By Associate Professor Christine Louise Chaffer

Journal articles

Bleach R; Bozkurt E; Xin J; Sheehan KM; Shirran S; Agbana S; Ola M; Young L; Spoelstra NS; Richer JK; Vargas AC; Goldstein LD; Milloli HH; Chaffer CL; O’Reilly MW; Prehn JHM; McIlroy M, 2026, 'Androgen receptor localisation and protein interactions provide insight into steroid mediated metabolic shifts in endocrine resistant breast cancer', Npj Breast Cancer, 12, http://dx.doi.org/10.1038/s41523-026-00924-1

King HE; O’Connell S; Kavanagh D; Mason S; McCool C; Fernandez-Chamorro J; Chaffer CL; Clark SJ; Vieira HGS; Sterne-Weiler T; Weatheritt RJ, 2026, 'Isoform-specific single-cell perturb-seq reveals distinct functions of alternative promoters in drug response', Nucleic Acids Research, 54, http://dx.doi.org/10.1093/nar/gkag118

Kohane FV; Johnstone C; Neumann DP; Gunawan I; Huang T; Vafaee F; Chaffer CL; Lock JG, 2026, 'Epithelial–mesenchymal cell state heterogeneity predetermines differential phospho-signaling responses to EGF stimulation', Molecular Biology of the Cell, 37, http://dx.doi.org/10.1091/mbc.E25-07-0349

Silvani G; Kopecky C; Romanazzo S; Rodríguez V; Das A; Pandzic E; Lock JG; Chaffer CL; Poole K; Kilian KA, 2025, 'Capillary constrictions prime cancer cell tumorigenicity through PIEZO1', Nature Communications, 16, http://dx.doi.org/10.1038/s41467-025-63374-6

Venkat A; Youlten SE; San Juan BP; Purcell CA; Gupta S; Amodio M; Neumann DP; Lock JG; Westacott AE; McCool CS; Burkhardt DB; Benz A; Mollbrink A; Lundeberg J; van Dijk D; Holst J; Goldstein LD; Kummerfeld S; Krishnaswamy S; Chaffer CL, 2025, 'AAnet Resolves a Continuum of Spatially Localized Cell States to Unveil Intratumoral Heterogeneity', Cancer Discovery, 15, pp. 2139 - 2165, http://dx.doi.org/10.1158/2159-8290.CD-24-0684

Dhenni R; Hoppé AC; Reynaldi A; Kyaw W; Handoko NT; Grootveld AK; Keith YH; Bhattacharyya ND; Ahel HI; Telfser AJ; McCorkindale AN; Yazar S; Bui CHT; Smith JT; Khoo WH; Boyd M; Obeid S; Milner B; Starr M; Brilot F; Milogiannakis V; Akerman A; Aggarwal A; Davenport MP; Deenick EK; Chaffer CL; Croucher PI; Brink R; Goldstein LD; Cromer D; Turville SG; Kelleher AD; Venturi V; Munier CML; Phan TG, 2025, 'Macrophages direct location-dependent recall of B cell memory to vaccination', Cell, 188, pp. 3477 - 3496.e22, http://dx.doi.org/10.1016/j.cell.2025.04.005

Chaffer CL; Milioli HH; San Juan BP; Dear RF; Liu JJ, 2025, 'Abstract 4744: State-gating cancer to prevent chemotherapy-resistance', Cancer Research, 85, pp. 4744 - 4744, http://dx.doi.org/10.1158/1538-7445.am2025-4744

Sahoo S; Ramu S; Nair MG; Pillai M; San Juan BP; Milioli HZ; Mandal S; Naidu CM; Mavatkar AD; Subramaniam H; Neogi AG; Chaffer CL; Prabhu JS; Somarelli JA; Jolly MK, 2024, 'Increased prevalence of hybrid epithelial/mesenchymal state and enhanced phenotypic heterogeneity in basal breast cancer', Iscience, 27, http://dx.doi.org/10.1016/j.isci.2024.110116

