By Scientia Professor Anthony D Kelleher

Journal articles

Venturi V; Chin HY; Asher TE; Ladell K; Scheinberg P; Bornstein E; van Bockel D; Kelleher AD; Douek DC; Price DA; Davenport MP, 2008, 'TCR beta-chain sharing in human CD8+ T cell responses to cytomegalovirus and EBV', Journal of Immunology, 181, pp. 7853 - 7862

Falster KA; Gelgor L; Shaik A; Zablotska Manos I; Prestage G; Grierson J; Thorpe R; Pitts M; Anderson JS; Chuah J; Mulhall BP; Petoumenos K; Kelleher AD; Law MG, 2008, 'Trends in antiretroviral treatment use and treatment response in three Australian states in the first decade of combination antiretroviral treatment', Sexual Health, 5, pp. 141 - 154

Lewin S; Murray JM; Solomon A; Wightman F; Cameron P; Purcell DJ; Zaunders J; Grey PA; Bloch M; Smith DE; Cooper DA; Kelleher AD, 2008, 'Virologic determinants of success after structured treatment interruptions in antiretrovirals in acute HIV-1 infection', JAIDS: Journal of Acquired Immune Deficiency Syndromes, 47, pp. 140 - 147

Zaunders J; Jing J; Leipold M; Maecker H; Kelleher AD; Koch I, 2007, 'Computationally efficient multidimensional analysis of complex flow cytometry data using second order polynomial histograms', Cytometry Part A, 89, pp. 44 - 58, http://dx.doi.org/10.1002/cyto.a.22704

Munier CM; Kelleher AD, 2007, 'Acutely dysregulated, chronically disabled by the enemy within: T-cell responses to HIV-1 infection', Immunology and Cell Biology, 85, pp. 6 - 15

Murray JM; Emery S; Kelleher AD; Law MG; Chen J; Hazuda DJ; Nguyen BT; Teppler H; Cooper DA, 2007, 'Antiretroviral therapy with the integrase inhibitor raltegravir alters decay kinetics of HIV, significantly reducing the second phase', AIDS, 21, pp. 2315 - 2321

Schneidewind A; Brockman M; Yang R; Adam RI; Li B; Le Gall S; Rinaldo C; Craggs SL; Allgaier RL; Power KA; Kuntzen T; Tung C; LaBute MX; Mueller SC; Harrer T; Mcmichael AJ; Goulder PJ; Aiken CM; Brander C; Kelleher AD; Allen TM, 2007, 'Escape from the Dominant HLA-B27-Restricted Cytotoxic T-Lymphocyte Response in Gag Is Associated with a Dramatic Reduction in Human Immunodeficiency Virus Type 1 Replication', Journal of Virology, 81, pp. 12382 - 12393

Emery S; Kelleher AD; Workman C; Puls R; Bloch MT; Baker D; Hoy JF; Ip S; Nalliah K; Ward L; Law MG; Cooper DA, 2007, 'Influence of IFN gamma co-expression on the safety and antiviral efficacy of recombinant fowlpox virus HIV therapeutic vaccines following interruption of antiretroviral therapy', Human Vaccines, 3, pp. 260 - 267

Lin BB; Gladden A; Altfeld M; Kaldor JM; Cooper DA; Kelleher AD; Allen TM, 2007, 'Rapid Reversion of Sequence Polymorphisms Dominates Early Human Immunodeficiency Virus Type 1 Evolution', Journal of Virology, 81, pp. 193 - 201

Streeck H; Lichterfeld M; Alter G; Meier A; Teigen N; Yassine-Diab B; Sidhu H; Little S; Kelleher AD; Routy J; Rosenberg E; Sekaly R; Walker BD; Altfeld M, 2007, 'Recognition of a defined region within p24 Gag by CD8(+) T cells during primary human immunodeficiency virus type I infection in individuals expressing protective HLA class I alleles', Journal of Virology, 81, pp. 7725 - 7731

Dyer W; Pett SL; Sullivan JS; Emery S; Cooper DA; Kelleher AD; Lloyd AR; Lewin S, 2007, 'Substantial improvements in performance indicators achieved in a peripheral blood mononuclear cell cryopreservation quality assurance program using single donor samples', Clinical and Vaccine Immunology, 14, pp. 52 - 59

Venturi V; Chin H; Asher T; Ladell K; Scheinberg P; Bornstein E; Van Bockel DJ; Kelleher AD; Douek DC; Price DA; Davenport MP, 2007, 'T cell receptor b-chain sharing in human CD8+ T cell responses to cytomegalovirus and Epstein-Barr virus', Journal of Immunology, 181, pp. 7853 - 7862

