By Associate Professor Christine Louise Chaffer

Journal articles

Sahoo S; Ramu S; Nair MG; Pillai M; San Juan BP; Milioli HZ; Mandal S; Naidu CM; Mavatkar AD; Subramaniam H; Neogi AG; Chaffer CL; Prabhu JS; Somarelli JA; Jolly MK, 2024, 'Increased prevalence of hybrid epithelial/mesenchymal state and enhanced phenotypic heterogeneity in basal breast cancer', iScience, 27, http://dx.doi.org/10.1016/j.isci.2024.110116

Dear RF-G; Liu JJ; Cosman R; Walsh N; Selga M; Perez San Juan B; Purcell C; Chaffer CL, 2024, '4CAST: A phase 1b dose exploration, open-label, single-center study evaluating the safety of INO-464 in combination with chemotherapy in patients with metastatic breast cancer.', Journal of Clinical Oncology, 42, pp. e13112 - e13112, http://dx.doi.org/10.1200/jco.2024.42.16_suppl.e13112

Mason S; Chung S; Perez San Juan B; McCool C; Day B; Zaccaron Milioli H; Dear RF-G; Sim H-W; Holst J; Chaffer CL, 2024, 'Targeting androgen receptor signaling in glioblastoma: A novel biomarker and therapeutic approach.', Journal of Clinical Oncology, 42, pp. e14016 - e14016, http://dx.doi.org/10.1200/jco.2024.42.16_suppl.e14016

Phan TG; Weilbaecher KN; Aft R; Croucher PI; Chaffer CL, 2024, 'Chemotherapy and the Extra-Tumor Immune Microenvironment: EXTRA-TIME', Cancer Discovery, 14, pp. 643 - 647, http://dx.doi.org/10.1158/2159-8290.CD-23-1543

Mason S; Chung S; Juan BPS; Sim H-W; Dear R; Day B; Holst J; Chaffer C, 2023, 'STEM-03. TARGETING ANDROGEN SIGNALING IN GLIOBLASTOMA', Neuro-Oncology, 25, pp. v33 - v33, http://dx.doi.org/10.1093/neuonc/noad179.0130

McKinnon JC; Milioli HH; Purcell CA; Chaffer CL; Wadie B; Alexandrov T; Mitchell TW; Ellis SR, 2023, 'Enhancing metabolite coverage in MALDI-MSI using laser post-ionisation (MALDI-2)', Analytical Methods, 15, pp. 4311 - 4320, http://dx.doi.org/10.1039/d3ay01046e

Waryah C; Cursons J; Foroutan M; Pflueger C; Wang E; Molania R; Woodward E; Sorolla A; Wallis C; Moses C; Glas I; Magalhães L; Thompson EW; Fearnley LG; Chaffer CL; Davis M; Papenfuss AT; Redfern A; Lister R; Esteller M; Blancafort P, 2023, 'Synthetic Epigenetic Reprogramming of Mesenchymal to Epithelial States Using the CRISPR/dCas9 Platform in Triple Negative Breast Cancer', Advanced Science, 10, http://dx.doi.org/10.1002/advs.202301802

Dear RF; Batty K; Perez B; Chaffer C, 2023, 'Abstract OT1-02-01: 4CAST: A Phase 1b dose exploration and dose expansion, open-label study evaluating the safety and efficacy of INO-464 in combination with Chemotherapy in patients with metASTatic breast cancer', Cancer Research, 83, http://dx.doi.org/10.1158/1538-7445.sabcs22-ot1-02-01

Amodio M; Youlten SE; Venkat A; San Juan BP; Chaffer CL; Krishnaswamy S, 2023, 'Single-cell multi-modal GAN reveals spatial patterns in single-cell data from triple-negative breast cancer', Patterns, http://dx.doi.org/10.1016/j.patter.2022.100577

Burkhardt DB; San Juan BP; Lock JG; Krishnaswamy S; Chaffer CL, 2022, 'Mapping Phenotypic Plasticity upon the Cancer Cell State Landscape Using Manifold Learning', Cancer Discovery, 12, pp. 1847 - 1859, http://dx.doi.org/10.1158/2159-8290.CD-21-0282

San Juan BP; Garcia-Leon MJ; Rangel L; Goetz JG; Chaffer CL, 2019, 'The complexities of metastasis', Cancers, 11, http://dx.doi.org/10.3390/cancers11101575

Juan BPS; Zadeh S; Ganju V; Vargas C; O'Toole S; Lim E; Davis M; Chaffer C, 2019, 'Unravelling the role of cell plasticity in BrCa development and metastasis', Oncology Abstracts, http://dx.doi.org/10.1530/oncolabs.1.p040

