Select Publications

Book Chapters

Kato D; Ikegami A; Horiuchi H; Moorhouse AJ; Nabekura J; Wake H, 2019, 'In Vivo Two-Photon Imaging of Microglial Synapse Contacts', in Methods in Molecular Biology, United States, pp. 281 - 286, http://dx.doi.org/10.1007/978-1-4939-9658-2_20

Wake H; Horiuchi H; Kato D; Moorhouse AJ; Nabekura J, 2019, 'Physiological Implications of Microglia–Synapse Interactions', in Methods in Molecular Biology, United States, pp. 69 - 80, http://dx.doi.org/10.1007/978-1-4939-9658-2_6

Moorhouse AJ, 2016, 'Membrane Potential: Concepts', in Encyclopedia of Cell Biology, pp. 218 - 236, http://dx.doi.org/10.1016/B978-0-12-394447-4.10027-6

Moorhouse AJ; Lewis TM; Barry PH, 2015, 'Analyzing Ion Permeation in Channels and Pumps Using Patch-Clamp Recording', in Clarke RJ; Khalid MAA (ed.), Pumps, Channels and Transporters Methods of Functional Analysis, John Wiley & Sons, Hoboken, New Jersey, pp. 51 - 88, http://dx.doi.org/10.1002/9781119085126.ch3

Ishibashi H; Moorhouse AJ; Nabekura J, 2012, 'Perforated Whole-Cell Patch-Clamp Technique: A User’s Guide', in Okada Y (ed.), Patch Clamp Techniques: From Beginning to Advanced Protocols, edn. 1st, Springer, Tokyo, pp. 71 - 83, http://dx.doi.org/10.1007/978-4-431-53993-3

Ishibashi H; Moorhouse AJ; Nabekura J, 2012, 'Perforated Whole-Cell Patch-Clamp Technique: A User’s Guide', in Springer Protocols Handbooks, Springer Japan, pp. 71 - 83, http://dx.doi.org/10.1007/978-4-431-53993-3_4

Moorhouse AJ; Nabekura J, 2011, 'Cellular Mechanisms of neuronal Homeostasis and its Modulation by Neuronal Injury', in Woodin MA; Maffei A (ed.), Inhibitory Synaptic Plasticity, Springer, New York, pp. 123 - 134, http://dx.doi.org/10.1007/978-1-4419-6978-1_9

Barry PH; Qu W; Moorhouse AJ, 2008, 'Biophysics of CNG Ion Channels', in Martinac B (ed.), Sensing with Ion Channels, edn. Original, Springer, Berlin Heidelberg, pp. 175 - 200

Journal articles

Okada T; Kato D; Nomura Y; Obata N; Quan X; Morinaga A; Yano H; Guo Z; Aoyama Y; Tachibana Y; Moorhouse AJ; Matoba O; Takiguchi T; Mizobuchi S; Wake H, 2021, 'Pain induces stable, active microcircuits in the somatosensory cortex that provide a therapeutic target', Science Advances, vol. 7, http://dx.doi.org/10.1126/sciadv.abd8261

Cheung DL; Cooke MJ; Goulton CS; Chaichim C; Cheung LF; Khoshaba A; Nabekura J; Moorhouse AJ, 2021, 'Global transgenic upregulation of KCC2 confers enhanced diazepam efficacy in treating sustained seizures', Epilepsia, http://dx.doi.org/10.1111/epi.17097

Ozaki K; Kato D; Ikegami A; Hashimoto A; Sugio S; Guo Z; Shibushita M; Tatematsu T; Haruwaka K; Moorhouse AJ; Yamada H; Wake H, 2020, 'Maternal immune activation induces sustained changes in fetal microglia motility', Scientific Reports, vol. 10, http://dx.doi.org/10.1038/s41598-020-78294-2

Karunanithi S; Lin YQ; Lorenzo Odierna G; Menon H; Gonzalez JM; Gregory Neely G; Noakes PG; Lavidis NA; Moorhouse AJ; van Swinderen B, 2020, 'Activity-dependent global downscaling of evoked neurotransmitter release across glutamatergic inputs in Drosophila', Journal of Neuroscience, vol. 40, pp. 8025 - 8041, http://dx.doi.org/10.1523/JNEUROSCI.0349-20.2020

Kato D; Wake H; Lee PR; Tachibana Y; Ono R; Sugio S; Tsuji Y; Tanaka YH; Tanaka YR; Masamizu Y; Hira R; Moorhouse AJ; Tamamaki N; Ikenaka K; Matsukawa N; Fields RD; Nabekura J; Matsuzaki M, 2020, 'Motor learning requires myelination to reduce asynchrony and spontaneity in neural activity', GLIA, vol. 68, pp. 193 - 210, http://dx.doi.org/10.1002/glia.23713