Samri A; Goodall RL; Burton C; Imami N; Pantaleo G; Kelleher AD; Poli G; Gotch F; Autran B, 2007, 'Three-year immune reconstitution in PI-sparing and PI-containing antiretroviral regimens in advanced HIV-1 disease', Antiviral Therapy, 12, pp. 553 - 558

Kaufmann D; Kavanagh D; Pereyra F; Zaunders J; Mackey E; Miura T; Palmer S; Brockman M; Rathod A; Piechocka-Trocha A; Baker B; Zhu B; Le Gall S; Waring M; Ahern R; Moss K; Kelleher AD; Coffin J; Freeman G; Rosenberg E; Walker BD, 2007, 'Upregulation of CTLA-4 by HIV-specific CD4(+) T cells correlates with disease progression and defines a reversible immune dysfunction', Nature Immunology, 8, pp. 1246 - 1254

van Bockel D; Price DA; Asher TE; Venturi V; Suzuki K; Warton K; Davenport MP; Cooper DA; Douek DC; Kelleher AD, 2007, 'Validation of RNA-based molecular clonotype analysis for virus-specific CD8+ T-cells in formaldehyde-fixed specimens isolated from peripheral blood', Journal of Immunological Methods, 326, pp. 127 - 138, http://dx.doi.org/10.1016/j.jim.2007.07.016

Hemelaar J; Gouws E; Ghys PD; Osmanov S, 2006, 'Global and regional distribution of HIV-1 genetic subtypes and recombinants in 2004.', AIDS, 20, pp. W13 - W23, http://dx.doi.org/10.1097/01.aids.0000247564.73009.bc

Hales GP; Birch C; Crowe S; Workman C; Hoy JF; Kelleher AD; Lincoln D; Lincoln D; Law MG; Emery S, 2006, 'A randomised trial comparing genotypic and virtual phenotypic interpretation of HIV drug resistance: The CREST study.', PLoS Clinical Trials, 1, pp. e18

Kelleher AD; Puls R; Bebbington M; Boyle D; Kent S; Kippax SC; Purcell D; Thomson S; Wand HC; Cooper DA; Emery S; Ffrench RA, 2006, 'A randomized, placebo-controlled phase I trial of DNA prime, recombinant fowlpox virus boost prophylactic vaccine for HIV-1', AIDS, 20, pp. 294 - 297

Zaunders J; Dyer W; Munier CM; Ip S; Liu J; Amyes E; Rawlinson WD; Rose RJ; Kent SJ; Sullivan JS; Cooper DA; Kelleher AD, 2006, 'CD127+CCR5+CD38+++CD4+ Th1 Effector Cells Are an Early Component of the Primary Immune Response to Vaccinia Virus and Precede Development of Interleukin-2+ Memory CD4+ T Cells', Journal of Virology, 80, pp. 10151 - 10161

Kelleher AD; Zaunders J, 2006, 'Decimated or missing in action:CD4+ T cells as targets and effectors in the pathogenesis of primary HIV infection. Curr HIV/AIDS Rep 2006;3(1):5-12.', Current HIV/AIDS Reports, 3, pp. 5 - 12

De Rose R; Sullivan MT; Dale CJ; Kelleher AD; Emery S; Cooper DA; Ramshaw I; Boyle D; Kent SJ, 2006, 'Dose-response relationship of DNA and recombinant fowlpox virus prime-boost HIV vaccines.', Human Vaccines, 2, pp. 134 - 136

Fazekos de St Groth B; Seddiki N; Santner-Nanan B; Martinson J; Zaunders J; Sasson SC; Landay A; Nanan R; Kelleher AD, 2006, 'Expression of IL-2 and IL-7 receptors discriminates between human regulatory and activated T-cells within CD45RA and CD45RO compartments', Clinical Immunology, 119, pp. S7 - S7

Seddiki N; Santner-Nanan B; Martinson J; Zaunders J; Sasson SC; Landay A; Solomon MJ; Selby W; Alexander S; Nanan R; Kelleher AD; Fazekas de St Groth B; Solomon M, 2006, 'Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells', Journal of Experimental Medicine, 203, pp. 1693 - 1700, http://dx.doi.org/10.1084/jem.20060468

Barbour J; Hecht FM; Little S; Markowitz M; Daar E; Kelleher AD; Routy J; Campbell T; Rosenberg E; Segal M; Weidler J; Grant R, 2006, 'Greater CD4 T-cell gains after one year of antiretroviral therapy are associated with lower HIV-1 pol replication capacity.', AIDS, 20, pp. 2123 - 2125

Sasson SC; Zaunders J; Zanetti G; King E; Merlin K; Smith DE; Stanley K; Cooper DA; Kelleher AD, 2006, 'Increased plasma interleukin-7 level correlates with decreased CD127 and increased CD132 extracellular expression on T cell subsets in patients with HIV-1 infection', Journal of Infectious Diseases, 193, pp. 505 - 514

