Select Publications

Journal articles

Cheung DL; Toda T; Narushima M; Eto K; Takayama C; Ooba T; Wake H; Moorhouse AJ; Nabekura J, 2023, 'KCC2 downregulation after sciatic nerve injury enhances motor function recovery', Scientific Reports, 13, pp. 7871,

Kato D; Aoyama Y; Nishida K; Takahashi Y; Sakamoto T; Takeda I; Tatematsu T; Go S; Saito Y; Kunishima S; Cheng J; Hou L; Tachibana Y; Sugio S; Kondo R; Eto F; Sato S; Moorhouse AJ; Yao I; Kadomatsu K; Setou M; Wake H, 2023, 'Regulation of lipid synthesis in myelin modulates neural activity and is required for motor learning', GLIA, 71, pp. 2591 - 2608,

Hashimoto A; Kawamura N; Tarusawa E; Takeda I; Aoyama Y; Ohno N; Inoue M; Kagamiuchi M; Kato D; Matsumoto M; Hasegawa Y; Nabekura J; Schaefer A; Moorhouse AJ; Yagi T; Wake H, 2023, 'Microglia enable cross-modal plasticity by removing inhibitory synapses', Cell Reports, 42, pp. 112383,

Tangalakis K; Lexis L; Hryciw DH; Towstoless M; Bakker AJ; Beckett E; Brown D; Cameron M; Choate J; Chopin L; Cooke MB; Douglas T; Estaphan S; Etherington S; Gaganis V; Moorhouse A; Moro C; Paravicini T; Perry B; Phillips R; Scott C; Todd G; Uebergang T; Wadley G; Watt M; Hayes A, 2023, 'Establishing consensus for the core concepts of physiology in the Australian higher education context using the Delphi method', Advances in Physiology Education, 47, pp. 419 - 426,

Parmar J; von Jonquieres G; Gorlamandala N; Chung B; Craig AJ; Pinyon JL; Birnbaumer L; Klugmann M; Moorhouse AJ; Power JM; Housley GD, 2023, 'TRPC Channels Activated by G Protein-Coupled Receptors Drive Ca2+ Dysregulation Leading to Secondary Brain Injury in the Mouse Model', Translational Stroke Research,

Etherington SJ; Moorhouse AJ; Paravicini TM; Towstoless M; Hayes A; Hryciw DH; Lexis L; Tangalakis K, 2023, 'Unpacking and validating the “cell membrane” core concept of physiology by an Australian team', Advances in Physiology Education, 47, pp. 575 - 581,

Takeda I; Yoshihara K; Cheung DL; Kobayashi T; Agetsuma M; Tsuda M; Eto K; Koizumi S; Wake H; Moorhouse AJ; Nabekura J, 2022, 'Controlled activation of cortical astrocytes modulates neuropathic pain-like behaviour', Nature Communications, 13, pp. 4100,

Cheung DL; Cooke MJ; Goulton CS; Chaichim C; Cheung LF; Khoshaba A; Nabekura J; Moorhouse AJ, 2022, 'Global transgenic upregulation of KCC2 confers enhanced diazepam efficacy in treating sustained seizures', Epilepsia, 63, pp. e15 - e22,

Okada T; Kato D; Nomura Y; Obata N; Quan X; Morinaga A; Yano H; Guo Z; Aoyama Y; Tachibana Y; Moorhouse AJ; Matoba O; Takiguchi T; Mizobuchi S; Wake H, 2021, 'Pain induces stable, active microcircuits in the somatosensory cortex that provide a therapeutic target', Science Advances, 7,

Takeda I; Yoshihara K; Cheung D; Agetsuma M; Tsuda M; Eto K; Moorhouse A; Nabekura J, 2021, 'Controlled activation of cortical astrocytes can reverse neuropathic chronic pain', ,

Ozaki K; Kato D; Ikegami A; Hashimoto A; Sugio S; Guo Z; Shibushita M; Tatematsu T; Haruwaka K; Moorhouse AJ; Yamada H; Wake H, 2020, 'Maternal immune activation induces sustained changes in fetal microglia motility', Scientific Reports, 10,