Chaffer CL; Goetz JG, 2018, 'CD44 Orchestrates Metastatic Teamwork', Developmental Cell, 47, pp. 691 - 693, http://dx.doi.org/10.1016/j.devcel.2018.11.038

Castaño Z; San Juan BP; Spiegel A; Pant A; DeCristo MJ; Laszewski T; Ubellacker JM; Janssen SR; Dongre A; Reinhardt F; Henderson A; del Rio AG; Gifford AM; Herbert ZT; Hutchinson JN; Weinberg RA; Chaffer CL; McAllister SS, 2018, 'IL-1β inflammatory response driven by primary breast cancer prevents metastasis-initiating cell colonization', Nature Cell Biology, 20, pp. 1084 - 1097, http://dx.doi.org/10.1038/s41556-018-0173-5

Li J; Choi PS; Chaffer CL; Labella K; Hwang JH; Giacomelli AO; Kim JW; Ilic N; Doench JG; Ly SH; Dai C; Hagel K; Hong AL; Gjoerup O; Goel S; Ge JY; Root DE; Zhao JJ; Brooks AN; Weinberg RA; Hahn WC, 2018, 'An alternative splicing switch in FLNB promotes the mesenchymal cell state in human breast cancer', eLife, 7, http://dx.doi.org/10.7554/eLife.37184

van Dijk D; Sharma R; Nainys J; Yim K; Kathail P; Carr AJ; Burdziak C; Moon KR; Chaffer CL; Pattabiraman D; Bierie B; Mazutis L; Wolf G; Krishnaswamy S; Pe'er D, 2018, 'Recovering Gene Interactions from Single-Cell Data Using Data Diffusion', Cell, 174, pp. 716 - 729.e27, http://dx.doi.org/10.1016/j.cell.2018.05.061

Bierie B; Pierce SE; Kroeger C; Stover DG; Pattabiraman DR; Thiru P; Donaher JL; Reinhardt F; Chaffer CL; Keckesova Z; Weinberg RA, 2017, 'Integrin-β4 identifies cancer stem cell-enriched populations of partially mesenchymal carcinoma cells', Proceedings of the National Academy of Sciences of the United States of America, 114, pp. E2337 - E2346, http://dx.doi.org/10.1073/pnas.1618298114

Chaffer CL; San Juan BP; Lim E; Weinberg RA, 2016, 'EMT, cell plasticity and metastasis', Cancer and Metastasis Reviews, 35, pp. 645 - 654, http://dx.doi.org/10.1007/s10555-016-9648-7

Katajisto P; Döhla J; Chaffer CL; Pentinmikko N; Marjanovic N; Iqbal S; Zoncu R; Chen W; Weinberg RA; Sabatini DM, 2015, 'Asymmetric apportioning of aged mitochondria between daughter cells is required for stemness', Science, 348, pp. 340 - 343, http://dx.doi.org/10.1126/science.1260384

Chaffer CL; Weinberg RA, 2015, 'How does multistep tumorigenesis really proceed?', Cancer Discovery, 5, pp. 22 - 24, http://dx.doi.org/10.1158/2159-8290.CD-14-0788

Marjanovic ND; Weinberg RA; Chaffer CL, 2013, 'Poised with purpose: Cell plasticity enhances tumorigenicity', Cell Cycle, 12, pp. 2713 - 2714, http://dx.doi.org/10.4161/cc.26075

Chaffer CL; Marjanovic ND; Lee T; Bell G; Kleer CG; Reinhardt F; D'Alessio AC; Young RA; Weinberg RA, 2013, 'XPoised chromatin at the ZEB1 promoter enables breast cancer cell plasticity and enhances tumorigenicity', Cell, 154, pp. 61, http://dx.doi.org/10.1016/j.cell.2013.06.005

Marjanovic ND; Weinberg RA; Chaffer CL, 2013, 'Cell plasticity and heterogeneity in cancer', Clinical Chemistry, 59, pp. 168 - 179, http://dx.doi.org/10.1373/clinchem.2012.184655

Scheel C; Eaton EN; Li SHJ; Chaffer CL; Reinhardt F; Kah KJ; Bell G; Guo W; Rubin J; Richardson AL; Weinberg RA, 2011, 'Paracrine and autocrine signals induce and maintain mesenchymal and stem cell states in the breast', Cell, 145, pp. 926 - 940, http://dx.doi.org/10.1016/j.cell.2011.04.029

Chaffer CL; Brueckmann I; Scheel C; Kaestli AJ; Wiggins PA; Rodrigues LO; Brooks M; Reinhardt F; Suc Y; Polyak K; Arendt LM; Kuperwasser C; Bierie B; Weinberg RA, 2011, 'Normal and neoplastic nonstem cells can spontaneously convert to a stem-like state', Proceedings of the National Academy of Sciences of the United States of America, 108, pp. 7950 - 7955, http://dx.doi.org/10.1073/pnas.1102454108