Zaunders J; Ip S; Munier CM; Munier M; Kaufmann D; Suzuki K; Brereton C; Seddiki N; Sasson SC; Koelsch KK; Landay A; Grey PA; Finlayson R; Kaldor JM; Rosenberg E; Walker BD; Fazekas de St Groth B; Cooper DA; Kelleher AD, 2006, 'Infection of CD127(+) (Interleukin-7 receptor+) CD4+ cells and overexpression of CTLA-4 are linked to loss of antigen-specific CD4 T cells during primary human immunodeficiency virus type 1 infection', Journal of Virology, 80, pp. 10162 - 10172

Carlin S; Moore JJ; Zaunders J; Kelleher AD; Ma DD, 2006, 'T lineage differentiation in vitro of adult Haematopoietic Stem Cells', CYTOMETRY PART A, 69A, pp. 399 - 400

Sasson SC; Zaunders J; Kelleher AD, 2006, 'The IL-7/IL-7 receptor axis: understanding its central role in T-cell homeostatis and the challenges facing its utilization as a novel therapy. 2006;7:1571-1582.', Current Drug Targets, 7, pp. 1571 - 1582

Bloch MT; Smith DE; Quan D; Kaldor JM; Zaunders J; Petoumenos K; Irvine K; Law MG; Grey PA; Finlayson R; Mcfarlane R; Kelleher AD; Carr AD; Cooper DA, 2006, 'The role of hydroxyurea in enhancing the virologic control achieved through structured treatment interruption in primary HIV infection: Final results from a randomized clinical trial (Pulse)', JAIDS: Journal of Acquired Immune Deficiency Syndromes, 42, pp. 192 - 202

Ammaranond P; Zaunders J; Satchell C; Van Bockel DJ; Cooper DA; Kelleher AD, 2005, 'A new variant cytotoxic T lymphocyte escape mutation in HLA-B27-positive individuals infected with HIV type 1', AIDS Research and Human Retroviruses, 21, pp. 395 - 397

Zaunders J; Munier M; Kaufmann D; Ip S; Grey PA; Smith DE; Ramacciotti TP; Quan D; Finlayson RJ; Kaldor JM; Rosenberg E; Walker BD; Cooper DA; Kelleher AD, 2005, 'Early proliferation of CCR5(+) CD38(+++) antigen-specific CD4(+) Th1 effector cells during primary HIV-1 infection', Blood, 106, pp. 1660 - 1667

Sedwell R; Mallon PW; Duarte NL; Zaunders J; Kelleher AD; Cooper DA; Carr AD, 2005, 'Impaired mitochondrial function induced by NRTIs is only detectable in the monocyte (CD14(+)) subset of human PBMC', Antiviral Therapy, 10, pp. L44 - L45

Mallon PW; Unemori P; Sedwell R; Morey AL; Rafferty M; Williams KM; Chisholm DJ; Samaras K; Emery S; Kelleher AD; Cooper DA; Carr AD, 2005, 'In vivo, nucleoside reverse-transcriptase inhibitors alter expression of both mitochondrial and lipid metabolism genes in the absence of depletion of mitochondrial DNA', Journal of Infectious Diseases, 191, pp. 1686 - 1696

Mallon PW; Sedwell R; Unemori P; Kelleher AD; Cooper DA; Carr AD, 2005, 'Methodological considerations in human studies of gene expression in HIV-associated lipodystrophy', Antiviral Therapy, 10, pp. M101 - M108

Lim H; Sedwell R; Duarte NL; Cooper DA; Kelleher AD; Carr AD; Mallon PW, 2005, 'Nucleoside reverse transcriptase inhibitor effects on adipocyte mitochondrial DNA quantity and quality in vitro', Antiviral Therapy, 10, pp. L41 - L42

Suzuki K; Shijuuku T; Fukamachi T; Zaunders J; Guillemin GJ; Cooper DA; Kelleher AD, 2005, 'Prolonged transcriptional silencing and CpG methylation induced by siRNAs targeted to the HIV-1 promoter region.', Journal of RNAi and Gene Silencing, 1, pp. 66 - 78

Emery S; Workman C; Puls R; Bloch M; Baker D; Bodsworth NJ; Anderson JA; Crowe SM; Hoy JF; Aichelburg A; Ward LA; Boyle D; Law MG; Kelleher AD; Cooper DA, 2005, 'Randomised, Placebo-Controlled, Phase 1/2a Evaluation of the Safety and Immunogenicity of Fowlpox Virus Expressing HIV gag-pol and Interferon-y in HIV-1 Infected Subjects', Human Vaccines, 1, pp. 232 - 238, http://www.landesbioscience.com/journals/vaccines/emeryHV1-6.pdf

