By Associate Professor Christine Louise Chaffer

Journal articles

Bleach R; Bozkurt E; Xin J; Sheehan KM; Shirran S; Agbana S; Ola M; Young L; Spoelstra NS; Richer JK; Vargas AC; Goldstein LD; Milloli HH; Chaffer CL; O’Reilly MW; Prehn JHM; McIlroy M, 2026, 'Androgen receptor localisation and protein interactions provide insight into steroid mediated metabolic shifts in endocrine resistant breast cancer', Npj Breast Cancer, 12, http://dx.doi.org/10.1038/s41523-026-00924-1

King HE; O’Connell S; Kavanagh D; Mason S; McCool C; Fernandez-Chamorro J; Chaffer CL; Clark SJ; Vieira HGS; Sterne-Weiler T; Weatheritt RJ, 2026, 'Isoform-specific single-cell perturb-seq reveals distinct functions of alternative promoters in drug response', Nucleic Acids Research, 54, http://dx.doi.org/10.1093/nar/gkag118

Kohane FV; Johnstone C; Neumann DP; Gunawan I; Huang T; Vafaee F; Chaffer CL; Lock JG, 2026, 'Epithelial–mesenchymal cell state heterogeneity predetermines differential phospho-signaling responses to EGF stimulation', Molecular Biology of the Cell, 37, http://dx.doi.org/10.1091/mbc.E25-07-0349

Silvani G; Kopecky C; Romanazzo S; Rodríguez V; Das A; Pandzic E; Lock JG; Chaffer CL; Poole K; Kilian KA, 2025, 'Capillary constrictions prime cancer cell tumorigenicity through PIEZO1', Nature Communications, 16, http://dx.doi.org/10.1038/s41467-025-63374-6

Venkat A; Youlten SE; San Juan BP; Purcell CA; Gupta S; Amodio M; Neumann DP; Lock JG; Westacott AE; McCool CS; Burkhardt DB; Benz A; Mollbrink A; Lundeberg J; van Dijk D; Holst J; Goldstein LD; Kummerfeld S; Krishnaswamy S; Chaffer CL, 2025, 'AAnet Resolves a Continuum of Spatially Localized Cell States to Unveil Intratumoral Heterogeneity', Cancer Discovery, 15, pp. 2139 - 2165, http://dx.doi.org/10.1158/2159-8290.CD-24-0684

Dhenni R; Hoppé AC; Reynaldi A; Kyaw W; Handoko NT; Grootveld AK; Keith YH; Bhattacharyya ND; Ahel HI; Telfser AJ; McCorkindale AN; Yazar S; Bui CHT; Smith JT; Khoo WH; Boyd M; Obeid S; Milner B; Starr M; Brilot F; Milogiannakis V; Akerman A; Aggarwal A; Davenport MP; Deenick EK; Chaffer CL; Croucher PI; Brink R; Goldstein LD; Cromer D; Turville SG; Kelleher AD; Venturi V; Munier CML; Phan TG, 2025, 'Macrophages direct location-dependent recall of B cell memory to vaccination', Cell, 188, pp. 3477 - 3496.e22, http://dx.doi.org/10.1016/j.cell.2025.04.005

Chaffer CL; Milioli HH; San Juan BP; Dear RF; Liu JJ, 2025, 'Abstract 4744: State-gating cancer to prevent chemotherapy-resistance', Cancer Research, 85, pp. 4744 - 4744, http://dx.doi.org/10.1158/1538-7445.am2025-4744

Sahoo S; Ramu S; Nair MG; Pillai M; San Juan BP; Milioli HZ; Mandal S; Naidu CM; Mavatkar AD; Subramaniam H; Neogi AG; Chaffer CL; Prabhu JS; Somarelli JA; Jolly MK, 2024, 'Increased prevalence of hybrid epithelial/mesenchymal state and enhanced phenotypic heterogeneity in basal breast cancer', Iscience, 27, http://dx.doi.org/10.1016/j.isci.2024.110116