Haruwaka K; Ikegami A; Tachibana Y; Ohno N; Konishi H; Hashimoto A; Matsumoto M; Kato D; Ono R; Kiyama H; Moorhouse AJ; Nabekura J; Wake H, 2019, 'Dual microglia effects on blood brain barrier permeability induced by systemic inflammation', Nature Communications, vol. 10, http://dx.doi.org/10.1038/s41467-019-13812-z

Nakamura K; Moorhouse AJ; Cheung DL; Eto K; Takeda I; Rozenbroek PW; Nabekura J, 2019, 'Overexpression of neuronal K + –Cl co-transporter enhances dendritic spine plasticity and motor learning', Journal of Physiological Sciences, vol. 69, pp. 453 - 463, http://dx.doi.org/10.1007/s12576-018-00654-5

Moorhouse AJ; Power JM, 2019, 'Making light work of fine-tuning channelrhodopsins', Journal of Biological Chemistry, vol. 294, pp. 3822 - 3823, http://dx.doi.org/10.1074/jbc.H119.007749

Gorlamandala N; Parmar J; Craig AJ; Power JM; Moorhouse AJ; Krishnan AV; Housley GD, 2018, 'Focal Ischaemic Infarcts Expand Faster in Cerebellar Cortex than Cerebral Cortex in a Mouse Photothrombotic Stroke Model', Translational Stroke Research, vol. 9, pp. 643 - 653, http://dx.doi.org/10.1007/s12975-018-0615-1

Akiyoshi R; Wake H; Kato D; Horiuchi H; Ono R; Ikegami A; Haruwaka K; Omori T; Tachibana Y; Moorhouse AJ; Nabekura J, 2018, 'Microglia enhance synapse activity to promote local network synchronization', eNeuro, vol. 5, http://dx.doi.org/10.1523/ENEURO.0088-18.2018

Goulton CS; Watanabe M; Cheung DL; Wang KW; Oba T; Khoshaba A; Lai D; Inada H; Eto K; Nakamura K; Power JM; Lewis TM; Housley GD; Wake H; Nabekura J; Moorhouse AJ, 2018, 'Conditional Upregulation of KCC2 selectively enhances neuronal inhibition during seizures', , http://dx.doi.org/10.1101/253831

Ishikawa T; Eto K; Kim SK; Wake H; Takeda I; Horiuchi H; Moorhouse AJ; Ishibashi H; Nabekura J, 2018, 'Cortical astrocytes prime the induction of spine plasticity and mirror image pain', Pain, vol. 159, pp. 1592 - 1606, http://dx.doi.org/10.1097/j.pain.0000000000001248

Nakahata Y; Eto K; Murakoshi H; Watanabe M; Kuriu T; Hirata H; Moorhouse AJ; Ishibashi H; Nabekura J, 2017, 'Activation-dependent rapid postsynaptic clustering of glycine receptors in mature spinal cord neurons', eNeuro, vol. 4, http://dx.doi.org/10.1523/ENEURO.0194-16.2017

Miyamoto A; Wake H; Ishikawa AW; Eto K; Shibata K; Murakoshi H; Koizumi S; Moorhouse AJ; Yoshimura Y; Nabekura J, 2016, 'Microglia contact induces synapse formation in developing somatosensory cortex', Nature Communications, vol. 7, http://dx.doi.org/10.1038/ncomms12540

Kim SK; Hayashi H; Ishikawa T; Shibata K; Shigetomi E; Shinozaki Y; Inada H; Roh SE; Kim SJ; Lee G; Bae H; Moorhouse AJ; Mikoshiba K; Fukazawa Y; Koizumi S; Nabekura J, 2016, 'Cortical astrocytes rewire somatosensory cortical circuits for peripheral neuropathic pain', Journal of Clinical Investigation, vol. 126, pp. 1983 - 1997, http://dx.doi.org/10.1172/JCI82859

Kato G; Inada H; Wake H; Akiyoshi R; Miyamoto A; Eto K; Ishikawa T; Moorhouse AJ; Strassman AM; Nabekura J, 2016, 'Microglial contact prevents excess depolarization and rescues neurons from excitotoxicity', eNeuro, vol. 3, pp. 9133 - 9144, http://dx.doi.org/10.1523/ENEURO.0004-16.2016

