Select Publications

Journal articles

Kato D; Wake H; Lee PR; Tachibana Y; Ono R; Sugio S; Tsuji Y; Tanaka YH; Tanaka YR; Masamizu Y; Hira R; Moorhouse AJ; Tamamaki N; Ikenaka K; Matsukawa N; Fields RD; Nabekura J; Matsuzaki M, 2020, 'Motor learning requires myelination to reduce asynchrony and spontaneity in neural activity', GLIA, vol. 68, pp. 193 - 210, http://dx.doi.org/10.1002/glia.23713

Haruwaka K; Ikegami A; Tachibana Y; Ohno N; Konishi H; Hashimoto A; Matsumoto M; Kato D; Ono R; Kiyama H; Moorhouse AJ; Nabekura J; Wake H, 2019, 'Dual microglia effects on blood brain barrier permeability induced by systemic inflammation', Nature Communications, vol. 10, http://dx.doi.org/10.1038/s41467-019-13812-z

Nakamura K; Moorhouse AJ; Cheung DL; Eto K; Takeda I; Rozenbroek PW; Nabekura J, 2019, 'Overexpression of neuronal K + –Cl co-transporter enhances dendritic spine plasticity and motor learning', Journal of Physiological Sciences, vol. 69, pp. 453 - 463, http://dx.doi.org/10.1007/s12576-018-00654-5

Moorhouse AJ; Power JM, 2019, 'Making light work of fine-tuning channelrhodopsins', Journal of Biological Chemistry, vol. 294, pp. 3822 - 3823, http://dx.doi.org/10.1074/jbc.H119.007749

Gorlamandala N; Parmar J; Craig AJ; Power JM; Moorhouse AJ; Krishnan AV; Housley GD, 2018, 'Focal Ischaemic Infarcts Expand Faster in Cerebellar Cortex than Cerebral Cortex in a Mouse Photothrombotic Stroke Model', Translational Stroke Research, vol. 9, pp. 643 - 653, http://dx.doi.org/10.1007/s12975-018-0615-1

Akiyoshi R; Wake H; Kato D; Horiuchi H; Ono R; Ikegami A; Haruwaka K; Omori T; Tachibana Y; Moorhouse AJ; Nabekura J, 2018, 'Microglia enhance synapse activity to promote local network synchronization', eNeuro, vol. 5, http://dx.doi.org/10.1523/ENEURO.0088-18.2018

Goulton CS; Watanabe M; Cheung DL; Wang KW; Oba T; Khoshaba A; Lai D; Inada H; Eto K; Nakamura K; Power JM; Lewis TM; Housley GD; Wake H; Nabekura J; Moorhouse AJ, 2018, 'Conditional Upregulation of KCC2 selectively enhances neuronal inhibition during seizures', , http://dx.doi.org/10.1101/253831

Ishikawa T; Eto K; Kim SK; Wake H; Takeda I; Horiuchi H; Moorhouse AJ; Ishibashi H; Nabekura J, 2018, 'Cortical astrocytes prime the induction of spine plasticity and mirror image pain', Pain, vol. 159, pp. 1592 - 1606, http://dx.doi.org/10.1097/j.pain.0000000000001248

Nakahata Y; Eto K; Murakoshi H; Watanabe M; Kuriu T; Hirata H; Moorhouse AJ; Ishibashi H; Nabekura J, 2017, 'Activation-dependent rapid postsynaptic clustering of glycine receptors in mature spinal cord neurons', eNeuro, vol. 4, http://dx.doi.org/10.1523/ENEURO.0194-16.2017

Miyamoto A; Wake H; Ishikawa AW; Eto K; Shibata K; Murakoshi H; Koizumi S; Moorhouse AJ; Yoshimura Y; Nabekura J, 2016, 'Microglia contact induces synapse formation in developing somatosensory cortex', Nature Communications, vol. 7, http://dx.doi.org/10.1038/ncomms12540

Kim SK; Hayashi H; Ishikawa T; Shibata K; Shigetomi E; Shinozaki Y; Inada H; Roh SE; Kim SJ; Lee G; Bae H; Moorhouse AJ; Mikoshiba K; Fukazawa Y; Koizumi S; Nabekura J, 2016, 'Cortical astrocytes rewire somatosensory cortical circuits for peripheral neuropathic pain', Journal of Clinical Investigation, vol. 126, pp. 1983 - 1997, http://dx.doi.org/10.1172/JCI82859