Dear RF-G; Liu JJ; Cosman R; Walsh N; Selga M; Perez San Juan B; Purcell C; Chaffer CL, 2024, '4CAST: A phase 1b dose exploration, open-label, single-center study evaluating the safety of INO-464 in combination with chemotherapy in patients with metastatic breast cancer.', Journal of Clinical Oncology, 42, pp. e13112 - e13112, http://dx.doi.org/10.1200/jco.2024.42.16_suppl.e13112

Mason S; Chung S; Perez San Juan B; McCool C; Day B; Zaccaron Milioli H; Dear RF-G; Sim H-W; Holst J; Chaffer CL, 2024, 'Targeting androgen receptor signaling in glioblastoma: A novel biomarker and therapeutic approach.', Journal of Clinical Oncology, 42, pp. e14016 - e14016, http://dx.doi.org/10.1200/jco.2024.42.16_suppl.e14016

Phan TG; Weilbaecher KN; Aft R; Croucher PI; Chaffer CL, 2024, 'Chemotherapy and the Extra-Tumor Immune Microenvironment: EXTRA-TIME', Cancer Discovery, 14, pp. 643 - 647, http://dx.doi.org/10.1158/2159-8290.CD-23-1543

Mason S; Chung S; San Juan BP; Sim H-W; Dear R; Day B; Holst J; Chaffer C, 2023, 'STEM-03. TARGETING ANDROGEN SIGNALING IN GLIOBLASTOMA', Neuro-Oncology, 25, pp. v33 - v33, http://dx.doi.org/10.1093/neuonc/noad179.0130

McKinnon JC; Milioli HH; Purcell CA; Chaffer CL; Wadie B; Alexandrov T; Mitchell TW; Ellis SR, 2023, 'Enhancing metabolite coverage in MALDI-MSI using laser post-ionisation (MALDI-2)', Analytical Methods, 15, pp. 4311 - 4320, http://dx.doi.org/10.1039/d3ay01046e

Waryah C; Cursons J; Foroutan M; Pflueger C; Wang E; Molania R; Woodward E; Sorolla A; Wallis C; Moses C; Glas I; Magalhães L; Thompson EW; Fearnley LG; Chaffer CL; Davis M; Papenfuss AT; Redfern A; Lister R; Esteller M; Blancafort P, 2023, 'Synthetic Epigenetic Reprogramming of Mesenchymal to Epithelial States Using the CRISPR/dCas9 Platform in Triple Negative Breast Cancer', Advanced Science, 10, http://dx.doi.org/10.1002/advs.202301802

Dear RF; Batty K; Perez B; Chaffer C, 2023, 'Abstract OT1-02-01: 4CAST: A Phase 1b dose exploration and dose expansion, open-label study evaluating the safety and efficacy of INO-464 in combination with Chemotherapy in patients with metASTatic breast cancer', Cancer Research, 83, pp. ot1-02-01-ot1-02-01, http://dx.doi.org/10.1158/1538-7445.sabcs22-ot1-02-01

Amodio M; Youlten SE; Venkat A; San Juan BP; Chaffer CL; Krishnaswamy S, 2023, 'Single-cell multi-modal GAN reveals spatial patterns in single-cell data from triple-negative breast cancer', Patterns, http://dx.doi.org/10.1016/j.patter.2022.100577

Burkhardt DB; San Juan BP; Lock JG; Krishnaswamy S; Chaffer CL, 2022, 'Mapping Phenotypic Plasticity upon the Cancer Cell State Landscape Using Manifold Learning', Cancer Discovery, 12, pp. 1847 - 1859, http://dx.doi.org/10.1158/2159-8290.CD-21-0282

San Juan BP; Garcia-Leon MJ; Rangel L; Goetz JG; Chaffer CL, 2019, 'The complexities of metastasis', Cancers, 11, http://dx.doi.org/10.3390/cancers11101575

