Can the response of different mouse strains to a high fat diet help find therapeutic targets to treat fatty liver disease?

Faculty: Medicine

Excess fat in the diet typically leads to weight gain and inappropriate deposition of lipid in organs such as liver and skeletal muscle. In a recent study we showed that compared to a number of other commonly used mouse strains, BALB/c mice displayed an unusual response to a high fat diet, selectively avoiding lipid accumulation in the liver. This project will investigate lipid metabolism in BALB/c mice to determine why they don’t develop a fatty liver when given excess fat in the diet.

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Faculty of Medicine
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