By Associate Professor Emma Sierecki

Conference Papers

Sinko W; Sierecki E; Newton AC; McCammon JA, 2012, 'Virtual and chemical screening leads to the discovery of small molecule inhibitors of the Akt phosphatase PHLPP', in ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, AMER CHEMICAL SOC, CA, San Diego, presented at 11th International Biorelated Polymer Symposium / 243rd National Spring Meeting of the American-Chemical-Society (ACS), CA, San Diego, 25 March 2012 - 29 March 2012

Sierecki E; Sinko W; Mc Cammon JA; Newton AC, 2010, 'Small molecule inhibitors of PHLPP determined by chemical and virtual screening', in FASEB JOURNAL, FEDERATION AMER SOC EXP BIOL, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000208675506488&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Gambin Y; Reffay M; Sierecki E; Homble F; Genest M; Hodges RS; Gov N; Taulier N; Urbach W, 2010, 'Modulation of the Lateral Mobility of Transmembrane Peptides with Hydrophobic Mismatch', in BIOPHYSICAL JOURNAL, CELL PRESS, pp. 224A - 225A, http://dx.doi.org/10.1016/j.bpj.2009.12.1215

Sierecki E; Newton AC, 2008, 'Biochemical characterization of the PP2C domain of PHLPP', in FASEB JOURNAL, FEDERATION AMER SOC EXP BIOL, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000208467808801&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Brognard J; Sierecki E; Gao T; Newton AC, 2007, 'Akt signaling is differentially terminated by the phosphatase PHLPP and a new isoform, PHLPP2', in FASEB JOURNAL, FEDERATION AMER SOC EXP BIOL, DC, Washington, pp. A619 - A619, presented at Experimental Biology 2007 Annual Meeting, DC, Washington, 28 April 2007 - 02 May 2007, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000245708505109&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

, 2005, 'Lateral mobility in membranes revisited: a simpler law from lipids to large proteins', in EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS, SPRINGER, pp. 611 - 611, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000231659200305&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Abstracts

Sunde M; Pham CLL; Shanmugam N; Baker MODG; Steain M; O'Carroll A; Brown JW; Sierecki E; Gambin Y, 2020, 'Competing Interactions between Viral RHIM Amyloid-forming Proteins and Host Functional Amyloid Structures Modulate the Cellular Response to Infection', in Biophysical Journal, Elsevier, CA, San Diego, Vol. 118, pp. 180a - 181a, presented at 64th Annual Meeting of the Biophysical-Society, CA, San Diego, 15 February 2020 - 19 February 2020, http://dx.doi.org/10.1016/j.bpj.2019.11.1103

Gambin Y; Monserrat-Martinez A; Sierecki E, 2019, 'ENTEROPATHOGENIC E. COLI HIJACKS PROGRAMMED HOST-CELL DEATH PATHWAYS BY INTERFERING WITH THE HIGHER ORDER OLIGOMERIZATION OF IMMUNE SYSTEM PROTEINS', in PROTEIN SCIENCE, WILEY, WA, Seattle, Vol. 28, pp. 131 - 132, presented at 33rd Annual Symposium of the Protein-Society, WA, Seattle, 30 June 2019 - 03 July 2019, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000488134600233&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Sierecki E; Leitao A; Brown J; Chappard A; Gambin Y, 2019, 'MODULATION OF INTERACTOME BY PROTEIN SELF-ASSEMBLY: THE CASE OF ALPHA-SYNUCLEIN', in PROTEIN SCIENCE, WILEY, WA, Seattle, Vol. 28, pp. 132 - 132, presented at 33rd Annual Symposium of the Protein-Society, WA, Seattle, 30 June 2019 - 03 July 2019, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000488134600234&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Sierecki E; Brown J; Leitao A; Chappard A; Gambin Y, 2018, 'The Shifting Interactome of Alpha-Synuclein along its Aggregation Pathway', in PROTEIN SCIENCE, WILEY, MA, Boston, Vol. 27, pp. 73 - 73, presented at 32nd Annual Symposium of the Protein-Society, MA, Boston, 09 July 2018 - 12 July 2018, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000450682700119&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