Kato G; Inada H; Wake H; Akiyoshi R; Miyamoto A; Eto K; Ishikawa T; Moorhouse AJ; Strassman AM; Nabekura J, 2016, 'Microglial contact prevents excess depolarization and rescues neurons from excitotoxicity', eNeuro, vol. 3, pp. 9133 - 9144, http://dx.doi.org/10.1523/ENEURO.0004-16.2016

Alexander SPH; Benson HE; Faccenda E; Pawson AJ; Sharman JL; McGrath JC; Catterall WA; Spedding M; Peters JA; Harmar AJ, 2013, 'THE CONCISE GUIDE TO PHARMACOLOGY 2013/14: OVERVIEW', BRITISH JOURNAL OF PHARMACOLOGY, vol. 170, pp. 1449 - 1458, http://dx.doi.org/10.1111/bph.12444

Barry PH; Lewis TM; Moorhouse AJ, 2013, 'An optimised 3 M KCl salt-bridge technique used to measure and validate theoretical liquid junction potential values in patch-clamping and electrophysiology', European Biophysics Journal, vol. 42, pp. 631 - 646, http://dx.doi.org/10.1007/s00249-013-0911-3

Miyamoto A; Wake H; Moorhouse AJ; Nabekura J, 2013, 'Microglia and synapse interactions: Fine tuning neural circuits and candidate molecules', Frontiers in Cellular Neuroscience, vol. 7, http://dx.doi.org/10.3389/fncel.2013.00070

Wake H; Moorhouse AJ; Miyamoto A; Nabekura J, 2013, 'Microglia: Actively surveying and shaping neuronal circuit structure and function', Trends in Neurosciences, vol. 36, pp. 209 - 217, http://dx.doi.org/10.1016/j.tins.2012.11.007

Kim YS; Wong AC; Power J; Tadros SF; Klugmann M; Moorhouse AJ; Bertrand PP; Housley GD, 2012, 'Alternative Splicing of the TRPC3 Ion Channel Calmodulin/ IP3 Receptor-Binding Domain in the Hindbrain Enhances Cation Flux', The Journal of Neuroscience, vol. 32, pp. 11414 - 11423, http://dx.doi.org/10.1523/JNEUROSCI.6446-11.2012

Eto K; Ishibashi H; Yoshimura T; Watanabe M; Miyamoto A; Ikenaka K; Moorhouse AJ; Nabekura J, 2012, 'Enhanced GABAergic activity in the mouse primary somatosensory cortex is insufficient to alleviate chronic pain behavior with reduced expression of neuronal potassium-chloride cotransporter', Journal of Neuroscience, vol. 32, pp. 16552 - 16559, http://dx.doi.org/10.1523/JNEUROSCI.2104-12.2012

Wake H; Moorhouse AJ; Nabekura J, 2012, 'Functions of microglia in the central nervous system-beyond the immune response', Neuron Glia Biology, vol. 7, pp. 47 - 53, http://dx.doi.org/10.1017/S1740925X12000063

Nakahata Y; Miyamoto A; Watanabe M; Moorhouse AJ; Nabekura J; Ishibashi H, 2010, 'Depolarizing shift in the GABA-induced current reversal potential by lidocaine hydrochloride', Brain Research, vol. 1345, pp. 19 - 27, http://dx.doi.org/10.1016/j.brainres.2010.05.052

Sugiharto S; Carland JE; Lewis TM; Moorhouse AJ; Barry PH, 2010, 'External divalent cations increase anion-cation permeability ratio in glycine receptor channels', Pflugers Archiv - European Journal of Physiology, vol. 460, pp. 131 - 152, http://dx.doi.org/10.1007/s00424-010-0792-6

Barry PH; Sugiharto S; Lewis TM; Moorhouse AJ, 2010, 'Further analysis of counterion permeation through anion-selective glycine receptor channels.', Channels, vol. 4, pp. 142 - 149, http://www.landesbioscience.com/journals/channels/article/11020

Carland JE; cooper MA; Sugiharto S; Jeong H; Lewis TM; Barry PH; Peters JA; Lambert J; Moorhouse AJ, 2009, 'Characterization of the effects of charged residues in the intracellular loop on ion permeation in α1 glycine receptor channels', The Journal of Biological Chemistry, vol. 284, pp. 2023 - 2030, http://dx.doi.org/10.1074/jbc.M806618200

Watanabe M; Wake H; Moorhouse AJ; Nabekura J, 2009, 'Clustering of Neuronal K+-Cl- Cotransporters in Lipid Raftsby Tyrosine Phosphorylation', The Journal of Biological Chemistry, vol. 284, pp. 27980 - 27988, http://dx.doi.org/10.1074/jbc.M109.043620