Dear RF-G; Liu JJ; Cosman R; Walsh N; Selga M; Perez San Juan B; Purcell C; Chaffer CL, 2024, '4CAST: A phase 1b dose exploration, open-label, single-center study evaluating the safety of INO-464 in combination with chemotherapy in patients with metastatic breast cancer.', Journal of Clinical Oncology, 42, pp. e13112 - e13112, http://dx.doi.org/10.1200/jco.2024.42.16_suppl.e13112

Mason S; Chung S; Perez San Juan B; McCool C; Day B; Zaccaron Milioli H; Dear RF-G; Sim H-W; Holst J; Chaffer CL, 2024, 'Targeting androgen receptor signaling in glioblastoma: A novel biomarker and therapeutic approach.', Journal of Clinical Oncology, 42, pp. e14016 - e14016, http://dx.doi.org/10.1200/jco.2024.42.16_suppl.e14016

Phan TG; Weilbaecher KN; Aft R; Croucher PI; Chaffer CL, 2024, 'Chemotherapy and the Extra-Tumor Immune Microenvironment: EXTRA-TIME', Cancer Discovery, 14, pp. 643 - 647, http://dx.doi.org/10.1158/2159-8290.CD-23-1543

Mason S; Chung S; San Juan BP; Sim H-W; Dear R; Day B; Holst J; Chaffer C, 2023, 'STEM-03. TARGETING ANDROGEN SIGNALING IN GLIOBLASTOMA', Neuro-Oncology, 25, pp. v33 - v33, http://dx.doi.org/10.1093/neuonc/noad179.0130

McKinnon JC; Milioli HH; Purcell CA; Chaffer CL; Wadie B; Alexandrov T; Mitchell TW; Ellis SR, 2023, 'Enhancing metabolite coverage in MALDI-MSI using laser post-ionisation (MALDI-2)', Analytical Methods, 15, pp. 4311 - 4320, http://dx.doi.org/10.1039/d3ay01046e

Waryah C; Cursons J; Foroutan M; Pflueger C; Wang E; Molania R; Woodward E; Sorolla A; Wallis C; Moses C; Glas I; Magalhães L; Thompson EW; Fearnley LG; Chaffer CL; Davis M; Papenfuss AT; Redfern A; Lister R; Esteller M; Blancafort P, 2023, 'Synthetic Epigenetic Reprogramming of Mesenchymal to Epithelial States Using the CRISPR/dCas9 Platform in Triple Negative Breast Cancer', Advanced Science, 10, http://dx.doi.org/10.1002/advs.202301802

Dear RF; Batty K; Perez B; Chaffer C, 2023, 'Abstract OT1-02-01: 4CAST: A Phase 1b dose exploration and dose expansion, open-label study evaluating the safety and efficacy of INO-464 in combination with Chemotherapy in patients with metASTatic breast cancer', Cancer Research, 83, pp. ot1-02-01-ot1-02-01, http://dx.doi.org/10.1158/1538-7445.sabcs22-ot1-02-01

Amodio M; Youlten SE; Venkat A; San Juan BP; Chaffer CL; Krishnaswamy S, 2023, 'Single-cell multi-modal GAN reveals spatial patterns in single-cell data from triple-negative breast cancer', Patterns, http://dx.doi.org/10.1016/j.patter.2022.100577

Burkhardt DB; San Juan BP; Lock JG; Krishnaswamy S; Chaffer CL, 2022, 'Mapping Phenotypic Plasticity upon the Cancer Cell State Landscape Using Manifold Learning', Cancer Discovery, 12, pp. 1847 - 1859, http://dx.doi.org/10.1158/2159-8290.CD-21-0282

San Juan BP; Garcia-Leon MJ; Rangel L; Goetz JG; Chaffer CL, 2019, 'The complexities of metastasis', Cancers, 11, http://dx.doi.org/10.3390/cancers11101575

