By Associate Professor Emma Sierecki

Journal articles

Sierecki E; Giles N; Bowden Q; Polinkovsky ME; Steinbeck J; Arrioti N; Rahman D; Bhumkar A; Nicovich PR; Ross I; Parton RG; Böcking T; Gambin Y; Ariotti N, 2016, 'Nanomolar oligomerization and selective co-aggregation of α-synuclein pathogenic mutants revealed by single-molecule fluorescence', Scientific Reports, 6, pp. 37630, http://dx.doi.org/10.1038/srep37630

Gambin Y; Polinkovsky M; Francois B; Giles N; Bhumkar A; Sierecki E, 2016, 'Confocal Spectroscopy to Study Dimerization, Oligomerization and Aggregation of Proteins: A Practical Guide', International journal of molecular sciences, 17, http://dx.doi.org/10.3390/ijms17050655

Hussein WM; Choi PM; Zhang C; Su M; Sierecki E; Johnston W; Fagan V; Alexandrov K; Skwarczynski M; Gambin Y; Toth I; Simerska P, 2016, 'Evaluation of lipopeptides as toll-like receptor 2 ligands', Current Drug Delivery, 13, http://dx.doi.org/10.2174/1567201813666160804114107

Chai YJ; Sierecki E; Tomatis VM; Gormal RS; Giles N; Morrow IC; Xia D; Götz J; Parton RG; Collins BM; Gambin Y; Meunier FA, 2016, 'Munc18-1 is a molecular chaperone for α-synuclein, controlling its self-replicating aggregation', Journal of Cell Biology, 214, http://dx.doi.org/10.1083/jcb.201512016

Martin S; Papadopulos A; Tomatis VM; Sierecki E; Malintan NT; Gormal RS; Giles N; Johnston WA; Alexandrov K; Gambin Y; Collins BM; Meunier FA, 2014, 'Increased polyubiquitination and proteasomal degradation of a Munc18-1 disease-linked mutant causes temperature-sensitive defect in exocytosis', Cell Reports, 9, pp. 206 - 218, http://dx.doi.org/10.1016/j.celrep.2014.08.059

Reyes G; Niederst M; Cohen-Katsenelson K; Stender JD; Kunkel MT; Chen M; Brognard J; Sierecki E; Gao T; Nowak DG; Trotman LC; Glass CK; Newton AC, 2014, 'Pleckstrin homology domain leucine-rich repeat protein phosphatases set the amplitude of receptor tyrosine kinase output', Proceedings of the National Academy of Sciences of the United States of America, 111, pp. E3957 - E3965, http://dx.doi.org/10.1073/pnas.1404221111

Sierecki E; Stevers LM; Giles N; Polinkovsky ME; Moustaqil M; Mureev S; Johnston WA; Dahmer-Heath M; Skalamera D; Gonda TJ; Gabrielli B; Collins BM; Alexandrov K; Gambin Y, 2014, 'Rapid mapping of interactions between human SNX-BAR proteins measured in vitro by alphascreen and single-molecule spectroscopy', Molecular and Cellular Proteomics, 13, pp. 2233 - 2245, http://dx.doi.org/10.1074/mcp.M113.037275

Sierecki E; Newton AC, 2014, 'Biochemical characterization of the phosphatase domain of the tumor suppressor PH domain leucine-rich repeat protein phosphatase', Biochemistry, 53, pp. 3971 - 3981, http://dx.doi.org/10.1021/bi500428j

Wang P; Zhou Z; Hu A; Pontede Albuquerque C; Zhou Y; Hong L; Sierecki E; Ajiro M; Kruhlak M; Harris C; Guan KL; Zheng ZM; Newton AC; Sun P; Zhou H; Fu XD, 2014, 'Both decreased and increased SRPK1 levels promote cancer by interfering with PHLPP-mediated dephosphorylation of Akt', Molecular Cell, 54, pp. 378 - 391, http://dx.doi.org/10.1016/j.molcel.2014.03.007

Han SP; Gambin Y; Gomez GA; Verma S; Giles N; Michael M; Wu SK; Guo Z; Johnston W; Sierecki E; Parton RG; Alexandrov K; Yap AS, 2014, 'Cortactin scaffolds Arp2/3 and WAVE2 at the epithelial zonula adherens', Journal of Biological Chemistry, 289, pp. 7764 - 7775, http://dx.doi.org/10.1074/jbc.M113.544478

Gambin Y; Ariotti N; McMahon KA; Bastiani M; Sierecki E; Kovtun O; Polinkovsky ME; Magenau A; Jung WR; Okano S; Zhou Y; Leneva N; Mureev S; Johnston W; Gaus K; Hancock JF; Collins BM; Alexandrov K; Parton RG, 2014, 'Single-molecule analysis reveals self assembly and nanoscale segregation of two distinct cavin subcomplexes on caveolae', eLife, 2014, pp. e01434, http://dx.doi.org/10.7554/eLife.01434.001