Sasson SC; Kelleher AD; Cooper DA, 2005, 'The modern ART of HIV infection management: Towards a tailored approach to maximize CD4 T cell reconstitution', Clinical Infectious Diseases, 41, pp. 373 - 375

Zaunders JJ; Dyer WB; Wang B; Munier ML; Miranda-Saksena M; Newton R; Moore J; Mackay CR; Cooper DA; Saksena NK; Kelleher AD, 2004, 'Identification of circulating antigen-specific CD4⁺ T lymphocytes with a CCR5⁺, cytotoxic phenotype in an HIV-1 long-term nonprogressor and in CMV infection', Blood, 103, pp. 2238 - 2247, http://dx.doi.org/10.1182/blood-2003-08-2765

Pett SL; Kelleher A, 2004, 'Antiretroviral therapy-induced immune restoration in HIV infection: A double-edged sword?', Expert Review of Anti-Infective Therapy, 2, pp. 335 - 339, http://dx.doi.org/10.1586/14787210.2.3.335

Mallon PW; Sedwell R; Unemori P; Rafferty M; Williams KM; Chisholm DJ; Samaras K; Emery S; Kelleher AD; Cooper DA; Carr AD, 2004, 'Changes in nuclear gene expression resulting from NRTI-induced inhibition of mitochondrial transcription reveal links between mitochondrial dysfunction and lipid metabolism', Antiviral Therapy, 9, pp. L56 - L56

Furutsuki T; Hosoya N; Kawana-Tachikawa A; Tomizawa M; Odawara T; Goto M; Kitamura Y; Nakamura T; Kelleher AD; Cooper DA; Iwamoto A, 2004, 'Frequent transmission of Cytotoxic-T-Lymphocyte escape mutants of human immunodeficiency virus type 1 in the highly HLA-A24-positive Japanese population', Journal of Virology, 78, pp. 8437 - 8445

Zaunders J; Dyer W; Wang B; Munier M; Miranda-Saksena M; Newton R; Moore JJ; MacKay CR; Cooper DA; Saksena NK; Kelleher AD, 2004, 'Identification of circulating antigen-specific CD4+ T lymphocytes with a CCR5+, cytotoxic phenotype in an HIV-1 long-term non-progressor and in CMV infection', Blood, 8, pp. 2765 - 2765

Mallon PW; Unemori P; Sedwell R; Morey AL; Rafferty M; Williams KM; Chisholm DJ; Samaras K; Emery S; Kelleher AD; Cooper DA; Carr AD, 2004, 'In vivo nucleoside reverse transcriptase inhibitors alter expression of both mitochondrial and lipid metabolism genes independent to HIV infection', Antiviral Therapy, 9, pp. L11 - L11

Mallon PW; Sedwell R; Unemori P; Merlin K; McGinley C; Ammaranond P; Peperias M; Rafferty M; Williams KM; Samaras K; Morey AL; Chisholm DJ; Kelleher AD; Cooper DA; Carr AD, 2004, 'Nucleoside reverse transcriptase inhibitors (NRTI) decrease adipocyte and monocyte mitochondrial (mt) messenger RNA transcription in the absence of changes in mtDNA or cell morphology', Antiviral Therapy, 9, pp. L56 - L57

Lomas M; Liauw WS; Packham D; Williams KM; Kelleher AD; Zaunders J; Ward RL, 2004, 'Phase I clinical trial of a human idiotypic p53 vaccine in patients with advanced malignancy', Annals of Oncology, 15, pp. 324 - 329

Pett SL; Kelleher AD, 2003, 'Cytokine therapies in HIV-1 infection: Present and future', Expert Review of Anti-Infective Therapy, 1, pp. 83 - 96, http://dx.doi.org/10.1586/14787210.1.1.83

Pett SL; Kelleher AD, 2003, 'Cytokine therapies in HIV-1 infection: present and future', Expert Review of Anti-Infective Therapy, 1, pp. 89 - 102

Wang B; Mikhail M; Dyer W; Zaunders J; Kelleher AD; Saksena N, 2003, 'First demonstration of a lack of viral sequence evolution in a nonprogressor, defining replication-incompetent HIV-1 infection', Virology, 312, pp. 135 - 135

Murray JM; Kaufmann GR; Hodgkin PD; Lewin SR; Kelleher AD; Davenport MP; Zaunders JJ, 2003, 'Naive T cells maintained by thymic output in early ages but by proliferation without phenotypic change after age twenty', Immunology and Cell Biology, 81, pp. 487 - 495

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