Juan BPS; Zadeh S; Ganju V; Vargas C; O'Toole S; Lim E; Davis M; Chaffer C, 2019, 'Unravelling the role of cell plasticity in BrCa development and metastasis', Oncology Abstracts, http://dx.doi.org/10.1530/oncolabs.1.p040

Chaffer CL; Goetz JG, 2018, 'CD44 Orchestrates Metastatic Teamwork', Developmental Cell, 47, pp. 691 - 693, http://dx.doi.org/10.1016/j.devcel.2018.11.038

Castaño Z; San Juan BP; Spiegel A; Pant A; DeCristo MJ; Laszewski T; Ubellacker JM; Janssen SR; Dongre A; Reinhardt F; Henderson A; del Rio AG; Gifford AM; Herbert ZT; Hutchinson JN; Weinberg RA; Chaffer CL; McAllister SS, 2018, 'IL-1β inflammatory response driven by primary breast cancer prevents metastasis-initiating cell colonization', Nature Cell Biology, 20, pp. 1084 - 1097, http://dx.doi.org/10.1038/s41556-018-0173-5

Li J; Choi PS; Chaffer CL; Labella K; Hwang JH; Giacomelli AO; Kim JW; Ilic N; Doench JG; Ly SH; Dai C; Hagel K; Hong AL; Gjoerup O; Goel S; Ge JY; Root DE; Zhao JJ; Brooks AN; Weinberg RA; Hahn WC, 2018, 'An alternative splicing switch in FLNB promotes the mesenchymal cell state in human breast cancer', Elife, 7, http://dx.doi.org/10.7554/eLife.37184

van Dijk D; Sharma R; Nainys J; Yim K; Kathail P; Carr AJ; Burdziak C; Moon KR; Chaffer CL; Pattabiraman D; Bierie B; Mazutis L; Wolf G; Krishnaswamy S; Pe'er D, 2018, 'Recovering Gene Interactions from Single-Cell Data Using Data Diffusion', Cell, 174, pp. 716 - 729.e27, http://dx.doi.org/10.1016/j.cell.2018.05.061

Bierie B; Pierce SE; Kroeger C; Stover DG; Pattabiraman DR; Thiru P; Donaher JL; Reinhardt F; Chaffer CL; Keckesova Z; Weinberg RA, 2017, 'Integrin-β4 identifies cancer stem cell-enriched populations of partially mesenchymal carcinoma cells', Proceedings of the National Academy of Sciences of the United States of America, 114, pp. E2337 - E2346, http://dx.doi.org/10.1073/pnas.1618298114

Chaffer CL; San Juan BP; Lim E; Weinberg RA, 2016, 'EMT, cell plasticity and metastasis', Cancer and Metastasis Reviews, 35, pp. 645 - 654, http://dx.doi.org/10.1007/s10555-016-9648-7

Katajisto P; Döhla J; Chaffer CL; Pentinmikko N; Marjanovic N; Iqbal S; Zoncu R; Chen W; Weinberg RA; Sabatini DM, 2015, 'Asymmetric apportioning of aged mitochondria between daughter cells is required for stemness', Science, 348, pp. 340 - 343, http://dx.doi.org/10.1126/science.1260384

Chaffer CL; Weinberg RA, 2015, 'How does multistep tumorigenesis really proceed?', Cancer Discovery, 5, pp. 22 - 24, http://dx.doi.org/10.1158/2159-8290.CD-14-0788

Marjanovic ND; Weinberg RA; Chaffer CL, 2013, 'Poised with purpose: Cell plasticity enhances tumorigenicity', Cell Cycle, 12, pp. 2713 - 2714, http://dx.doi.org/10.4161/cc.26075

Chaffer CL; Marjanovic ND; Lee T; Bell G; Kleer CG; Reinhardt F; D'Alessio AC; Young RA; Weinberg RA, 2013, 'XPoised chromatin at the ZEB1 promoter enables breast cancer cell plasticity and enhances tumorigenicity', Cell, 154, pp. 61, http://dx.doi.org/10.1016/j.cell.2013.06.005