Juan BPS; Zadeh S; Ganju V; Vargas C; O'Toole S; Lim E; Davis M; Chaffer C, 2019, 'Unravelling the role of cell plasticity in BrCa development and metastasis', Oncology Abstracts, http://dx.doi.org/10.1530/oncolabs.1.p040

Chaffer CL; Goetz JG, 2018, 'CD44 Orchestrates Metastatic Teamwork', Developmental Cell, 47, pp. 691 - 693, http://dx.doi.org/10.1016/j.devcel.2018.11.038

Castaño Z; San Juan BP; Spiegel A; Pant A; DeCristo MJ; Laszewski T; Ubellacker JM; Janssen SR; Dongre A; Reinhardt F; Henderson A; del Rio AG; Gifford AM; Herbert ZT; Hutchinson JN; Weinberg RA; Chaffer CL; McAllister SS, 2018, 'IL-1β inflammatory response driven by primary breast cancer prevents metastasis-initiating cell colonization', Nature Cell Biology, 20, pp. 1084 - 1097, http://dx.doi.org/10.1038/s41556-018-0173-5

Li J; Choi PS; Chaffer CL; Labella K; Hwang JH; Giacomelli AO; Kim JW; Ilic N; Doench JG; Ly SH; Dai C; Hagel K; Hong AL; Gjoerup O; Goel S; Ge JY; Root DE; Zhao JJ; Brooks AN; Weinberg RA; Hahn WC, 2018, 'An alternative splicing switch in FLNB promotes the mesenchymal cell state in human breast cancer', Elife, 7, http://dx.doi.org/10.7554/eLife.37184

van Dijk D; Sharma R; Nainys J; Yim K; Kathail P; Carr AJ; Burdziak C; Moon KR; Chaffer CL; Pattabiraman D; Bierie B; Mazutis L; Wolf G; Krishnaswamy S; Pe'er D, 2018, 'Recovering Gene Interactions from Single-Cell Data Using Data Diffusion', Cell, 174, pp. 716 - 729.e27, http://dx.doi.org/10.1016/j.cell.2018.05.061

Bierie B; Pierce SE; Kroeger C; Stover DG; Pattabiraman DR; Thiru P; Donaher JL; Reinhardt F; Chaffer CL; Keckesova Z; Weinberg RA, 2017, 'Integrin-β4 identifies cancer stem cell-enriched populations of partially mesenchymal carcinoma cells', Proceedings of the National Academy of Sciences of the United States of America, 114, pp. E2337 - E2346, http://dx.doi.org/10.1073/pnas.1618298114

Chaffer CL; San Juan BP; Lim E; Weinberg RA, 2016, 'EMT, cell plasticity and metastasis', Cancer and Metastasis Reviews, 35, pp. 645 - 654, http://dx.doi.org/10.1007/s10555-016-9648-7

Katajisto P; Döhla J; Chaffer CL; Pentinmikko N; Marjanovic N; Iqbal S; Zoncu R; Chen W; Weinberg RA; Sabatini DM, 2015, 'Asymmetric apportioning of aged mitochondria between daughter cells is required for stemness', Science, 348, pp. 340 - 343, http://dx.doi.org/10.1126/science.1260384

Chaffer CL; Weinberg RA, 2015, 'How does multistep tumorigenesis really proceed?', Cancer Discovery, 5, pp. 22 - 24, http://dx.doi.org/10.1158/2159-8290.CD-14-0788

Marjanovic ND; Weinberg RA; Chaffer CL, 2013, 'Poised with purpose: Cell plasticity enhances tumorigenicity', Cell Cycle, 12, pp. 2713 - 2714, http://dx.doi.org/10.4161/cc.26075

Chaffer CL; Marjanovic ND; Lee T; Bell G; Kleer CG; Reinhardt F; D'Alessio AC; Young RA; Weinberg RA, 2013, 'XPoised chromatin at the ZEB1 promoter enables breast cancer cell plasticity and enhances tumorigenicity', Cell, 154, pp. 61, http://dx.doi.org/10.1016/j.cell.2013.06.005

