By Associate Professor Emma Sierecki

Preprints

O’Carroll A; Chauvin B; Brown J; Meagher A; Coyle J; Hunter D; Bhumkhar A; Ve T; Kobe B; Sierecki E; Gambin Y, 2018, Effects of Pathological Mutations on the Prion-Like Polymerisation of MyD88, http://dx.doi.org/10.1101/351726

Pham C; Strange M; O’ Carroll A; Shanmugam N; Sierecki E; Gambin Y; Steain M; Sunde M, 2018, The RHIM within the M45 protein from murine cytomegalovirus forms heteromeric amyloid fibrils with RIPK1 and RIPK3, http://dx.doi.org/10.1101/324590

McCann A; Lou J; Moustaqil M; Blum A; Fontaine F; Liu H; Luu W; Koopman P; Sierecki E; Gambin Y; Meunier FA; Liu Z; Hinde E; Francois M, A dominant-negative SOX18 mutant disrupts multiple regulatory layers essential to transcription factor activity, http://dx.doi.org/10.1101/2020.11.11.378968

Tillu V; Hunter D; Chen K-E; Smith J; Nassar O; Rae J; Sierecki E; Kobe B; Collins BM; Gambin Y; Parton RG; Ariotti N, An efficient eukaryotic cell-free expression and correlative cryo-electron tomography platform for structural biology of macromolecular complexes, http://dx.doi.org/10.1101/2025.10.18.683253

McMahon K-A; Stroud DA; Gambin Y; Tillu VA; Bastiani M; Sierecki E; Polinkovsky M; Hall TE; Gomez GA; Wu Y; Parat M-O; Martel N; Lo HP; Khanna KK; Alexandrov K; Daly R; Yap AS; Ryan MT; Parton RG, Cavin3 released from caveolae interacts with BRCA1 to regulate the cellular stress response, http://dx.doi.org/10.1101/2020.07.26.222158

Meyer B; Chiaravalli J; Gellenoncourt S; Brownridge P; Bryne DP; Daly LA; Grauslys A; Walter M; Agou F; Chakrabarti LA; Craik CS; Eyers CE; Eyers PA; Gambin Y; Jones AR; Sierecki E; Verdin E; Vignuzzi M; Emmott E, Characterisation of protease activity during SARS-CoV-2 infection identifies novel viral cleavage sites and cellular targets with therapeutic potential, http://dx.doi.org/10.1101/2020.09.16.297945

Akefe IO; Matthews B; Saber SH; Venkatesh BG; Gormal RS; Blackmore DG; Sieriecki E; Gambin Y; Bertran-Gonzalez J; Michaels AA; Xue M; Cravatt B; Joensuu M; Wallis TP; Meunier FA, DDHD2 interacts with STXBP1 to mediate long-term memory via the generation of myristic acid, http://dx.doi.org/10.1101/2023.05.11.540316

Uckelmann M; Levina V; Taveneau C; Ng XH; Pandey V; Martinez J; Mendiratta S; Houx J; Boudes M; Venugopal H; Trépout S; Zhang Q; Flanigan S; Li M; Sierecki E; Gambin Y; Das PP; Bell O; de Marco A; Davidovich C, Dynamic PRC1-CBX8 stabilizes a porous structure of chromatin condensates, http://dx.doi.org/10.1101/2023.05.08.539931

Dickson CF; Hertel S; Ruan J; Ariotti N; Tuckwell A; Li N; Al-Izzi SC; Sierecki E; Gambin Y; Morris RG; Towers GJ; Böcking T; Jacques DA, Karyopherin mimicry explains how the HIV capsid penetrates nuclear pores, http://dx.doi.org/10.1101/2023.03.23.534032

Houx J; Copie T; Gambin Y; Sierecki E, Quantification of nanocondensates formation at the single molecule level, http://dx.doi.org/10.1101/2024.05.05.592604

Lau D; Walsh JC; Dickson CF; Tuckwell A; Stear JH; Hunter DJB; Bhumkar A; Shah V; Turville SG; Sierecki E; Gambin Y; Böcking T; Jacques DA, Rapid HIV-1 capsid interaction screening using fluorescence fluctuation spectroscopy, http://dx.doi.org/10.1101/2020.11.13.382242

Moustaqil M; Ollivier E; Chiu H-P; Van Tol S; Rudolffi-Soto P; Stevens C; Bhumkar A; Hunter DJB; Freiberg A; Jacques D; Lee B; Sierecki E; Gambin Y, SARS-CoV-2 proteases cleave IRF3 and critical modulators of inflammatory pathways (NLRP12 and TAB1): implications for disease presentation across species and the search for reservoir hosts, http://dx.doi.org/10.1101/2020.06.05.135699

Leitão ADG; Soto PR; Chappard A; Bhumkar A; Hunter DJB; Sierecki E; Gambin Y, Selectivity of Protein Interactions along the Aggregation Pathway of α-Synuclein, http://dx.doi.org/10.1101/2021.01.29.428744

Lau D; Magnan C; Hill K; Cooper A; Gambin Y; Sierecki E, Single molecule fingerprinting reveals different amplification properties of α-synuclein oligomers and preformed fibrils in seeding assay, http://dx.doi.org/10.1101/2021.08.09.455607

Lau D; Tang Y; Kenche V; Copie T; Kempe D; Jary E; Graves NJ; Biro M; Masters CL; Dzamko N; Gambin Y; Sierecki E, Single molecule fingerprinting reveals different growth mechanisms in seed amplification assays for different polymorphs of αSynuclein fibrils, http://dx.doi.org/10.1101/2024.03.05.583619

He C; Varghese NR; Keeler EG; Pham CLL; Williams B; Tetter S; Semaan C; Wilde KL; Brown SHJ; Bouwer JC; Gambin Y; Sierecki E; Steain M; Sunde M; McDermott AE, Structural Studies of an Anti-necroptosis Viral:Human Functional Hetero-amyloid M45:RIPK3 using SSNMR, http://dx.doi.org/10.1101/2025.03.26.644761

Chiang IK-N; Luu W; Jiang K; Kirschnick N; Moustaqil M; Davidson T; Lesieur E; Skoczylas R; Kouskoff V; Kazenwadel J; Arriola-Martinez L; Sierecki E; Gambin Y; Alitalo K; Kiefer F; Harvey NL; Francois M, The blood vasculature instructs lymphatics patterning in a SOX7 dependent manner, http://dx.doi.org/10.1101/2021.07.02.450967

Pang SS; Bayly-Jones C; Radjainia M; Spicer BA; Law RHP; Hodel AW; Ekkel SM; Conroy PJ; Ramm G; Venugopal H; Bird PI; Hoogenboom BW; Voskoboinik I; Gambin Y; Sierecki E; Dunstone MA; Whisstock JC, The structure of Macrophage Expressed Gene-1, a phagolysosome immune effector that is activated upon acidification, http://dx.doi.org/10.1101/580712

Steain M; Baker MODG; Pham CLL; Gambin Y; Sierecki E; McSharry BP; Avdic S; Slobedman B; Sunde M; Abendroth A, Varicella zoster virus encodes a viral decoy RHIM to inhibit cell death, http://dx.doi.org/10.1101/2020.03.12.988659

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