Marjanovic ND; Weinberg RA; Chaffer CL, 2013, 'Cell plasticity and heterogeneity in cancer', Clinical Chemistry, 59, pp. 168 - 179, http://dx.doi.org/10.1373/clinchem.2012.184655

Scheel C; Eaton EN; Li SHJ; Chaffer CL; Reinhardt F; Kah KJ; Bell G; Guo W; Rubin J; Richardson AL; Weinberg RA, 2011, 'Paracrine and autocrine signals induce and maintain mesenchymal and stem cell states in the breast', Cell, 145, pp. 926 - 940, http://dx.doi.org/10.1016/j.cell.2011.04.029

Chaffer CL; Brueckmann I; Scheel C; Kaestli AJ; Wiggins PA; Rodrigues LO; Brooks M; Reinhardt F; Suc Y; Polyak K; Arendt LM; Kuperwasser C; Bierie B; Weinberg RA, 2011, 'Normal and neoplastic nonstem cells can spontaneously convert to a stem-like state', Proceedings of the National Academy of Sciences of the United States of America, 108, pp. 7950 - 7955, http://dx.doi.org/10.1073/pnas.1102454108

Chaffer CL; Weinberg RA, 2011, 'A perspective on cancer cell metastasis', Science, 331, pp. 1559 - 1564, http://dx.doi.org/10.1126/science.1203543

Chaffer CL; Weinberg RA, 2010, 'Cancer cell of origin: Spotlight on luminal progenitors', Cell Stem Cell, 7, pp. 271 - 272, http://dx.doi.org/10.1016/j.stem.2010.08.008

Tilkorn DJ; Lokmic Z; Chaffer CL; Mitchell GM; Morrison WA; Thompson EW, 2010, 'Disparate companions: Tissue engineering meets cancer research', Cells Tissues Organs, 192, pp. 141 - 157, http://dx.doi.org/10.1159/000308892

Gupta PB; Chaffer CL; Weinberg RA, 2009, 'Cancer stem cells: Mirage or reality?', Nature Medicine, 15, pp. 1010 - 1012, http://dx.doi.org/10.1038/nm0909-1010

Chaffer CL; Dopheide B; Savagner P; Thompson EW; Williams ED, 2007, 'Aberrant fibroblast growth factor receptor signaling in bladder and other cancers', Differentiation, 75, pp. 831 - 842, http://dx.doi.org/10.1111/j.1432-0436.2007.00210.x

Chaffer CL; Brennan JP; Slavin JL; Blick T; Thompson EW; Williams ED, 2006, 'Mesenchymal-to-epithelial transition facilitates bladder cancer metastasis: Role of fibroblast growth factor receptor-2', Cancer Research, 66, pp. 11271 - 11278, http://dx.doi.org/10.1158/0008-5472.CAN-06-2044

Chaffer CL; Thomas DM; Thompson EW; Williams ED, 2006, 'PPARγ-independent induction of growth arrest and apoptosis in prostate and bladder carcinoma', BMC Cancer, 6, http://dx.doi.org/10.1186/1471-2407-6-53

Chaffer CL; Dopheide B; McCulloch DR; Lee AB; Moseley JM; Thompson EW; Williams ED, 2005, 'Upregulated MT1-MMP/TIMP-2 axis in the TSU-Pr1-B1/B2 model of metastatic progression in transitional cell carcinoma of the bladder', Clinical and Experimental Metastasis, 22, pp. 115 - 125, http://dx.doi.org/10.1007/s10585-005-5141-3

Chaffer CL, 2002, 'The Feeding Response to Melanin-Concentrating Hormone Is Attenuated by Antagonism of the NPY Y1-Receptor in the Rat', Endocrinology, 143, pp. 191 - 197, http://dx.doi.org/10.1210/en.143.1.191

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