Brooks AJ; Dai W; O'Mara ML; Abankwa D; Chhabra Y; Pelekanos RA; Gardon O; Tunny KA; Blucher KM; Morton CJ; Parker MW; Sierecki E; Gambin Y; Gomez GA; Alexandrov K; Wilson IA; Doxastakis M; Mark AE; Waters MJ, 2014, 'Mechanism of activation of protein kinase JAK2 by the growth hormone receptor', Science, 344, http://dx.doi.org/10.1126/science.1249783

Gambin Y; Ariotti N; McMahon KA; Bastiani M; Sierecki E; Kovtun O; Polinkovsky ME; Magenau A; Jung W; Okano S; Zhou Y; Leneva N; Mureev S; Johnston W; Gaus K; Hancock JF; Collins BM; Alexandrov K; Parton RG, 2014, 'Single-molecule analysis reveals self assembly and nanoscale segregation of two distinct cavin subcomplexes on caveolae', eLife, 3, pp. e01434, http://dx.doi.org/10.7554/eLife.01434

Gambin Y; Sierecki E; Polinkovsky M; Alexandrov K; Parton R, 2014, 'Single molecule analysis reveals self assembly and nanoscale segregation of two distinct cavin subcomplexes on caveolae (602.1)', The FASEB Journal, 28, http://dx.doi.org/10.1096/fasebj.28.1_supplement.602.1

Sierecki E; Giles N; Polinkovsky M; Moustaqil M; Alexandrov K; Gambin Y, 2013, 'A cell-free approach to accelerate the study of protein-protein interactions in vitro', Interface Focus, 3, http://dx.doi.org/10.1098/rsfs.2013.0018

Sinko W; Sierecki E; De Oliveira CAF; McCammon JA, 2012, 'Guide to virtual screening: Application to the akt phosphatase PHLPP', Methods in Molecular Biology, 819, pp. 561 - 573, http://dx.doi.org/10.1007/978-1-61779-465-0_33

Sierecki E; Errasti G; Martens T; Royer J, 2010, 'Diastereoselective α-allylation of secondary amines', Tetrahedron, 66, pp. 10002 - 10007, http://dx.doi.org/10.1016/j.tet.2010.10.031

Sierecki E; Sinko W; McCammon JA; Newton AC, 2010, 'Discovery of small molecule inhibitors of the ph domain leucine-rich repeat protein phosphatase (PHLPP) by chemical and virtual screening', Journal of Medicinal Chemistry, 53, pp. 6899 - 6911, http://dx.doi.org/10.1021/jm100331d

Gambin Y; Reffay M; Sierecki E; Homblé F; Hodges RS; Gov NS; Taulier N; Urbach W, 2010, 'Variation of the lateral mobility of transmembrane peptides with hydrophobic mismatch', Journal of Physical Chemistry B, 114, pp. 3559 - 3566, http://dx.doi.org/10.1021/jp911354y

Sierecki E; Newton AC, 2009, 'Modulation of PHLPP activity: screening for specific inhibitors', The FASEB Journal, 23, http://dx.doi.org/10.1096/fasebj.23.1_supplement.lb289

Turcaud S; Sierecki E; Martens T; Royer J, 2007, 'Asymmetric α‐Alkynylation of Piperidine via N‐Sulfinyliminium Salts.', ChemInform, 38, http://dx.doi.org/10.1002/chin.200749155

Turcaud S; Sierecki E; Martens T; Royer J, 2007, 'Asymmetric α-alkynylation of piperidine via N-sulfinyliminium salts', Journal of Organic Chemistry, 72, pp. 4882 - 4885, http://dx.doi.org/10.1021/jo070631c

Brognard J; Sierecki E; Gao T; Newton AC, 2007, 'PHLPP and a Second Isoform, PHLPP2, Differentially Attenuate the Amplitude of Akt Signaling by Regulating Distinct Akt Isoforms', Molecular Cell, 25, pp. 917 - 931, http://dx.doi.org/10.1016/j.molcel.2007.02.017

Sierecki E; Turcaud S; Martens T; Royer J, 2006, 'Phosphorus-derived chiral auxiliaries for α-alkylation of secondary amines by anodic oxidation', Synthesis, pp. 3199 - 3208, http://dx.doi.org/10.1055/s-2006-950226

Gambin Y; Lopez-Esparza R; Reffay M; Sierecki E; Gov NS; Genest M; Hodges RS; Urbach W, 2006, 'Lateral mobility of proteins in liquid membranes revisited', Proceedings of the National Academy of Sciences of the United States of America, 103, pp. 2098 - 2102, http://dx.doi.org/10.1073/pnas.0511026103

Turcaud S; Martens T; Sierecki E; Perard‐Viret J; Royer J, 2005, 'Anodic Oxidation of Chiral Sulfinylamines: A New Route to Highly Diastereoselective α‐Alkylation of Piperidine.', ChemInform, 36, http://dx.doi.org/10.1002/chin.200547134

Turcaud S; Martens T; Sierecki E; Pérard-Viret J; Royer J, 2005, 'Anodic oxidation of chiral sulfinylamines: A new route to highly diastereoselective α-alkylation of piperidine', Tetrahedron Letters, 46, pp. 5131 - 5134, http://dx.doi.org/10.1016/j.tetlet.2005.05.123

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