Marjanovic ND; Weinberg RA; Chaffer CL, 2013, 'Cell plasticity and heterogeneity in cancer', Clinical Chemistry, 59, pp. 168 - 179, http://dx.doi.org/10.1373/clinchem.2012.184655

Scheel C; Eaton EN; Li SHJ; Chaffer CL; Reinhardt F; Kah KJ; Bell G; Guo W; Rubin J; Richardson AL; Weinberg RA, 2011, 'Paracrine and autocrine signals induce and maintain mesenchymal and stem cell states in the breast', Cell, 145, pp. 926 - 940, http://dx.doi.org/10.1016/j.cell.2011.04.029

Chaffer CL; Brueckmann I; Scheel C; Kaestli AJ; Wiggins PA; Rodrigues LO; Brooks M; Reinhardt F; Suc Y; Polyak K; Arendt LM; Kuperwasser C; Bierie B; Weinberg RA, 2011, 'Normal and neoplastic nonstem cells can spontaneously convert to a stem-like state', Proceedings of the National Academy of Sciences of the United States of America, 108, pp. 7950 - 7955, http://dx.doi.org/10.1073/pnas.1102454108

Chaffer CL; Weinberg RA, 2011, 'A perspective on cancer cell metastasis', Science, 331, pp. 1559 - 1564, http://dx.doi.org/10.1126/science.1203543

Chaffer CL; Weinberg RA, 2010, 'Cancer cell of origin: Spotlight on luminal progenitors', Cell Stem Cell, 7, pp. 271 - 272, http://dx.doi.org/10.1016/j.stem.2010.08.008

Tilkorn DJ; Lokmic Z; Chaffer CL; Mitchell GM; Morrison WA; Thompson EW, 2010, 'Disparate companions: Tissue engineering meets cancer research', Cells Tissues Organs, 192, pp. 141 - 157, http://dx.doi.org/10.1159/000308892

Gupta PB; Chaffer CL; Weinberg RA, 2009, 'Cancer stem cells: Mirage or reality?', Nature Medicine, 15, pp. 1010 - 1012, http://dx.doi.org/10.1038/nm0909-1010

Chaffer CL; Dopheide B; Savagner P; Thompson EW; Williams ED, 2007, 'Aberrant fibroblast growth factor receptor signaling in bladder and other cancers', Differentiation, 75, pp. 831 - 842, http://dx.doi.org/10.1111/j.1432-0436.2007.00210.x

Chaffer CL; Brennan JP; Slavin JL; Blick T; Thompson EW; Williams ED, 2006, 'Mesenchymal-to-epithelial transition facilitates bladder cancer metastasis: Role of fibroblast growth factor receptor-2', Cancer Research, 66, pp. 11271 - 11278, http://dx.doi.org/10.1158/0008-5472.CAN-06-2044

Chaffer CL; Thomas DM; Thompson EW; Williams ED, 2006, 'PPARγ-independent induction of growth arrest and apoptosis in prostate and bladder carcinoma', BMC Cancer, 6, http://dx.doi.org/10.1186/1471-2407-6-53

Chaffer CL; Dopheide B; McCulloch DR; Lee AB; Moseley JM; Thompson EW; Williams ED, 2005, 'Upregulated MT1-MMP/TIMP-2 axis in the TSU-Pr1-B1/B2 model of metastatic progression in transitional cell carcinoma of the bladder', Clinical and Experimental Metastasis, 22, pp. 115 - 125, http://dx.doi.org/10.1007/s10585-005-5141-3

Chaffer CL, 2002, 'The Feeding Response to Melanin-Concentrating Hormone Is Attenuated by Antagonism of the NPY Y1-Receptor in the Rat', Endocrinology, 143, pp. 191 - 197, http://dx.doi.org/10.1210/en.143.1.191