Karunanithi S; Lin YQ; Lorenzo Odierna G; Menon H; Gonzalez JM; Gregory Neely G; Noakes PG; Lavidis NA; Moorhouse AJ; van Swinderen B, 2020, 'Activity-dependent global downscaling of evoked neurotransmitter release across glutamatergic inputs in Drosophila', Journal of Neuroscience, 40, pp. 8025 - 8041,

Kato D; Wake H; Lee PR; Tachibana Y; Ono R; Sugio S; Tsuji Y; Tanaka YH; Tanaka YR; Masamizu Y; Hira R; Moorhouse AJ; Tamamaki N; Ikenaka K; Matsukawa N; Fields RD; Nabekura J; Matsuzaki M, 2020, 'Motor learning requires myelination to reduce asynchrony and spontaneity in neural activity', GLIA, 68, pp. 193 - 210,

Haruwaka K; Ikegami A; Tachibana Y; Ohno N; Konishi H; Hashimoto A; Matsumoto M; Kato D; Ono R; Kiyama H; Moorhouse AJ; Nabekura J; Wake H, 2019, 'Dual microglia effects on blood brain barrier permeability induced by systemic inflammation', Nature Communications, 10,

Nakamura K; Moorhouse AJ; Cheung DL; Eto K; Takeda I; Rozenbroek PW; Nabekura J, 2019, 'Overexpression of neuronal K + –Cl co-transporter enhances dendritic spine plasticity and motor learning', Journal of Physiological Sciences, 69, pp. 453 - 463,

Moorhouse AJ; Power JM, 2019, 'Making light work of fine-tuning channelrhodopsins', Journal of Biological Chemistry, 294, pp. 3822 - 3823,

Gorlamandala N; Parmar J; Craig AJ; Power JM; Moorhouse AJ; Krishnan AV; Housley GD, 2018, 'Focal Ischaemic Infarcts Expand Faster in Cerebellar Cortex than Cerebral Cortex in a Mouse Photothrombotic Stroke Model', Translational Stroke Research, 9, pp. 643 - 653,

Akiyoshi R; Wake H; Kato D; Horiuchi H; Ono R; Ikegami A; Haruwaka K; Omori T; Tachibana Y; Moorhouse AJ; Nabekura J, 2018, 'Microglia enhance synapse activity to promote local network synchronization', eNeuro, 5,

Ishikawa T; Eto K; Kim SK; Wake H; Takeda I; Horiuchi H; Moorhouse AJ; Ishibashi H; Nabekura J, 2018, 'Cortical astrocytes prime the induction of spine plasticity and mirror image pain', Pain, 159, pp. 1592 - 1606,

Goulton CS; Watanabe M; Cheung DL; Wang KW; Oba T; Khoshaba A; Lai D; Inada H; Eto K; Nakamura K; Power JM; Lewis TM; Housley GD; Wake H; Nabekura J; Moorhouse AJ, 2018, 'Conditional Upregulation of KCC2 selectively enhances neuronal inhibition during seizures', ,

Nakahata Y; Eto K; Murakoshi H; Watanabe M; Kuriu T; Hirata H; Moorhouse AJ; Ishibashi H; Nabekura J, 2017, 'Activation-dependent rapid postsynaptic clustering of glycine receptors in mature spinal cord neurons', eNeuro, 4,

Miyamoto A; Wake H; Ishikawa AW; Eto K; Shibata K; Murakoshi H; Koizumi S; Moorhouse AJ; Yoshimura Y; Nabekura J, 2016, 'Microglia contact induces synapse formation in developing somatosensory cortex', Nature Communications, 7,

Kim SK; Hayashi H; Ishikawa T; Shibata K; Shigetomi E; Shinozaki Y; Inada H; Roh SE; Kim SJ; Lee G; Bae H; Moorhouse AJ; Mikoshiba K; Fukazawa Y; Koizumi S; Nabekura J, 2016, 'Cortical astrocytes rewire somatosensory cortical circuits for peripheral neuropathic pain', Journal of Clinical Investigation, 126, pp. 1983 - 1997,

