By Associate Professor Jelena Rnjak-Kovacina

Journal articles

Atienza-Roca P; Kieser DC; Cui X; Bathish B; Ramaswamy Y; Hooper GJ; Clarkson AN; Rnjak-Kovacina J; Martens PJ; Wise LM; Woodfield TBF; Lim KS, 2020, 'Visible light mediated PVA-tyramine hydrogels for covalent incorporation and tailorable release of functional growth factors', Biomaterials Science, 8, pp. 5005 - 5019, http://dx.doi.org/10.1039/d0bm00603c

Lin X; Tang F; Jiang S; Khamis H; Bongers A; Whitelock JM; Lord MS; Rnjak-Kovacina J, 2020, 'A Biomimetic Approach toward Enhancing Angiogenesis: Recombinantly Expressed Domain V of Human Perlecan Is a Bioactive Molecule That Promotes Angiogenesis and Vascularization of Implanted Biomaterials', Adv. Sci., 7, pp. 2000900, http://dx.doi.org/10.1002/advs.202000900

Tang F; Manz XD; Bongers A; Odell RA; Joukhdar H; Whitelock JM; Lord MS; Rnjak-Kovacina J, 2020, 'Microchannels are an architectural cue that promotes integration and vascularization of silk biomaterials in vivo', ACS Biomaterials Science and Engineering, 6, pp. 1476 - 1486, http://dx.doi.org/10.1021/acsbiomaterials.9b01624

Cui X; Soliman BG; Alcala-Orozco CR; Li J; Vis MAM; Santos M; Wise SG; Levato R; Malda J; Woodfield TBF; Rnjak-Kovacina J; Lim KS, 2020, 'Rapid Photocrosslinking of Silk Hydrogels with High Cell Density and Enhanced Shape Fidelity', Advanced Healthcare Materials, 9, pp. e1901667, http://dx.doi.org/10.1002/adhm.201901667

Vettori L; Sharma P; Rnjak-Kovacina J; Gentile C, 2020, '3D Bioprinting of Cardiovascular Tissues for In Vivo and In Vitro Applications Using Hybrid Hydrogels Containing Silk Fibroin: State of the Art and Challenges', Current Tissue Microenvironment Reports, 1, pp. 261 - 276, http://dx.doi.org/10.1007/s43152-020-00026-5

Chan AHP; Filipe EC; Tan RP; Santos M; Yang N; Hung J; Feng J; Nazir S; Benn AJ; Ng MKC; Rnjak-Kovacina J; Wise SG, 2019, 'Altered processing enhances the efficacy of small-diameter silk fibroin vascular grafts', Scientific Reports, 9, http://dx.doi.org/10.1038/s41598-019-53972-y

Rnjak-Kovacina J; Gerrand YW; Wray LS; Tan B; Joukhdar H; Kaplan DL; Morrison WA; Mitchell GM, 2019, 'Vascular Pedicle and Microchannels: Simple Methods Toward Effective In Vivo Vascularization of 3D Scaffolds', Advanced Healthcare Materials, 8, http://dx.doi.org/10.1002/adhm.201901106

Lim KS; Baptista M; Moon S; Woodfield TBF; Rnjak-Kovacina J, 2019, 'Microchannels in Development, Survival, and Vascularisation of Tissue Analogues for Regenerative Medicine', Trends in Biotechnology, 37, pp. 1189 - 1201, http://dx.doi.org/10.1016/j.tibtech.2019.04.004

Holland C; Numata K; Rnjak-Kovacina J; Seib FP, 2019, 'The Biomedical Use of Silk: Past, Present, Future', Advanced Healthcare Materials, 8, pp. e1800465, http://dx.doi.org/10.1002/adhm.201800465

Lord MS; Tang F; Rnjak-Kovacina J; Smith JGW; Melrose J; Whitelock JM, 2018, 'The multifaceted roles of perlecan in fibrosis', Matrix Biology, 68-69, pp. 150 - 166, http://dx.doi.org/10.1016/j.matbio.2018.02.013

Kondyurin A; Lau K; Tang F; Akhavan B; Chrzanowski W; Lord MS; Rnjak-Kovacina J; Bilek MM, 2018, 'Plasma Ion Implantation of Silk Biomaterials Enabling Direct Covalent Immobilization of Bioactive Agents for Enhanced Cellular Responses', ACS Applied Materials and Interfaces, 10, pp. 17605 - 17616, http://dx.doi.org/10.1021/acsami.8b03182