Conference Papers

Mason SRE; Chung S; Satgunaseelan L; McCool C; Juan BP-S; Gupta S; Zaman A; Day BW; Dear R; Sim H-W; Holst J; Chaffer CL, 2024, 'EXTH-26. EXPLORING THE ROLE OF ANDROGEN RECEPTOR SIGNALING IN GLIOBLASTOMA IN AN ORTHOTOPIC ANIMAL MODEL', in Neuro-Oncology, Oxford University Press (OUP), pp. viii242 - viii242, http://dx.doi.org/10.1093/neuonc/noae165.0957

Tong A; Juan BPS; Zhu B; Chaffer CL; Krishnaswamy S, 2021, 'Abstract 2839: Understanding the mesenchymal-to-epithelial transition and its drivers in triple-negative breast cancer with continuous normalizing flows', in Cancer Research, American Association for Cancer Research (AACR), pp. 2839 - 2839, http://dx.doi.org/10.1158/1538-7445.am2021-2839

Li J; Choi P; Chaffer C; Labella K; Kim JW; Doench J; Dai C; Giacomelli A; Ly SH; Hwang J; Hong A; Ilic N; Gjoerup O; Meyerson M; Brooks A; Weinberg R; Hahn W, 2017, 'Abstract A36: Genome-scale ORF screening to identify modulators of the epithelial-to-mesenchymal transition', in Molecular Cancer Therapeutics, American Association for Cancer Research (AACR), pp. A36 - A36, http://dx.doi.org/10.1158/1538-8514.synthleth-a36

Li J; Choi P; Chaffer C; Labella K; Kim JW; Doench J; Dai C; Giacomelli A; Ly SH; Hwang J; Hong A; Ilic N; Gjoerup O; Meyerson M; Brooks A; Weinberg R; Hahn W, 2017, 'Abstract 5020: A genome-scale ORF screen reveals an alternative splicing program that regulates mesenchymal and stem-like cell states in breast cancer', in Cancer Research, American Association for Cancer Research (AACR), pp. 5020 - 5020, http://dx.doi.org/10.1158/1538-7445.am2017-5020

Castano Z; Chaffer CL; Spiegel A; Pant A; Richardson AL; Reinhardt F; Marsh T; Janssen S; Gifford AM; Weinberg RA; McAllister SS, 2016, 'Understanding the systemic interactions between primary tumors and disseminated tumor initiating cells', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, CA, San Diego, presented at AACR Special Conference on Function of Tumor Microenvironment in Cancer Progression, CA, San Diego, 07 January 2016 - 10 January 2016, http://dx.doi.org/10.1158/1538-7445.TME16-PR13

Scheel C; NgEaton E; Li SH-J; Chaffer CL; Reinhardt F; Kah K-J; Bell G; Guo W; Rubin J; Richardson A; Weinberg RA, 2011, 'Formation and maintenance of mesenchymal and stem-cell states in the breast by paracrine and autocrine signals', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, http://dx.doi.org/10.1158/1538-7445.AM2011-LB-108

Chaffer CL; Thompson EW; Williams ED, 2007, 'Mesenchymal to epithelial transition in development and disease', in Cells Tissues Organs, pp. 7 - 19, http://dx.doi.org/10.1159/000101298

Williams ED; Chaffer CL; Oakes SR; Ormandy CJ; Blick T; Thompson EW, 2007, 'Mesenchymal to epithetial transition in the establishment of secondary tumours: insights from a bladder carcinoma progression series', in CLINICAL & EXPERIMENTAL METASTASIS, SPRINGER, pp. 262 - 262, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000248687200097&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Williams ED; Chaffer CL; Oakes SR; Ormandy CJ; Blick T; Thompson EW, 2006, 'Mesenchymal to epithelial transition in the establishment of secondary tumors: Insights from a bladder carcinoma progression series', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000454606204397&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

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