Chaffer CL; Weinberg RA, 2011, 'A perspective on cancer cell metastasis', Science, 331, pp. 1559 - 1564, http://dx.doi.org/10.1126/science.1203543

Chaffer CL; Weinberg RA, 2010, 'Cancer cell of origin: Spotlight on luminal progenitors', Cell Stem Cell, 7, pp. 271 - 272, http://dx.doi.org/10.1016/j.stem.2010.08.008

Tilkorn DJ; Lokmic Z; Chaffer CL; Mitchell GM; Morrison WA; Thompson EW, 2010, 'Disparate companions: Tissue engineering meets cancer research', Cells Tissues Organs, 192, pp. 141 - 157, http://dx.doi.org/10.1159/000308892

Gupta PB; Chaffer CL; Weinberg RA, 2009, 'Cancer stem cells: Mirage or reality?', Nature Medicine, 15, pp. 1010 - 1012, http://dx.doi.org/10.1038/nm0909-1010

Chaffer CL; Dopheide B; Savagner P; Thompson EW; Williams ED, 2007, 'Aberrant fibroblast growth factor receptor signaling in bladder and other cancers', Differentiation, 75, pp. 831 - 842, http://dx.doi.org/10.1111/j.1432-0436.2007.00210.x

Chaffer CL; Brennan JP; Slavin JL; Blick T; Thompson EW; Williams ED, 2006, 'Mesenchymal-to-epithelial transition facilitates bladder cancer metastasis: Role of fibroblast growth factor receptor-2', Cancer Research, 66, pp. 11271 - 11278, http://dx.doi.org/10.1158/0008-5472.CAN-06-2044

Chaffer CL; Thomas DM; Thompson EW; Williams ED, 2006, 'PPARγ-independent induction of growth arrest and apoptosis in prostate and bladder carcinoma', BMC Cancer, 6, http://dx.doi.org/10.1186/1471-2407-6-53

Chaffer CL; Dopheide B; McCulloch DR; Lee AB; Moseley JM; Thompson EW; Williams ED, 2005, 'Upregulated MT1-MMP/TIMP-2 axis in the TSU-Pr1-B1/B2 model of metastatic progression in transitional cell carcinoma of the bladder', Clinical and Experimental Metastasis, 22, pp. 115 - 125, http://dx.doi.org/10.1007/s10585-005-5141-3

Chaffer CL; Morris MJ, 2002, 'The Feeding Response to Melanin-Concentrating Hormone Is Attenuated by Antagonism of the NPY Y1-Receptor in the Rat', Endocrinology, 143, pp. 191 - 197, http://dx.doi.org/10.1210/en.143.1.191

Conference Papers

Tong A; Juan BPS; Zhu B; Chaffer CL; Krishnaswamy S, 2021, 'Abstract 2839: Understanding the mesenchymal-to-epithelial transition and its drivers in triple-negative breast cancer with continuous normalizing flows', in Cancer Research, American Association for Cancer Research (AACR), pp. 2839 - 2839, http://dx.doi.org/10.1158/1538-7445.am2021-2839

Li J; Choi P; Chaffer C; Labella K; Kim JW; Doench J; Dai C; Giacomelli A; Ly SH; Hwang J; Hong A; Ilic N; Gjoerup O; Meyerson M; Brooks A; Weinberg R; Hahn W, 2017, 'Abstract A36: Genome-scale ORF screening to identify modulators of the epithelial-to-mesenchymal transition', in Molecular Cancer Therapeutics, American Association for Cancer Research (AACR), pp. A36 - A36, http://dx.doi.org/10.1158/1538-8514.synthleth-a36

Li J; Choi P; Chaffer C; Labella K; Kim JW; Doench J; Dai C; Giacomelli A; Ly SH; Hwang J; Hong A; Ilic N; Gjoerup O; Meyerson M; Brooks A; Weinberg R; Hahn W, 2017, 'Abstract 5020: A genome-scale ORF screen reveals an alternative splicing program that regulates mesenchymal and stem-like cell states in breast cancer', in Cancer Research, American Association for Cancer Research (AACR), pp. 5020 - 5020, http://dx.doi.org/10.1158/1538-7445.am2017-5020

Castano Z; Chaffer CL; Spiegel A; Pant A; Richardson AL; Reinhardt F; Marsh T; Janssen S; Gifford AM; Weinberg RA; McAllister SS, 2016, 'Understanding the systemic interactions between primary tumors and disseminated tumor initiating cells', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, CA, San Diego, presented at AACR Special Conference on Function of Tumor Microenvironment in Cancer Progression, CA, San Diego, 07 January 2016 - 10 January 2016, http://dx.doi.org/10.1158/1538-7445.TME16-PR13