Lord M; Rnjak-Kovacina J; Tang F; Whitelock J, 2018, 'Glycosaminoglycan and Proteoglycan-Based Biomaterials: Current Trends and Future Perspectives', Advanced Healthcare Materials, 7, pp. 1701042 - 1701042, http://dx.doi.org/10.1002/adhm.201701042

Tan RP; Chan AHP; Lennartsson K; Miravet MM; Lee BSL; Rnjak-Kovacina J; Clayton ZE; Cooke JP; Ng MKC; Patel S; Wise SG, 2018, 'Integration of induced pluripotent stem cell-derived endothelial cells with polycaprolactone/gelatin-based electrospun scaffolds for enhanced therapeutic angiogenesis', Stem Cell Research and Therapy, 9, http://dx.doi.org/10.1186/s13287-018-0824-2

Filipe EC; Santos M; Hung J; Lee BSL; Yang N; Chan AHP; Ng MKC; Rnjak-Kovacina J; Wise SG, 2018, 'Rapid Endothelialization of Off-the-Shelf Small Diameter Silk Vascular Grafts', JACC: Basic to Translational Science, 3, pp. 38 - 53, http://dx.doi.org/10.1016/j.jacbts.2017.12.003

Rnjak-Kovacina J; Tang F; Lin X; Whitelock JM; Lord MS, 2017, 'Recombinant Domain V of Human Perlecan Is a Bioactive Vascular Proteoglycan', Biotechnology Journal, 12, http://dx.doi.org/10.1002/biot.201700196

Rnjak-Kovacina J; Tang F; Whitelock JM; Lord MS, 2016, 'Silk biomaterials functionalized with recombinant domain V of human perlecan modulate endothelial cell and platelet interactions for vascular applications', Colloids and Surfaces B: Biointerfaces, 148, pp. 130 - 138, http://dx.doi.org/10.1016/j.colsurfb.2016.08.039

Lord MS; Cheng B; Tang F; Lyons JG; Rnjak-Kovacina J; Whitelock JM, 2016, 'Bioengineered human heparin with anticoagulant activity', Metabolic Engineering, 38, pp. 105 - 114, http://dx.doi.org/10.1016/j.ymben.2016.07.006

Roberts JJ; Farrugia BL; Green RA; Rnjak-Kovacina J; Martens PJ, 2016, 'In situ formation of poly(vinyl alcohol)–heparin hydrogels for mild encapsulation and prolonged release of basic fibroblast growth factor and vascular endothelial growth factor', Journal of Tissue Engineering, 7, http://dx.doi.org/10.1177/2041731416677132

Ghezzi CE; Wang L; Behlau I; Rnjak-Kovacina J; Wang S; Goldstein MH; Liu J; Marchant JK; Rosenblatt MI; Kaplan DL, 2016, 'Degradation of silk films in multipocket corneal stromal rabbit models', Journal of Applied Biomaterials and Functional Materials, 14, pp. e266 - e276, http://dx.doi.org/10.5301/jabfm.5000274

Lord M; Chuang C; Rnjak‐Kovacina J; Cheng B; Lyons G; Whitelock J, 2016, 'Bioengineering Proteoglycan‐based Matrices For Blood Contacting Applications', The FASEB Journal, 30, http://dx.doi.org/10.1096/fasebj.30.1_supplement.622.2

Filipe E; Santos M; Hung J; Rnjak-Kovacina J; Ng M; Wise S, 2016, 'Bioengineering Synthetic Silk Conduits for Arterial Revascularisation', Heart, Lung and Circulation, 25, pp. S32 - S32, http://dx.doi.org/10.1016/j.hlc.2016.06.072

Rnjak-Kovacina J; Wray LS; Burke KA; Torregrosa T; Golinski JM; Huang W; Kaplan DL, 2015, 'Lyophilized Silk Sponges: A Versatile Biomaterial Platform for Soft Tissue Engineering', ACS Biomaterials Science and Engineering, 1, pp. 260 - 270, http://dx.doi.org/10.1021/ab500149p

Chen Y; Lin Y; Davis KM; Wang Q; Rnjak-Kovacina J; Li C; Isberg RR; Kumamoto CA; Mecsas J; Kaplan DL, 2015, 'Robust bioengineered 3D functional human intestinal epithelium', Scientific Reports, 5, http://dx.doi.org/10.1038/srep13708