Wake H; Moorhouse AJ; Jinno S; Kohsaka S; Nabekura J, 2009, 'Resting microglia directly monitor the functional state of synapses in vivo and determine the fate of ischemic terminals', Journal of Neuroscience, vol. 29, pp. 3974 - 3980, http://dx.doi.org/10.1523/JNEUROSCI.4363-08.2009

Sugiharto S; Lewis TM; Moorhouse AJ; Schofield PR; Barry PH, 2008, 'Anion-cation permeability correlates with hydrated counterion size in glycine receptor channels', Biophysical Journal, vol. 95, pp. 4698 - 4715, http://dx.doi.org/10.1529/biophysj.107.125690

Park E; Choi I; Cho J; Nakamura M; Lee J; Lee M; Choi B; Moorhouse AJ; Jang I, 2008, 'Zinc modulation of glycine receptors in acutely isolated rat CA3 neurons', Life Sciences, vol. 83, pp. 149 - 154, http://dx.doi.org/10.1016/j.lfs.2008.04.024

Wake H; Watanabe M; Moorhouse AJ; Kanematsu T; Horibe S; Matsukawa N; Asai K; Ojika K; Hirata M; Nabekura J, 2007, 'Early changes in KCC2 phosphorylation in response to neuronal stress result in functional downregulation', Journal of Neuroscience, vol. 27, pp. 1642 - 1650, http://dx.doi.org/10.1523/JNEUROSCI.3104-06.2007

Qu W; Moorhouse AJ; Chandra M; Pierce KD; Lewis TM; Barry PH, 2006, 'A single P-loop glutamate point mutation to either lysine or arginine switches the cation-anion selectivity of the CNGA2 channel', Journal of General Physiology, vol. 127, pp. 375 - 389, http://dx.doi.org/10.1085/jgp.200509378

Qu W; Moorhouse AJ; Lewis TM; Pierce KD; Barry PH, 2005, 'Mutation of the pore glutamate affects both cytoplasmic and external dequalinium block in the rat olfactory CNGA2 channel', European Biophysics Journal with Biophysics Letters, vol. 34, pp. 442 - 453, http://dx.doi.org/10.1007/s00249-005-0479-7

Moorhouse AJ; Li S; Vickery RM; Hill MA; Morley JW, 2004, 'A patch-clamp investigation of membrane currents in a novel mammalian retinal ganglion cell line', Brain Research, vol. 1003, pp. 205 - 208, http://dx.doi.org/10.1016/j.brainres.2004.01.027

Carland JE; Moorhouse AJ; Barry PH; Johnston G; Chebib M, 2004, 'Charged residues at the 2 ` position of human GABA(c) rho 1 receptorsinvert ion selectivity and influence open state probability', The Journal of Biological Chemistry, vol. 279, pp. 54153 - 54160, http://dx.doi.org/10.1074/jbc.M410625200

Katsurabayashi S; Kubota H; Moorhouse AJ; Akaike N, 2004, 'Differential modulation of evoked and spontaneous glycine release fromrat spinal cord glycinergic terminals by the cyclic AMP/protein kinaseA transduction cascade', Journal of Neurochemistry, vol. 91, pp. 657 - 666, http://dx.doi.org/10.1111/j.1471-4159.2004.02741.x

Keramidas A; Moorhouse AJ; Schofield PR; Barry PH, 2004, 'Ligand-gated ion channels: mechanisms underlying ion selectivity', Progress in Biophysics and Molecular Biology, vol. 86, pp. 161 - 204, http://dx.doi.org/10.1016/j.pbiomolbio.2003.09.002

Kubota H; Katsurabayashi S; Moorhouse AJ; Murakami N; Koga H; Akaike N, 2003, 'GABAB receptor transduction mechanisms, and cross-talk between protein kinases A and C, in GABAergic terminals synapsing onto neurons of the rat nucleus basalis of Meynert', Journal of Physiology, vol. 551, pp. 263 - 276, http://dx.doi.org/10.1113/jphysiol.2003.046524

Jeong H; Jan I; Moorhouse AJ; Akaike N, 2003, 'Activation of presynaptic glycine receptors facilitate glycine release from presynaptic terminals synapsing onto rat spinal sacral dorsal commissural nucleus nerons', The Journal of Physiology, vol. 550, pp. 373 - 383, http://dx.doi.org/10.1113/jphysiol.2003.041053