Scheel C; NgEaton E; Li SH-J; Chaffer CL; Reinhardt F; Kah K-J; Bell G; Guo W; Rubin J; Richardson A; Weinberg RA, 2011, 'Formation and maintenance of mesenchymal and stem-cell states in the breast by paracrine and autocrine signals', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, http://dx.doi.org/10.1158/1538-7445.AM2011-LB-108

Chaffer CL; Thompson EW; Williams ED, 2007, 'Mesenchymal to epithelial transition in development and disease', in Cells Tissues Organs, pp. 7 - 19, http://dx.doi.org/10.1159/000101298

Williams E; Chaffer C; Oakes SR; Ormandy CJ; Blick T; Thompson E, 2007, 'Mesenchymal to epithetial transition in the establishment of secondary tumours: insights from a bladder carcinoma progression series', in Clinical and Experimental Metastasis, Kluwer Academic Publ, pp. 262 - 262

Williams ED; Chaffer CL; Oakes SR; Ormandy CJ; Blick T; Thompson EW, 2006, 'Mesenchymal to epithelial transition in the establishment of secondary tumors: Insights from a bladder carcinoma progression series', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000454606204397&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Brennan JP; Chaffer CL; Slavin J; Temelcos C; Goad J; Williams ED, 2006, 'Patterns of spread in an orthotopic mouse model of bladder cancer', in BJU INTERNATIONAL, BLACKWELL PUBLISHING, pp. 9 - 9, http://dx.doi.org/10.1111/j.1464-410X.2006.06085_31.x

Brennan JP; Williams ED; Chaffer CL; Goad J; Temelcos C; Slavin J, 2005, 'A novel orthotopic model of muscle-invasive bladder cancer', in BJU INTERNATIONAL, BLACKWELL PUBLISHING, AUSTRALIA, Melbourne, pp. 27 - 27, presented at Annual Scientific Meeting of the Urological- Society-of-Australasia, AUSTRALIA, Melbourne, 13 February 2005 - 17 February 2005, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000236061300125&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Abstracts

Juan BPS; Hediyah-Zadeh S; Rangel L; Rodriguez V; Milioli HH; Kohane F; Purcell CA; Hickey TE; Goldstein LD; Lock JG; Davis MJ; Chaffer CL, 2022, 'Abstract 1029: The anti-androgen seviteronel sensitizes triple-negative breast cancer to chemotherapy', in Cancer Research, American Association for Cancer Research (AACR), Vol. 82, pp. 1029 - 1029, http://dx.doi.org/10.1158/1538-7445.am2022-1029

Preprints

Venkat A; Youlten SE; Juan BPS; Purcell C; Amodio M; Burkhardt DB; Benz A; Holst J; McCool C; Mollbrink A; Lundeberg J; van Dijk D; Goldstein LD; Kummerfeld S; Krishnaswamy S; Chaffer CL, 2024, AAnet resolves a continuum of spatially-localized cell states to unveil tumor complexity, http://dx.doi.org/10.1101/2024.05.11.593705

Krishnaswamy S; Tong A; Kuchroo M; Gupta S; Venkat A; Juan BS; Rangel L; Zhu B; Lock J; Chaffer C, 2023, Revealing dynamic temporal regulatory networks driving cancer cell state plasticity with neural ODE-based optimal transport, http://dx.doi.org/10.21203/rs.3.rs-3605296/v1

Sahoo S; Ramu S; Nair MG; Pillai M; San Juan BP; Milioli HZ; Mandal S; Naidu CM; Mavatkar AD; Subramaniam H; Neogi AG; Chaffer CL; Prabhu JS; Somarelli JA; Jolly MK, 2023, Multi-modal transcriptomic analysis unravels enrichment of hybrid epithelial/mesenchymal state and enhanced phenotypic heterogeneity in basal breast cancer., http://dx.doi.org/10.1101/2023.09.30.558960

Mckinnon J; Milioli H; Purcell C; Chaffer C; Wadie B; Alexandrov T; Mitchell T; Ellis S, 2023, Enhancing Metabolite Coverage in MALDI-MSI using Laser Post-Ionisation (MALDI-2)., http://dx.doi.org/10.26434/chemrxiv-2023-sptss

Tong A; Kuchroo M; Gupta S; Venkat A; San Juan B; Rangel L; Zhu B; Lock J; Chaffer C; Krishnaswamy S, 2023, Learning transcriptional and regulatory dynamics driving cancer cell plasticity using neural ODE-based optimal transport, http://dx.doi.org/10.1101/2023.03.28.534644

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