Zhang W; Wray LS; Rnjak-Kovacina J; Xu L; Zou D; Wang S; Zhang M; Dong J; Li G; Kaplan DL; Jiang X, 2015, 'Vascularization of hollow channel-modified porous silk scaffolds with endothelial cells for tissue regeneration', Biomaterials, 56, pp. 68 - 77, http://dx.doi.org/10.1016/j.biomaterials.2015.03.053

Ghezzi CE; Rnjak-Kovacina J; Kaplan DL, 2015, 'Corneal Tissue Engineering: Recent Advances and Future Perspectives', Tissue Engineering - Part B: Reviews, 21, pp. 278 - 287, http://dx.doi.org/10.1089/ten.teb.2014.0397

Rnjak-Kovacina J; Desrochers TM; Burke KA; Kaplan DL, 2015, 'The effect of sterilization on silk fibroin biomaterial properties', Macromolecular Bioscience, 15, pp. 861 - 874, http://dx.doi.org/10.1002/mabi.201500013

Lord MS; Farrugia BL; Rnjak-Kovacina J; Whitelock JM, 2015, 'Current serological possibilities for the diagnosis of arthritis with special focus on proteins and proteoglycans from the extracellular matrix', Expert Review of Molecular Diagnostics, 15, pp. 77 - 95, http://dx.doi.org/10.1586/14737159.2015.979158

Partlow BP; Hanna CW; Rnjak-Kovacina J; Moreau JE; Applegate MB; Burke KA; Marelli B; Mitropoulos AN; Omenetto FG; Kaplan DL, 2014, 'Highly tunable elastomeric silk biomaterials', Advanced Functional Materials, 24, pp. 4615 - 4624, http://dx.doi.org/10.1002/adfm.201400526

Rnjak-Kovacina J; Wray LS; Golinski JM; Kaplan DL, 2014, 'Arrayed hollow channels in silk-based scaffolds provide functional outcomes for engineering critically sized tissue constructs', Advanced Functional Materials, 24, pp. 2188 - 2196, http://dx.doi.org/10.1002/adfm.201302901

Wu J; Rnjak-Kovacina J; Du Y; Funderburgh ML; Kaplan DL; Funderburgh JL, 2014, 'Corneal stromal bioequivalents secreted on patterned silk substrates', Biomaterials, 35, pp. 3744 - 3755, http://dx.doi.org/10.1016/j.biomaterials.2013.12.078

Liu H; Wise SG; Rnjak-Kovacina J; Kaplan DL; Bilek MMM; Weiss AS; Fei J; Bao S, 2014, 'Biocompatibility of silk-tropoelastin protein polymers', Biomaterials, 35, pp. 5138 - 5147, http://dx.doi.org/10.1016/j.biomaterials.2014.03.024

McNamara SL; Rnjak-Kovacina J; Schmidt DF; Lo TJ; Kaplan DL, 2014, 'Silk as a biocohesive sacrificial binder in the fabrication of hydroxyapatite load bearing scaffolds', Biomaterials, 35, pp. 6941 - 6953, http://dx.doi.org/10.1016/j.biomaterials.2014.05.013

Wise SG; Yeo GC; Hiob MA; Rnjak-Kovacina J; Kaplan DL; Ng MKC; Weiss AS, 2014, 'Tropoelastin: A versatile, bioactive assembly module', Acta Biomaterialia, 10, pp. 1532 - 1541, http://dx.doi.org/10.1016/j.actbio.2013.08.003

Liu H; Bao S; Wise SG; Weiss AS; Rnjak-Kovacina J; Kaplan DL; Bilek MMM; Fei J, 2014, 'Biocompatibility of silk-tropoelastin protein polymers', Biomaterials, http://dx.doi.org/10.1016/j.biomaterials.2014.03.024

Wu J; Funderburgh JL; Rnjak-Kovacina J; Kaplan DL; Du Y; Funderburgh ML, 2014, 'Corneal stromal bioequivalents secreted on patterned silk substrates', Biomaterials, http://dx.doi.org/10.1016/j.biomaterials.2013.12.078

McNamara SL; Rnjak-Kovacina J; Lo TJ; Kaplan DL; Schmidt DF, 2014, 'Silk as a biocohesive sacrificial binder in the fabrication of hydroxyapatite load bearing scaffolds', Biomaterials, http://dx.doi.org/10.1016/j.biomaterials.2014.05.013

