaldor JM; Zaunders J; Petoumenos K; Irvine K; Law MG; Grey PA; Finlayson R; Mcfarlane R; Kelleher AD; Carr AD; Cooper DA, 2006, 'The role of hydroxyurea in enhancing the virologic control achieved through structured treatment interruption in primary HIV infection: Final results from a randomized clinical trial (Pulse)', JAIDS: Journal of Acquired Immune Deficiency Syndromes, 42, pp. 192 - 202

Emery S; Workman C; Puls RL; Bloch M; Baker D; Bodsworth N; Anderson J; Crowe SM; French MA; Hoy J; Aichelburg A; Ward LD; Boyle DB; Law MG; Kelleher AD; Cooper DA, 2005, 'Randomized, placebo-controlled, phase I/IIa evaluation of the safety and immunogenicity of fowlpox virus expressing HIV gag-pol and interferon-gamma in HIV-1 infected subjects.', Human Vaccines, 1, pp. 232 - 238, http://dx.doi.org/10.4161/hv.1.6.2342

Ammaranond P; Zaunders J; Satchell C; Van Bockel DJ; Cooper DA; Kelleher AD, 2005, 'A new variant cytotoxic T lymphocyte escape mutation in HLA-B27-positive individuals infected with HIV type 1', AIDS Research and Human Retroviruses, 21, pp. 395 - 397

Zaunders J; Munier M; Kaufmann D; Ip S; Grey PA; Smith DE; Ramacciotti TP; Quan D; Finlayson RJ; Kaldor JM; Rosenberg E; Walker BD; Cooper DA; Kelleher AD, 2005, 'Early proliferation of CCR5(+) CD38(+++) antigen-specific CD4(+) Th1 effector cells during primary HIV-1 infection', Blood, 106, pp. 1660 - 1667

Sedwell R; Mallon PW; Duarte NL; Zaunders J; Kelleher AD; Cooper DA; Carr AD, 2005, 'Impaired mitochondrial function induced by NRTIs is only detectable in the monocyte (CD14(+)) subset of human PBMC', Antiviral Therapy, 10, pp. L44 - L45

Mallon PW; Unemori P; Sedwell R; Morey AL; Rafferty M; Williams KM; Chisholm DJ; Samaras K; Emery S; Kelleher AD; Cooper DA; Carr AD, 2005, 'In vivo, nucleoside reverse-transcriptase inhibitors alter expression of both mitochondrial and lipid metabolism genes in the absence of depletion of mitochondrial DNA', Journal of Infectious Diseases, 191, pp. 1686 - 1696

Mallon PW; Sedwell R; Unemori P; Kelleher AD; Cooper DA; Carr AD, 2005, 'Methodological considerations in human studies of gene expression in HIV-associated lipodystrophy', Antiviral Therapy, 10, pp. M101 - M108

Lim H; Sedwell R; Duarte NL; Cooper DA; Kelleher AD; Carr AD; Mallon PW, 2005, 'Nucleoside reverse transcriptase inhibitor effects on adipocyte mitochondrial DNA quantity and quality in vitro', Antiviral Therapy, 10, pp. L41 - L42

Suzuki K; Shijuuku T; Fukamachi T; Zaunders J; Guillemin GJ; Cooper DA; Kelleher AD, 2005, 'Prolonged transcriptional silencing and CpG methylation induced by siRNAs targeted to the HIV-1 promoter region.', Journal of RNAi and Gene Silencing, 1, pp. 66 - 78

Sasson SC; Kelleher AD; Cooper DA, 2005, 'The modern ART of HIV infection management: Towards a tailored approach to maximize CD4 T cell reconstitution', Clinical Infectious Diseases, 41, pp. 373 - 375

Zaunders JJ; Dyer WB; Wang B; Munier ML; Miranda-Saksena M; Newton R; Moore J; Mackay CR; Cooper DA; Saksena NK; Kelleher AD, 2004, 'Identification of circulating antigen-specific CD4+ T lymphocytes with a CCR5+, cytotoxic phenotype in an HIV-1 long-term nonprogressor and in CMV infection', Blood, 103, pp. 2238 - 2247, http://dx.doi.org/10.1182/blood-2003-08-2765

Pett SL; Kelleher A, 2004, 'Antiretroviral therapy-induced immune restoration in HIV infection: A double-edged sword?', Expert Review of Anti Infective Therapy, 2, pp. 335 - 339, http://dx.doi.org/10.1586/14787210.2.3.335

Lomas M; Liauw W; Packham D; Williams K; Kelleher A; Zaunders J; Ward R, 2004, 'Phase I clinical trial of a human idiotypic p53 vaccine in patients with advanced malignancy', Annals of Oncology, 15, pp. 324 - 329, http://dx.doi.org/10.1093/annonc/mdh053

Mallon PW; Sedwell R; Unemori P; Rafferty M; Williams KM; Chisholm DJ; Samaras K; Emery S; Kelleher AD; Cooper DA; Carr AD, 2004, 'Changes in nuclear gene expression resulting from NRTI-induced inhibition of mitochondrial transcription reveal links between mitochondrial dysfunction and lipid metabolism', Antiviral Therapy, 9, pp. L56 - L56

Furutsuki T; Hosoya N; Kawana-Tachikawa A; Tomizawa M; Odawara T; Goto M; Kitamura Y; Nakamura T; Kelleher AD; Cooper DA; Iwamoto A, 2004, 'Frequent transmission of Cytotoxic-T-Lymphocyte escape mutants of human immunodeficiency virus type 1 in the highly HLA-A24-positive Japanese population', Journal of Virology, 78, pp. 8437 - 8445

Zaunders J; Dyer W; Wang B; Munier M; Miranda-Saksena M; Newton R; Moore JJ; MacKay CR; Cooper DA; Saksena NK; Kelleher AD, 2004, 'Identification of circulating antigen-specific CD4+ T lymphocytes with a CCR5+, cytotoxic phenotype in an HIV-1 long-term non-progressor and in CMV infection', Blood, 8, pp. 2765 - 2765

Mallon PW; Unemori P; Sedwell R; Morey AL; Rafferty M; Williams KM; Chisholm DJ; Samaras K; Emery S; Kelleher AD; Cooper DA; Carr AD, 2004, 'In vivo nucleoside reverse transcriptase inhibitors alter expression of both mitochondrial and lipid metabolism genes independent to HIV infection', Antiviral Therapy, 9, pp. L11 - L11

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