Project 1: Mathematical modelling of T cell trafficking in the liver
This project aims to design a mathematical model to study the trafficking of CD8 T cells in the full body of mice in the absence or presence of antigen.
By taking advantage of ad hoc experimental data we aim at estimating key parameters that regulate T cell trafficking and the subsequent T cell response against antigens presented in lymphoid and non-lymphoid organs. In particular, we are interested in the liver, as this is the only non-lymphoid organ capable of antigen presentation. In collaboration with Dr Patrick Bertolino and Dr David Bowen from the Centenary Institute at Sydney University, we are investigating how T cells traffick to liver in absence and in presence of antigen, and how T cells are eliminated via tolerance mechanisms.
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Please contact me for further details (luciani@unsw.edu.au)
HCV founder viruses guide vaccine development. [nid:105459]
Understanding the selection pressures driving the evolutionary dynamics in acute HCV infection [nid:102728]
Modelling the evolution of Hepatitis C virus by integrating large sequence- and immunological-databases. [nid:88576]
Project 2
Mathematical models of viral transmission among heterogeneous human populations
Project 3
Network and transmission dynamics of HCV infections among injecting drug users