Ghezzi CE; Rnjak-Kovacina J; Weiss AS; Kaplan DL, 2013, 'Multifunctional silk-tropoelastin biomaterial systems', Israel Journal of Chemistry, 53, pp. 777 - 786, http://dx.doi.org/10.1002/ijch.201300082

Reddel CJ; Cultrone D; Rnjak-Kovacina J; Weiss AS; Burgess JK, 2013, 'Tropoelastin modulates TGF-β1-induced expression of VEGF and CTGF in airway smooth muscle cells', Matrix Biology, 32, pp. 407 - 413, http://dx.doi.org/10.1016/j.matbio.2013.04.003

Shang K; Rnjak-Kovacina J; Lin Y; Hayden RS; Tao H; Kaplan DL, 2013, 'Accelerated In Vitro Degradation of Optically Clear Low beta-Sheet Silk Films by Enzyme-Mediated Pretreatment', TRANSLATIONAL VISION SCIENCE & TECHNOLOGY, 2, http://dx.doi.org/10.1167/tvst.2.3.2

Seib FP; Jones GT; Rnjak-Kovacina J; Lin Y; Kaplan DL, 2013, 'pH-Dependent Anticancer Drug Release from Silk Nanoparticles', Advanced Healthcare Materials, 2, pp. 1606 - 1611, http://dx.doi.org/10.1002/adhm.201300034

Wray LS; Rnjak-Kovacina J; Mandal BB; Schmidt DF; Gil ES; Kaplan DL, 2012, 'A silk-based scaffold platform with tunable architecture for engineering critically-sized tissue constructs', Biomaterials, 33, pp. 9214 - 9224, http://dx.doi.org/10.1016/j.biomaterials.2012.09.017

Rnjak-kovacina J; Wise SG; Li Z; Maitz PK; Young C; Wang Y; Weiss AS, 2012, 'Electrospun synthetic human elastin:collagen composite scaffolds for dermal tissue engineering', ACTA Biomaterialia, 8, pp. 3714 - 3722, http://dx.doi.org/10.1016/j.actbio.2012.06.032

Rnjak J; Annabi N; Dehghani F; Weiss AS, 2011, 'Elastin-based dermal substitutes', 24th European Conference on Biomaterials - Annual Conference of the European Society for Biomaterials

Rnjak-Kovacina J; Weiss AS, 2011, 'Increasing the pore size of electrospun scaffolds', Tissue Engineering - Part B: Reviews, 17, pp. 365 - 372, http://dx.doi.org/10.1089/ten.teb.2011.0235

Rnjak J; Wise SG; Mithieux SM; Weiss AS, 2011, 'Severe burn injuries and the role of Elastin in the design of dermal substitutes', Tissue Engineering - Part B: Reviews, 17, pp. 81 - 91, http://dx.doi.org/10.1089/ten.teb.2010.0452

Rnjak-kovacina J; Wise SG; Li Z; Maitz PK; Young C; Wang Y; Weiss A, 2011, 'Tailoring the porosity and pore size of electrospun synthetic human elastin scaffolds for dermal tissue engineering', Biomaterials, 32, pp. 6729 - 6736, http://dx.doi.org/10.1016/j.biomaterials.2011.05.065

Almine JF; Bax DV; Mithieux SM; Nivison‐Smith L; Rnjak J; Waterhouse A; Wise SG; Weiss AS, 2010, 'ChemInform Abstract: Elastin‐Based Materials', ChemInform, 41, http://dx.doi.org/10.1002/chin.201051252

Hu X; Wang X; Rnjak J; Weiss AS; Kaplan DL, 2010, 'Biomaterials derived from silk-tropoelastin protein systems', Biomaterials, 31, pp. 8121 - 8131, http://dx.doi.org/10.1016/j.biomaterials.2010.07.044

Almine JF; Bax DV; Mithieux SM; Smith LN; Rnjak J; Waterhouse A; Wise SG; Weiss AS, 2010, 'Elastin-based materials', Chemical Society Reviews, 39, pp. 3371 - 3379, http://dx.doi.org/10.1039/b919452p

Nivison-Smith L; Rnjak J; Weiss AS, 2010, 'Synthetic human elastin microfibers: Stable cross-linked tropoelastin and cell interactive constructs for tissue engineering applications', Acta Biomaterialia, 6, pp. 354 - 359, http://dx.doi.org/10.1016/j.actbio.2009.08.011

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