O'Carroll A; Ve T; Moustaqil M; Giles N; Bhumkar A; Hunter D; Kobe B; Sierecki E; Gambin Y, 2017, 'Prion - like protein polymerisation underlies signal transduction in innate immunity: The emergence of a universal mechanism ?', in FASEB JOURNAL, WILEY, IL, Chicago, Vol. 31, presented at Experimental Biology (EB) Annual Meeting, IL, Chicago, 22 April 2017 - 26 April 2017, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000405461402427&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Patents

Gambin Y; Bauer A; Sierecki E; Gaus K, 2024, A confocal microscopy apparatus, Patent No. Australia - 2019230452;

Gambin Y; Gaus K; Sierecki E; Bauer A, 2024, Confocal microscope, Patent No. United States - 11960069;

Preprints

Tillu V; Hunter D; Chen K-E; Smith J; Rae J; Sierecki E; Kobe B; Collins BM; Parton RG; Gambin Y; Ariotti N, 2025, An efficient eukaryotic cell-free expression and correlative cryo-electron tomography platform for structural biology of macromolecular complexes, http://dx.doi.org/10.1101/2025.10.18.683253

He C; Varghese N; Keeler E; Pham C; Williams B; Tetter S; Semaan C; Wilde K; Brown S; Bouwer J; Gambin Y; Sierecki E; Steain M; Sunde M; McDermott A, 2025, Structural Studies of an Anti-necroptosis Viral:Human Functional Hetero-amyloid M45:RIPK3 using SSNMR, http://dx.doi.org/10.1101/2025.03.26.644761

Uckelmann M; Levina V; Taveneau C; Ng XH; Pandey V; Martinez J; Mendiratta S; Houx J; Boudes M; Venugopal H; Trépout S; Zhang Q; Flanigan S; Li M; Sierecki E; Gambin Y; Das PP; Bell O; de Marco A; Davidovich C, 2024, Dynamic PRC1-CBX8 stabilizes a porous structure of chromatin condensates., http://dx.doi.org/10.1101/2023.05.08.539931

Lau D; Tang Y; Kenche V; Copie T; Kempe D; Jary E; Graves NJ; Biro M; Masters CL; Dzamko N; Gambin Y; Sierecki E, 2024, Single molecule fingerprinting reveals different growth mechanisms in seed amplification assays for different polymorphs of αSynuclein fibrils, http://dx.doi.org/10.1101/2024.03.05.583619

Houx J; Copie T; Gambin Y; Sierecki E, 2024, Quantification of nanocondensates formation at the single molecule level, http://dx.doi.org/10.1101/2024.05.05.592604

Dickson CF; Hertel S; Ruan J; Ariotti N; Tuckwell A; Li N; Al-Izzi SC; Sierecki E; Gambin Y; Morris RG; Towers GJ; Böcking T; Jacques DA, 2023, Karyopherin mimicry explains how the HIV capsid penetrates nuclear pores, http://dx.doi.org/10.1101/2023.03.23.534032

Leitão A; Soto PR; Chappard A; Bhumkar A; Hunter D; Sierecki E; Gambin Y, 2021, Selectivity of Protein Interactions along the Aggregation Pathway of α-Synuclein, http://dx.doi.org/10.1101/2021.01.29.428744

Lau D; Magnan C; Hill K; Cooper A; Gambin Y; Sierecki E, 2021, Single molecule fingerprinting reveals different amplification properties of α-synuclein oligomers and preformed fibrils in seeding assay, http://dx.doi.org/10.1101/2021.08.09.455607