Alexander SPH; Benson HE; Faccenda E; Pawson AJ; Sharman JL; McGrath JC; Catterall WA; Spedding M; Peters JA; Harmar AJ, 2013, 'THE CONCISE GUIDE TO PHARMACOLOGY 2013/14: OVERVIEW', BRITISH JOURNAL OF PHARMACOLOGY, vol. 170, pp. 1449 - 1458, http://dx.doi.org/10.1111/bph.12444

Barry PH; Lewis TM; Moorhouse AJ, 2013, 'An optimised 3 M KCl salt-bridge technique used to measure and validate theoretical liquid junction potential values in patch-clamping and electrophysiology', European Biophysics Journal, vol. 42, pp. 631 - 646, http://dx.doi.org/10.1007/s00249-013-0911-3

Miyamoto A; Wake H; Moorhouse AJ; Nabekura J, 2013, 'Microglia and synapse interactions: Fine tuning neural circuits and candidate molecules', Frontiers in Cellular Neuroscience, vol. 7, http://dx.doi.org/10.3389/fncel.2013.00070

Wake H; Moorhouse AJ; Miyamoto A; Nabekura J, 2013, 'Microglia: Actively surveying and shaping neuronal circuit structure and function', Trends in Neurosciences, vol. 36, pp. 209 - 217, http://dx.doi.org/10.1016/j.tins.2012.11.007

Kim YS; Wong AC; Power J; Tadros SF; Klugmann M; Moorhouse AJ; Bertrand PP; Housley GD, 2012, 'Alternative Splicing of the TRPC3 Ion Channel Calmodulin/ IP3 Receptor-Binding Domain in the Hindbrain Enhances Cation Flux', The Journal of Neuroscience, vol. 32, pp. 11414 - 11423, http://dx.doi.org/10.1523/JNEUROSCI.6446-11.2012

Eto K; Ishibashi H; Yoshimura T; Watanabe M; Miyamoto A; Ikenaka K; Moorhouse AJ; Nabekura J, 2012, 'Enhanced GABAergic activity in the mouse primary somatosensory cortex is insufficient to alleviate chronic pain behavior with reduced expression of neuronal potassium-chloride cotransporter', Journal of Neuroscience, vol. 32, pp. 16552 - 16559, http://dx.doi.org/10.1523/JNEUROSCI.2104-12.2012

Wake H; Moorhouse AJ; Nabekura J, 2012, 'Functions of microglia in the central nervous system-beyond the immune response', Neuron Glia Biology, vol. 7, pp. 47 - 53, http://dx.doi.org/10.1017/S1740925X12000063

Nakahata Y; Miyamoto A; Watanabe M; Moorhouse AJ; Nabekura J; Ishibashi H, 2010, 'Depolarizing shift in the GABA-induced current reversal potential by lidocaine hydrochloride', Brain Research, vol. 1345, pp. 19 - 27, http://dx.doi.org/10.1016/j.brainres.2010.05.052

Sugiharto S; Carland JE; Lewis TM; Moorhouse AJ; Barry PH, 2010, 'External divalent cations increase anion-cation permeability ratio in glycine receptor channels', Pflugers Archiv - European Journal of Physiology, vol. 460, pp. 131 - 152, http://dx.doi.org/10.1007/s00424-010-0792-6

Barry PH; Sugiharto S; Lewis TM; Moorhouse AJ, 2010, 'Further analysis of counterion permeation through anion-selective glycine receptor channels.', Channels, vol. 4, pp. 142 - 149, http://www.landesbioscience.com/journals/channels/article/11020

Carland JE; cooper MA; Sugiharto S; Jeong H; Lewis TM; Barry PH; Peters JA; Lambert J; Moorhouse AJ, 2009, 'Characterization of the effects of charged residues in the intracellular loop on ion permeation in α1 glycine receptor channels', The Journal of Biological Chemistry, vol. 284, pp. 2023 - 2030, http://dx.doi.org/10.1074/jbc.M806618200

Watanabe M; Wake H; Moorhouse AJ; Nabekura J, 2009, 'Clustering of Neuronal K+-Cl- Cotransporters in Lipid Raftsby Tyrosine Phosphorylation', The Journal of Biological Chemistry, vol. 284, pp. 27980 - 27988, http://dx.doi.org/10.1074/jbc.M109.043620

Wake H; Moorhouse AJ; Jinno S; Kohsaka S; Nabekura J, 2009, 'Resting microglia directly monitor the functional state of synapses in vivo and determine the fate of ischemic terminals', Journal of Neuroscience, vol. 29, pp. 3974 - 3980, http://dx.doi.org/10.1523/JNEUROSCI.4363-08.2009

