Imaging genetics in schizophrenia and bipolar disorder: shared neurocognitive endophenotypes

Endophenotypes across the psychosis spectrum

This research investigates shared biological vulnerability for schizophrenia and bipolar disorder in terms of genetic association with common neurocognitive dysfunction. This approach challenges the traditional segregation of psychotic and mood disorders within an innovative study design that will integrate cognitive, functional imaging and genetic data across diagnostic groups. The outcomes will (a) identify common genetic variants that contribute to cognitive endophenotypes for these conditions, (b) facilitate the employment of personalized pharmacological treatments that may improve cognition, based on genotype, and (c) facilitate early detection of cognitive markers of vulnerability to psychosis, promoting early intervention.

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