Chiang IK-N; Luu W; Jiang K; Kirschnick N; Moustaqil M; Davidson T; Lesieur E; Skoczylas R; Kouskoff V; Kazenwadel J; Arriola-Martinez L; Sierecki E; Gambin Y; Alitalo K; Kiefer F; Harvey N; Francois M, 2021, The blood vasculature instructs lymphatics patterning in a SOX7 dependent manner, http://dx.doi.org/10.1101/2021.07.02.450967

McCann A; Lou J; Moustaqil M; Blum A; Fontaine F; Liu H; Luu W; Koopman P; Sierecki E; Gambin Y; Meunier F; Liu Z; Hinde E; Francois M, 2020, A dominant-negative SOX18 mutant disrupts multiple regulatory layers essential to transcription factor activity, http://dx.doi.org/10.1101/2020.11.11.378968

McMahon K-A; Stroud D; Gambin Y; Tillu V; Bastiani M; Sierecki E; Polinkovsky M; Hall T; Gomez G; Wu Y; Parat M-O; Martel N; Lo H; Khanna KK; Alexandrov K; Daly R; Yap A; Ryan M; Parton R, 2020, Cavin3 released from caveolae interacts with BRCA1 to regulate the cellular stress response, http://dx.doi.org/10.1101/2020.07.26.222158

Meyer B; Chiaravalli J; Gellenoncourt S; Brownridge P; Bryne D; Daly L; Grauslys A; Walter M; Agou F; Chakrabarti L; Chakrabarti L; Craik C; Eyers C; Eyers P; Gambin Y; Jones A; Sierecki E; Verdin E; Vignuzzi M; Emmott E, 2020, Characterisation of protease activity during SARS-CoV-2 infection identifies novel viral cleavage sites and cellular targets with therapeutic potential, http://dx.doi.org/10.1101/2020.09.16.297945

Lau D; Walsh J; Dickson C; Tuckwell A; Stear J; Hunter D; Bhumkar A; Shah V; Turville S; Sierecki E; Gambin Y; Böcking T; Jacques D, 2020, Rapid HIV-1 capsid interaction screening using fluorescence fluctuation spectroscopy, http://dx.doi.org/10.1101/2020.11.13.382242

Moustaqil M; Ollivier E; Chiu H-P; Van Tol S; Rudolffi-Soto P; Stevens C; Bhumkar A; Hunter DJB; Freiberg A; Jacques D; Lee B; Sierecki E; Gambin Y, 2020, SARS-CoV-2 proteases cleave IRF3 and critical modulators of inflammatory pathways (NLRP12 and TAB1): implications for disease presentation across species and the search for reservoir hosts, http://dx.doi.org/10.1101/2020.06.05.135699

Steain M; Baker MODG; Pham CLL; Gambin Y; Sierecki E; McSharry B; Avdic S; Slobedman B; Sunde M; Abendroth A, 2020, Varicella zoster virus encodes a viral decoy RHIM to inhibit cell death, http://dx.doi.org/10.1101/2020.03.12.988659

Pang SS; Bayly-Jones C; Radjainia M; Spicer B; Law RHP; Hodel A; Ekkel S; Conroy P; Ramm G; Venugopal H; Bird P; Hoogenboom B; Voskoboinik I; Gambin Y; Sierecki E; Dunstone M; Whisstock J, 2019, The structure of Macrophage Expressed Gene-1, a phagolysosome immune effector that is activated upon acidification, http://dx.doi.org/10.1101/580712

O’Carroll A; Chauvin B; Brown J; Meagher A; Coyle J; Hunter D; Bhumkhar A; Ve T; Kobe B; Sierecki E; Gambin Y, 2018, Effects of Pathological Mutations on the Prion-Like Polymerisation of MyD88, http://dx.doi.org/10.1101/351726

Pham C; Strange M; O’ Carroll A; Shanmugam N; Sierecki E; Gambin Y; Steain M; Sunde M, 2018, The RHIM within the M45 protein from murine cytomegalovirus forms heteromeric amyloid fibrils with RIPK1 and RIPK3, http://dx.doi.org/10.1101/324590

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