Sugiharto S; Lewis TM; Moorhouse AJ; Schofield PR; Barry PH, 2008, 'Anion-cation permeability correlates with hydrated counterion size in glycine receptor channels', Biophysical Journal, vol. 95, pp. 4698 - 4715, http://dx.doi.org/10.1529/biophysj.107.125690

Park E; Choi I; Cho J; Nakamura M; Lee J; Lee M; Choi B; Moorhouse AJ; Jang I, 2008, 'Zinc modulation of glycine receptors in acutely isolated rat CA3 neurons', Life Sciences, vol. 83, pp. 149 - 154, http://dx.doi.org/10.1016/j.lfs.2008.04.024

Wake H; Watanabe M; Moorhouse AJ; Kanematsu T; Horibe S; Matsukawa N; Asai K; Ojika K; Hirata M; Nabekura J, 2007, 'Early changes in KCC2 phosphorylation in response to neuronal stress result in functional downregulation', Journal of Neuroscience, vol. 27, pp. 1642 - 1650, http://dx.doi.org/10.1523/JNEUROSCI.3104-06.2007

Qu W; Moorhouse AJ; Chandra M; Pierce KD; Lewis TM; Barry PH, 2006, 'A single P-loop glutamate point mutation to either lysine or arginine switches the cation-anion selectivity of the CNGA2 channel', Journal of General Physiology, vol. 127, pp. 375 - 389, http://dx.doi.org/10.1085/jgp.200509378

Qu W; Moorhouse AJ; Lewis TM; Pierce KD; Barry PH, 2005, 'Mutation of the pore glutamate affects both cytoplasmic and external dequalinium block in the rat olfactory CNGA2 channel', European Biophysics Journal with Biophysics Letters, vol. 34, pp. 442 - 453, http://dx.doi.org/10.1007/s00249-005-0479-7

Moorhouse AJ; Li S; Vickery RM; Hill MA; Morley JW, 2004, 'A patch-clamp investigation of membrane currents in a novel mammalian retinal ganglion cell line', Brain Research, vol. 1003, pp. 205 - 208, http://dx.doi.org/10.1016/j.brainres.2004.01.027

Carland JE; Moorhouse AJ; Barry PH; Johnston G; Chebib M, 2004, 'Charged residues at the 2 ` position of human GABA(c) rho 1 receptorsinvert ion selectivity and influence open state probability', The Journal of Biological Chemistry, vol. 279, pp. 54153 - 54160, http://dx.doi.org/10.1074/jbc.M410625200

Katsurabayashi S; Kubota H; Moorhouse AJ; Akaike N, 2004, 'Differential modulation of evoked and spontaneous glycine release fromrat spinal cord glycinergic terminals by the cyclic AMP/protein kinaseA transduction cascade', Journal of Neurochemistry, vol. 91, pp. 657 - 666, http://dx.doi.org/10.1111/j.1471-4159.2004.02741.x

Keramidas A; Moorhouse AJ; Schofield PR; Barry PH, 2004, 'Ligand-gated ion channels: mechanisms underlying ion selectivity', Progress in Biophysics and Molecular Biology, vol. 86, pp. 161 - 204, http://dx.doi.org/10.1016/j.pbiomolbio.2003.09.002

Kubota H; Katsurabayashi S; Moorhouse AJ; Murakami N; Koga H; Akaike N, 2003, 'GABAB receptor transduction mechanisms, and cross-talk between protein kinases A and C, in GABAergic terminals synapsing onto neurons of the rat nucleus basalis of Meynert', Journal of Physiology, vol. 551, pp. 263 - 276, http://dx.doi.org/10.1113/jphysiol.2003.046524

Jeong H; Jan I; Moorhouse AJ; Akaike N, 2003, 'Activation of presynaptic glycine receptors facilitate glycine release from presynaptic terminals synapsing onto rat spinal sacral dorsal commissural nucleus nerons', The Journal of Physiology, vol. 550, pp. 373 - 383, http://dx.doi.org/10.1113/jphysiol.2003.041053

Kubota H; Katsurabayashi S; Moorhouse AJ; Murakami N; Koga H; Akaike N, 2003, 'GABAB receptor transduction mechanisms, and cross-talk between protein kinases A and C, in GABAergic terminals synapsing onto neurons of the rat nucleus basalis of Meynert', The Journal of Physiology, vol. 551, pp. 263 - 276, http://dx.doi.org/10.1113/jphysiol.2003.046524

Akaike N; Moorhouse AJ, 2003, 'Techniques: Applications of the Nerve - bouton preparation in Neuropharmacology', Trends in Pharmacological Sciences, vol. 24, pp. 44 - 47, http://dx.doi.org/10.1016/S0165-6147(02)00010-X


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