Kubota H; Katsurabayashi S; Moorhouse AJ; Murakami N; Koga H; Akaike N, 2003, 'GABAB receptor transduction mechanisms, and cross-talk between protein kinases A and C, in GABAergic terminals synapsing onto neurons of the rat nucleus basalis of Meynert', The Journal of Physiology, vol. 551, pp. 263 - 276, http://dx.doi.org/10.1113/jphysiol.2003.046524

Akaike N; Moorhouse AJ, 2003, 'Techniques: Applications of the Nerve - bouton preparation in Neuropharmacology', Trends in Pharmacological Sciences, vol. 24, pp. 44 - 47, http://dx.doi.org/10.1016/S0165-6147(02)00010-X

Lee DJ; Keramidas A; Moorhouse AJ; Schofield PR; Barry PH, 2003, 'The contribution of P250 (P-2`D) to ion selectivity and pore diameter in the human glycine receptor.', Neuroscience Letters, vol. 351, pp. 196 - 200, http://dx.doi.org/10.1016/j.neulet.2003.08.005

Keramidas A; Moorhouse AJ; Pierce K; Schofield PR; Barry PH, 2002, 'Cation-selective mutations in the M2 domain of the inhibitory glycine receptor channel reveal determinants of ion charge selectivity', Journal of General Physiology, vol. 119, pp. 393 - 410, http://dx.doi.org/10.1085/jgp.20028552

Moorhouse AJ; Keramidas A; Zaikine A; Zaykin A; Schofield PR; Barry PH, 2002, 'Single channel analysis of conductance and rectification in cation-selective, mutant glycine receptor channels', Journal of General Physiology, vol. 119, pp. 411 - 425, http://dx.doi.org/10.1085/jgp.20028553

Kaur R; Zhu XO; Moorhouse AJ; Barry PH, 2001, 'Ip3-gated channels and their occurrence relative to CNG channels in the soma and dendritic knob of rat olfactory receptor neurons', Journal of Membrane Biology, vol. 181, pp. 91 - 105, http://dx.doi.org/10.1007/s00232-001-0013-5

Qu W; Moorhouse AJ; Cunningham AM; Barry PH, 2001, 'Anomalous Mole-Fraction Effects in Recombinat & Native Cyclic Nucleotide-Gated Channels in Rat Olfactory Receptor Neurons', Proceedings of the Royal Society of London Series B - Biological Sciences, vol. 268, pp. 1395 - 1403, http://dx.doi.org/10.1098/rspb.2001.1663

Kaur R; Zhu X; Moorhouse AJ; Barry PH, 2001, 'IP3-Gated Channels and their Occurrence Relative to CNG Channels in the Soma and Dendritic Knob of Rat Olfactory Receptor Neurons', Journal of Membrane Biology, vol. 181, pp. 91 - 105, https://www.ncbi.nlm.nih.gov/pubmed/11420596

Qu W; Zhu X; Moorhouse AJ; Bieri S; Cunningham AM, 2000, 'Ion permeation and selectivity of wild-type recombinant rat (CNG (rOCNC1) chanels expressed in HEK293 cells', Journal of Membrane Biology, vol. 178, pp. 137 - 150, http://dx.doi.org/10.1007/s002320010021

Keramidas A; Moorhouse AJ; French C; Schofield PR; Barry PH, 2000, 'M2 pore mutations convert the glycine receptor channel from being anion to cation selective', Biophysical Journal, vol. 78, pp. 247 - 259, http://dx.doi.org/10.1016/S0006-3495(00)76287-4

Keramidas A; Moorhouse AJ; French CD; Schofield PR; Barry PH, 2000, 'M2 pore mutations convert the glycine receptor channel from being anion- to cation-selective', Biophysical Journal, pp. 247 - 259

Qu W; Moorhouse AJ; Rajendra S; Barry PH, 2000, 'Very negative potential for half-inactivation of and effects of anions on voltage-dependent sodium currents in acutely isolated rat olfactory receptor neurons', Journal of Membrane Biology, vol. 175, pp. 123 - 138, http://dx.doi.org/10.1007/s002320001061

Smith PR; Proks P; Moorhouse AJ, 1999, 'Direct effects of tolutamide on mitochondrial function, intracellular Ca2+ and exocytosis in pancreatic beta-cells', Pflugers Archiv - European Journal of Physiology, vol. 437, pp. 577 - 588, http://dx.doi.org/10.1007/s004240050820

Barry PH; Schofield PR; Moorhouse AJ, 1999, 'Glycine receptors: What gets in and why', Clinical and Experimental Pharmacology and Physiology, vol. 26, pp. 935 - 936, http://dx.doi.org/10.1046/j.1440-1681.1999.03149.x


Back to profile page