Kato G; Inada H; Wake H; Akiyoshi R; Miyamoto A; Eto K; Ishikawa T; Moorhouse AJ; Strassman AM; Nabekura J, 2016, 'Microglial contact prevents excess depolarization and rescues neurons from excitotoxicity', eNeuro, 3, pp. 9133 - 9144,

Alexander SPH; Benson HE; Faccenda E; Pawson AJ; Sharman JL; McGrath JC; Catterall WA; Spedding M; Peters JA; Harmar AJ, 2013, 'THE CONCISE GUIDE TO PHARMACOLOGY 2013/14: OVERVIEW', BRITISH JOURNAL OF PHARMACOLOGY, 170, pp. 1449 - 1458,

Barry PH; Lewis TM; Moorhouse AJ, 2013, 'An optimised 3 M KCl salt-bridge technique used to measure and validate theoretical liquid junction potential values in patch-clamping and electrophysiology', European Biophysics Journal, 42, pp. 631 - 646,

Miyamoto A; Wake H; Moorhouse AJ; Nabekura J, 2013, 'Microglia and synapse interactions: Fine tuning neural circuits and candidate molecules', Frontiers in Cellular Neuroscience, 7,

Wake H; Moorhouse AJ; Miyamoto A; Nabekura J, 2013, 'Microglia: Actively surveying and shaping neuronal circuit structure and function', Trends in Neurosciences, 36, pp. 209 - 217,

Kim YS; Wong AC; Power J; Tadros SF; Klugmann M; Moorhouse AJ; Bertrand PP; Housley GD, 2012, 'Alternative Splicing of the TRPC3 Ion Channel Calmodulin/ IP3 Receptor-Binding Domain in the Hindbrain Enhances Cation Flux', The Journal of Neuroscience, 32, pp. 11414 - 11423,

Eto K; Ishibashi H; Yoshimura T; Watanabe M; Miyamoto A; Ikenaka K; Moorhouse AJ; Nabekura J, 2012, 'Enhanced GABAergic activity in the mouse primary somatosensory cortex is insufficient to alleviate chronic pain behavior with reduced expression of neuronal potassium-chloride cotransporter', Journal of Neuroscience, 32, pp. 16552 - 16559,

Wake H; Moorhouse AJ; Nabekura J, 2012, 'Functions of microglia in the central nervous system-beyond the immune response', Neuron Glia Biology, 7, pp. 47 - 53,

Nakahata Y; Miyamoto A; Watanabe M; Moorhouse AJ; Nabekura J; Ishibashi H, 2010, 'Depolarizing shift in the GABA-induced current reversal potential by lidocaine hydrochloride', Brain Research, 1345, pp. 19 - 27,

Sugiharto S; Carland JE; Lewis TM; Moorhouse AJ; Barry PH, 2010, 'External divalent cations increase anion-cation permeability ratio in glycine receptor channels', Pflugers Archiv - European Journal of Physiology, 460, pp. 131 - 152,

Barry PH; Sugiharto S; Lewis TM; Moorhouse AJ, 2010, 'Further analysis of counterion permeation through anion-selective glycine receptor channels.', Channels, 4, pp. 142 - 149,

Carland JE; cooper MA; Sugiharto S; Jeong H; Lewis TM; Barry PH; Peters JA; Lambert J; Moorhouse AJ, 2009, 'Characterization of the effects of charged residues in the intracellular loop on ion permeation in α1 glycine receptor channels', The Journal of Biological Chemistry, 284, pp. 2023 - 2030,

Watanabe M; Wake H; Moorhouse AJ; Nabekura J, 2009, 'Clustering of Neuronal K+-Cl- Cotransporters in Lipid Raftsby Tyrosine Phosphorylation', The Journal of Biological Chemistry, 284, pp. 27980 - 27988,

Wake H; Moorhouse AJ; Jinno S; Kohsaka S; Nabekura J, 2009, 'Resting microglia directly monitor the functional state of synapses in vivo and determine the fate of ischemic terminals', Journal of Neuroscience, 29, pp. 3974 - 3980,

Sugiharto S; Lewis TM; Moorhouse AJ; Schofield PR; Barry PH, 2008, 'Anion-cation permeability correlates with hydrated counterion size in glycine receptor channels', Biophysical Journal, 95, pp. 4698 - 4715,

Park E; Choi I; Cho J; Nakamura M; Lee J; Lee M; Choi B; Moorhouse AJ; Jang I, 2008, 'Zinc modulation of glycine receptors in acutely isolated rat CA3 neurons', Life Sciences, 83, pp. 149 - 154,

Wake H; Watanabe M; Moorhouse AJ; Kanematsu T; Horibe S; Matsukawa N; Asai K; Ojika K; Hirata M; Nabekura J, 2007, 'Early changes in KCC2 phosphorylation in response to neuronal stress result in functional downregulation', Journal of Neuroscience, 27, pp. 1642 - 1650,

Qu W; Moorhouse AJ; Chandra M; Pierce KD; Lewis TM; Barry PH, 2006, 'A single P-loop glutamate point mutation to either lysine or arginine switches the cation-anion selectivity of the CNGA2 channel', Journal of General Physiology, 127, pp. 375 - 389,

Qu W; Moorhouse AJ; Lewis TM; Pierce KD; Barry PH, 2005, 'Mutation of the pore glutamate affects both cytoplasmic and external dequalinium block in the rat olfactory CNGA2 channel', European Biophysics Journal with Biophysics Letters, 34, pp. 442 - 453,

Moorhouse AJ; Li S; Vickery RM; Hill MA; Morley JW, 2004, 'A patch-clamp investigation of membrane currents in a novel mammalian retinal ganglion cell line', Brain Research, 1003, pp. 205 - 208,

Carland JE; Moorhouse AJ; Barry PH; Johnston G; Chebib M, 2004, 'Charged residues at the 2 ` position of human GABA(c) rho 1 receptorsinvert ion selectivity and influence open state probability', The Journal of Biological Chemistry, 279, pp. 54153 - 54160,

Katsurabayashi S; Kubota H; Moorhouse AJ; Akaike N, 2004, 'Differential modulation of evoked and spontaneous glycine release fromrat spinal cord glycinergic terminals by the cyclic AMP/protein kinaseA transduction cascade', Journal of Neurochemistry, 91, pp. 657 - 666,

Keramidas A; Moorhouse AJ; Schofield PR; Barry PH, 2004, 'Ligand-gated ion channels: mechanisms underlying ion selectivity', Progress in Biophysics and Molecular Biology, 86, pp. 161 - 204,

Kubota H; Katsurabayashi S; Moorhouse AJ; Murakami N; Koga H; Akaike N, 2003, 'GABAB receptor transduction mechanisms, and cross-talk between protein kinases A and C, in GABAergic terminals synapsing onto neurons of the rat nucleus basalis of Meynert', Journal of Physiology, 551, pp. 263 - 276,

Jeong H; Jan I; Moorhouse AJ; Akaike N, 2003, 'Activation of presynaptic glycine receptors facilitate glycine release from presynaptic terminals synapsing onto rat spinal sacral dorsal commissural nucleus nerons', The Journal of Physiology, 550, pp. 373 - 383,

Kubota H; Katsurabayashi S; Moorhouse AJ; Murakami N; Koga H; Akaike N, 2003, 'GABAB receptor transduction mechanisms, and cross-talk between protein kinases A and C, in GABAergic terminals synapsing onto neurons of the rat nucleus basalis of Meynert', The Journal of Physiology, 551, pp. 263 - 276,

Akaike N; Moorhouse AJ, 2003, 'Techniques: Applications of the Nerve - bouton preparation in Neuropharmacology', Trends in Pharmacological Sciences, 24, pp. 44 - 47,

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